Antigen recognition by human γδ T lymphocytes

International Archives of Allergy and Immunology

Volumn 122, Issue 1, 2000, Pages 1-7

  Kabelitz, Dieter ^a   Glatzel, Andrea ^a   Wesch, Daniela ^a  

^a UNIVERSITY OF KIEL   (Germany)

Author keywords

MHC class I related chain; MHC restriction; Phosphoantigens; T cell receptor repertoire; T cells

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; T LYMPHOCYTE RECEPTOR;

ANTIGEN RECOGNITION; HUMAN; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE SUBPOPULATION;

EID: 0034025969     PISSN: 10182438     EISSN: None     Source Type: Journal    
DOI: 10.1159/000024353     Document Type: Review

References (73)

1. Saito H, Kranz DM, Tagagaki Y, Hayday AC, Eisen HN, Tonegawa S: Complete primary structure of a heterodimeric T-cell receptor deduced from cDNA sequences. Nature 1984;309:757-762.
2. Kabelitz D, Wesch D, Hinz T: γδ T cells, their T cell receptor usage and role in human diseases. Springer Semin Immunopathol 1999;21:55-75.
3. McVay LD, Carding SR: Generation of human γδ T-cell repertoires. Crit Rev Immunol 1999;19:431-460.
4. Kabelitz D: Effector functions and control of human γδT-cell activation. Microbes Infect 1999;1:255-261.
5. Born W, Cady C, Jones-Carson J, Mukasa A, Lahn M, O'Brien R: Immunoregulatory functions of γδ T cells. Adv Immunol 1999;71:77-144.
6. Hinz T, Wesch D, Halary F, Marx S, Choudhary A, Arden B, Janssen O, Bonneville M, Kabelitz D: Identification of the complete expressed human TCR Vγ repertoire by flow cytometry. Int Immunol 1997;9:1065-1072.
7. Wesch D, Hinz T, Kabelitz D: Analysis of the TCR Vγ repertoire in healthy donors and HIV-1-infected individuals. Int Immunol 1998;10:1067-1075.
8. Parker CM, Groh V, Band H, Porcelli SA, Morita G, Fabbi M, Glass D, Strominger JL, Brenner MB: Evidence for extrathymic changes in the T-cell receptor γδ repertoire. J Exp Med 1990;171:1597-1612.
9. Boullier S, Cochet M, Poccia F, Gougeon M-L: CDR3-independent γδ Vδ1+ T cell expansion in the peripheral blood of HIV-infected persons. J Immunol 1995;154:1418-1431.
10. Dechanet J, Merville P, Lim A, Retiere C, Pilard V, Lafarge X, Michelson S, Merie C, Hallet M-M, Kourilsky P, Potaux L, Bonneville M, Moreau J-F: Implication of γδ T cells in the human immune response to cytomegalovirus. J Clin Invest 1999;103:1437-1449.
11. Porcelli S, Brenner MB, Band H: Biology of the human γδ T-cell receptor. Immunol Rev 1991;120:137-183.
12. Li H, Lebedeva MI, Llera AS, Fields BA, Brenner MB, Mariuzza RA: Structure of the Vδ domain of a human γδ T-cell antigen receptor. Nature 1998;391:502-506.
13. Rock EP, Sibbald PR, Davis MM, Chien YH: CDR3 length in antigen-specific immune rsponses. J Exp Med 1994;179:323-328.
14. Schild H, Mavaddat N, Litzenberger C, Ehrich EW, Davis MM, Bluestone JA, Matis L, Draper RK, Chien YH: The nature of major histocompatibility complex recognition by gamma delta T cells. Cell 1994;76:29-37.
15. Crowley MP, Reich Z, Mavaddat N, Altman JD, Chien Y: The recognition of the nonclassical major histocompatibility complex (MHC) class I molecule. T10, by the gamma delta T cell, G8. J Exp Med 1997;185:1223-1230.
16. +, CD8+ T lymphocytes recognize tetanus toxoid in an MHC-restricted fashion. J Exp Med 1989;169:1847-1851.
17. Pfeffer K, Schoel B, Gulle B, Kaufmann SH, Wagner H: Primary responses of human T cells to mycobacteria: A frequent set of gamma/delta T cells are stimulated by protease-resistant ligands. Eur J Immunol 1990;20:1175-1179.
18. + T cells is activated by Mycobacterium tuberculosis but not by its 65-kD heat shock protein. J Exp Med 1990;171:667-679.
