Influence of genetic background on alcohol drinking and behavioral phenotypes of 5-HT3 receptor over-expressing mice

Pharmacology Biochemistry and Behavior

Volumn 84, Issue 1, 2006, Pages 120-127

  Metz, Amber V ^a   Chynoweth, Julie ^a   Allan, Andrea M ^a  

^a UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

Author keywords

Anxiety; C57Bl 6; Congenic; DBA 2; Ethanol consumption; Fear conditioning; Novelty; Serotonin receptor

Indexed keywords

ALCOHOL; COCAINE; SEROTONIN 3 RECEPTOR;

ALCOHOL CONSUMPTION; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; CONGENIC STRAIN; CONTROLLED STUDY; EXPLORATORY BEHAVIOR; FEAR; FEMALE; GENE OVEREXPRESSION; GENETIC ASSOCIATION; GENETIC MANIPULATION; GENOTYPE; HEREDITY; HIPPOCAMPUS; LEARNING; LOCOMOTION; MALE; MAZE TEST; MOUSE; MOUSE STRAIN; NONHUMAN; PHENOTYPE; PLACE PREFERENCE; PLEIOTROPY; PRIORITY JOURNAL; STRAIN DIFFERENCE; TRANSGENE; TRANSGENIC MOUSE;

ALCOHOL DRINKING; ANIMALS; BEHAVIOR, ANIMAL; ETHANOL; LOCOMOTION; MICE; MICE, TRANSGENIC; PHENOTYPE; RECEPTORS, SEROTONIN, 5-HT3;

MUS MUSCULUS;

EID: 33745660828     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbb.2006.04.016     Document Type: Article

References (60)

