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Volumn 497, Issue 2, 2004, Pages 161-171

The involvement of α 2A-adrenoceptors in morphine analgesia, tolerance and withdrawal in mice

Author keywords

2 Adrenoceptor agonist; 2A Adrenoceptor; Analgesia; Morphine tolerance; Morphine withdrawal; Prazosin

Indexed keywords

ADRENERGIC RECEPTOR; ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CLONIDINE; DEXMEDETOMIDINE; MORPHINE; NALOXONE; PRAZOSIN;

EID: 4143124564     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2004.06.051     Document Type: Article
Times cited : (38)

References (76)
  • 1
    • 0032961248 scopus 로고    scopus 로고
    • The involvement of noradrenergic transmission in the morphine-induced locomotor hyperactivity in mice withdrawn from repeated morphine treatment
    • J. Airio, and L. Ahtee The involvement of noradrenergic transmission in the morphine-induced locomotor hyperactivity in mice withdrawn from repeated morphine treatment Br. J. Pharmacol. 126 1999 1609 1619
    • (1999) Br. J. Pharmacol. , vol.126 , pp. 1609-1619
    • Airio1    Ahtee, L.J.2
  • 2
    • 0031029783 scopus 로고    scopus 로고
    • Multiple receptors involved in peripheral alpha 2, mu, and A1 antinociception, tolerance, and withdrawal
    • K.O. Aley, and J.D. Levine Multiple receptors involved in peripheral alpha 2, mu, and A1 antinociception, tolerance, and withdrawal J. Neurosci. 17 1997 735 744
    • (1997) J. Neurosci. , vol.17 , pp. 735-744
    • Aley1    Levine, J.D.K.O.2
  • 4
    • 0026237055 scopus 로고
    • Effect of alpha-adrenoreceptors in the control of spontaneous motility and morphine withdrawal syndrome
    • T. Antonelli, M. Morari, A. Magri, and C. Bianchi Effect of alpha-adrenoreceptors in the control of spontaneous motility and morphine withdrawal syndrome Boll. Soc. Ital. Biol. Sper. 67 1991 965 971
    • (1991) Boll. Soc. Ital. Biol. Sper. , vol.67 , pp. 965-971
    • Antonelli, T.1    Morari, M.2    Magri3    Bianchi, C.A.4
  • 5
    • 0032779967 scopus 로고    scopus 로고
    • The bed nucleus of the stria terminalis. A target site for noradrenergic actions in opiate withdrawal
    • G. Aston-Jones, J.M. Delfs, J. Druhan, and Y. Zhu The bed nucleus of the stria terminalis. A target site for noradrenergic actions in opiate withdrawal Ann. N. Y. Acad. Sci. 877 1999 486 498
    • (1999) Ann. N. Y. Acad. Sci. , vol.877 , pp. 486-498
    • Aston-Jones, G.1    Delfs, J.M.2    Druhan3    Zhu, Y.J.4
  • 6
    • 0020533056 scopus 로고
    • Studies on the antinociceptive action of alpha-agonist drugs and their interactions with opioid mechanisms
    • G.A. Bentley, S.H. Newton, and J. Starr Studies on the antinociceptive action of alpha-agonist drugs and their interactions with opioid mechanisms Br. J. Pharmacol. 79 1983 125 134
    • (1983) Br. J. Pharmacol. , vol.79 , pp. 125-134
    • Bentley, G.A.1    Newton2    Starr, J.S.H.3
  • 8
    • 0037007035 scopus 로고    scopus 로고
    • Desensitization of mu-opioid receptors-evoked potassium currents: Initiation at the receptor, expression at the effector
    • C. Blanchet, and C. Luscher Desensitization of mu-opioid receptors-evoked potassium currents: initiation at the receptor, expression at the effector Proc. Natl. Acad. Sci. U. S. A. 99 2002 4674 4679
    • (2002) Proc. Natl. Acad. Sci. U. S. A. , vol.99 , pp. 4674-4679
    • Blanchet1    Luscher, C.C.2
