메뉴 건너뛰기




Volumn 23, Issue 4, 2002, Pages 345-357

Interactions between taurine and ethanol in the central nervous system

Author keywords

Acamprosate; Central nervous system (CNS); Ethanol; Locomotor activity; Sedation; Self administration; Taurine

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR BLOCKING AGENT; 4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; 6 AMINOMETHYL 3 METHYL 4H 1,2,4 BENZOTHIADIAZINE 1,1 DIOXIDE; ACAMPROSATE; ALCOHOL; AMINO ACID DERIVATIVE; BETA ALANINE; BICUCULLINE; CALCIUM CHANNEL; CATION CHANNEL; CHLORIDE CHANNEL; DEXAMPHETAMINE; GLYCINE RECEPTOR; GLYCINE RECEPTOR ANTAGONIST; HOMOTAURINE; HYPOTAURINE; ISETHIONIC ACID; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PROTEIN INHIBITOR; STRYCHNINE; TAURINE; 4 AMINOBUTYRIC ACID; DRUG DERIVATIVE; DRUGS USED IN THE TREATMENT OF ADDICTION;

EID: 0036451194     PISSN: 09394451     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00726-002-0203-1     Document Type: Review
Times cited : (90)

References (173)
  • 1
    • 0031813519 scopus 로고    scopus 로고
    • Mechanism of action of acamprosate. Part II. Ethanol dependence modifies effects of acamprosate on NMDA receptor binding in membranes from rat cerebral cortex
    • al Qatari M, Bouchenafa O, Littleton J (1998) Mechanism of action of acamprosate. Part II. Ethanol dependence modifies effects of acamprosate on NMDA receptor binding in membranes from rat cerebral cortex. Alcohol Clin Exp Res 22: 810-814
    • (1998) Alcohol Clin Exp Res , vol.22 , pp. 810-814
    • Al Qatari, M.1    Bouchenafa, O.2    Littleton, J.3
  • 2
    • 0034820542 scopus 로고    scopus 로고
    • Acamprosate is neuroprotective against glutamate-induced excitotoxicity when enhanced by ethanol withdrawal in neocortical cultures of fetal rat brain
    • al Qatari M, Khan S, Harris B, Littleton J (2001) Acamprosate is neuroprotective against glutamate-induced excitotoxicity when enhanced by ethanol withdrawal in neocortical cultures of fetal rat brain. Alcohol Clin Exp Res 25: 1276-1283
    • (2001) Alcohol Clin Exp Res , vol.25 , pp. 1276-1283
    • Al Qatari, M.1    Khan, S.2    Harris, B.3    Littleton, J.4
  • 4
    • 0025831679 scopus 로고
    • Immunocytochemistry of the taurine biosynthesis enzyme, cysteine sulfinate decarboxylase, in the cerebellum: Evidence for a glial localization
    • Almarghini K, Remy A, Tappaz M (1991) Immunocytochemistry of the taurine biosynthesis enzyme, cysteine sulfinate decarboxylase, in the cerebellum: Evidence for a glial localization. Neuroscience 43: 111-119
    • (1991) Neuroscience , vol.43 , pp. 111-119
    • Almarghini, K.1    Remy, A.2    Tappaz, M.3
  • 5
    • 0027397951 scopus 로고
    • Taurine and ethanol-induced conditioned taste aversion
    • Aragon CM, Amit Z (1993) Taurine and ethanol-induced conditioned taste aversion. Pharmacol Biochem Behav 44: 236-263
    • (1993) Pharmacol Biochem Behav , vol.44 , pp. 236-263
    • Aragon, C.M.1    Amit, Z.2
  • 6
    • 0026600413 scopus 로고
    • Effect of taurine on ethanol-induced changes in open-field locomotor activity
    • Aragon CM, Trudeau LE, Amit Z (1992) Effect of taurine on ethanol-induced changes in open-field locomotor activity. Psychopharmacology 107: 337-340
    • (1992) Psychopharmacology , vol.107 , pp. 337-340
    • Aragon, C.M.1    Trudeau, L.E.2    Amit, Z.3
  • 7
    • 0021911385 scopus 로고
    • Failure to establish a conditioned place preference with ethanol in rats
    • Asin KE, Wirtshafter D, Tabakoff B (1985) Failure to establish a conditioned place preference with ethanol in rats. Pharmacol Biochem Behav 22: 169-173
    • (1985) Pharmacol Biochem Behav , vol.22 , pp. 169-173
    • Asin, K.E.1    Wirtshafter, D.2    Tabakoff, B.3
  • 9
    • 0029037991 scopus 로고
    • Taurine transport at the blood-brain barrier: An in vivo brain perfusion study
    • Benrabh H, Bourre JM, Lefauconnier JM (1995) Taurine transport at the blood-brain barrier: An in vivo brain perfusion study. Brain Res 692: 57-65
    • (1995) Brain Res , vol.692 , pp. 57-65
    • Benrabh, H.1    Bourre, J.M.2    Lefauconnier, J.M.3
  • 10
    • 0031885253 scopus 로고    scopus 로고
    • Acamprosate enhances N-methyl-D-apartate receptor-mediated neurotransmission but inhibits presynaptic GABA(B) receptors in nucleus accumbens neurons
    • Berton F, Francesconi WG, Madamba SG, Zieglgänsberger W, Siggins GRF (1998) Acamprosate enhances N-methyl-D-apartate receptor-mediated neurotransmission but inhibits presynaptic GABA(B) receptors in nucleus accumbens neurons. Alcohol Clin Exp Res 22: 183-191
    • (1998) Alcohol Clin Exp Res , vol.22 , pp. 183-191
    • Berton, F.1    Francesconi, W.G.2    Madamba, S.G.3    Zieglgänsberger, W.4    Siggins, G.R.F.5
  • 11
    • 0026779128 scopus 로고
    • Ethanol-induced locomotor activity: Involvement of central nicotinic acetylcholine receptors?
    • Blomqvist O, Soderpalm B, Engel JA (1992) Ethanol-induced locomotor activity: Involvement of central nicotinic acetylcholine receptors? Brain Res Bull 29: 173-178
    • (1992) Brain Res Bull , vol.29 , pp. 173-178
    • Blomqvist, O.1    Soderpalm, B.2    Engel, J.A.3
  • 12
    • 0018236621 scopus 로고
    • Effect of taurine on some pharmacological properties of ethanol
    • Boggan WO, Medberry C, Hopkins DH (1978) Effect of taurine on some pharmacological properties of ethanol. Pharmacol Biochem Behav 9: 469-472
    • (1978) Pharmacol Biochem Behav , vol.9 , pp. 469-472
    • Boggan, W.O.1    Medberry, C.2    Hopkins, D.H.3
  • 14
    • 0032550733 scopus 로고    scopus 로고
    • Central effects of acamprosate: Part 2. Acamprosate modifies the brain in-vivo proton magnetic resonance spectrum in healthy young male volunteers
    • Bolo N, Nédélec JF, Muzet M, De Witte P, Dahchour A, Durbin P, Macher JP (1998) Central effects of acamprosate: Part 2. Acamprosate modifies the brain in-vivo proton magnetic resonance spectrum in healthy young male volunteers. Psychiatry Res 82: 115-127
    • (1998) Psychiatry Res , vol.82 , pp. 115-127
    • Bolo, N.1    Nédélec, J.F.2    Muzet, M.3    De Witte, P.4    Dahchour, A.5    Durbin, P.6    Macher, J.P.7
  • 15
    • 0025137874 scopus 로고
    • Evidence for the rewarding effects of ethanol using the conditioned place preference method
    • Bozarth MA (1990) Evidence for the rewarding effects of ethanol using the conditioned place preference method. Pharmacol Biochem Behav 35: 485-487
    • (1990) Pharmacol Biochem Behav , vol.35 , pp. 485-487
    • Bozarth, M.A.1
  • 16
    • 0025771096 scopus 로고
    • Neuroadaptive responses to chronic ethanol
    • Buck KJ, Harris RA (1991) Neuroadaptive responses to chronic ethanol. Alcohol Clin Exp Res 15: 460-470
    • (1991) Alcohol Clin Exp Res , vol.15 , pp. 460-470
    • Buck, K.J.1    Harris, R.A.2
  • 18
    • 0027903934 scopus 로고
    • The role of calcium homeostasis and calcium currents in ethanol actions on central mammalian neurons
    • Carlen PL, Jahromi SS, Valiante TA, Velumian AA, Weiner JL, Zhang L (1993) The role of calcium homeostasis and calcium currents in ethanol actions on central mammalian neurons. Alcohol Alcohol [Suppl 2]: 395-401
    • (1993) Alcohol Alcohol , Issue.SUPPL. 2 , pp. 395-401
    • Carlen, P.L.1    Jahromi, S.S.2    Valiante, T.A.3    Velumian, A.A.4    Weiner, J.L.5    Zhang, L.6
  • 19
    • 0032937280 scopus 로고    scopus 로고
    • Effects of ethanol on calcium homeostasis in the nervous system: Implications for astrocytes
    • Catlin MC, Guizzetti M, Costa LG (1999) Effects of ethanol on calcium homeostasis in the nervous system: Implications for astrocytes. Mol Neurobiol 19: 1-24
    • (1999) Mol Neurobiol , vol.19 , pp. 1-24
    • Catlin, M.C.1    Guizzetti, M.2    Costa, L.G.3
  • 21
    • 0033958458 scopus 로고    scopus 로고
    • Acamprosate, but not naltrexone, inhibits conditioned abstinence behaviour associated with repeated ethanol administration and exposure to a plus-maze
    • Cole JC, Littleton JM, Little HJ (2000) Acamprosate, but not naltrexone, inhibits conditioned abstinence behaviour associated with repeated ethanol administration and exposure to a plus-maze. Psychopharmacology 147: 403-411