19. Behr C, Dubois P: Preferential expansion of V gamma 9 V delta 2 T cells following stimulation of peripheral blood lymphocytes with extracts of Plasmodium falciparum. Int Immunol 1992;4:361-366.
20. Subauste CS, Chung JY, Do D, Koniaris AH, Hunter CA, Montoya JG, Porcelli S, Remington JS: Preferential activation and expansion of human peripheral blood γδ T cells in response to Toxoplasma gondii in vitro and their cytokine production and cytotoxic activity against T. gondii-infectcd cells. J Clin Invest 1995;96:610-619.
21. Young JL, Goodall JC, Beacock-Sharp H, Gaston JS: Human γδ T-cell recognition of Yersinia enterocolitica. Immunology 1997;91:503-510.
22. Poquet Y, Kroca M, Halary F, Stenmark S, Peyrat MA, Bonneville M, Fournie JJ, Sjostedt A: Expansion of Vgamma9 Vdelta2 T cells is triggered by Francisella tularensis-derived phosphoantigens in tularemia but not after tularemia vaccination. Infect Immun 1998;66:2107-2114.
23. Schoel B, Sprenger S, Kaufmann SH: Phosphate is essential for stimulation of Vgamma9 Vdelta2 T lymphocytes by mycobacterial low molecular weight ligand. Eur J Immunol 1994;24:1886-1892.
24. Constant P, Davodeau F, Peyrat MA, Poquet Y, Puzo C, Bonneville M, Fournie JJ: Stimulation of human gamma delta T cells by nonpeptidic mycobacterial ligands. Science 1994;264:267-270.
25. Tanaka Y, Morita CT, Tanaka Y, Nieves E, Brenner MB, Bloom BR: Natural and synthetic non-peptide antigens recognized by human γδ T cells. Nature 1995;375:155-158.
26. Fournie JJ, Bonneville M: Stimulation of gamma delta T cells by phosphoantigens. Res Immunol 1996;147:338-346.
27. De Libero G: Sentinel function of broadly reactive human gamma delta T cells. Immunol Today 1997;18:2272-2279.
28. Tanaka Y, Sano S, Nieves E, de Libero G, Rosa D, Modlin RL, Brenner MB, Bloom BR, Morita CT: Nonpeptide ligands for human gamma delta T cells. Proc Natl Acad Sci USA 1994;91:8175-8179.
29. Behr C, Poupot R, Peyrat MA, Poquet Y, Constant P, Dubois P, Bonneville M, Fournie JJ: Plasmodium falciparum stimuli for human gamma delta T cells are related to phosphorylated antigens of mycobacteria. Infect Immun 1996;64:2892-2896.
30. Fischer S, Scheffler A, Kabelitz D: Activation of human gamma delta T cells by heat-treated mistletoe extracts. Immunol Lett 1996;52:69-72.
31. Betyia ED, Porter JW: Biochemistry of polyisoprenoid biosynthesis. Annu Rev Biochem 1976;45:113-142.
32. Rohmer M; Knani M, Simonin P; Sutter B, Sahm H: Isoprenoid biosynthesis in bacteria: A novel pathway for early steps leading to isopentenyl diphosphate. Biochem J 1993;95:517-524.
33. Horbach S, Sahm H, Welle R: Isoprenoid biosynthesis in bacteria: Two different pathways? FEMS Microbiol Lett 1993;111:135-140.
34. Rohmer M: The discovery of a mevalonate-independent pathway for isoprenoid biosynthesis in bacteria, algae and higher plants. Nat Prod Rep 1999;16:565-574.
35. Jomaa H, Feurle J, Lühs K, Kunzmann V, Tony H-P, Herderich M, Wilhelm M: Vγ9/Vδ2 T cell activation induced by bacterial low molecular mass compounds depends on the 1-deoxy-D-xylulose 5-phosphate pathway of isoprenoid biosynthesis. FEMS Immunol Med Microbiol 1999;25:371-378.
36. Belmant C, Espinosa E, Poupot R, Peyrat M-A, Guiraud M, Poquet Y, Bonneville M, Fournie JJ: 3-Formyl-1-butyl pyrophosphate: A novel mycobacterial metabolite-activating human γδ T cells. J Biol Chem 1999;274:32079-32084.
37. Bukowski JF, Morita CT, Brenner MB: Human gamma delta T cells recognize alkylamines derived from microbes, edible plants, and tea: Implications for innate immunity. Immunity 1999;11:57-65.
38. Sturm E, Braakman E, Fisch P, Vreugdenhil RJ, Sondet P, Bolhuis RLH: Human Vγ9-Vδ2 T cell receptor-γδ lymphocytes show specificity to Daudi Burkitt's lymphoma cells. J Immunol 1990;145:3202-3208.