1. Allan A.M., Galindo R., Chynoweth J., Engel S.R., and Savage D.D. Conditioned place preference for cocaine is attenuated in mice over-expressing the 5-HT(3) receptor. Psychopharmacology (Berl) 158 (2001) 18-27
2. Ammassari-Teule M., Passino E., Restivo L., and de Marsanich B. Fear conditioning in C57/BL/6 and DBA/2 mice: variability in nucleus accumbens function according to the strain predisposition to show contextual- or cue-based responding. Eur J Neurosci 12 (2000) 4467-4474
3. Barnes J.M., Barnes N.M., Champaneria S., Costall B., and Naylor R.J. Characterisation and autoradiographic localisation of 5-HT3 receptor recognition sites identified with [3H]-(S)-zacopride in the forebrain of the rat. Neuropharmacology 29 (1990) 1037-1045
4. Barnes J.M., Costall B., Coughlan J., Domeney A.M., Gerrard P.A., Kelly M.E., et al. The effects of ondansetron, a 5-HT3 receptor antagonist, on cognition in rodents and primates. Pharmacol Biochem Behav 35 (1990) 955-962
5. Barrera N.P., Herbert P., Henderson R.M., Martin I.L., and Edwardson J.M. Atomic force microscopy reveals the stoichiometry and subunit arrangement of 5-HT3 receptors. Proc Natl Acad Sci USA 102 (2005) 12595-12600
6. Becker D.J., Myers J.T., Ruff M.M., Smith P.L., Gillespie B.W., Ginsburg D.W., et al. Strain-specific modification of lethality in fucose-deficient mice. Mamm Genome 14 (2003) 130-139
7. Belknap J.K., Crabbe J.C., and Young E.R. Voluntary consumption of ethanol in 15 inbred mouse strains. Psychopharmacology (Berl) 112 (1993) 503-510
8. Berns G.S., Cohen J.D., and Mintun M.A. Brain regions responsive to novelty in the absence of awareness. Science 276 (1997) 1272-1275
9. Bowers B.J., Christensen S.C., Pauley J.R., Paylor R., Yuva L., Dunbar S.E., et al. Protein and molecular characterization of hippocampal protein kinase C in C57BL/6 and DBA/2 mice. J Neurochem 64 (1995) 2737-2746
10. Bratt A.M., Kelly M.E., Domeney A.M., Naylor R.J., and Costall B. Ondansetron fails to attenuate a scopolamine-induced deficit in a Stone maze task. NeuroReport 5 (1994) 1921-1924
11. Campbell A.D., and McBride W.J. Serotonin-3 receptor and ethanol-stimulated dopamine release in the nucleus accumbens. Pharmacol Biochem Behav 51 (1995) 835-842
12. Contet C., Rawlins J.N., and Deacon R.M. A comparison of 129S2/SvHsd and C57BL/6JOlaHsd mice on a test battery assessing sensorimotor, affective and cognitive behaviours: implications for the study of genetically modified mice. Behav Brain Res 124 (2001) 33-46
13. Crabbe J.C., Wahlsten D., and Dudek B.C. Genetics of mouse behavior: interactions with laboratory environment. Science 284 (1999) 1670-1672
14. Crawley J.N. Behavioral phenotyping of transgenic and knockout mice: experimental design and evaluation of general health, sensory functions, motor abilities, and specific behavioral tests. Brain Res 835 (1999) 18-26
15. Crawley J.N., Belknap J.K., Collins A., Crabbe J.C., Frankel W., Henderson N., et al. Behavioral phenotypes of inbred mouse strains: implications and recommendations for molecular studies. Psychopharmacology (Berl) 132 (1997) 107-124
16. Davies P., Pistis M., Hanna M., Peters J., Lambert J., Hales T., et al. The 5-HT3B subunit is a major determinant of serotonin-receptor function. Nature 397 (1999) 359-363
17. Davis M., and Whalen P.J. The amygdala: vigilance and emotion. Mol Psychiatry 6 (2001) 13-34
18. Dellu F., Contarino A., Simon H., Koob G.F., and Gold L.H. Genetic differences in response to novelty and spatial memory using a two-trial recognition task in mice. Neurobiol Learn Mem 73 (2000) 31-48
19. Dubin A.E., Huvar R., D'Andrea M.R., Pyati J., Zhu J.Y., Joy K.C., et al. The pharmacological and functional characteristics of the serotonin 5-HT(3A) receptor are specifically modified by a 5-HT(3B) receptor subunit. J Biol Chem 274 (1999) 30799-30810
20. Engel S.R., and Allan A.M. 5-HT3 receptor over-expression enhances ethanol sensitivity in mice. Psychopharmacology (Berl) 144 (1999) 411-415
21. Engel S.R., Lyons C.R., and Allan A.M. 5-HT3 receptor over-expression decreases ethanol self administration in transgenic mice. Psychopharmacology (Berl) 140 (1998) 243-248
22. Falconer D.S. Introduction to quantitative genetics. 2nd ed. (1981), Wiley and Sons, New York
23. File S.E., Kenny P.J., and Cheeta S. The role of the dorsal hippocampal serotonergic and cholinergic systems in the modulation of anxiety. Pharmacol Biochem Behav 66 (2000) 65-72
24. Gonzalez L.E., Ouagazzal A.M., and File S.E. Stimulation of benzodiazepine receptorsin the dorsal hippocampus and median raphe reveals differential GABAergic control in two animal tests of anxiety. Eur J Neurosci 10 (1998) 3673-3680
25. Grailhe R., Waeber C., Dulawa S.C., Hornung J.P., Zhuang X., Brunner D., et al. Increased exploratory activity and altered response to LSD in mice lacking the 5-HT(5A) receptor. Neuron 22 (1999) 581-591
26. Griebel G., Belzung C., Perrault G., and Sanger D.J. Differences in anxiety-related behaviours and in sensitivity to diazepam in inbred and outbred strains of mice. Psychopharmacology (Berl) 148 (2000) 164-170
27. Haralambous T., and Westbrook R.F. An infusion of bupivacaine into the nucleus accumbens disrupts the acquisition but not the expression of contextual fear conditioning. Behav Neurosci 113 (1999) 925-940
28. Harrell A.V., and Allan A.M. Improvements in hippocampal-dependent learning and decremental attention in 5-HT(3) receptor overexpressing mice. Learn Mem 10 (2003) 410-419
29. Hodge C.W., Kelley S.P., Bratt A.M., Iller K., Schroeder J.P., and Besheer J. 5-HT(3A) receptor subunit is required for 5-HT3 antagonist-induced reductions in alcohol drinking. Neuropsychopharmacology 29 (2004) 1807-1813