  • 9
    • 0034619796 scopus 로고    scopus 로고
    • Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence
    • L.M. Bohn, R.R. Gainetdinov, F.T. Lin, R.J. Lefkowitz, and M.G. Caron Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence Nature 408 2000 720 723
    • (2000) Nature , vol.408 , pp. 720-723
    • Bohn, L.M.1    Gainetdinov, R.R.2    Lin, F.T.3    Lefkowitz4    Caron, M.G.R.J.5
  • 10
    • 0034671185 scopus 로고    scopus 로고
    • Potentiated opioid analgesia in norepinephrine transporter knock-out mice
    • L.M. Bohn, F. Xu, R.R. Gainetdinov, and M.G. Caron Potentiated opioid analgesia in norepinephrine transporter knock-out mice J. Neurosci. 20 2000 9040 9045
    • (2000) J. Neurosci. , vol.20 , pp. 9040-9045
    • Bohn, L.M.1    Xu, F.2    Gainetdinov3    Caron, M.G.R.R.4
  • 11
    • 0036895747 scopus 로고    scopus 로고
    • Differential mechanisms of morphine antinociceptive tolerance revealed in (beta)arrestin-2 knock-out mice
    • L.M. Bohn, R.J. Lefkowitz, and M.G. Caron Differential mechanisms of morphine antinociceptive tolerance revealed in (beta)arrestin-2 knock-out mice J. Neurosci. 22 2002 10494 10500
    • (2002) J. Neurosci. , vol.22 , pp. 10494-10500
    • Bohn, L.M.1    Lefkowitz2    Caron, M.G.R.J.3
  • 12
    • 0030637031 scopus 로고    scopus 로고
    • Imidazoline receptors
    • P. Bousquet Imidazoline receptors Neurochem. Int. 30 1997 3 7
    • (1997) Neurochem. Int. , vol.30 , pp. 3-7
    • Bousquet, P.1
  • 13
    • 0019946031 scopus 로고
    • Interactions of drugs active at opiate receptors and drugs active at alpha 2-receptors on various test systems
    • S. Browning, D. Lawrence, A. Livingston, and B. Morris Interactions of drugs active at opiate receptors and drugs active at alpha 2-receptors on various test systems Br. J. Pharmacol. 77 1982 487 491
    • (1982) Br. J. Pharmacol. , vol.77 , pp. 487-491
    • Browning, S.1    Lawrence, D.2    Livingston3    Morris, B.A.4
  • 14
    • 0029822432 scopus 로고    scopus 로고
    • Local opioid withdrawal in rat single periaqueductal gray neurons in vitro
    • B. Chieng, and M.D. Christie Local opioid withdrawal in rat single periaqueductal gray neurons in vitro J. Neurosci. 16 1996 7128 7136
    • (1996) J. Neurosci. , vol.16 , pp. 7128-7136
    • Chieng1    Christie, M.D.B.2
  • 15
    • 0025913092 scopus 로고
    • Effects of sympathomimetic agents on opiate analgesia, tolerance and dependence in mice
    • Y.M. Dambisya, C.L. Wong, and K. Chan Effects of sympathomimetic agents on opiate analgesia, tolerance and dependence in mice Methods Find. Exp. Clin. Pharmacol. 13 1991 239 248
    • (1991) Methods Find. Exp. Clin. Pharmacol. , vol.13 , pp. 239-248
    • Dambisya, Y.M.1    Wong2    Chan, K.C.L.3
  • 16
    • 0002261078 scopus 로고
    • A method of determining loss of pain sensation
    • F.E. D'Amour, and D.L. Smith A method of determining loss of pain sensation J. Pharmacol. Exp. Ther. 72 1941 74 79
    • (1941) J. Pharmacol. Exp. Ther. , vol.72 , pp. 74-79
    • D'Amour1    Smith, D.L.F.E.2
  • 17
    • 0034719355 scopus 로고    scopus 로고
    • Noradrenaline in the ventral forebrain is critical for opiate withdrawal-induced aversion
    • J.M. Delfs, Y. Zhu, J.P. Druhan, and G. Aston-Jones Noradrenaline in the ventral forebrain is critical for opiate withdrawal-induced aversion Nature 403 2000 430 434