    • (2000) Psychopharmacology , vol.147 , pp. 403-411
    • Cole, J.C.1    Littleton, J.M.2    Little, H.J.3
  • 24
    • 0019531181 scopus 로고
    • Spatial aversion conditioning with ethanol
    • Cunningham CL (1981) Spatial aversion conditioning with ethanol. Pharmacol Biochem Behav 14: 263-264
    • (1981) Pharmacol Biochem Behav , vol.14 , pp. 263-264
    • Cunningham, C.L.1
  • 25
    • 0033635051 scopus 로고    scopus 로고
    • Ethanol-induced conditioned place aversion in mice
    • Cunningham CL, Henderson CM (2000) Ethanol-induced conditioned place aversion in mice. Behav Pharmacol 11: 591-602
    • (2000) Behav Pharmacol , vol.11 , pp. 591-602
    • Cunningham, C.L.1    Henderson, C.M.2
  • 27
    • 0014389928 scopus 로고
    • A pharmacological study of the depression of spinal neurones by glycine and related amino acids
    • Curtis DR, Hosli L, Johnston GA (1968a) A pharmacological study of the depression of spinal neurones by glycine and related amino acids. Exp Brain Res 6: 1-18
    • (1968) Exp Brain Res , vol.6 , pp. 1-18
    • Curtis, D.R.1    Hosli, L.2    Johnston, G.A.3
  • 28
    • 0014390175 scopus 로고
    • The hyperpolarization of spinal motoneurones by glycine and related amino acids
    • Curtis DR, Hosli L, Johnston GA, Johnston IH (1968b) The hyperpolarization of spinal motoneurones by glycine and related amino acids. Exp Brain Res 5: 235-258
    • (1968) Exp Brain Res , vol.5 , pp. 235-258
    • Curtis, D.R.1    Hosli, L.2    Johnston, G.A.3    Johnston, I.H.4
  • 29
    • 0035106434 scopus 로고    scopus 로고
    • Effects of acamprosate on ethanol-seeking and self-administration in the rat
    • Czachowski CL, Legg BH, Samson HH (2001) Effects of acamprosate on ethanol-seeking and self-administration in the rat. Alcohol Clin Exp Res 25: 344-350
    • (2001) Alcohol Clin Exp Res , vol.25 , pp. 344-350
    • Czachowski, C.L.1    Legg, B.H.2    Samson, H.H.3
  • 30
    • 0032969446 scopus 로고    scopus 로고
    • Acamprosate decreases the hypermotility during repeated ethanol withdrawal
    • Dahchour A, De Witte P (1999) Acamprosate decreases the hypermotility during repeated ethanol withdrawal. Alcohol 18: 77-81
    • (1999) Alcohol , vol.18 , pp. 77-81
    • Dahchour, A.1    De Witte, P.2
  • 31
    • 0033990736 scopus 로고    scopus 로고
    • Ethanol and amino acids in the central nervous system: Assessment of the pharmacological actions of acamprosate
    • Dahchour A, De Witte P (2000a) Ethanol and amino acids in the central nervous system: Assessment of the pharmacological actions of acamprosate. Prog Neurobiol 60: 343-362
    • (2000) Prog Neurobiol , vol.60 , pp. 343-362
    • Dahchour, A.1    De Witte, P.2
  • 32
    • 0033953660 scopus 로고    scopus 로고
    • Taurine blocks the glutamate increase in the nucleus accumbens microdialysate of ethanol-dependent rats
    • Dahchour A, De Witte P (2000b) Taurine blocks the glutamate increase in the nucleus accumbens microdialysate of ethanol-dependent rats. Pharmacol Biochem Behav 65: 345-350
    • (2000) Pharmacol Biochem Behav , vol.65 , pp. 345-350
    • Dahchour, A.1    De Witte, P.2
  • 33
    • 0028040710 scopus 로고
    • Acute ethanol increases taurine but neither glutamate nor GABA in the nucleus accumbens of male rats: A microdialysis study
    • Dahchour A, Quertemont E, De Witte P (1994) Acute ethanol increases taurine but neither glutamate nor GABA in the nucleus accumbens of male rats: A microdialysis study. Alcohol Alcohol 29: 485-487
    • (1994) Alcohol Alcohol , vol.29 , pp. 485-487
    • Dahchour, A.1    Quertemont, E.2    De Witte, P.3
  • 34
    • 0001239905 scopus 로고
    • Ethanol and acamprosate increase the extracellular taurine in the nucleus accumbens: A microdialysis study
    • Dahchour A, Durbin P, De Witte P (1995) Ethanol and acamprosate increase the extracellular taurine in the nucleus accumbens: A microdialysis study. Alcohol Alcohol 30: 483
    • (1995) Alcohol Alcohol , vol.30 , pp. 483
    • Dahchour, A.1    Durbin, P.2    De Witte, P.3
  • 35
    • 0030607211 scopus 로고    scopus 로고
    • Taurine increases in the nucleus accumbens microdialysate after acute ethanol administration to naive and chronically alcoholised rats
    • Dahchour A, Quertemont E, De Witte P (1996) Taurine increases in the nucleus accumbens microdialysate after acute ethanol administration to naive and chronically alcoholised rats. Brain Res 735: 9-19
    • (1996) Brain Res , vol.735 , pp. 9-19
    • Dahchour, A.1    Quertemont, E.2    De Witte, P.3
  • 36
    • 0032550745 scopus 로고    scopus 로고
    • Central effects of acamprosate: Part 1. Acamprosate blocks the glutamate increase in the nucleus accumbens microdialysate in ethanol withdrawn rats
    • Dahchour A, De Witte P, Bolo N, Nédélec JF, Muzet M, Durbin P, Macher JP (1998) Central effects of acamprosate: Part 1. Acamprosate blocks the glutamate increase in the nucleus accumbens microdialysate in ethanol withdrawn rats. Psychiatry Res 82: 107-114
    • (1998) Psychiatry Res , vol.82 , pp. 107-114
    • Dahchour, A.1    De Witte, P.2    Bolo, N.3    Nédélec, J.F.4    Muzet, M.5    Durbin, P.6    Macher, J.P.7
  • 37
    • 0033672654 scopus 로고    scopus 로고
    • Effects of ethanol on extracellular amino acid levels in high- and low-alcohol sensitive rats: A microdialysis study
    • Dahchour A, Hoffman A, Deitrich R, De Witte P (2000) Effects of ethanol on extracellular amino acid levels in high- and low-alcohol sensitive rats: A microdialysis study. Alcohol Alcohol 35: 548-553
    • (2000) Alcohol Alcohol , vol.35 , pp. 548-553
    • Dahchour, A.1    Hoffman, A.2    Deitrich, R.3    De Witte, P.4
  • 38
    • 0023503487 scopus 로고
    • Noradrenaline and GABA brain receptors are co-involved in the voluntary intake of ethanol by rats
    • Daoust M, Lhuintre JP, Saligaut C, Moore N, Flipo JL, Boismare F (1987) Noradrenaline and GABA brain receptors are co-involved in the voluntary intake of ethanol by rats. Alcohol Alcohol [Suppl 1]: 319-322
    • (1987) Alcohol Alcohol , Issue.SUPPL. 1 , pp. 319-322
    • Daoust, M.1    Lhuintre, J.P.2    Saligaut, C.3    Moore, N.4    Flipo, J.L.5    Boismare, F.6
  • 41
    • 0028889055 scopus 로고
    • An empirical classification of drinking patterns among alcoholics: Binge, episodic, sporadic, and steady
    • Epstein EE, Kahler CW, McCrady BS, Lewis KD, Lewis S (1995) An empirical classification of drinking patterns among alcoholics: Binge, episodic, sporadic, and steady. Addict Behav 20: 23-41
    • (1995) Addict Behav , vol.20 , pp. 23-41
    • Epstein, E.E.1    Kahler, C.W.2    McCrady, B.S.3    Lewis, K.D.4    Lewis, S.5
  • 42
    • 0031688235 scopus 로고    scopus 로고
    • Chronic ethanol consumption: From neuroadaptation to neurodegeneration
    • Fadda F, Rossetti ZL (1998) Chronic ethanol consumption: From neuroadaptation to neurodegeneration. Prog Neurobiol 56: 385-431
    • (1998) Prog Neurobiol , vol.56 , pp. 385-431
    • Fadda, F.1    Rossetti, Z.L.2
  • 43
    • 0023220574 scopus 로고
    • Ethanol-induced sleep time: Interaction with taurine and a taurine antagonist
    • Ferko AP (1987) Ethanol-induced sleep time: Interaction with taurine and a taurine antagonist. Pharmacol Biochem Behav 27: 235-238
    • (1987) Pharmacol Biochem Behav , vol.27 , pp. 235-238
    • Ferko, A.P.1
  • 44
    • 0024158720 scopus 로고
    • Effect of taurine on ethanol-induced sleep time in mice genetically bred for differences in ethanol sensitivity
    • Ferko AP, Bobyock E (1988) Effect of taurine on ethanol-induced sleep time in mice genetically bred for differences in ethanol sensitivity. Pharmacol Biochem Behav 31: 667-673
    • (1988) Pharmacol Biochem Behav , vol.31 , pp. 667-673
    • Ferko, A.P.1    Bobyock, E.2
  • 45
    • 0035163898 scopus 로고    scopus 로고
    • Behavioral consequences of the hypotaurine-ethanol interaction
    • Font L, Miquel M, Aragon CMG (2001) Behavioral consequences of the hypotaurine-ethanol interaction. Pharmacol Biochem Behav 70: 333-339