30. Holmes A., Wrenn C.C., Harris A.P., Thayer K.E., and Crawley J.N. Behavioral profiles of inbred strains on novel olfactory, spatial and emotional tests for reference memory in mice. Genes Brain Behav 1 (2002) 55-69
31. Hooks M.S., Jones G.H., Smith A.D., Neill D.B., and Justice Jr. J.B. Response to novelty predicts the locomotor and nucleus accumbens dopamine response to cocaine. Synapse 9 (1991) 121-128
32. Horvitz J.C. Mesolimbocortical and nigrostriatal dopamine responses to salient non-reward events. Neuroscience 96 (2000) 651-656
33. Horvitz J.C. Dopamine gating of glutamatergic sensorimotor and incentive motivational input signals to the striatum. Behav Brain Res 137 (2002) 65-74
34. Jiang L.H., Ashby Jr. C.R., Kasser R.J., and Wang R.Y. The effect of intraventricular administration of the 5-HT3 receptor agonist 2-methylserotonin on the release of dopamine in the nucleus accumbens: an in vivo chronocoulometric study. Brain Res 513 (1990) 156-160
35. Kelley S.P., Bratt A.M., and Hodge C.W. Targeted gene deletion of the 5-HT3A receptor subunit produces an anxiolytic phenotype in mice. Eur J Pharmacol 461 (2003) 19-25
36. Kilpatrick G.J., Jones B.J., and Tyers M.B. Identification and distribution of 5-HT3 receptors in rat brain using radioligand binding. Nature 330 (1987) 746-748
37. Kim J.J., and Fanselow M.S. Modality-specific retrograde amnesia of fear. Science 256 (1992) 675-677
38. Logue S.F., Owen E.H., Rasmussen D.L., and Wehner J.M. Assessment of locomotor activity, acoustic and tactile startle, and prepulse inhibition of startle in inbred mouse strains and F1 hybrids: implications of genetic background for single gene and quantitative trait loci analyses. Neuroscience 80 (1997) 1075-1086
39. Lu Y., and Wehner J.M. Enhancement of contextual fear-conditioning by putative (+/-)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor modulators and N-methyl-d-aspartate (NMDA) receptor antagonists in DBA/2J mice. Brain Res 768 (1997) 197-207
40. Mason N.S., Hewlett W.A., Ebert M.H., Schmidt D.E., and de Paulis T. Labeling of (S)-des-4-amino-3-[125I]iodozacopride (DAIZAC), a high-affinity radioligand for the 5-HT-3 receptor. J Label Compd Radiopharm 38 (1996) 955-961
41. Nguyen P.V., Abel T., Kandel E.R., and Bourtchouladze R. Strain-dependent differences in LTP and hippocampus-dependent memory in inbred mice. Learn Mem 7 (2000) 170-179
42. Nie T., and Abel T. Fear conditioning in inbred mouse strains: an analysis of the time course of memory. Behav Neurosci 115 (2001) 951-956
43. Paylor R., and Crawley J.N. Inbred strain differences in prepulse inhibition of the mouse startle response. Psychopharmacology (Berl) 132 (1997) 169-180
44. Paylor R., Tracy R., Wehner J., and Rudy J.W. DBA/2 and C57BL/6 mice differ in contextual fear but not auditory fear conditioning. Behav Neurosci 108 (1994) 810-817
45. Pellow S., Johnston A.L., and Pellow S.E. Selective agonists and antagonists for 5-hydroxytryptamine receptor subtypes, and interactions with yohimbine and FG 7142 using the elevated plus-maze test in the rat. J Pharm Pharmacol 39 (1987) 917-928
46. Phillips R.G., and LeDoux J.E. Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning. Behav Neurosci 106 (1992) 274-285
47. Riedel G., Harrington N.R., Hall G., and Macphail E.M. Nucleus accumbens lesions impair context, but not cue, conditioning in rats. NeuroReport 8 (1997) 2477-2481
48. Rogan M.T., and LeDoux J.E. Emotion: systems, cells, synaptic plasticity. Cell 85 (1996) 469-475
49. Schultz W. Getting formal with dopamine and reward. Neuron 36 (2002) 241-263
50. Stiedl O., Radulovic J., Lohmann R., Birkenfeld K., Palve M., Kammermeier J., et al. Strain and substrain differences in context- and tone-dependent fear conditioning of inbred mice. Behav Brain Res 104 (1999) 1-12
51. Sun H., Hu X.Q., Moradel E.M., Weight F.F., and Zhang L. Modulation of 5-HT3 receptor-mediated response and trafficking by activation of protein kinase C. J Biol Chem 278 (2003) 34150-34157
52. Sung K.W., Engel S.R., Allan A.M., and Lovinger D.M. 5-HT(3) receptor function and potentiation by alcohols in frontal cortex neurons from transgenic mice overexpressing the receptor. Neuropharmacology 39 (2000) 2346-2351
53. Tecott L.H., Maricq A.V., and Julius D. Nervous system distribution of the serotonin 5-HT3 receptor mRNA. Proc Natl Acad Sci U S A 90 (1993) 1430-1434
54. Thinus-Blanc C., Save E., Rossi-Arnaud C., Tozzi A., and Ammassari-Teule M. The differences shown by C57BL/6 and DBA/2 inbred mice in detecting spatial novelty are subserved by a different hippocampal and parietal cortex interplay. Behav Brain Res 80 (1996) 33-40
55. Waeber C., Dixon K., Hoyer D., and Palacios J.M. Localisation by autoradiography of neuronal 5-HT3 receptors in the mouse CNS. Eur J Pharmacol 151 (1988) 351-352
56. Wehner J.M., Sleight S., and Upchurch M. Hippocampal protein kinase C activity is reduced in poor spatial learners. Brain Res 523 (1990) 181-187
57. Westbrook R.F., Good A.J., and Kiernan M.J. Microinjection of morphine into the nucleus accumbens impairs contextual learning in rats. Behav Neurosci 111 (1997) 996-1013
58. Wong G.T. Speed congenics: applications for transgenic and knock-out mouse strains. Neuropeptides 36 (2002) 230-236
59. Wozniak K.M., Pert A., and Linnoila M. Antagonism of 5-HT3 receptors attenuates the effects of ethanol on extracellular dopamine. Eur J Pharmacol 187 (1990) 287-289
60. Zhang L., Oz M., and Weight F.F. Potentiation of 5-HT3 receptor-mediated responses by protein kinase C activation. NeuroReport 6 (1995) 1464-1468