Five mutations in the GABAA α6 gene 5′ flanking region are associated with a reduced basal and ethanol-induced α6 upregulation in mutated Sardinian alcohol non-preferring rats

Molecular Brain Research

Volumn 137, Issue 1-2, 2005, Pages 252-257

  Saba, Luisella ^a   Porcella, Anna ^b   Sanna, Angela ^a   Congeddu, Elena ^a   Marziliano, Nicola ^c   Mongeau, Raymond ^a   Grayson, Dennis ^d   Pani, Luca ^a,b  

^a Neuroscienze PharmaNess Scarl   (Italy)

^b CNR   (Italy)

^c Laboratory of Molecular Biology   (Italy)

^d UNIVERSITY OF ILLINOIS   (United States)

Author keywords

Alcohol; Animal models; GABA A; Gene regulation; Transcription

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ALCOHOL; MESSENGER RNA; NUCLEOTIDE; RECEPTOR SUBUNIT; 4 AMINOBUTYRIC ACID; ALPHA6 SUBUNIT, GABA A RECEPTOR; ALPHA6 SUBUNIT, GABA-A RECEPTOR;

ALCOHOL CONSUMPTION; ANALYTIC METHOD; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BASE PAIRING; BINDING SITE; BRAIN LEVEL; BREEDING; CONTROLLED STUDY; DIET; DNA BINDING; DNA FLANKING REGION; GENE EXPRESSION; GENE MUTATION; HOMOZYGOSITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; RAT; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION; ALCOHOLISM; ANIMAL; CEREBELLUM; CONSENSUS SEQUENCE; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION; GENETICS; METABOLISM; MOLECULAR GENETICS; MUTATION; RAT STRAIN; REGULATOR GENE;

ANIMALIA;

5' FLANKING REGION; ALCOHOL-INDUCED DISORDERS, NERVOUS SYSTEM; ALCOHOLISM; ANIMALS; BASE PAIRING; BASE SEQUENCE; BINDING SITES; BRAIN CHEMISTRY; CEREBELLUM; CONSENSUS SEQUENCE; ETHANOL; GAMMA-AMINOBUTYRIC ACID; GENE EXPRESSION REGULATION; GENES, REGULATOR; GENETIC PREDISPOSITION TO DISEASE; MOLECULAR SEQUENCE DATA; MUTATION; NUCLEOTIDES; PROMOTER REGIONS (GENETICS); RATS; RATS, MUTANT STRAINS; RECEPTORS, GABA-A; RNA, MESSENGER; UP-REGULATION;

EID: 20444387957     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molbrainres.2004.07.024     Document Type: Article

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