Occupancy of a single anesthetic binding pocket is sufficient to enhance glycine receptor function

Journal of Biological Chemistry

Volumn 281, Issue 6, 2006, Pages 3305-3311

  Roberts, Michael T ^a   Phelan, Rachel ^a   Erlichman, Beth S ^a   Pillai, Rathi N ^a   Ma, Lan ^a   Lopreato, Gregory F ^a   Mihic, S John ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOLS; BIOLOGICAL MEMBRANES; DRUG PRODUCTS; ETHANOL; PROTEINS; SULFUR COMPOUNDS;

ANESTHETIC BINDING SITES; INHIBITORY GLYCINE RECEPTORS (GLYRS); POTENTIATION; TRANSMEMBRANE;

BINDING ENERGY;

ALCOHOL; AMINO ACID SERINE 267; ANESTHETIC AGENT; CHLOROFORM; GLYCINE RECEPTOR; PROPYL METHANETHIOSULFONIC ACID; SERINE DERIVATIVE; SULFONIC ACID DERIVATIVE; UNCLASSIFIED DRUG; ALCOHOL DERIVATIVE; COMPLEMENTARY DNA; CYSTEINE; GLYCINE; MESYLIC ACID DERIVATIVE; N PROPYL METHANE SULFONATE; N-PROPYL METHANE SULFONATE;

ARTICLE; DRUG POTENTIATION; MUTATION; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN INTERACTION; XENOPUS LAEVIS; ANIMAL; BINDING SITE; CHEMISTRY; ELECTROPHYSIOLOGY; METABOLISM; PATCH CLAMP; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN TERTIARY STRUCTURE;

XENOPUS LAEVIS;

ALCOHOLS; ANESTHETICS; ANIMALS; BINDING SITES; CHLOROFORM; CYSTEINE; DNA, COMPLEMENTARY; ELECTROPHYSIOLOGY; ETHANOL; GLYCINE; MESYLATES; MUTATION; OOCYTES; PATCH-CLAMP TECHNIQUES; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, GLYCINE; XENOPUS LAEVIS;

EID: 33645646015     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M502000200     Document Type: Article

References (31)

1. Mihic, S. J. (1999) Neurochem. Int. 35, 115-123
2. Rudolph, U., and Antkowiak, B. (2004) Nat. Rev. Neurosci. 5, 709-720
3. Legendre, P. (2001) Cell. Mol. Life Sci. 58, 760-793
4. Zhang, Y., Laster, M. J., Hara, K., Harris, R. A., Eger, E. I., Stabernack, C. R., and Sonner, J. M. (2003) Anesth. Analg. 96, 97-101
5. Findlay, G. S., Wick, M. J., Mascia, M. P., Wallace, D., Miller, G. W., Harris, R. A., and Blednov, Y. A. (2002) J. Pharmacol. Exp. Ther. 300, 526-534
6. Mascia, M. P., Machu, T. K., and Harris, R. A. (1996) Br. J. Pharmacol. 119, 1331-1336
7. Downie, D. L., Hall, A. C., Lieb, W. R., and Franks, N. P. (1996) Br. J. Pharmacol. 118, 493-502
8. Beckstead, M. J., Phelan, R., and Mihic, S. J. (2001) J. Biol. Chem. 276, 24959-24964
9. Daniels, S., and Roberts, R. J. (1998) Toxicol. Lett. (Shannon) 100-101, 71-76
10. Langosch, D., Thomas, L., and Betz, H. (1988) Proc. Natl. Acad. Sci. U. S. A. 85, 7394-7398
11. Lynch, J. W. (2004) Physiol. Rev. 84, 1051-1095
12. Mihic, S. J., Ye, Q., Wick, M. J., Koltchine, V. V., Krasowski, M. D., Finn, S. E., Mascia, M. P., Valenzuela, C. F., Hanson, K. K., Greenblatt, E. P., Harris, R. A., and Harrison, N. L. (1997) Nature 389, 385-389
13. Mascia, M. P., Trudell, J. R., and Harris, R. A. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 9305-9310
14. Miyazawa, A., Fujiyoshi, Y., and Unwin, N. (2003) Nature 423, 949-955
15. Beckstead, M. J., Weiner, J. L., Eger, E. I., Gong, D. H., and Mihic, S. J. (2000) Mol. Pharmacol. 57, 1199-1205
16. Eger, E. I., Ionescu, P., Laster, M. J., Gong, D., Hudlicky, T., Kendig, J. J., Harris, R. A., Trudell, J. R., and Pohorille, A. (1999) Anesth. Analg. 88, 867-876
17. Findlay, G. S., Phelan, R., Roberts, M. T., Homanics, G. E., Bergeson, S. E., Lopreato, G. F., Mihic, S. J., Blednov, Y. A., and Harris, R. A. (2003) J. Neurosci. 23, 8051-8059
18. Ye, Q., Koltchine, V. V., Mihic, S. J., Mascia, M. P., Wick, M. J., Finn, S. E., Harrison, N. L., and Harris, R. A. (1998) J. Biol. Chem. 273, 3314-3319
19. Breitinger, H. G., and Becker, C. M. (2002) Neurosci. Lett. 331, 21-24
20. Aguayo, L. G., Peoples, R. W., Yeh, H. H., and Yevenes, G. E. (2002) Curr. Top. Med. Chem. 2, 869-885
21. Mascia, M. P., Wick, M. J., Martinez, L. D., and Harris, R. A. (1998) Br. J. Pharmacol. 125, 263-270
22. Lobo, I. A., Mascia, M. P., Trudell, J. R., and Harris, R. A. (2004) J. Biol. Chem. 279, 33919-33927
23. Griffon, N., Buttner, C., Nicke, A., Kuhse, J., Schmalzing, G., and Betz, H. (1999) EMBO J. 18, 4711-4721
24. Bhattacharya, A. A., Curry, S., and Franks, N. P. (2000) J. Biol. Chem. 275, 38731-38738
25. Franks, N. P., Jenkins, A., Conti, E., Lieb, W. R., and Brick, P. (1998) Biophys. J. 75, 2205-2211
26. Kruse, S. W., Zhao, R., Smith, D. P., and Jones, D. N. (2003) Nat. Struct. Biol. 10, 694-700
27. Kash, T. L., Jenkins, A., Kelley, J. C., Trudell, J. R., and Harrison, N. L. (2003) Nature 421, 272-275
28. Beato, M., Groot-Kormelink, P. J., Colquhoun, D., and Sivilotti, L. G. (2004) J. Neurosci. 24, 895-906
29. Burzomato, V., Beato, M., Groot-Kormelink, P. J., Colquhoun, D., and Sivilotti, L. G. (2004) J. Neurosci. 24, 10924-10940
30. Miller, K. W. (2002) Br. J. Anaesth. 89, 17-31
31. Changeux, J. P., and Edelstein, S. J. (1998) Neuron 21, 959-980