    • (2001) Pharmacol Biochem Behav , vol.70 , pp. 333-339
    • Font, L.1    Miquel, M.2    Aragon, C.M.G.3
  • 46
    • 0019791730 scopus 로고
    • An evaluation of the locomotor stimulating action of ethanol in rats and mice
    • Frye GD, Breese GR (1981) An evaluation of the locomotor stimulating action of ethanol in rats and mice. Psychopharmacology 75: 372-379
    • (1981) Psychopharmacology , vol.75 , pp. 372-379
    • Frye, G.D.1    Breese, G.R.2
  • 47
    • 0024970442 scopus 로고
    • Influence of ethanol on calcium, inositol phospholipids and intracellular signalling mechanisms
    • Gandhi CR, Ross DH (1989) Influence of ethanol on calcium, inositol phospholipids and intracellular signalling mechanisms. Experientia 45: 407-413
    • (1989) Experientia , vol.45 , pp. 407-413
    • Gandhi, C.R.1    Ross, D.H.2
  • 48
    • 0026534038 scopus 로고
    • Historical factors in the development of ETOH-conditioned place preference
    • Gauvin DV, Holloway FA (1992) Historical factors in the development of ETOH-conditioned place preference. Alcohol 9: 1-7
    • (1992) Alcohol , vol.9 , pp. 1-7
    • Gauvin, D.V.1    Holloway, F.A.2
  • 49
    • 0025854386 scopus 로고
    • Acamprosate and diazepam differentially modulate alcohol-induced behavioural and cortical alterations in rats following chronic inhalation of ethanol vapour
    • Gewiss M, Heidbreder C, Opsomer L, Durbin P, De Witte P (1991) Acamprosate and diazepam differentially modulate alcohol-induced behavioural and cortical alterations in rats following chronic inhalation of ethanol vapour. Alcohol Alcohol 26: 129-137
    • (1991) Alcohol Alcohol , vol.26 , pp. 129-137
    • Gewiss, M.1    Heidbreder, C.2    Opsomer, L.3    Durbin, P.4    De Witte, P.5
  • 50
    • 0020037134 scopus 로고
    • Aminomethyl-1,2,4-benzothiadiazines as potential analogues of gamma-aminobutyric acid. Unexpected discovery of a taurine antagonist
    • Girard Y, Atkinson JG, Haubrich DR, Williams M, Yarbrough GG (1982) Aminomethyl-1,2,4-benzothiadiazines as potential analogues of gamma-aminobutyric acid. Unexpected discovery of a taurine antagonist. J Med Chem 25: 113-116
    • (1982) J Med Chem , vol.25 , pp. 113-116
    • Girard, Y.1    Atkinson, J.G.2    Haubrich, D.R.3    Williams, M.4    Yarbrough, G.G.5
  • 51
    • 0011950383 scopus 로고    scopus 로고
    • Electrophysiological changes after repeated alcohol withdrawal
    • Gonzalez LP (1998) Electrophysiological changes after repeated alcohol withdrawal. Alcohol Health Res 22: 34-37
    • (1998) Alcohol Health Res , vol.22 , pp. 34-37
    • Gonzalez, L.P.1
  • 52
    • 0024403638 scopus 로고
    • Reinforcing and discriminative stimulus effects of Ca-acetyl homotaurine in animals
    • Grant KA, Woolverton WL (1989) Reinforcing and discriminative stimulus effects of Ca-acetyl homotaurine in animals. Pharmacol Biochem Behav 32: 607-611
    • (1989) Pharmacol Biochem Behav , vol.32 , pp. 607-611
    • Grant, K.A.1    Woolverton, W.L.2
  • 54
    • 0025731207 scopus 로고
    • Brain regional specificity and time-course of changes in the NMDA receptor-ionophore complex during ethanol withdrawal
    • Gulya K, Grant KA, Valverius P, Hoffman PL, Tabakoff B (1991) Brain regional specificity and time-course of changes in the NMDA receptor-ionophore complex during ethanol withdrawal. Brain Res 547: 129-134
    • (1991) Brain Res , vol.547 , pp. 129-134
    • Gulya, K.1    Grant, K.A.2    Valverius, P.3    Hoffman, P.L.4    Tabakoff, B.5
  • 55
    • 0025197743 scopus 로고
    • Brain lipid changes after ethanol exposure
    • Gustavsson L (1990) Brain lipid changes after ethanol exposure. Ups J Med Sci [Suppl 48]: 245-266
    • (1990) Ups J Med Sci , Issue.SUPPL. 48 , pp. 245-266
    • Gustavsson, L.1
  • 56
    • 0015875758 scopus 로고
    • The depression of brain stem neurones by taurine and its interaction with strychnine and bicuculline
    • Haas HL, Hösli L (1973) The depression of brain stem neurones by taurine and its interaction with strychnine and bicuculline. Brain Res 52: 399-402
    • (1973) Brain Res , vol.52 , pp. 399-402
    • Haas, H.L.1    Hösli, L.2
  • 57
    • 0032746874 scopus 로고    scopus 로고
    • Ethanol actions on multiple ion channels: Which are important?
    • Harris RA (1999) Ethanol actions on multiple ion channels: Which are important? Alcohol Clin Exp Res 23: 1563-1570
    • (1999) Alcohol Clin Exp Res , vol.23 , pp. 1563-1570
    • Harris, R.A.1
  • 58
    • 0026560048 scopus 로고
    • Taurine and glycine activate the same Cl-conductance in substantia nigra dopamine neurones
    • Häusser MA, Yung WH, Lacey MG (1992) Taurine and glycine activate the same Cl-conductance in substantia nigra dopamine neurones. Brain Res 571: 103-108
    • (1992) Brain Res , vol.571 , pp. 103-108
    • Häusser, M.A.1    Yung, W.H.2    Lacey, M.G.3
  • 59
    • 0032007883 scopus 로고    scopus 로고
    • Chronic acamprosate eliminates the alcohol deprivation effect while having limited effects on baseline responding for ethanol in rats
    • Heyser CJ, Schulteis G, Durbin P, Koob GF (1998) Chronic acamprosate eliminates the alcohol deprivation effect while having limited effects on baseline responding for ethanol in rats. Neuropsychopharmacology 18: 125-133
    • (1998) Neuropsychopharmacology , vol.18 , pp. 125-133
    • Heyser, C.J.1    Schulteis, G.2    Durbin, P.3    Koob, G.F.4
  • 61
    • 0026393998 scopus 로고
    • The contribution of voltage-gated and NMDA receptor-gated calcium channels to ethanol withdrawal seizures
    • Hoffman PL, Tabakoff B (1991) The contribution of voltage-gated and NMDA receptor-gated calcium channels to ethanol withdrawal seizures. Alcohol Alcohol [Suppl 1]: 171-175
    • (1991) Alcohol Alcohol , Issue.SUPPL. 1 , pp. 171-175
    • Hoffman, P.L.1    Tabakoff, B.2
  • 62
    • 0026547971 scopus 로고
    • Role of context in ethanol tolerance and subsequent hedonic effects
    • Holloway FA, King DA, Bedingfield JB, Gauvin DV (1992) Role of context in ethanol tolerance and subsequent hedonic effects. Alcohol 9: 109-116
    • (1992) Alcohol , vol.9 , pp. 109-116
    • Holloway, F.A.1    King, D.A.2    Bedingfield, J.B.3    Gauvin, D.V.4
  • 63
    • 0021149437 scopus 로고
    • Periodic availability: Factors affecting alcohol selection in rats
    • Holloway FA, Bird DC, Devenport JA (1984) Periodic availability: Factors affecting alcohol selection in rats. Alcohol 1: 19-25
    • (1984) Alcohol , vol.1 , pp. 19-25
    • Holloway, F.A.1    Bird, D.C.2    Devenport, J.A.3
  • 64
    • 0343683410 scopus 로고    scopus 로고
    • Time course of acamprosate action on operant ethanol self-administration after ethanol deprivation
    • Hölter SM, Landgraf R, Zieglgansberger W, Spanagel R (1997) Time course of acamprosate action on operant ethanol self-administration after ethanol deprivation. Alcohol Clin Exp Res 21: 862-868
    • (1997) Alcohol Clin Exp Res , vol.21 , pp. 862-868
    • Hölter, S.M.1    Landgraf, R.2    Zieglgansberger, W.3    Spanagel, R.4
  • 65
    • 0023128168 scopus 로고
    • Conditioned taste aversion induced by self-administered drugs: Paradox revisited
    • Hunt T, Amit Z (1987) Conditioned taste aversion induced by self-administered drugs: Paradox revisited. Neurosci Biobehav Rev 11: 107-130
    • (1987) Neurosci Biobehav Rev , vol.11 , pp. 107-130
    • Hunt, T.1    Amit, Z.2
  • 66
    • 0024486498 scopus 로고
    • Taurine in the central nervous system and the mammalian actions of taurine
    • Huxtable RJ (1989) Taurine in the central nervous system and the mammalian actions of taurine. Prog Neurobiol 32: 471-533
    • (1989) Prog Neurobiol , vol.32 , pp. 471-533
    • Huxtable, R.J.1
  • 67
    • 0026595620 scopus 로고
    • Physiological actions of taurine
    • Huxtable RJ (1992) Physiological actions of taurine. Physiol Rev 72: 101-163
    • (1992) Physiol Rev , vol.72 , pp. 101-163
    • Huxtable, R.J.1
  • 68
    • 0017273294 scopus 로고
    • Effect of taurine on ethanol-induced sleeping time in mice
    • Ida S, Hikichi M (1976) Effect of taurine on ethanol-induced sleeping time in mice. J Stud Alcohol 37: 19-26
