Low levels of perforin expression in CD8+ T lymphocyte granules in lymphoid tissue during acute human immunodeficiency virus type 1 infection

Journal of Infectious Diseases

Volumn 185, Issue 9, 2002, Pages 1355-1358

  Andersson, Jan ^a   Kinloch, Sabine ^b   Sönnerborg, Anders ^a   Nilsson, Jakob ^a   Fehniger, Thomas E ^a   Spetz, Anna Lena ^a   Behbahani, Homira ^a   Goh, Li Ean ^d   McDade, Hugh ^d   Gazzard, Brian ^c   Stellbrink, Hans ^e   Cooper, David ^f   Perrin, Luc ^g  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b ROYAL FREE HOSPITAL   (United Kingdom)

^c CHELSEA AND WESTMINSTER HOSPITAL   (United Kingdom)

^d GLAXOSMITHKLINE   (United Kingdom)

^e UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^f UNIVERSITY OF NEW SOUTH WALES   (Australia)

^g GENEVA UNIVERSITY HOSPITALS   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; GRANZYME B; PERFORIN; VIRUS DNA; VIRUS RNA;

ARTICLE; BLOOD SAMPLING; CELL GRANULE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; IMMUNOSUPPRESSIVE TREATMENT; LYMPHOCYTOTOXICITY; LYMPHOID TISSUE; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE; VIRUS REPLICATION;

ACQUIRED IMMUNODEFICIENCY SYNDROME; ACUTE DISEASE; CD8-POSITIVE T-LYMPHOCYTES; DNA, VIRAL; GRANZYMES; HIV-1; HUMANS; LYMPHOID TISSUE; MEMBRANE GLYCOPROTEINS; PORE FORMING CYTOTOXIC PROTEINS; RNA, MESSENGER; RNA, VIRAL; SERINE ENDOPEPTIDASES; VIRAL LOAD;

EID: 0036569216     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/340124     Document Type: Article

References (15)

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9. + T cells apoptosis: A possible mechanism of bystander cell death in HIV infection
10. Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice
11. Skewed maturation of memory HIV-specific CD8 T lymphocytes
12. Perforin is not co-expressed with granzyme A within cytotoxic granules in CD8 T lymphocytes present in lymphoid tissue during chronic HIV infection
13. Viral load and immunophenotype of cells obtained from lymph nodes by fine needle aspiration as compared with peripheral blood cells in HIV-infected patients
14. Granzyme A loading induces rapid cytolysis and a novel form of DNA damage independently of caspase activation
15. CD8 T cells specific for human immunodeficiency virus, Epstein-Barr virus, and cytomegalovirus lack molecules for homing to lymphoid sites of infection