    • (2000) Nature , vol.403 , pp. 430-434
    • Delfs, J.M.1    Zhu, Y.2    Druhan3    Aston-Jones, G.J.P.4
  • 18
    • 0036200362 scopus 로고    scopus 로고
    • Co-release of noradrenaline and dopamine in the prefrontal cortex after acute morphine and during morphine withdrawal
    • P. Devoto, G. Flore, L. Pira, M. Diana, and G.L. Gessa Co-release of noradrenaline and dopamine in the prefrontal cortex after acute morphine and during morphine withdrawal Psychopharmacology 160 2002 220 224
    • (2002) Psychopharmacology , vol.160 , pp. 220-224
    • Devoto, P.1    Flore, G.2    Pira, L.3    Diana4    Gessa, G.L.M.5
  • 19
    • 0030831243 scopus 로고    scopus 로고
    • The influence of chronic treatment with clonidine, yohimbine and idazoxan on morphine withdrawal
    • A.O. El-Kadi, and S.I. Sharif The influence of chronic treatment with clonidine, yohimbine and idazoxan on morphine withdrawal Psychopharmacology (Berl.) 132 1997 67 73
    • (1997) Psychopharmacology (Berl.) , vol.132 , pp. 67-73
    • El-Kadi1    Sharif, S.I.A.O.2
  • 20
    • 0033015422 scopus 로고    scopus 로고
    • Spinal antinociceptive synergism between morphine and clonidine persists in mice made acutely or chronically tolerant to morphine
    • C.A. Fairbanks, and G.L. Wilcox Spinal antinociceptive synergism between morphine and clonidine persists in mice made acutely or chronically tolerant to morphine J. Pharmacol. Exp. Ther. 288 1999 1107 1116
    • (1999) J. Pharmacol. Exp. Ther. , vol.288 , pp. 1107-1116
    • Fairbanks1    Wilcox, G.L.C.A.2
  • 21
    • 0033912781 scopus 로고    scopus 로고
    • Chronic morphine treatment and withdrawal increase extracellular levels of norepinephrine in the rat bed nucleus of the stria terminalis
    • J.A. Fuentealba, M.I. Forray, and K. Gysling Chronic morphine treatment and withdrawal increase extracellular levels of norepinephrine in the rat bed nucleus of the stria terminalis J. Neurochem. 75 2000 741 748
    • (2000) J. Neurochem. , vol.75 , pp. 741-748
    • Fuentealba, J.A.1    Forray2    Gysling, K.M.I.3
  • 22
    • 0028926310 scopus 로고
    • Antinociception produced by an ascending spino-supraspinal pathway
    • R.W. Gear, and J.D. Levine Antinociception produced by an ascending spino-supraspinal pathway J. Neurosci. 15 1995 3154 3161
    • (1995) J. Neurosci. , vol.15 , pp. 3154-3161
    • Gear1    Levine, J.D.R.W.2
  • 23
    • 0036006998 scopus 로고    scopus 로고
    • Alpha2-adrenergic agonists in opioid withdrawal
    • L.R. Gowing, M. Farrell, R.L. Ali, and J.M. White Alpha2-adrenergic agonists in opioid withdrawal Addiction 97 2002 49 58
    • (2002) Addiction , vol.97 , pp. 49-58
    • Gowing, L.R.1    Farrell, M.2    Ali3    White, J.M.R.L.4
  • 24
    • 0025985720 scopus 로고
    • Central alpha 1-adrenoceptor stimulation functionally antagonizes the hypnotic response to dexmedetomidine, an alpha 2-adrenoceptor agonist
    • T.Z. Guo, J. Tinklenberg, R. Oliker, and M. Maze Central alpha 1-adrenoceptor stimulation functionally antagonizes the hypnotic response to dexmedetomidine, an alpha 2-adrenoceptor agonist Anesthesiology 75 1991 252 256
    • (1991) Anesthesiology , vol.75 , pp. 252-256
    • Guo, T.Z.1    Tinklenberg, J.2    Oliker3    Maze, M.R.4
  • 26
    • 9544234585 scopus 로고    scopus 로고
    • Hypnotic and analgesic effects of the alpha 2-adrenergic agonist dexmedetomidine in morphine-tolerant rats