    • (1976) J Stud Alcohol , vol.37 , pp. 19-26
    • Ida, S.1    Hikichi, M.2
  • 69
    • 0023500865 scopus 로고
    • Antisera against taurine: Quantitative characterization of the antibody specificity and its application to immunohistochemical study in the rat brain
    • Ida S, Kuriyama K, Tomida Y, Kimura H (1987) Antisera against taurine: Quantitative characterization of the antibody specificity and its application to immunohistochemical study in the rat brain. J Neurosci Res 18: 626-631
    • (1987) J Neurosci Res , vol.18 , pp. 626-631
    • Ida, S.1    Kuriyama, K.2    Tomida, Y.3    Kimura, H.4
  • 70
    • 0018895485 scopus 로고
    • Effect of ethanol on taurine concentration in the brain
    • Iwata H, Matsuda T, Lee E, Yamagami S, Baba A (1980) Effect of ethanol on taurine concentration in the brain. Experientia 36: 332-333
    • (1980) Experientia , vol.36 , pp. 332-333
    • Iwata, H.1    Matsuda, T.2    Lee, E.3    Yamagami, S.4    Baba, A.5
  • 71
    • 0021264498 scopus 로고
    • Effect of taurine on a benzodiazepine-GABA-chloride ionophore receptor complex in rat brain membranes
    • Iwata H, Nakayama K, Matsuda T, Baba A (1984) Effect of taurine on a benzodiazepine-GABA-chloride ionophore receptor complex in rat brain membranes. Neurochem Res 9: 535-544
    • (1984) Neurochem Res , vol.9 , pp. 535-544
    • Iwata, H.1    Nakayama, K.2    Matsuda, T.3    Baba, A.4
  • 72
    • 0021333015 scopus 로고
    • Veratridine-induced release in vivo and in vitro of amino acids in the rabbit olfactory bulb
    • Jacobson I, Hamberger A (1984) Veratridine-induced release in vivo and in vitro of amino acids in the rabbit olfactory bulb. Brain Res 299: 103-112
    • (1984) Brain Res , vol.299 , pp. 103-112
    • Jacobson, I.1    Hamberger, A.2
  • 73
    • 0022404730 scopus 로고
    • Mass transfer in brain dialysis devices - A new method for the estimation of extracellular amino acids concentration
    • Jacobson I, Sandberg M, Hamberger A (1985) Mass transfer in brain dialysis devices - A new method for the estimation of extracellular amino acids concentration. J Neurosci Meth 15: 263-268
    • (1985) J Neurosci Meth , vol.15 , pp. 263-268
    • Jacobson, I.1    Sandberg, M.2    Hamberger, A.3
  • 74
    • 0034071789 scopus 로고    scopus 로고
    • Neuropharmacological treatments for alcoholism: Scientific basis and clinical findings
    • Johnson BA, Ait-Daoud N (2000) Neuropharmacological treatments for alcoholism: Scientific basis and clinical findings. Psychopharmacology 149: 327-344
    • (2000) Psychopharmacology , vol.149 , pp. 327-344
    • Johnson, B.A.1    Ait-Daoud, N.2
  • 75
    • 0025193629 scopus 로고
    • Interactions of taurine with GABAB binding sites in mouse brain
    • Kontro P, Oja SS (1990) Interactions of taurine with GABAB binding sites in mouse brain. Neuropharmacology 29: 243-247
    • (1990) Neuropharmacology , vol.29 , pp. 243-247
    • Kontro, P.1    Oja, S.S.2
  • 77
    • 0033662326 scopus 로고    scopus 로고
    • Pharmacotherapy of alcoholism: Gaps in knowledge and opportunities for research
    • Kranzler HR (2000) Pharmacotherapy of alcoholism: Gaps in knowledge and opportunities for research. Alcohol Alcohol 35: 537-547
    • (2000) Alcohol Alcohol , vol.35 , pp. 537-547
    • Kranzler, H.R.1
  • 78
    • 0344352496 scopus 로고    scopus 로고
    • The anti-craving drug acamprosate inhibits the conditioned place aversion induced by naloxone-precipitated morphine withdrawal in rats
    • Kratzer U, Schmidt WJ (1998) The anti-craving drug acamprosate inhibits the conditioned place aversion induced by naloxone-precipitated morphine withdrawal in rats. Neurosci Lett 252: 53-56
    • (1998) Neurosci Lett , vol.252 , pp. 53-56
    • Kratzer, U.1    Schmidt, W.J.2
  • 79
    • 0023687152 scopus 로고
    • Identification of two taurine receptor subtypes on the primary afferent terminal of frog spinal cord
    • Kudo Y, Akiyoshi E, Akagi H (1988) Identification of two taurine receptor subtypes on the primary afferent terminal of frog spinal cord. Br J Pharmacol 94: 1051-1056
    • (1988) Br J Pharmacol , vol.94 , pp. 1051-1056
    • Kudo, Y.1    Akiyoshi, E.2    Akagi, H.3
  • 80
    • 0021925440 scopus 로고
    • The action of taurine on the response to glutamate in the motoneuron of the isolated frog spinal cord
    • Kurachi M, Aihara H (1985) The action of taurine on the response to glutamate in the motoneuron of the isolated frog spinal cord. Neuropharmacology 24: 775-781
    • (1985) Neuropharmacology , vol.24 , pp. 775-781
    • Kurachi, M.1    Aihara, H.2
  • 81
    • 0021042025 scopus 로고
    • Effect of taurine on depolarizations induced by L-glutamate and other excitatory amino acids in the isolated spinal cord of the frog
    • Kurachi M, Yoshihara K, Aihara H (1983) Effect of taurine on depolarizations induced by L-glutamate and other excitatory amino acids in the isolated spinal cord of the frog. Jap J Pharmacol 33: 1247-1254
    • (1983) Jap J Pharmacol , vol.33 , pp. 1247-1254
    • Kurachi, M.1    Yoshihara, K.2    Aihara, H.3
  • 82
    • 0018820117 scopus 로고
    • Taurine as a neuromodulator
    • Kuriyama K (1980) Taurine as a neuromodulator. Fed Proc 39: 2680-2684
    • (1980) Fed Proc , vol.39 , pp. 2680-2684
    • Kuriyama, K.1
  • 83
    • 0021691417 scopus 로고
    • A role for taurine in the maintenance of homeostasis in the central nervous system during hyperexcitation?
    • Lehmann A, Hegberg H, Hamberger A (1984) A role for taurine in the maintenance of homeostasis in the central nervous system during hyperexcitation? Neurosci Lett 52: 341-346
    • (1984) Neurosci Lett , vol.52 , pp. 341-346
    • Lehmann, A.1    Hegberg, H.2    Hamberger, A.3
  • 84
    • 0023277432 scopus 로고
    • Lack of effects of Ca-acetyl homotaurinate on chronic and acute toxicities of ethanol in rats
    • Le Magnen J, Tran G, Durlach J (1987a) Lack of effects of Ca-acetyl homotaurinate on chronic and acute toxicities of ethanol in rats. Alcohol 4: 103-108
    • (1987) Alcohol , vol.4 , pp. 103-108
    • Le Magnen, J.1    Tran, G.2    Durlach, J.3
  • 85
    • 0023216221 scopus 로고
    • Dose-dependent suppression of the high alcohol intake of chronically intoxicated rats by Ca-acetyl homotaurinate
    • Le Magnen J, Tran G, Durlach J, Martin C (1987b) Dose-dependent suppression of the high alcohol intake of chronically intoxicated rats by Ca-acetyl homotaurinate. Alcohol 4: 97-102
    • (1987) Alcohol , vol.4 , pp. 97-102
    • Le Magnen, J.1    Tran, G.2    Durlach, J.3    Martin, C.4
  • 86
    • 0025120394 scopus 로고
    • Neurobehavioral studies of ethanol reward and activation
    • Lewis MJ, June HL (1990) Neurobehavioral studies of ethanol reward and activation. Alcohol 7: 213-219
    • (1990) Alcohol , vol.7 , pp. 213-219
    • Lewis, M.J.1    June, H.L.2
  • 87
    • 0026059333 scopus 로고
    • A characterization of glycinergic receptors present in cultured rat medullary neurons
    • Lewis CA, Ahmed Z, Faber DS (1991) A characterization of glycinergic receptors present in cultured rat medullary neurons. J Neurophysiol 66: 1291-1303
    • (1991) J Neurophysiol , vol.66 , pp. 1291-1303
    • Lewis, C.A.1    Ahmed, Z.2    Faber, D.S.3
  • 90
    • 0023184428 scopus 로고
    • Alcohol consumption in free-feeding rats: Procedural, genetic and pharmacokinetic factors
    • Linseman MA (1987) Alcohol consumption in free-feeding rats: Procedural, genetic and pharmacokinetic factors. Psychopharmacology 92: 254-261
    • (1987) Psychopharmacology , vol.92 , pp. 254-261
    • Linseman, M.A.1
  • 91
    • 0032786231 scopus 로고    scopus 로고
    • The contribution of electrophysiology to knowledge of the acute and chronic effects of ethanol
    • Little HJ (1999) The contribution of electrophysiology to knowledge of the acute and chronic effects of ethanol. Pharmacol Ther 84: 333-353
    • (1999) Pharmacol Ther , vol.84 , pp. 333-353
    • Little, H.J.1
  • 92
    • 0029129027 scopus 로고
    • Acamprosate in alcohol dependence: How does it work?
