T-cell exhaustion in HIV infection

Current HIV/AIDS Reports

Volumn 5, Issue 1, 2008, Pages 13-19

  El Far, Mohamed ^b   Halwani, Rabih ^b   Said, Elias ^b   Trautmann, Lydie ^b   Doroudchi, Mehrnoosh ^b   Janbazian, Loury ^b   Fonseca, Simone ^b   Van Grevenynghe, Julien ^b   Yassine Diab, Bader ^b   Sékaly, Rafick Pierre ^a   Haddad, Elias K ^b  

^a UNIVERSITY OF MONTREAL   (Canada)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE;

ANTIGEN PRESENTATION; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CYTOKINE PRODUCTION; DENDRITIC CELL; DISEASE COURSE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOREGULATION; IMMUNOSTIMULATION; IN VITRO STUDY; INNATE IMMUNITY; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; MACROPHAGE; MOLECULAR MECHANICS; MONOCYTE; NONHUMAN; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; UPREGULATION; VIRUS REPLICATION;

HIV INFECTIONS; HIV-1; HUMANS; IMMUNOLOGIC MEMORY; LYMPHOCYTE ACTIVATION; T-LYMPHOCYTES;

EID: 41649118631     PISSN: 15483568     EISSN: 15483576     Source Type: Journal    
DOI: 10.1007/s11904-008-0003-7     Document Type: Article

References (49)