    • Y. Hayashi, T.Z. Guo, and M. Maze Hypnotic and analgesic effects of the alpha 2-adrenergic agonist dexmedetomidine in morphine-tolerant rats Anesth. Analg. 83 1996 606 610
    • (1996) Anesth. Analg. , vol.83 , pp. 606-610
    • Hayashi, Y.1    Guo2    Maze, M.T.Z.3
  • 27
    • 0034772584 scopus 로고    scopus 로고
    • Alpha-1A adrenoceptors modulate potentiation of spinal nociceptive pathways in the rat spinal cord in vitro
    • G. Hedo, and J.A. Lopez-Garcia Alpha-1A adrenoceptors modulate potentiation of spinal nociceptive pathways in the rat spinal cord in vitro Neuropharmacology 41 2001 862 869
    • (2001) Neuropharmacology , vol.41 , pp. 862-869
    • Hedo1    Lopez-Garcia, J.A.G.2
  • 28
    • 0030609171 scopus 로고    scopus 로고
    • Assessment of the role of alpha2-adrenoceptor subtypes in the antinociceptive, sedative and hypothermic action of dexmedetomidine in transgenic mice
    • J.C. Hunter, D.J. Fontana, L.R. Hedley, J.R. Jasper, R. Lewis, R.E. Link, R. Secchi, J. Sutton, and R.M. Eglen Assessment of the role of alpha2-adrenoceptor subtypes in the antinociceptive, sedative and hypothermic action of dexmedetomidine in transgenic mice Br. J. Pharmacol. 122 1997 1339 1344
    • (1997) Br. J. Pharmacol. , vol.122 , pp. 1339-1344
    • Hunter, J.C.1    Fontana, D.J.2    Hedley, L.R.3    Jasper, J.R.4    Lewis, R.5    Link, R.E.6    Secchi, R.7    Sutton8    Eglen, R.M.J.9
  • 29
    • 0026084861 scopus 로고
    • Spinal opioid analgesic effects are enhanced in a model of unilateral inflammation/hyperalgesia: Possible involvement of noradrenergic mechanisms
    • J.L. Hylden, D.A. Thomas, M.J. Iadarola, R.L. Nahin, and R. Dubner Spinal opioid analgesic effects are enhanced in a model of unilateral inflammation/hyperalgesia: possible involvement of noradrenergic mechanisms Eur. J. Pharmacol. 194 1991 135 143
    • (1991) Eur. J. Pharmacol. , vol.194 , pp. 135-143
    • Hylden, J.L.1    Thomas, D.A.2    Iadarola, M.J.3    Nahin4    Dubner, R.R.L.5
  • 30
    • 0029869259 scopus 로고    scopus 로고
    • Neuroendocrine effects of dexmedetomidine: Evidence of cross-tolerance between a mu-opioid agonist and an alpha 2-adrenoceptor agonist in growth hormone secretion of the male rat
    • J.J. Idänpään-Heikkilä, P. Rauhala, and P.T. Männistö Neuroendocrine effects of dexmedetomidine: evidence of cross-tolerance between a mu-opioid agonist and an alpha 2-adrenoceptor agonist in growth hormone secretion of the male rat Pharmacol. Toxicol. 78 1996 136 142
    • (1996) Pharmacol. Toxicol. , vol.78 , pp. 136-142
    • Idänpään-Heikkilä, J.J.1    Rauhala, P.2    Männistö, P.T.3
  • 31
    • 0026586059 scopus 로고
    • Effects of yohimbine on morphine analgesia and physical dependence in the rat
    • V. Iglesias, L.F. Alguacil, C. Alamo, and E. Cuenca Effects of yohimbine on morphine analgesia and physical dependence in the rat Eur. J. Pharmacol. 211 1992 35 38
    • (1992) Eur. J. Pharmacol. , vol.211 , pp. 35-38
    • Iglesias, V.1    Alguacil, L.F.2    Alamo3    Cuenca, E.C.4
  • 32
    • 0027437659 scopus 로고
    • Cross-tolerance between mu opioid and alpha-2 adrenergic receptors, but not between mu and delta opioid receptors in the spinal cord of the rat
    • E.A. Kalso, A.F. Sullivan, H.J. McQuay, A.H. Dickenson, and B.P. Roques Cross-tolerance between mu opioid and alpha-2 adrenergic receptors, but not between mu and delta opioid receptors in the spinal cord of the rat J. Pharmacol. Exp. Ther. 265 1993 551 558