    • Littleton J (1995) Acamprosate in alcohol dependence: How does it work? Addiction 90: 1179-1188
    • (1995) Addiction , vol.90 , pp. 1179-1188
    • Littleton, J.1
  • 93
    • 0002456867 scopus 로고    scopus 로고
    • Neurochemical mechanisms underlying alcohol withdrawal
    • Littleton J (1998) Neurochemical mechanisms underlying alcohol withdrawal. Alcohol Health Res 22: 13-24
    • (1998) Alcohol Health Res , vol.22 , pp. 13-24
    • Littleton, J.1
  • 94
    • 0028132287 scopus 로고
    • The inhibitory effects of taurine on protein phosphorylation: Comparison of various characteristics of the taurine-affected phosphoproteins present in rat retina, brain and heart
    • Lombardini JB (1994) The inhibitory effects of taurine on protein phosphorylation: Comparison of various characteristics of the taurine-affected phosphoproteins present in rat retina, brain and heart. Adv Exp Med Biol 359: 9-17
    • (1994) Adv Exp Med Biol , vol.359 , pp. 9-17
    • Lombardini, J.B.1
  • 95
    • 0030000009 scopus 로고    scopus 로고
    • Acamprosate (calcium acetylhomotaurinate) enhances the N-methyl-D-aspartate component of excitatory neurotransmission in rat hippocampal CA1 neurons in vitro
    • Madamba SG, Schweitzer P, Zieglgänsberger W, Siggins GR (1996) Acamprosate (calcium acetylhomotaurinate) enhances the N-methyl-D-aspartate component of excitatory neurotransmission in rat hippocampal CA1 neurons in vitro. Alcohol Clin Exp Res 20: 651-658
    • (1996) Alcohol Clin Exp Res , vol.20 , pp. 651-658
    • Madamba, S.G.1    Schweitzer, P.2    Zieglgänsberger, W.3    Siggins, G.R.4
  • 96
    • 0022371008 scopus 로고
    • Immunocytochemical visualization of taurine: Neuronal localization in the rat cerebellum
    • Madsen S, Ottersen OP, Storm-Mathisen J (1985) Immunocytochemical visualization of taurine: Neuronal localization in the rat cerebellum. Neurosci Lett 60: 255-260
    • (1985) Neurosci Lett , vol.60 , pp. 255-260
    • Madsen, S.1    Ottersen, O.P.2    Storm-Mathisen, J.3
  • 97
    • 0022657980 scopus 로고
    • Modulation of the GABA-benzodiazepine receptor complex by taurine in rat brain membranes
    • Malminen O, Kontro P (1986) Modulation of the GABA-benzodiazepine receptor complex by taurine in rat brain membranes. Neurochem Res 11: 85-94
    • (1986) Neurochem Res , vol.11 , pp. 85-94
    • Malminen, O.1    Kontro, P.2
  • 98
    • 0024343513 scopus 로고
    • Gamma-aminobutyric acid and benzodiazepine receptors in cultured cerebellar granule cells: Effects of taurine and its lipophilic derivatives
    • Malminen O, Kontro P (1989) Gamma-aminobutyric acid and benzodiazepine receptors in cultured cerebellar granule cells: Effects of taurine and its lipophilic derivatives. Neuropharmacology 28: 907-912
    • (1989) Neuropharmacology , vol.28 , pp. 907-912
    • Malminen, O.1    Kontro, P.2
  • 99
    • 0021169521 scopus 로고
    • Patterns of ethanol consumption as a function of the schedule of ethanol access
    • Marcucella H, Munro I, MacDonall JS (1984) Patterns of ethanol consumption as a function of the schedule of ethanol access. J Pharmacol Exp Ther 230: 658-664
    • (1984) J Pharmacol Exp Ther , vol.230 , pp. 658-664
    • Marcucella, H.1    Munro, I.2    MacDonall, J.S.3
  • 100
    • 0034816006 scopus 로고    scopus 로고
    • Treatment of alcohol-dependent outpatients with acamprosate: A clinical review
    • Mason BJ (2001) Treatment of alcohol-dependent outpatients with acamprosate: A clinical review. J Clin Psychiatry 62 [Suppl 20]: 42-48
    • (2001) J Clin Psychiatry , vol.62 , Issue.SUPPL. 20 , pp. 42-48
    • Mason, B.J.1
  • 101
    • 0018361463 scopus 로고
    • Noradrenergic processes involved in the locomotor effects of ethanol
    • Mason ST, Corcoran ME, Fibiger HC (1979) Noradrenergic processes involved in the locomotor effects of ethanol. Eur J Pharmacol 54: 383-387
    • (1979) Eur J Pharmacol , vol.54 , pp. 383-387
    • Mason, S.T.1    Corcoran, M.E.2    Fibiger, H.C.3
  • 103
    • 0022405995 scopus 로고
    • Acute effects of taurine and a taurine antagonist on ethanol-induced central nervous system depression
    • Mattucci-Schiavone L, Ferko AP (1985) Acute effects of taurine and a taurine antagonist on ethanol-induced central nervous system depression. Eur J Pharmacol 113: 275-278
    • (1985) Eur J Pharmacol , vol.113 , pp. 275-278
    • Mattucci-Schiavone, L.1    Ferko, A.P.2
  • 104
    • 0019481019 scopus 로고
    • Inhibitory actions of amino acids in the preoptic-anterior hypothalamus of the rat
    • Mayer ML (1981) Inhibitory actions of amino acids in the preoptic-anterior hypothalamus of the rat. Exp Brain Res 43: 154-158
    • (1981) Exp Brain Res , vol.43 , pp. 154-158
    • Mayer, M.L.1
  • 105
    • 0018966722 scopus 로고
    • Taurine as a possible inhibitory transmitter in the cerebellum
    • McBride WJ, Frederickson RC (1980) Taurine as a possible inhibitory transmitter in the cerebellum. Fed Proc 39: 2701-2705
    • (1980) Fed Proc , vol.39 , pp. 2701-2705
    • McBride, W.J.1    Frederickson, R.C.2
  • 106
    • 0022645359 scopus 로고
    • Taurine and ethanol-induced sleeping time in mice: Route and time course effects
    • McBroom MJ, Elkhawad AO, Dlouha H (1986) Taurine and ethanol-induced sleeping time in mice: Route and time course effects. Gen Pharmacol 17: 97-100
    • (1986) Gen Pharmacol , vol.17 , pp. 97-100
    • McBroom, M.J.1    Elkhawad, A.O.2    Dlouha, H.3
  • 107
    • 0021336370 scopus 로고
    • Taurine modulation of the benzodiazepine-gamma-aminobutyric acid receptor complex in brain membranes
    • Medina JH, De Robertis E (1984) Taurine modulation of the benzodiazepine-gamma-aminobutyric acid receptor complex in brain membranes. J Neurochem 42: 1212-1217
    • (1984) J Neurochem , vol.42 , pp. 1212-1217
    • Medina, J.H.1    De Robertis, E.2
  • 108
    • 0014025931 scopus 로고
    • Experimental analysis of drinking behavior of chronic alcoholics
    • Mendelson JH, Mello NK (1966) Experimental analysis of drinking behavior of chronic alcoholics. Ann N Y Acad Sci 133: 828-845
    • (1966) Ann N Y Acad Sci , vol.133 , pp. 828-845
    • Mendelson, J.H.1    Mello, N.K.2
  • 109
    • 0029060075 scopus 로고
    • Low-dose effect of ethanol on locomotor activity induced by activation of the mesolimbic system
    • Milton GV, Randall PK, Erickson CK (1995) Low-dose effect of ethanol on locomotor activity induced by activation of the mesolimbic system. Alcohol Clin Exp Res 19: 768-776
    • (1995) Alcohol Clin Exp Res , vol.19 , pp. 768-776
    • Milton, G.V.1    Randall, P.K.2    Erickson, C.K.3
  • 110
    • 0033605771 scopus 로고    scopus 로고
    • The ethanol-induced open-field activity in rodents treated with isethionic acid acid, a central metabolite of taurine
    • Miquel M, Correa M, Sanchis-Segura C, Aragon CMG (1999) The ethanol-induced open-field activity in rodents treated with isethionic acid acid, a central metabolite of taurine. Life Sci 64: 1613-1621
    • (1999) Life Sci , vol.64 , pp. 1613-1621
    • Miquel, M.1    Correa, M.2    Sanchis-Segura, C.3    Aragon, C.M.G.4
  • 111
    • 0031702238 scopus 로고    scopus 로고
    • Cyamemazine decreases ethanol intake in rats and convulsions during ethanol withdrawal syndrome in mice
    • Naassila M, Legrand E, d'Alche-Birée F, Daoust M (1998) Cyamemazine decreases ethanol intake in rats and convulsions during ethanol withdrawal syndrome in mice. Psychopharmacology 140: 421-428
    • (1998) Psychopharmacology , vol.140 , pp. 421-428
    • Naassila, M.1    Legrand, E.2    D'Alche-Birée, F.3    Daoust, M.4
  • 112
    • 0031868767 scopus 로고    scopus 로고
    • Mechanism of action of acamprosate. Part I. Characterization of spermidine-sensitive acamprosate binding site in rat brain
