GABA-system and alcohol: Does an "ethanol receptor" exist? (review)

Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova

Volumn 107, Issue SPEC. ISS. 1, 2007, Pages 56-62

  Balashov, A M ^a  

^a NONE

Author keywords

CABA system; Cellular effect of ethanol

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ALCOHOL; CENTRAL DEPRESSANT AGENT;

ANIMAL; BRAIN; CYTOLOGY; DRUG EFFECT; HUMAN; METABOLISM; NERVE CELL; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; BRAIN; CENTRAL NERVOUS SYSTEM DEPRESSANTS; ETHANOL; HUMANS; NEURONS; RECEPTORS, GABA-A; SIGNAL TRANSDUCTION;

EID: 41549093109     PISSN: 19977298     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (44)

1. Russian source
2. Russian source
3. Beleslin D.B., Djukanovic V., Jovanovic F. et al. Opposite effects of GABAA and NMDA receptor antagonists on ethanol-induced behavioral sleep in rats. Alcohol 1997; 14:2:167-173.
4. Besheer J., Lepoutre K., Mole B., Hodge C.W. GABA(A) receptor regulation of voluntary ethanol drinking requires PKCepsilon. Synapse 2006:60:6:411-419.
5. Biggio F., Gorini G., Caria S. et al. Flumazenil selectively prevents the increase in alpha(4)-subunit gene expression and an associated change in GABA(A) receptor function induced by ethanol withdrawal. J Neurochem 2007;PMID: 17403139.
6. Boehm S.L. 2nd, Peden L., Jennings A. W. et al. Over-expression of the fyn-kinase gene reduces hypnotic sensitivity to ethanol in mice. Neurosci Lett 2004;372:1-2:6-11.
7. Cagetti E., Liang J., Spigelman I., Olsen R. W. Withdrawal from chronic intermittent ethanol treatment changes subunit composition, reduces synaptic function, and decreases behavioral responses to positive allosteric modulators of GABA(A) receptors. Mol Pharmacol 2003;63:1:53-64.
8. Chester J.A., Cunningham C.L. GABA(A) receptor modulation of the rewarding and aversive effects of ethanol. Alcohol 2002;26:3:131 -143.
9. Davis T.J., de Fiebre C.M. Alcohol's actions on neuronal nicotinic acetylcholine receptors. Alcohol Res Health 2006;29:3:179- 185.
10. DuBois D.W., Parrish A.R, Trzeciakowski J.P., Frye G.D. Binge ethanol exposure delays development of GABAergic miniature postsynaptic currents in septal neurons. Brain Res Dev Brain Res 2004:152:2:199-212.
11. Dupre M.L., Broyles J.M., Mihic S.J. Effects of a mutation in the TM2-TM3 linker region of the glycine receptor alphal subunit on gating and allosteric modulation. Brain Res 2007; 1152C: 1-9.
12. Follesa P., Biggio F., Mancuso L. et al. Ethanol withdrawal-induced up-regulation of the alpha2 subunit of the GABA(A) receptor and its prevention by diazepam or gamma-hydroxybutyric acid. Brain Res Mol Brain Res 2004; 120:2:130-137.
13. Follesa P., Biggio F., Talani G. et al. Neurosteroids, GABAAreceptors, and ethanol dependence. Psychopharmacology (Berl) 2006; 186:3:267-280.
14. Ford M.M., Nickel J.D., Finn D.A. Treatment with and withdrawal from finasteride alter ethanol intake patterns in male C57BL/6J mice: potential role of endogenous neurosteroids? Alcohol 2005;37:1:23-33.
15. Ford M.M.,Nickel J.D.,Phillips T.J.,Finn D.A. Neurosteroid modulators of GABA(A) receptors differentially modulate ethanol intake patterns in male C57BL/6J mice. Alcohol Clin Exp Res 2005:29:9:1630-1640.
16. Ford M.M., Mark G.P., Nickel J.D. et al. Allopregnanolone influences the consummately processes that govern ethanol drinking in C57BL/6J mice. Behav Brain Res 2007;179:2:265-272.
17. Freund R.K., van Home C. G., Harlan T., Palmer M.R Electrophysiological interactions of ethanol with GABAergic mechanisms in the rat cerebellum in vivo. Alcohol Clin Exp Res 1993; 17:2:321-328.
18. Hayrapetyan V., Jenschke M., Dillon G.M., Machu T.K. Co-expression of the 5-HT(3B) subunit with the 5-HT(3A) receptor reduces alcohol sensitivity. Brain Res Mol Brain Res 2005; 142:2:146- 150.
19. Hejazi N., Zhou C., Oz M. et al. Delta9-tetrahydrocannabinol and endogenous cannabinoid anandamide directly potentiate the function of glycine receptors. Mol Pharmacol 2006;69:3:991-997.
20. Hsiao S.H., Acevedo J.J., DuBois D. W. et al. Early postnatal ethanol intubation blunts GABA(A) receptor up-regulation and modifies 3-alpha-hydroxy-5-alpha-pregnan-20-one sensitivity in rat MS/DB neurons. Brain Res Dev Brain Res 2001:130:1:25-40.
21. Hsiao S.H., DuBois D. W., Miranda R.C., Frye G.D. Critically timed ethanol exposure reduces GABAAR function on septal neurons developing in vivo but not in vitro. Brain Res 2004; 1008:1:69-80.
22. Hyytia P., Koob G.F. GABA(A) receptor antagonism in the extended amygdala decreases ethanol self-administration in rats. Eur J Pharmacol 1995;283:1 3:151 -159.
