5-HT3 receptors, alcohol and aggressive behavior in mice

Behavioural Pharmacology

Volumn 16, Issue 3, 2005, Pages 163-169

  McKenzie Quirk, S D ^a   Girasa, K A ^a   Allan, A M ^c   Miczek, Klaus A ^a,b  

^a TUFTS UNIVERSITY   (United States)

^b TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF NEW MEXICO HEALTH SCIENCES CENTER   (United States)

Author keywords

5 HT3; Aggression; Alcohol; Ethanol; Mouse; Self administration; Serotonin

Indexed keywords

ALCOHOL; ONDANSETRON; SEROTONIN 3 ANTAGONIST; SEROTONIN 3 RECEPTOR; ZACOPRIDE;

AGGRESSION; ALCOHOL BLOOD LEVEL; ALCOHOL CONSUMPTION; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; FIGHTING; MALE; MOUSE; NONHUMAN; TRANSGENIC MOUSE; WALKING;

AGGRESSION; ANIMALS; BENZAMIDES; BICYCLO COMPOUNDS, HETEROCYCLIC; CENTRAL NERVOUS SYSTEM DEPRESSANTS; ETHANOL; MALE; MICE; ONDANSETRON; RECEPTORS, SEROTONIN, 5-HT3; SEROTONIN ANTAGONISTS;

EID: 18844444259     PISSN: 09558810     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008877-200505000-00005     Document Type: Article

References (35)