39. Fisch P, Malkovsky M, Kovats S, Sturm E, Braakman E, Klein BS, Voss SD, Morrissey LW, De Mars R, Welch WJ, Bolhuis RLH, Sondel PM: Recognition by human Vγ9/Vδ2 T cells of a GroEL homolog on Daudi Burkitt's lymphoma cells. Science 1990;250:1269-1273.
40. L'Faqihi FE, Guiraud M, Dastugue N, Brousset P, Le Bouteiller P, Halary F, Bonneville M, Fournie JJ, Champagne E: Acquisition of a stimulatory activity for Vgamma9/Vdelta2 T cells by a Burkitt's lymphoma cell line without loss of HLA class I expression. Hum Immunol 1999;60:928-938.
41. Fisch P, Meuer E, Pende D, Rothenfusser S, Viale O, Kock S, Ferrone S, Fradelizi D, Klein G, Moretta L, Rammensee HG, Boon T, Coulic P, van der Bruggen P: Control of B cell lymphoma recognition via natural killer inhibitory receptors implies a role for human Vγ9/Vδ2 T cells in tumor immunity. EurJ Immunol 1997;27:3368-3379.
42. Boullier S, Poquet Y, Halary F, Bonneville M, Fournie JJ, Gougeon ML: Phosphoantigen activation induces surface translocation of intracellular CD94/NKG2A class I receptor on CD94-peripheral Vgamma9 Vdelta2 T cells ut not on CD94-thymic or mature gammadelta T cell clones. Eur J Immunol 1998;28:3399-3410.
43. Lang F, Peyrat MA, Constant P, Davodeau F, David-Ameline J, Poquet Y, Vie H, Fournie JJ, Bonneville M: Early activation of human V gamma 9 V delta 2 T cell broad cytotoxicity and TNF production by nonpeptidic mycobacterial ligands. J Immunol 1995;154:5986-5994.
44. Poccia F, Battistini L, Cipriani B, Mancino G, Martini F, Gougeon ML, Colizzi V: Phosphoantigen-reactive Vgamma9 Vdelta2 T lymphocytes suppress in vitro human immunodeficiency virus type I replication by cell-released antiviral factors including CC chemokines. J Infect Dis 1999;180:858-861.
45. Tsukaguchi K, Balaji KN, Boom WH: CD4+ alpha beta T cell and gamma delta T cell responses to Mycobacterium tuberculosis. Similarities and differences in Ag recognition, cytotoxic effector function, and cytokine production. J Immunol 1995;154:1786-1796.
46. Bukowski JF, Monta CT, Tanaka Y, Bloom BR, Brenner MB, Band H: V gamma 2 V delta 2 TCR-dependent recognition of non-peptide antigens and Daudi cells analyzed by TCR gene transfer. J Immunol 1995;154:998-1006.
47. Morita CT, Beckman EM, Bukowski JF, Tanaka Y, Band H, Bloom BR, Golan DE, Brenner MB: Direct presentation of nonpeptide prenyl pyrophosphate antigens to human gamma delta T cells. Immunity 1995;3:495-507.
48. Deusch K, Luling F, Reich K, Classen M, Wagner H, Pfeffer K: A major fraction of human intraepithelial lymphocytes simultaneously expresses the γ/δ cell receptor, the CD8 accessory molecule and preferentially uses the Vδ1 gene segment. Eur J Immunol 1991;21:1053-1059.
49. + phenotypes are increased in coeliac disease. Scand J Immunol 1989;30:665-672.
50. Spencer J, lsaacson PG, MacDonald TT, Thomas AJ, Walker-Smith JA: Gamma/delta T cells and the diagnosis of coeliac disease. Clin Exp Immunol 1991;85:109-113.
51. Bucht A, Söderström K, Esin S, Grunewald J, Hagelberg S, Magnusson I, Wigzell H, Gronberg A, Kiessling R: Analysis of γδ V region usage in normal and diseased human intestinal biopsies and peripheral blood by polymerase chain reaction (PCR) and flow cytometry. Clin Exp Immunol 1995;99:57-64.
52. McVay LD, Li B, Biancaniello R, Creighton MA, Bachwich D, Lichtenstein G, Rombeau JL, Carding SR: Changes in human mucosal γδ T cell repertoire and function associated with the disease process in inflammatory bowel disease. Mol Med 1997;3:183-203.
53. Groh V, Steinle A, Bauer S, Spies T: Recognition of stress-induced MHC molecules by intestinal epithelial γδ T cells. Science 1998;279:1737-1740.
