Human γδ-T lymphocytes express and synthesize connective tissue growth factor: Effect of IL-15 and TGF-β1 and comparison with αβ-T lymphocytes

Journal of Immunology

Volumn 170, Issue 1, 2003, Pages 153-157

  Workalemahu, Grefachew ^a,b   Foerster, Martin ^a   Kroegel, Claus ^a   Braun, Ruedi K ^a  

^a Pneumology   (Germany)

^b FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CONNECTIVE TISSUE GROWTH FACTOR; INTERLEUKIN 15; MESSENGER RNA; RECEPTOR SUBTYPE; T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR ALPHA,BETA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN; T LYMPHOCYTE RECEPTOR DELTA CHAIN; T LYMPHOCYTE RECEPTOR GAMMA CHAIN; T LYMPHOCYTE RECPETOR DELTA,GAMMA CHAIN; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ARTICLE; CELL FUNCTION; CELL SECRETION; CELL TYPE; COMPARATIVE STUDY; CONTROLLED STUDY; FIBROBLAST; FIBROGENESIS; HUMAN; HUMAN CELL; INFLAMMATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; RNA ISOLATION; RNA SYNTHESIS; SIGNAL TRANSDUCTION; T LYMPHOCYTE; WOUND HEALING;

EID: 0037221567     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.170.1.153     Document Type: Article

References (23)

1. Bradham, D. M., A. Igarashi, R. L. Potter, and G. R. Grotendorst. 1991. Connective tissue growth factor: A cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10. J. Cell Biol. 114:1285.
2. Igarashi, A., H. Okochi, D. M. Bradham, and G. R. Grotendorst. 1993. Regulation of connective tissue growth factor gene expression in human skin fibroblasts and during wound repair. Mol. Biol. Cell 4:637.
3. Grotendorst, G. R. 1997. Connective tissue growth factor: A mediator of TGF-β action on fibroblasts. Cytokine Growth Factor Rev. 8:171.
4. Frazier, K., S. Williams, D. Kothapalli, H. Klapper, and G. R. Grotendorst. 1996. Stimulation of fibroblast cell growth, matrix production, and granulation tissue formation by connective tissue growth factor. J. Invest. Dermatol. 107:404.
5. Igarashi, A., K. Nashiro, K. Kikuchi, S. Sato, H. Ihn, G. R. Grotendorst, and K. Takehara. 1995. Significant correlation between connective tissue growth factor gene expression and skin sclerosis in tissue sections from patients with systemic sclerosis. J. Invest. Dermatol. 105:280.
6. Igarashi, A., K. Nashiro, K. Kikuchi, S. Sato, H. Ihn, M. Fujimoto, G. R. Grotendorst, and K. Takehara. 1996. Connective tissue growth factor gene expression in tissue sections from localized scleroderma, keloid, and other fibrotic skin disorders. J. Invest. Dermatol. 106:729.
7. Martin, P. 1997. Wound healing: Aiming for perfect skin regeneration. Science 276:75.
8. Haas, W., P. Pereira, and S. Tonegawa. 1993. γ/δ cells. Annu. Rev. Immunol. 11:637.
9. Modlin, R. L., C. Pirmez, F. M. Hofman, V. Torigian, K. Uyemura, T. H. Rea, B. R. Bloom, and M. B. Brenner. 1989. Lymphocytes bearing antigen-specific γδ T-cell receptors accumulate in human infectious disease lesions. Nature 339:544.
10. Janis, E. M., S. H. Kaufmann, R. H. Schwartz, and D. M. Pardoll. 1989. Activation of γδ T cells in the primary immune response to Mycobacterium tuberculosis. Science 244:713.
11. Havran, W. L. 2000. A role for epithelial γδ T cells in tissue repair. Immunol. Res. 21:63.
12. Boismenu, R., L. Feng, Y. Y. Xia, J. C. Chang, and W. L. Havran. 1996. Chemokine expression by intraepithelial γδ T cells: Implications for the recruitment of inflammatory cells to damaged epithelia. J. Immunol. 157:985.
13. DiTirro, J., E. R. Rhoades, A. D. Roberts, J. M. Burke, A. Mukasa, A. M. Cooper, A. A. Frank, W. K. Born, and I. M. Orme. 1998. Disruption of the cellular inflammatory response to Listeria monocytogenes infection in mice with disruptions in targeted genes. Infect. Immun. 66:2284.
14. Ferrick, D. A., M. D. Schrenzel, T. Mulvania, B. Hsieh, W. G. Ferlin, and H. Lepper. 1995. Differential production of interferon-γ and interleukin-4 in response to Th1- and Th2-stimulating pathogens by γδ T cells in vivo. Nature 373:255.
15. Boismenu, R., and W. L. Havran. 1994. Modulation of epithelial cell growth by intraepithelial γδ T cells. Science 266:1253.
16. 7 expression on human γ-δ T-lymphocytes by IL-2 and IL-15. Am. J. Respir. Crit. Care Med. 161:A20.
17. Fahrer, A. M., Y. Konigshofer, E. M. Kerr, G. Ghandour, D. H. Mack, M. M. Davis, and Y. H. Chien. 2001. Attributes of γδ intraepithelial lymphocytes as suggested by their transcriptional profile. Proc. Natl. Acad. Sci. USA 98:10261.
18. King, D. P., D. M. Hyde, K. A. Jackson, D. M. Novosad, T. N. Ellis, L. Putney, M. Y. Stovall, L. S. Van-Winkle, B. L. Beaman, and D. A. Ferrick. 1999. Cutting edge: Protective response to pulmonary injury requires γδ T lymphocytes. J. Immunol. 162:5033.
19. Kothapalli, D., K. S. Frazier, A. Welply, P. R. Segarini, and G. R. Grotendorst. 1997. Transforming growth factor β induces anchorage-independent growth of NRK fibroblasts via a connective tissue growth factor-dependent signaling pathway. Cell Growth Differ. 8:61.
20. +, and γδ T-cells in bleomycin-induced lung fibrosis in mouse. Eur. Respir. J. 9:673.
21. Carding, S. R., S. Kyes, E. J. Jenkinson, R. Kingston, K. Bottomly, J. J. Owen, and A. C. Hayday. 1990. Developmentally regulated fetal thymic and extrathymic T-cell receptor γδ gene expression. Genes Dev. 4:1304.
22. Atabai, K., M. Ishigaki, T. Geiser, I. Ueki, M. A. Matthay, and L. B. Ware. 2002. Keratinocyte growth factor can enhance alveolar epithelial repair by nonmitogenic mechanisms. Am. J. Physiol. 283:L163.
23. Yi, E. S., M. Salgado, S. Williams, S. J. Kim, E. Masliah, S. Yin, and T. R. Ulich. 1998. Keratinocyte growth factor decreases pulmonary edema, transforming growth factor-β and platelet-derived growth factor-BB expression, and alveolar type 11 cell loss in bleomycin-induced lung injury. Inflammation 22:315.