    • Naassila M, Hammoumi S, Legrand E, Durbin P, Daoust M (1998) Mechanism of action of acamprosate. Part I. Characterization of spermidine-sensitive acamprosate binding site in rat brain. Alcohol Clin Exp Res 22: 802-809
    • (1998) Alcohol Clin Exp Res , vol.22 , pp. 802-809
    • Naassila, M.1    Hammoumi, S.2    Legrand, E.3    Durbin, P.4    Daoust, M.5
  • 113
    • 0034495209 scopus 로고    scopus 로고
    • Intracerebroventricular injection of antisense oligos to nNOS decreases rat ethanol intake
    • Naassila M, Beauge FJ, Sebire N, Daoust M (2000) Intracerebroventricular injection of antisense oligos to nNOS decreases rat ethanol intake. Pharmacol Biochem Behav 67: 629-636
    • (2000) Pharmacol Biochem Behav , vol.67 , pp. 629-636
    • Naassila, M.1    Beauge, F.J.2    Sebire, N.3    Daoust, M.4
  • 114
    • 0025059156 scopus 로고
    • Neuromodulatory and trophic actions of taurine
    • Oja SS, Kontro P (1990) Neuromodulatory and trophic actions of taurine. Prog Clin Biol Res 351: 69-76
    • (1990) Prog Clin Biol Res , vol.351 , pp. 69-76
    • Oja, S.S.1    Kontro, P.2
  • 115
    • 0029893380 scopus 로고    scopus 로고
    • Taurine as osmoregulator and neuromodulator in the brain
    • Oja SS, Saransaari P (1996) Taurine as osmoregulator and neuromodulator in the brain. Metabol Brain Dis 11: 153-164
    • (1996) Metabol Brain Dis , vol.11 , pp. 153-164
    • Oja, S.S.1    Saransaari, P.2
  • 116
    • 0018821277 scopus 로고
    • Localization of sensitive sites to taurine, gamma-aminobutyric acid, glycine and beta-alanine in the molecular layer of guinea-pig cerebellar slices
    • Okamoto K, Sakai Y (1980) Localization of sensitive sites to taurine, gamma-aminobutyric acid, glycine and beta-alanine in the molecular layer of guinea-pig cerebellar slices. Br J Pharmacol 69: 407-413
    • (1980) Br J Pharmacol , vol.69 , pp. 407-413
    • Okamoto, K.1    Sakai, Y.2
  • 117
    • 0020663253 scopus 로고
    • Effects of taurine and GABA on Ca spikes and Na spikes in cerebellar purkinje cells in vitro: Intrasomatic study
    • Okamoto K, Kimura H, Sakai Y (1983a) Effects of taurine and GABA on Ca spikes and Na spikes in cerebellar purkinje cells in vitro: Intrasomatic study. Brain Res 260: 249-259
    • (1983) Brain Res , vol.260 , pp. 249-259
    • Okamoto, K.1    Kimura, H.2    Sakai, Y.3
  • 118
    • 0020574508 scopus 로고
    • Evidence for taurine as an inhibitory neurotransmitter in cerebellar stellate interneurons: Selective antagonism by TAG (6-aminomethyl-3-methyl-4H,1,2,4-benzothiadiazine-1,1-dioxide)
    • Okamoto K, Kimura H, Sakai Y (1983b) Evidence for taurine as an inhibitory neurotransmitter in cerebellar stellate interneurons: Selective antagonism by TAG (6-aminomethyl-3-methyl-4H,1,2,4-benzothiadiazine-1,1-dioxide). Brain Res 265: 163-168
    • (1983) Brain Res , vol.265 , pp. 163-168
    • Okamoto, K.1    Kimura, H.2    Sakai, Y.3
  • 119
    • 0020687116 scopus 로고
    • Ionic mechanisms of the action of taurine on cerebellar Purkinje cell dendrites in vitro: Intradendritic study
    • Okamoto K, Kimura H, Sakai Y (1983c) Ionic mechanisms of the action of taurine on cerebellar Purkinje cell dendrites in vitro: Intradendritic study. Brain Res 260: 261-269
    • (1983) Brain Res , vol.260 , pp. 261-269
    • Okamoto, K.1    Kimura, H.2    Sakai, Y.3
  • 120
    • 4243261986 scopus 로고    scopus 로고
    • Taurine-related compounds differentially alter ethanol consumption and ethanol-stimulated dopamine release in rats: Comparison with acamprosate
    • Olive MF, Hodge CW (2001) Taurine-related compounds differentially alter ethanol consumption and ethanol-stimulated dopamine release in rats: Comparison with acamprosate. Alcohol Clin Exp Res 25: 17A
    • (2001) Alcohol Clin Exp Res , vol.25
    • Olive, M.F.1    Hodge, C.W.2
  • 121
    • 0034672454 scopus 로고    scopus 로고
    • Modulation of extracellular neurotransmitter levels in the nucleus accumbens by a taurine uptake inhibitor
    • Olive MF, Mehmert KK, Hodge CW (2000a) Modulation of extracellular neurotransmitter levels in the nucleus accumbens by a taurine uptake inhibitor. Eur J Pharmacol 409: 291-294
    • (2000) Eur J Pharmacol , vol.409 , pp. 291-294
    • Olive, M.F.1    Mehmert, K.K.2    Hodge, C.W.3
  • 122
    • 0033777799 scopus 로고    scopus 로고
    • Reduced operant ethanol self-administration and in vivo mesolimbic dopamine responses to ethanol in PKCε deficient mice
    • Olive MF, Mehmert KK, Messing RO, Hodge CW (2000b) Reduced operant ethanol self-administration and in vivo mesolimbic dopamine responses to ethanol in PKCε deficient mice. Eur J Neurosci 12: 4131-4140
    • (2000) Eur J Neurosci , vol.12 , pp. 4131-4140
    • Olive, M.F.1    Mehmert, K.K.2    Messing, R.O.3    Hodge, C.W.4
  • 123
    • 0023037893 scopus 로고
    • Taurine levels in discrete brain nuclei of rats
    • Palkovits M, Elekes I, Lang T, Patthy A (1986) Taurine levels in discrete brain nuclei of rats. J Neurochem 47: 1333-1335
    • (1986) J Neurochem , vol.47 , pp. 1333-1335
    • Palkovits, M.1    Elekes, I.2    Lang, T.3    Patthy, A.4
  • 124
    • 0032437380 scopus 로고    scopus 로고
    • Neuronal signaling systems and ethanol dependence
    • Pandey SC (1998) Neuronal signaling systems and ethanol dependence. Mol Neurobiol 17: 1-15
    • (1998) Mol Neurobiol , vol.17 , pp. 1-15
    • Pandey, S.C.1
  • 125
    • 0032824985 scopus 로고    scopus 로고
    • Acamprosate does not antagonise the discriminative stimulus properties of amphetamine and morphine in rats
    • Pascucci T, Cioli I, Pisetzky F, Dupre S, Spirito A, Nencini P (1999) Acamprosate does not antagonise the discriminative stimulus properties of amphetamine and morphine in rats. Pharmacol Res 40: 333-338
    • (1999) Pharmacol Res , vol.40 , pp. 333-338
    • Pascucci, T.1    Cioli, I.2    Pisetzky, F.3    Dupre, S.4    Spirito, A.5    Nencini, P.6
  • 126
    • 0034646855 scopus 로고    scopus 로고
    • Interaction of acamprosate with ethanol and spermine on NMDA receptors in primary cultured neurons
    • Popp RL, Lovinger DM (2000) Interaction of acamprosate with ethanol and spermine on NMDA receptors in primary cultured neurons. Eur J Pharmacol 394: 221-231
    • (2000) Eur J Pharmacol , vol.394 , pp. 221-231
    • Popp, R.L.1    Lovinger, D.M.2
  • 127
    • 18744422986 scopus 로고    scopus 로고
    • Anti-craving drug acamprosate reduces c-fos expression in rats undergoing ethanol withdrawal
    • Putzke J, Spanagel R, Tolle TR, Zieglgansberger W (1996) Anti-craving drug acamprosate reduces c-fos expression in rats undergoing ethanol withdrawal. Eur J Pharmacol 317: 39-48
    • (1996) Eur J Pharmacol , vol.317 , pp. 39-48
    • Putzke, J.1    Spanagel, R.2    Tolle, T.R.3    Zieglgansberger, W.4
  • 128
    • 0031671198 scopus 로고    scopus 로고
    • Changes in the amygdala amino acid microdialysate after conditioning with a cue associated with ethanol
    • Quertemont E, de Neuville J, De Witte P (1998a) Changes in the amygdala amino acid microdialysate after conditioning with a cue associated with ethanol. Psychopharmacology 139: 71-78
    • (1998) Psychopharmacology , vol.139 , pp. 71-78
    • Quertemont, E.1    De Neuville, J.2    De Witte, P.3
  • 129
    • 0031662253 scopus 로고    scopus 로고
    • Oral taurine supplementation modulates ethanol-conditioned stimulus preference
    • Quertemont E, Goffaux V, Vlaminck A-M, Wolf C, De Witte P (1998b) Oral taurine supplementation modulates ethanol-conditioned stimulus preference. Alcohol 16: 201-206
    • (1998) Alcohol , vol.16 , pp. 201-206
    • Quertemont, E.1    Goffaux, V.2    Vlaminck, A.-M.3    Wolf, C.4    De Witte, P.5
  • 130
    • 0032999855 scopus 로고    scopus 로고