23. Jackson A., Duka T., Stephens D.N. Effects of alcohol and lorazepam during extinction of alcohol self-administration in rats. J Psychopharmacol 2003; 17:3:293-299.
24. Klein R.L., Mascia M.P., Whiting P.J., Harris R.A. GABA(A) receptor function and binding in stably transfected cells: chronic ethanol treatment. Alcohol Clin Exp Res 1995; 19:5:1338-1344.
25. Marutha Ravindran C.R., Ticku M.K. Tyrosine kinase phosphorylation of CABA(A) receptor subunits following chronic ethanol exposure of cultured cortical neurons of mice. Brain Res 2006; 1086:1:35-41.
26. Marutha Ravindran C.R., Mehta A.K., Ticku M.K. Effect of chronic administration of tthanol on the regulation of tyrosine kinase phosphorylation of the GABA(A) receptor subunits in the rat brain. Neurochem Res 2007;32:7:1179-1187.
27. McKenzie-Quirk S.D., Girasa K.A., Allan A.M., Miczek K.A. 5-HT(3) receptors, alcohol and aggressive behavior in mice. Behav Pharmacol 2005;16:3:163-169.
28. Mehta A.K., Ticku M.K Prevalence of the GABAA receptor assemblies containing alpha 1-subunit in the rat cerebellum and cerebral cortex as determined by immunoprecipitation: lackof modulation by chronic ethanol administration. Brain Res Mol Brain Res 1999;67:1:194-199.
29. Mehta A.K, Ticku M.K. Effect of chronic administration of ethanol on GABA(A) receptor assemblies derived from alpha2-, alpha3-, beta2- and gamma2-subunits in the rat cerebral cortex. Brain Res 2005;1031:1:134-137.
30. Metz A. V., Chynoweth J., Allan A.M. Influence of genetic background on alcohol drinking and behavioral phenotypes of 5-HT3 receptor over-expressing mice. Pharmacol Biochem Behav 2006;84:1:120-127.
31. O'Dell L.E., Purdy R.H., Covey D.F. et al. Epipregnanolone and a novel synthetic neuroactive steroid reduce alcohol self-administration in rats. Pharmacol Biochem Behav 2005;81:3:543-550.
32. Olive M.F. Interactions between taurine and ethanol in the central nervous system. Amino Acids 2002;23:4:345-357.
33. Papadeas S., Grobin A. C., Morrow A.L. Chronic ethanol consumption differentially alters GABA(A) receptor alpha I and alpha4 subunit peptide expression and GABA(A) receptor-mediated 36 Cl(-) uptake in mesocorticolimbic regions of rat brain. Alcohol Clin Exp Res 2001;25:9:1270-1275.
34. Reeves D.C., Lummis S.C. The molecular basis of the structure and function of the 5-HT3 receptor: a model ligand-gated ion channel (review). Mol Membr Biol 2002; 19:1:11-26.
35. Roberts M. T., Phelan R., Erlichman B.S. et al. Occupancy of a single anesthetic binding pocket is sufficient to enhance glycine receptor function. J Biol Chem 2006;281:6:3305-3311.
36. Saba L., Porcella A., Sanna A. et al. Five mutations in the GABA A alpha6 gene 5' flanking region are associated with a reduced basal and ethanol-induced alpha6 upregulation in mutated Sardinian alcohol non-preferring rats. Brain Res Mol Brain Res 2005; 137:1-2:252-257.
37. Sanna E., Mostallino M.C., Busonero F. et al. Changes in GABA(A) receptor gene expression associated with selective alterations in receptor function and pharmacology after ethanol withdrawal. J Neurosci 2003:23:37:11711-11724.
38. Setra M., Mostallino M.C., Talani G. et al. Social isolation-induced increase in alpha and delta subunit gene expression is associated with a greater efficacy of ethanol on steroidogenesis and GABA receptor function. J Neurochem 2006;98:1:122-133.
39. Smith S.S., Gong Q.M. Ethanol administration rapidly reverses alpha4 GABA(A) receptor subunit upregulation following steroid exposure. Neuropharmacology 2004;47:1:9-16.
40. Toso L., Roberson R., Woodard J. et al. Prenatal alcohol exposure alters GABA(A)alpha5 expression: a mechanism of alcohol-induced learning dysfunction. Am J Obstet Gynecol 2006; 195:2:522-527.
41. Ueno S., Lin A., Nikolaeva N. et al. Tryptophan scanning mutagenesis in TM2 of the GABA(A) receptor alpha subunit: effects on channel gating and regulation by ethanol. Br J Pharmacol 2000; 131:2:296-302.
42. Vanover K.E., Suruki M., Robledo S. et al. Positive allosteric modulators of the GABA(A) receptor: differential interaction of benzodiazepines and neuroactive steroids with ethanol. Psychopharmacology (Berl) 1999:141:1:77-82.
43. Whiting P.J. GABA(A) receptor subtypes in the brain: a paradigm for CNS drug discovery? Drug Discov Today 2003;8.T0:445-450.
44. Wick M.J., Mihic S.J., Ueno S. et al. Mutations of gamma-aminobutyric acid and glycine receptors change alcohol cutoff: evidence for an alcohol receptor? Proc Natl Acad Sei USA 1998;95:11:6504-6509.