1. Dutton RW, Bradley LM, Swain SL: T cell memory. Annu Rev Immunol 1998, 16:201-223.
2. Mahnke YD, Schwendemann J, Beckhove P, Schirrmacher V: Maintenance of long-term tumour-specific T-cell memory by residual dormant tumour cells. Immunology 2005, 115:325-336.
3. Swain SL: CD4 T-cell memory can persist in the absence of class II. Philos Trans R Soc Lond B Biol Sci 2000, 355:407-411.
4. Barber DL, Wherry EJ, Masopust D, et al.: Restoring function in exhausted CD8 T cells during chronic viral infection. Nature 2006, 439:682-687. This article reported the first evidence regarding the implication of PD-1 in T-cell exhaustion in a murine model.
5. Matloubian M, Concepcion RJ, Ahmed R: CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infection. J Virol 1994, 68:8056-8063.
6. Zajac AJ, Blattman JN, Murali-Krishna K, et al.: Viral immune evasion due to persistence of activated T cells without effector function. J Exp Med 1998, 188:2205-2213.
7. Wherry EJ, Blattman JN, Murali-Krishna K, et al.: Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment. J Virol 2003, 77:4911-4927.
8. Wodarz D, Klenerman P, Nowak MA: Dynamics of cytotoxic T-lymphocyte exhaustion. Proc Biol Sci 1998, 265:191-203.
9. Day CL, Kaufmann DE, Kiepiela P, et al.: PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression. Nature 2006, 443:350-354. PD-1 expression controls T-cell exhaustion on Ag-specific T cells and is related to disease progression.
10. Douek DC, Brenchley JM, Betts MR, et al.: HIV preferentially infects HIV-specific CD4+ T cells. Nature 2002, 417:95-98.
11. Papagno L, Spina CA, Marchant A, et al.: Immune activation and CD8+ T-cell differentiation towards senescence in HIV-1 infection. PLoS Biol 2004, 2:E20.
12. Seth N, Kaufmann D, Lahey T, et al.: Expansion and contraction of HIV-specific CD4 T cells with short bursts of viremia, but physical loss of the majority of these cells with sustained viral replication. J Immunol 2005, 175:6948-6958.
13. Younes SA, Trautmann L, Yassine-Diab B, et al.: The duration of exposure to HIV modulates the breadth and the magnitude of HIV-specific memory CD4+ T cells. J Immunol 2007, 178:788-797.
14. Sun Y, Permar SR, Buzby AP, Letvin NL: Memory CD4+ T-lymphocyte loss and dysfunction during primary simian immunodeficiency virus infection. J Virol 2007, 81:8009-8015.
15. Mackewicz CE, Yang LC, Lifson JD, Levy JA: Non-cytolytic CD8 T-cell anti-HIV responses in primary HIV-1 infection. Lancet 1994, 344:1671-1673.
16. Andersson J, Kinloch S, Sonnerborg A, et al.: Low levels of perforin expression in CD8+ T lymphocyte granules in lymphoid tissue during acute human immunodeficiency virus type 1 infection. J Infect Dis 2002, 185:1355-1358.
17. Lichterfeld M, Kaufmann DE, Yu XG, et al.: Loss of HIV-1-specific CD8+ T cell proliferation after acute HIV-1 infection and restoration by vaccine-induced HIV-1-specific CD4+ T cells. J Exp Med 2004, 200:701-712.
18. Petrovas C, Price DA, Mattapallil J, et al.: SIV-specific CD8+ T cells express high levels of PD1 and cytokines but have impaired proliferative capacity in acute and chronic SIVmac251 infection. Blood 2007, 110:928-936.
19. Sallusto F, Lenig D, Forster R, et al.: Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 1999, 401:708-712.
20. Trautmann L, Janbazian L, Chomont N, et al.: Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction. Nat Med 2006, 12:1198-1202. This work demonstrates for the first time that PD-1 is implicated in the exhaustion of Ags CD8 T cells in HIV infection. This exhaustion could be restored by blocking the PD-1 pathway leading to recovery of cell proliferation and cytokine secretion.
21. Petrovas C, Casazza JP, Brenchley JM, et al.: PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection. J Exp Med 2006, 203:2281-2292.
22. Champagne P, Ogg GS, King AS, et al.: Skewed maturation of memory HIV-specific CD8 T lymphocytes. Nature 2001, 410:106-111.
23. Appay V, Dunbar PR, Callan M, et al.: Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections. Nat Med 2002, 8:379-385.
24. Kaufmann DE, Kavanagh DG, Pereyra F, et al.: Upregulation of CTLA-4 by HIV-specific CD4(+) T cells correlates with disease progression and defines a reversible immune dysfunction. Nat Immunol 2007, 8:1246-1254. CTLA-4 expression on Ag-specific CD4 T cells in HIV infection is highly involved in T-cell exhaustion and is related to disease progression. Antibody blockade of CTLA-4 restores CD4 functions.
25. Greenwald RJ, Latchman YE, Sharpe AH: Negative co-receptors on lymphocytes. Curr Opin Immunol 2002, 14:391-396.
26. Shiratori T, Miyatake S, Ohno H, et al.: Tyrosine phosphorylation controls internalization of CTLA-4 by regulating its interaction with clathrin-associated adaptor complex AP-2. Immunity 1997, 6:583-589.
27. Chemnitz JM, Parry RV, Nichols KE, et al.: SHP-1 and SHP-2 associate with immunoreceptor tyrosine-based switch motif of programmed death 1 upon primary human T cell stimulation, but only receptor ligation prevents T cell activation. J Immunol 2004, 173:945-954.
28. Lee KM, Chuang E, Griffin M, et al.: Molecular basis of T cell inactivation by CTLA-4. Science 1998, 282:2263-2266.
29. Schneider H, Downey J, Smith A, et al.: Reversal of the TCR stop signal by CTLA-4. Science 2006, 313:1972-1975.
30. Nishimura H, Honjo T, Minato N: Facilitation of beta selection and modification of positive selection in the thymus of PD-1-deficient mice. J Exp Med 2000, 191:891-898.
31. Carreno BM, Collins M: The B7 family of ligands and its receptors: new pathways for costimulation and inhibition of immune responses. Annu Rev Immunol 2002, 20:29-53.
32. Freeman GJ, Long AJ, Iwai Y, et al.: Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J Exp Med 2000, 192:1027-1034.
33. Fiorentino DF, Zlotnik A, Mosmann TR, et al.: IL-10 inhibits cytokine production by activated macrophages. J Immunol 1991, 147:3815-3822.
34. Mosmann TR, Moore KW: The role of IL-10 in cross-regulation of TH1 and TH2 responses. Immunol Today 1991, 12:A49-53.
35. McBride JM, Jung T, de Vries JE, Aversa G: IL-10 alters DC function via modulation of cell surface molecules resulting in impaired T-cell responses. Cell Immunol 2002, 215:162-172.
36. Brooks DG, Trifilo MJ, Edelmann KH, et al.: Interleukin-10 determines viral clearance or persistence in vivo. Nat Med 2006, 12:1301-1309.
37. Boasso A, Herbeuval JP, Hardy AW, et al.: HIV inhibits CD4+ T-cell proliferation by inducing indoleamine 2,3-dioxygenase in plasmacytoid dendritic cells. Blood 2007, 109:3351-3359.
38. Donaghy H, Gazzard B, Gotch F, Patterson S: Dysfunction and infection of freshly isolated blood myeloid and plasmacytoid dendritic cells in patients infected with HIV-1. Blood 2003, 101:4505-4511.
39. Lore K, Sonnerborg A, Brostrom C, et al.: Accumulation of DC-SIGN+CD40+ dendritic cells with reduced CD80 and CD86 expression in lymphoid tissue during acute HIV-1 infection. AIDS 2002, 16:683-692.
40. Macatonia SE, Lau R, Patterson S, et al.: Dendritic cell infection, depletion and dysfunction in HIV-infected individuals. Immunology 1990, 71:38-45.
41. Yonezawa A, Morita R, Takaori-Kondo A, et al.: Natural alpha interferon-producing cells respond to human immunodeficiency virus type 1 with alpha interferon production and maturation into dendritic cells. J Virol 2003, 77:3777-3784.
42. Polyak S, Chen H, Hirsch D, et al.: Impaired class II expression and antigen uptake in monocytic cells after HIV-1 infection. J Immunol 1997, 159:2177-2188.
43. Louie AT, Wahl LM, Hewlett IK, et al.: Impaired antigen presentation to CD4+ T-cells by HIV-infected monocytes is related to down-modulation of CD4 expression on helper T-cells: possible involvement of HIV-induced cellular factors. FEBS Lett 1996, 398:1-6.
44. Kedzierska K, Crowe SM, Turville S, Cunningham AL: The influence of cytokines, chemokines and their receptors on HIV-1 replication in monocytes and macrophages. Rev Med Virol 2003, 13:39-56.
45. Clerici M, Wynn TA, Berzofsky JA, et al.: Role of interleukin-10 in T helper cell dysfunction in asymptomatic individuals infected with the human immunodeficiency virus. J Clin Invest 1994, 93:768-775.
46. Kumar A, Angel JB, Daftarian MP, et al.: Differential production of IL-10 by T cells and monocytes of HIV-infected individuals: association of IL-10 production with CD28-mediated immune responsiveness. Clin Exp Immunol 1998, 114:78-86.
47. Trabattoni D, Saresella M, Biasin M, et al.: B7-H1 is upregulated in HIV infection and is a novel surrogate marker of disease progression. Blood 2003, 101:2514-2520.
48. Vlad G, Piazza F, Colovai A, et al.: Interleukin-10 induces the upregulation of the inhibitory receptor ILT4 in monocytes from HIV positive individuals. Hum Immunol 2003, 64:483-489.
49. Hryniewicz A, Boasso A, Edghill-Smith Y, et al.: CTLA-4 blockade decreases TGF-beta, IDO, and viral RNA expression in tissues of SIVmac251-infected macaques. Blood 2006, 108:3834-3842.