    • Ethanol induces taurine release in the amygdala: An in vivo microdialysis study
    • Quertemont E, Dahchour A, Ward RJ, De Witte P (1999) Ethanol induces taurine release in the amygdala: An in vivo microdialysis study. Addict Biol 4: 47-54
    • (1999) Addict Biol , vol.4 , pp. 47-54
    • Quertemont, E.1    Dahchour, A.2    Ward, R.J.3    De Witte, P.4
  • 131
    • 0034996278 scopus 로고    scopus 로고
    • Conditioned stimulus preference after acetaldehyde but not ethanol injections
    • Quertemont E, De Witte P (2001) Conditioned stimulus preference after acetaldehyde but not ethanol injections. Pharmacol Biochem Behav 68: 449-454
    • (2001) Pharmacol Biochem Behav , vol.68 , pp. 449-454
    • Quertemont, E.1    De Witte, P.2
  • 133
    • 0029616450 scopus 로고
    • Taurine allosterically inhibits binding of [35S]-t-butylbicyclophosphorothionate (TBPS) to rat brain synaptic membranes
    • Quinn MR, Harris CL (1995) Taurine allosterically inhibits binding of [35S]-t-butylbicyclophosphorothionate (TBPS) to rat brain synaptic membranes. Neuropharmacology 34: 1607-1613
    • (1995) Neuropharmacology , vol.34 , pp. 1607-1613
    • Quinn, M.R.1    Harris, C.L.2
  • 134
    • 0026649442 scopus 로고
    • Taurine allosterically modulates flunitrazepam binding to synaptic membranes
    • Quinn MR, Miller CL (1992) Taurine allosterically modulates flunitrazepam binding to synaptic membranes. J Neurosci Res 33: 136-141
    • (1992) J Neurosci Res , vol.33 , pp. 136-141
    • Quinn, M.R.1    Miller, C.L.2
  • 135
    • 0035001893 scopus 로고    scopus 로고
    • The anti-craving compound acamprosate acts as a weak NMDA-receptor antagonist, but modulates NMDA-receptor subunit expression similar to memantine and MK-801
    • Rammes G, Mahal B, Putzke J, Parsons C, Spielmanns P, Pestel E, Spanagel R, Zieglgansberger W, Schadrack J (2001) The anti-craving compound acamprosate acts as a weak NMDA-receptor antagonist, but modulates NMDA-receptor subunit expression similar to memantine and MK-801. Neuropharmacology 40: 749-760
    • (2001) Neuropharmacology , vol.40 , pp. 749-760
    • Rammes, G.1    Mahal, B.2    Putzke, J.3    Parsons, C.4    Spielmanns, P.5    Pestel, E.6    Spanagel, R.7    Zieglgansberger, W.8    Schadrack, J.9
  • 136
    • 0021916366 scopus 로고
    • Toward understanding ethanol's capacity to be reinforcing: A conditioned place preference following injections of ethanol
    • Reid LD, Hunter GA, Beaman CM, Hubbell CL (1985) Toward understanding ethanol's capacity to be reinforcing: A conditioned place preference following injections of ethanol. Pharmacol Biochem Behav 22: 483-487
    • (1985) Pharmacol Biochem Behav , vol.22 , pp. 483-487
    • Reid, L.D.1    Hunter, G.A.2    Beaman, C.M.3    Hubbell, C.L.4
  • 137
    • 0029119866 scopus 로고
    • Ethanol withdrawal is associated with increased extracellular glutamate in the rat striatum
    • Rossetti ZL, Carboni S (1995) Ethanol withdrawal is associated with increased extracellular glutamate in the rat striatum. Eur J Pharmacol 283: 177-183
    • (1995) Eur J Pharmacol , vol.283 , pp. 177-183
    • Rossetti, Z.L.1    Carboni, S.2
  • 138
    • 0032773638 scopus 로고    scopus 로고
    • Glutamate-induced increase of extracellular glutamate through N-methyl-D-aspartate receptors in ethanol withdrawal
    • Rossetti ZL, Carboni S, Fadda F (1999) Glutamate-induced increase of extracellular glutamate through N-methyl-D-aspartate receptors in ethanol withdrawal. Neuroscience 93: 1135-1140
    • (1999) Neuroscience , vol.93 , pp. 1135-1140
    • Rossetti, Z.L.1    Carboni, S.2    Fadda, F.3
  • 139
    • 0001870655 scopus 로고    scopus 로고
    • Introduction to alcohol withdrawal
    • Saitz R (1998) Introduction to alcohol withdrawal. Alcohol Health Res 22: 5-12
    • (1998) Alcohol Health Res , vol.22 , pp. 5-12
    • Saitz, R.1
  • 141
    • 0022497706 scopus 로고
    • Initiation of ethanol reinforcement using a sucrose-substitution procedure in food- and water-sated rats
    • Samson HH (1986) Initiation of ethanol reinforcement using a sucrose-substitution procedure in food- and water-sated rats. Alcohol Clin Exp Res 10: 436-442
    • (1986) Alcohol Clin Exp Res , vol.10 , pp. 436-442
    • Samson, H.H.1
  • 142
    • 0026079334 scopus 로고
    • Ethanol self-administration in a nonrestricted access situation: Effect of ethanol initiation
    • Samson HH, Tolliver GA, Schwarz-Stevens K (1991) Ethanol self-administration in a nonrestricted access situation: Effect of ethanol initiation. Alcohol 8: 43-53
    • (1991) Alcohol , vol.8 , pp. 43-53
    • Samson, H.H.1    Tolliver, G.A.2    Schwarz-Stevens, K.3
  • 143
    • 0033662484 scopus 로고    scopus 로고
    • Taurine and neural cell damage
    • Saransaari P, Oja SS (2000) Taurine and neural cell damage. Amino Acids 19: 509-526
    • (2000) Amino Acids , vol.19 , pp. 509-526
    • Saransaari, P.1    Oja, S.S.2
  • 144
    • 0021202340 scopus 로고
    • Conditioned place preference induced by intraventricular infusions of acetaldehyde
    • Smith BR, Amit Z, Splawinsky J (1984) Conditioned place preference induced by intraventricular infusions of acetaldehyde. Alcohol 1: 193-195
    • (1984) Alcohol , vol.1 , pp. 193-195
    • Smith, B.R.1    Amit, Z.2    Splawinsky, J.3
  • 145
    • 0034114914 scopus 로고    scopus 로고
    • Pharmacological validation of a new animal model of alcoholism
    • Spanagel R, Hölter SM (2000) Pharmacological validation of a new animal model of alcoholism. J Neural Trans 107: 669-680
    • (2000) J Neural Trans , vol.107 , pp. 669-680
    • Spanagel, R.1    Hölter, S.M.2
  • 146
    • 0031081578 scopus 로고    scopus 로고
    • Anti-craving compounds for ethanol: New pharmacological tools to study addictive processes
    • Spanagel R, Zieglgansberger W (1997) Anti-craving compounds for ethanol: New pharmacological tools to study addictive processes. Trends Pharmacol Sci 18: 54-59
    • (1997) Trends Pharmacol Sci , vol.18 , pp. 54-59
    • Spanagel, R.1    Zieglgansberger, W.2
  • 147
  • 149
    • 17044458222 scopus 로고    scopus 로고
    • Acamprosate and alcohol: III. Effects of alcohol discrimination in the rat
    • Spanagel R, Zieglgansberger W, Hundt W (1996c) Acamprosate and alcohol: III. Effects of alcohol discrimination in the rat. Eur J Pharmacol 305: 51-56
    • (1996) Eur J Pharmacol , vol.305 , pp. 51-56
    • Spanagel, R.1    Zieglgansberger, W.2    Hundt, W.3
  • 150
    • 0031697417 scopus 로고    scopus 로고
    • Acamprosate suppresses the expression of morphine-induced sensitization in rats but does not affect heroin self-administration or relapse induced by heroin or stress
    • Spanagel R, Sillaber I, Zieglansberger W, Corrigall WA, Stewart J, Shaham Y (1998) Acamprosate suppresses the expression of morphine-induced sensitization in rats but does not affect heroin self-administration or relapse induced by heroin or stress. Psychopharmacology 139: 391-401
    • (1998) Psychopharmacology , vol.139 , pp. 391-401
    • Spanagel, R.1    Sillaber, I.2    Zieglansberger, W.3    Corrigall, W.A.4    Stewart, J.5    Shaham, Y.6
  • 151
    • 0035028059 scopus 로고    scopus 로고
    • Effect of acamprosate and naltrexone, along or in combinations, on ethanol consumption
    • Stromberg MF, Mackler SA, Volpicelli JR, O'Brien CP (2001) Effect of acamprosate and naltrexone, along or in combinations, on ethanol consumption. Alcohol 23: 109-116
    • (2001) Alcohol , vol.23 , pp. 109-116
    • Stromberg, M.F.1    Mackler, S.A.2    Volpicelli, J.R.3    O'Brien, C.P.4
  • 152
    • 0020418231 scopus 로고
    • Role of dopaminergic neurotransmission in locomotor stimulation by dexamphetamine and ethanol
    • Strombom UH, Liedman B (1982) Role of dopaminergic neurotransmission in locomotor stimulation by dexamphetamine and ethanol. Psychopharmacology 78: 271-276