1. Campbell AD, Kohl RR, McBride WJ (1996). Serotonin-3 receptor and ethanol-stimulated somatodendritic dopamine release. Alcohol 13:569-574.
2. de Almeida RMM, Faccidomo S, Fish E, Miczek KA (2001). Inhibition of alcohol-heightened aggression by action at post-synaptic 5-HT1b receptors in male mice. Aggress Behav 3:234-235.
3. Eckardt MJ, File SE, Gessa GL, Grant KA, Guerri C, Huffman PL, et al. (1998). Effects of moderate alcohol consumption on the central nervous system. Alcohol Clin Exp Res 22:998-1040.
4. Engel SR, Allan AM (1999). 5-HT3 receptor over-expression enhances ethanol sensitivity in mice. Psychopharmacology (Berl) 144:411-415.
5. Engel SR, Lyons CR, Allan AM (1998). 5-HT3 receptor over-expression decreases ethanol self administration in transgenic mice. Psychopharmacology (Berl) 140:243-248.
6. Fish EW, Faccidomo S, Miczek KA (1999). Aggression heightened by alcohol or social instigation in mice: reduction by the 5-HT1B receptor agonist CP-94,253. Psychopharmacology (Berl) 146:391-399.
7. Grant KA (1994). Emerging neurochemical concepts in the actions of ethanol at ligand-gated ion channels. Behav Pharmacol 5:383-404.
8. Hodge CW, Samson HH, Lewis RS, Erickson HL (1993). Specific decreases in ethanol- but not water-reinforced responding produced by the 5-HT3 antagonist ICS 205-930. Alcohol 10:191-196.
9. Johnson BA, Roache JD, Javors MA, DiClemente CC, Cloninger CR, Prihoda TJ, et al. (2000). Ondansetron for reduction of drinking among biologically predisposed alcoholic patients: A randomized controlled trial. JAMA 284: 963-971.
10. Johnson BA, Roache JD, Ait-Daoud N, Zanca NA, Velazquez M (2002). Ondansetron reduces the craving of biologically predisposed alcoholics. Psychopharmacology (Berl) 160:408-413.
11. Kiianmaa K, Nurmi M, Nykanen I, Sinclair JD (1995). Effect of ethanol on extracellular dopamine in the nucleus-accumbens of alcohol-preferring AA and alcohol-avoiding ANA rats. Pharmacol Biochem Behav 52:29-34.
12. Knapp DJ, Pohorecky LA (1992). Zacopride, a 5-HT3 receptor antagonist, reduces voluntary ethanol consumption in rats. Pharmacol Biochem Behav 41:847-850.
13. Lovinger DM, White G (1991). Ethanol potentiation of 5-hydroxytryptamine3 receptor-mediated ion current in neuroblastoma-cells and isolated adult mammalian neurons. Mol Pharmacol 40:263-270.
14. McKinzie DL, Eha R, Cox R, Stewart RB, Dyr W, Murphy JM, et al. (1998). SerotoninS receptor antagonism of alcohol intake: Effects of drinking conditions. Alcohol 15:291-298.
15. McKinzie DL, McBride WJ, Murphy JM, Lumeng L, Li TK (2000). Effects of MDL 72222, a serotoninS antagonist, on operant responding for ethanol by alcohol-preferring P rats. Alcohol Clin Exp Res 24:1500-1504.
16. Miczek KA, de Almeida RMM (2001). Oral drug self-administration in the home cage of mice: alcohol-heightened aggression and inhibition by the 5-HT1B agonist anpirtoline. Psychopharmacology (Berl) 157:421-429.
17. Miczek KA, O'Donnell JM (1978). Intruder-evoked aggression in isolated and nonisolated mice: Effects of psychomotor stimulants and L-dopa. Psychopharmacology (Berl) 57:47-55.
18. Miczek KA, Weerts EM, Tornatzky W, DeBold JF, Vatne TM (1992). Alcohol and 'bursts' of aggressive behavior: Ethological analysis of individual differences in rats. Psychopharmacology (Berl) 107:551-563.
19. Miczek KA, Weerts EM, DeBold JF (1993). Alcohol, benzodiazepine-GABA-A receptor complex and aggression: Ethological analysis of individual differences in rodents and primates. J Stud Alcohol Suppl 11:170-179.
20. Miczek KA, Hussain S, Faccidomo S (1998). Alcohol-heightened aggression in mice: attenuation by 5-HT1A receptor agonists. Psychopharmacology (Berl) 139:160-168.
21. Ricci LA, Grimes JM, Melloni RH, Jr (2004). Serotonin type 3 receptors modulate the aggression-stimulating effects of adolescent cocaine exposure in Syrian hamsters (Mesocricetus auratus). Behav Neurosci 118:1097-1110.
22. Rodd-Henricks ZA, McKinzie DL, Edmundson VE, Dagon CL, Murphy JM, McBride WJ, et al. (2000). Effects of 5-HT3 receptor antagonists on daily alcohol intake under acquisition, maintenance, and relapse conditions in alcohol-preferring (P) rats. Alcohol 21:73-85.
23. Rodd-Henricks ZA, McKinzie DL, Melendez RI, Berry N, Murphy JM, McBride WJ (2003). Effects of serotonin-3 receptor antagonists on the intracranial self-administration of ethanol within the ventral tegmental area of Wistar rats. Psychopharmacology (Berl) 165:252-259.
24. Rudissaar R, Pruus K, Skrebuhhova T, Allikmets L, Matto V (1999). Modulatory role of 5-HT3 receptors in mediation of apomorphine-induced aggressive behaviour in male rats. Behav Brain Res 106:91-96.
25. Sanchez C, Arnt J, Hyttel J, Moltzen EK (1993). The role of serotonergic mechanisms in inhibition of isolation-induced aggression in male mice. Psychopharmacology (Berl) 110:53-59.
26. Schneider R, Hoffmann HJ, Schicknick H, Moutier R (1992). Genetic analysis of isolation-induced aggression. 1. Comparison between closely related inbred mouse strains. Behav Neural Biol 57:198-204.
27. Southwick CH, Clark LH (1968). Interstrain differences in aggressive behavior and exploratory activity of inbred mice. Commun Behav Biol 1:49-59.
28. Tomkins DM, Le AD, Sellers EM (1995). Effect of the 5-HT3 antagonist ondansetron on voluntary ethanol intake in rats and mice maintained on a limited access procedure. Psychopharmacology (Berl) 117:479-485.
29. Van Erp AMM, Miczek KA (1995). Alcohol self-administration and aggression in rats: Dopamine and serotonin in n. accumbens. Soc Neurosci Abstr 19:1702.
30. Virkkunen M, Linnoila M (1993). Brain serotonin, Type II alcoholism and impulsive violence. J Stud Alcohol Suppl 11:163-169.
31. White SM, Kucharik RF, Moyer JA (1991). Effects of serotonergic agents on isolation-induced aggression. Pharmacol Biochem Behav 39:729-736.
32. Winslow JT, Miczek KA (1985). Social status as determinant of alcohol effects on aggressive behavior in squirrel monkeys (Saimiri sciureus). Psychopharmacology (Berl) 85:167-172.
33. Wozniak KM, Pert A, Linnoila M (1990). Antagonism of 5-HT3 receptors attenuates the effects of ethanol on extracellular dopamine. Eur J Pharmacol 187:287-289.
34. Wozniak KM, Pert A, Mele A, Linnoila M (1991). Focal application of alcohols elevates extracellular dopamine in rat brain - A microdialysis study. Brain Res 540:31-40.
35. Yoshimoto K, McBride WJ, Lumeng L, Li TK (1992). Alcohol stimulates the release of dopamine and serotonin in the nucleus accumbens. Alcohol 9:17-22.