Over-expression of the fyn-kinase gene reduces hypnotic sensitivity to ethanol in mice

Neuroscience Letters

Volumn 372, Issue 1-2, 2004, Pages 6-11

  Boehm II, Stephen L ^a   Peden, Laura ^a   Jennings, Andrew W ^a   Kojima, Nobuhiko ^b   Harris, R Adron ^a   Blednov, Yuri A ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^b RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

Author keywords

Behavior; Ethanol; Fyn kinase; Transgenic mouse

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; 4 AMINOBUTYRIC ACID DERIVATIVE; ALCOHOL; ETOMIDATE; GABOXADOL; PROTEIN KINASE FYN; PROTEIN TYROSINE KINASE;

ALCOHOL BLOOD LEVEL; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRINKING BEHAVIOR; FEMALE; FOREBRAIN; GENE OVEREXPRESSION; GENOTYPE; MALE; NONHUMAN; PRIORITY JOURNAL; RIGHTING REFLEX; TRANSGENIC MOUSE; WILD TYPE;

ANIMALS; ETHANOL; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HYPNOTICS AND SEDATIVES; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NEOPLASM PROTEINS; PROTEIN-TYROSINE KINASES; REFLEX; SRC-FAMILY KINASES;

EID: 8644229424     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2004.08.028     Document Type: Article

References (21)

1. D.L. Anders, T. Blevins, G. Sutton, S. Swope, L.J. Chandler, and J.J. Woodward Fyn tyrosine kinase reduces the ethanol inhibition of recombinant NR1/NR2A but not NR1/NR2B NMDA receptors expressed HEK 293 cells J. Neurochem. 72 1999 1389 1393
2. S.L. Boehm II, L. Peden, R. Chang, R.A. Harris, and Y.A. Blednov Deletion of the fyn-kinase gene alters behavioral sensitivity to ethanol Alcohol Clin. Exp. Res. 27 2003 1033 1040
3. A receptor subunits J. Pharmacol. Exp. Ther. 309 2004 1154 1159
4. M.S. Cowen, G. Schumann, T. Yagi, and R. Spanagel Role of fyn tyrosine kinase in ethanol consumption by mice Alcohol Clin. Exp. Res. 27 2003 1213 1219
5. V.G. Erwin, and R.A. Deitrich Genetic selection and characterization of mouse lines for acute functional tolerance to ethanol J. Pharmacol. Exp. Ther. 279 1996 1310 1317
6. R.A. Harris, S.J. McQuilkin, R. Paylor, A. Abelovich, S. Tonegawa, and J.M. Wehner Mutant mice lacking the γ isoform of protein kinase C show decreased behavioral actions of ethanol and altered function of γ-aminobutyrate type A receptors Proc. Natl. Acad. Sci. U.S.A. 92 1995 3658 3662
7. H. Kitazawa, T. Yagi, T. Miyakawa, H. Niki, and N. Kawai Abnormal synaptic transmission in olfactory bulb of fyn-kinase-deficient mice J. Neurophysiol. 79 1998 137 142
8. N. Kojima, H. Ishibashi, K. Obata, and E.R. Kandel Higher seizure susceptibility and enhanced tyrosine phosphorylation of N-ethyl-d-aspartate receptor subunit 2B in fyn transgenic mice Learn. Mem. 5 1998 429 445
9. N. Kojima, J. Wang, I.M. Mansuy, S.G.N. Grant, M. Mayford, and E.R. Kandel Rescuing impairment of long-term potentiation in fyn-deficient mice by introducing fyn trangene Proc. Natl. Acad. Sci. U.S.A. 94 1997 4761 4765
10. G.F. Koob Alcoholism: allostasis and beyond Alcohol Clin. Exp. Res. 27 2003 232 243
11. Y.-F. Lu, N. Kojima, K. Tomizawa, A. Moriwaki, M. Matsushita, K. Obata, and H. Matsui Enhanced synaptic transmission and reduced threshold for LTP in fyn-transgenic mice Eur. J. Neurosci. 11 1999 75 82
12. Z. Ming, D.J. Knapp, R.A. Mueller, G.R. Breese, and H.E. Criswell Differential modulation of GABA- and NMDA-gated currents by ethanol and isoflurane in cultured rat cerebral cortical neurons Brain Res. 920 2001 117 124
13. T. Miyakawa, T. Yagi, H. Kitazawa, M. Yasuda, N. Kawai, K. Tsuboi, and H. Niki Fyn-kinase as a determinant of ethanol sensitivity: relation to NMDA-receptor function Science 278 1997 698 701
14. T. Miyakawa, T. Yagi, K. Tateishi, and H. Niki Susceptibility to drug-induced seizures of fyn tyrosine kinase-deficient mice Neuroreport 7 1996 2723 2726
15. A responses differs in lines of mice and rats genetically selected for behavioral sensitivity or insensitivity to ethanol J. Pharmacol. Exp. Ther. 295 2000 741 746
16. A receptor-mediated responses in protein kinase C gamma and PKC epsilon null mice J. Pharmacol. Exp. Ther. 305 2003 264 270
17. O. Stork, N. Kojima, S. Stork, N. Kume, and K. Obata Resistance to ethanol withdrawal-induced behaviour in fyn transgenic mice and its reversal by ifenprodil Brain Res. Mol. Brain Res. 105 2002 126 135
18. T. Yagi Src family kinases control neuronal development and function Dev. Growth Differ. 36 1994 543 550
19. T. Yagi, Y. Shigetani, N. Okado, T. Tokunaga, Y. Ikawa, and S. Aizawa Regional localization of fyn in adult brain: studies with mice in which Fyn gene was replaced by lacZ Oncogene 8 1993 3343 3351
20. R. Yaka, K. Phamluong, and D. Ron Scaffolding of fyn kinase to the NMDA receptor determines brain region sensitivity to ethanol J. Neurosci. 23 2003 3623 3632
21. R. Yaka, K.C. Tang, R. Camarini, P.H. Janak, and D. Ron Fyn kinase and NR2B-containing NMDA receptors regulate acute ethanol sensitivity but not ethanol intake or conditioned reward Alcohol Clin. Exp. Res. 27 2003 1736 1742