    • (1982) Psychopharmacology , vol.78 , pp. 271-276
    • Strombom, U.H.1    Liedman, B.2
  • 154
    • 0023007797 scopus 로고
    • Taurine in hippocampus: Localization and postsynaptic action
    • Taber KH, Lin CT, Liu JW, Thalmann RH, Wu JY (1986) Taurine in hippocampus: Localization and postsynaptic action. Brain Res 386: 113-121
    • (1986) Brain Res , vol.386 , pp. 113-121
    • Taber, K.H.1    Lin, C.T.2    Liu, J.W.3    Thalmann, R.H.4    Wu, J.Y.5
  • 155
    • 0029416927 scopus 로고
    • Na(+)- and Cl(-)-dependent transport of taurine at the blood-brain barrier
    • Tamai I, Senmaru M, Terasaki T, Tsuji A (1995) Na(+)- and Cl(-)-dependent transport of taurine at the blood-brain barrier. Biochem Pharmacol 50: 1783-1793
    • (1995) Biochem Pharmacol , vol.50 , pp. 1783-1793
    • Tamai, I.1    Senmaru, M.2    Terasaki, T.3    Tsuji, A.4
  • 156
    • 0031863984 scopus 로고    scopus 로고
    • The effects of taurine and biogenetically related sulfur-containing compounds on the metabolism of and hypothermia by ethanol in the rat
    • Theofanopoulos V, Lau-Cam CA (1998a) The effects of taurine and biogenetically related sulfur-containing compounds on the metabolism of and hypothermia by ethanol in the rat. Adv Exp Med Biol 442: 299-307
    • (1998) Adv Exp Med Biol , vol.442 , pp. 299-307
    • Theofanopoulos, V.1    Lau-Cam, C.A.2
  • 157
    • 0031839133 scopus 로고    scopus 로고
    • Modification by taurine of the metabolism and hypothermic effect of ethanol in the rat
    • Theofanopoulos V, Lau-Cam CA (1998b) Modification by taurine of the metabolism and hypothermic effect of ethanol in the rat. Adv Exp Med Biol 442: 309-318
    • (1998) Adv Exp Med Biol , vol.442 , pp. 309-318
    • Theofanopoulos, V.1    Lau-Cam, C.A.2
  • 158
    • 0031959272 scopus 로고    scopus 로고
    • The role of glutamatergic neurotransmission in the pathophysiology of alcoholism
    • Tsai G, Coyle JT (1998) The role of glutamatergic neurotransmission in the pathophysiology of alcoholism. Annu Rev Med 49: 173-184
    • (1998) Annu Rev Med , vol.49 , pp. 173-184
    • Tsai, G.1    Coyle, J.T.2
  • 160
    • 0030889522 scopus 로고    scopus 로고
    • Acetaldehyde-induced changes in the monoamine and amino acid extracellular microdialysate content of the nucleus accumbens
    • Ward RJ, Colantuoni C, Dahchour A, Quertemont E, De Witte P (1997) Acetaldehyde-induced changes in the monoamine and amino acid extracellular microdialysate content of the nucleus accumbens. Neuropharmacology 36: 225-232
    • (1997) Neuropharmacology , vol.36 , pp. 225-232
    • Ward, R.J.1    Colantuoni, C.2    Dahchour, A.3    Quertemont, E.4    De Witte, P.5
  • 161
    • 0033040290 scopus 로고    scopus 로고
    • Homeostasis of taurine and glutamate plasma levels after acute and chronic ethanol administration in man
    • Ward RJ, Marshall EJ, Ball D, Martinez J, De Witte P (1999) Homeostasis of taurine and glutamate plasma levels after acute and chronic ethanol administration in man. Neurosci Res Comm 24: 41-49
    • (1999) Neurosci Res Comm , vol.24 , pp. 41-49
    • Ward, R.J.1    Marshall, E.J.2    Ball, D.3    Martinez, J.4    De Witte, P.5
  • 162
    • 0035143752 scopus 로고    scopus 로고
    • Taurine modulates catalase, aldehyde dehydrogenase, and ethanol elimination rates in rat brain
    • Ward RJ, Kest W, Bruyeer P, Lallemand F, De Witte P (2001) Taurine modulates catalase, aldehyde dehydrogenase, and ethanol elimination rates in rat brain. Alcohol Alcohol 36: 39-43
    • (2001) Alcohol Alcohol , vol.36 , pp. 39-43
    • Ward, R.J.1    Kest, W.2    Bruyeer, P.3    Lallemand, F.4    De Witte, P.5
  • 163
    • 0022405097 scopus 로고
    • Lowering of liver acetaldehyde but not ethanol concentrations by pretreatment with taurine in ethanol-loaded rats
    • Watanabe A, Hobara N, Nagashima H (1985) Lowering of liver acetaldehyde but not ethanol concentrations by pretreatment with taurine in ethanol-loaded rats. Experientia 41: 1421-1422
    • (1985) Experientia , vol.41 , pp. 1421-1422
    • Watanabe, A.1    Hobara, N.2    Nagashima, H.3
  • 164
    • 0028816575 scopus 로고
    • Increased NMDA receptor and calcium channel activity underlying ethanol withdrawal hyperexcitability
    • Whittington MA, Lambert JD, Little HJ (1995) Increased NMDA receptor and calcium channel activity underlying ethanol withdrawal hyperexcitability. Alcohol Alcohol 30: 105-114
    • (1995) Alcohol Alcohol , vol.30 , pp. 105-114
    • Whittington, M.A.1    Lambert, J.D.2    Little, H.J.3
  • 165
    • 0031005968 scopus 로고    scopus 로고
    • Acamprosate: A review of its pharmacology and clinical potential in the management of alcohol dependence after detoxification
    • Wilde MI, Wagstaff AJ (1997) Acamprosate: A review of its pharmacology and clinical potential in the management of alcohol dependence after detoxification. Drugs 53: 1038-1053
    • (1997) Drugs , vol.53 , pp. 1038-1053
    • Wilde, M.I.1    Wagstaff, A.J.2
  • 166
    • 0018909215 scopus 로고
    • Interactions of taurine and beta-alanine with central nervous system neurotransmitter receptors
    • Williams M, Risley EA, Totaro JA (1980) Interactions of taurine and beta-alanine with central nervous system neurotransmitter receptors. Life Sci 26: 557-560
    • (1980) Life Sci , vol.26 , pp. 557-560
    • Williams, M.1    Risley, E.A.2    Totaro, J.A.3
  • 169
    • 0019839655 scopus 로고
    • Neuropharmacological characterization of a taurine antagonist
    • Yarbrough GG, Singh DK, Taylor DA (1981) Neuropharmacological characterization of a taurine antagonist. J Pharmacol Exp Ther 219: 604-613
    • (1981) J Pharmacol Exp Ther , vol.219 , pp. 604-613
    • Yarbrough, G.G.1    Singh, D.K.2    Taylor, D.A.3
  • 170
    • 0022508770 scopus 로고
    • Demonstration of taurine-like immunoreactive structures in the rat brain
    • Yoshida M, Karasawa N, Ito M, Sakai M, Nagatsu I (1986) Demonstration of taurine-like immunoreactive structures in the rat brain. Neurosci Res 3: 356-363
    • (1986) Neurosci Res , vol.3 , pp. 356-363
    • Yoshida, M.1    Karasawa, N.2    Ito, M.3    Sakai, M.4    Nagatsu, I.5
  • 171
    • 0012006592 scopus 로고
    • Immunohistochemistry of taurine and GABA in serial brain sections of the rat
    • Yoshida M, Teramura M, Karasawa N, Sakai M, Nagatsu I (1987) Immunohistochemistry of taurine and GABA in serial brain sections of the rat. Biogen Amines 4: 135-144
    • (1987) Biogen Amines , vol.4 , pp. 135-144
    • Yoshida, M.1    Teramura, M.2    Karasawa, N.3    Sakai, M.4    Nagatsu, I.5
  • 172
    • 0025035137 scopus 로고
    • Calciumdiacetylhomotaurinate (CA-AOTA) decreases the action of excitatory amino acids in the rat neocortex in vitro
    • Zeise ML, Kasparow S, Capogna M, Zieglgänsberger W (1990) Calciumdiacetylhomotaurinate (CA-AOTA) decreases the action of excitatory amino acids in the rat neocortex in vitro. Prog Clin Biol Res 351: 237-242
    • (1990) Prog Clin Biol Res , vol.351 , pp. 237-242
    • Zeise, M.L.1    Kasparow, S.2    Capogna, M.3    Zieglgänsberger, W.4
  • 173
    • 0027402518 scopus 로고
    • Acamprosate (calciumacetylhomotaurinate) decreases postsynaptic potentials in the rat neocortex: Possible involvement of excitatory amino acid receptors
    • Zeise ML, Kasparov S, Capogna M, Zieglgänsberger W (1993) Acamprosate (calciumacetylhomotaurinate) decreases postsynaptic potentials in the rat neocortex: Possible involvement of excitatory amino acid receptors. Eur J Pharmacol 231: 47-52
    • (1993) Eur J Pharmacol , vol.231 , pp. 47-52
    • Zeise, M.L.1    Kasparov, S.2    Capogna, M.3    Zieglgänsberger, W.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.