54. Griffith E, Ramsburg E, Hayday A: Recognition by human gut gamma delta cells of stress inducible major histocompatibility molecules on enterocytes. Gut 1998;43:166-167.
55. Groh V, Bahram S; Bauer S, Herman A, Beauchamp M, Spies T: Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium. Proc Natl Acad Sci USA 1996;93:12445-12450.
56. Li P, Willie S, Bauer S, Morris DL, Spies T, Strong RK: Crystal structure of the MHC class homolog MIC-A, a γδ T cell ligand. Immunity 1999;10:577-584.
57. Groh V, Rhinehart R, Secrist H, Bauer S, Grabstein KH, Spies T: Broad tumor-associated expression and recognition by tumor-derived γδ T cells of MICA and MICB. Proc Natl Acad Sci USA 1999;96:6879-6884.
58. high γδ T cells in Lyme arthritis. J Exp Med 1996;184:2109-2117.
59. Vincent MS, Roessner K, Sellati T, Huston CD, Sigal LH, Behar SM, Radolf JD, Budd RC: Lyme arthritis synovial γδ T cells respond to Borrelia burgdorferi lipoproteins and lipidated hexapeptides. J Immunol 1998;161:5762-5771.
60. Born W, Hall L, Dallas A, Boymel J, Shinnick T, Young D, Brennan P, O'Brien R: Recognition of a peptide antigen by heat shock reactive γδ T lymphocytes. Science 1990;249:67-69.
61. Haregewoin A, Singh B, Gupta RS, Finberg RW: A mycobacterial heat shock protein responsive γδ T cell clone also responds to the homologous human heat shock protein: A possible link between infection and autoimmunity. J Infect Dis 1990;163:156-160.
62. Laad AD, Thomas ML, Fakih AR, Chiplunkar SV: Human gamma delta T cells recognize heat shock protein-60 on oral tumor cells. Int J Cancer 1999;80:709-714.
63. Holoshitz J, Vila LM, Keroack BJ, McKinley DR, Bayne NK: Dual antigenic recognition by cloned human gamma delta T cells. J Clin Invest 1992;89:308-314.
64. Pao W, Wen L, Smith AL, Gulbranson-Judge A, Zhcng B, Kelsoe G, MacLennan ICM, Owen MJ, Hayday AC: γδ T cell help of B cells is induced by repeated parasitic infection, in the absence of other T cells. Curr Biol 1996;6:1317-1325.
65. Szczepanik M, Nowak B, Askenase PW, Ptak W: Cross-talk betwen gamma delta T lymphocytes and immune cells in humoral response. Immunology 1958;95:612-617.
66. Skeen MJ, Ziegler HK: Intercellular interactions and cytokine responsiveness of peritoneal α/β and γ/δ T cells from Listeria-infected mice: Synergistic effects of interleukin 1 and 7 on γ/δ T cells. J Exp Med 1993;178:985-996.
67. Dieli F, Ptak W, Sireci G, Romano GC, Potestio M, Salerno A, Asherson GL: Cross-talk between V beta 8+ and gamma delta+ T lymphocytes in contact sensitivity. Immunology 1998;93:469-477.
68. Stinissen P, Zhang J, Vandevyver C, Hermans G, Raus J: Gamma delta T cell responses to activated T cells in multiple sclerosis patients induced by T cell vaccination. J Neuroimmunol 1998;87:94-104.
69. Collins RA, Werling D; Duggan SE, Bland AP, Parsons KR, Howard CJ: γδ T cells present antigen to CD4+ γβT cells. J Leukoc Biol 1998;63:707-714.
70. Peehhold K, Wesch D, Schondelmaier S, Kabelitz D: Primary activation of V gamma 9-expressing gamma delta T cells by Mycobacterium tuberculosis. Requirement for Th1-type CD4 T cell help and inhibition by IL-10. J Immunol 1994;152:4984-4992.
71. Wesch D, Marx S, Kabelitz D: Comparative analysis of alpha beta and gamma delta T cell activation by Mycobacterium tuberculosis and isopentenyl pyrophosphate. Eur J Immunol 1997;27:952-956.
72. Zuany-Amorim C, Ruffie C, Haile S, Vargaftig BB, Pereira P, Pretolani M: Requirement for γδ T cells in allergic airway inflammation. Science 1998;280:1265-1267.
73. Lahn M, Kanehio A, Takeda K, Joetham A, Schwarze J, Köhler G, O'Brien R, Gelfand EW, Born W: Negative regulation of airway responsiveness that is dependent on γδ T cells and independent of αβ T cells. Nat Med 1999;5:1150-1156.