    • (1993) J. Pharmacol. Exp. Ther. , vol.265 , pp. 551-558
    • Kalso, E.A.1    Sullivan, A.F.2    McQuay, H.J.3    Dickenson4    Roques, B.P.A.H.5
  • 33
    • 0036095186 scopus 로고    scopus 로고
    • Exploring the opioid system by gene knockout
    • B.L. Kieffer, and C. Gaveriaux-Ruff Exploring the opioid system by gene knockout Prog. Neurobiol. 66 2002 285 306
    • (2002) Prog. Neurobiol. , vol.66 , pp. 285-306
    • Kieffer1    Gaveriaux-Ruff, C.B.L.2
  • 34
    • 0037067998 scopus 로고    scopus 로고
    • Behavioral and neurochemical characterization of alpha(2A)-adrenergic receptor knockout mice
    • J. Lähdesmäki, J. Sallinen, E. MacDonald, B.K. Kobilka, V. Fagerholm, and M. Scheinin Behavioral and neurochemical characterization of alpha(2A)-adrenergic receptor knockout mice Neuroscience 113 2002 289 299
    • (2002) Neuroscience , vol.113 , pp. 289-299
    • Lähdesmäki, J.1    MacDonald, E.2    Kobilka, B.K.3    Fagerholm, V.4    Scheinin, M.5
  • 35
    • 0041843625 scopus 로고    scopus 로고
    • Alpha2-adrenergic drug effects on brain monoamines, locomotion, and body temperature are largely abolished in mice lacking the alpha2A-adrenoceptor subtype
    • J. Lähdesmäki, J. Sallinen, E. MacDonald, J. Sirviö, and M. Scheinin Alpha2-adrenergic drug effects on brain monoamines, locomotion, and body temperature are largely abolished in mice lacking the alpha2A-adrenoceptor subtype Neuropharmacology 44 2003 882 892
    • (2003) Neuropharmacology , vol.44 , pp. 882-892
    • Lähdesmäki, J.1    Sallinen, J.2    MacDonald, E.3    Sirviö4    Scheinin, M.J.5
  • 36
    • 0037499834 scopus 로고    scopus 로고
    • The alpha2A-adrenoceptor subtype is not involved in inflammatory hyperalgesia or morphine-induced antinociception
    • J. Lähdesmäki, M. Scheinin, A. Pertovaara, and H. Mansikka The alpha2A-adrenoceptor subtype is not involved in inflammatory hyperalgesia or morphine-induced antinociception Eur. J. Pharmacol. 468 2003 183 189
    • (2003) Eur. J. Pharmacol. , vol.468 , pp. 183-189
    • Lähdesmäki, J.1    Scheinin, M.2    Pertovaara3    Mansikka, H.A.4
  • 37
    • 0030610424 scopus 로고    scopus 로고
    • Substitution of a mutant alpha2a-adrenergic receptor via hit and run gene targeting reveals the role of this subtype in sedative, analgesic, and anesthetic-sparing responses in vivo
    • P.P. Lakhlani, L.B. MacMillan, T.Z. Guo, B.A. McCool, D.M. Lovinger, M. Maze, and L.E. Limbird Substitution of a mutant alpha2a-adrenergic receptor via hit and run gene targeting reveals the role of this subtype in sedative, analgesic, and anesthetic-sparing responses in vivo Proc. Natl. Acad. Sci. U. S. A. 94 1997 9950 9955
    • (1997) Proc. Natl. Acad. Sci. U. S. A. , vol.94 , pp. 9950-9955
    • Lakhlani, P.P.1    MacMillan, L.B.2    Guo, T.Z.3    McCool, B.A.4    Lovinger, D.M.5    Maze6    Limbird, L.E.M.7
  • 38
    • 0034747195 scopus 로고    scopus 로고
    • Alpha2A-adrenoceptor stimulation reduces capsaicin-induced glutamate release from spinal cord synaptosomes
    • X. Li, and J.C. Eisenach Alpha2A-adrenoceptor stimulation reduces capsaicin-induced glutamate release from spinal cord synaptosomes J. Pharmacol. Exp. Ther. 299 2001 939 944
    • (2001) J. Pharmacol. Exp. Ther. , vol.299 , pp. 939-944
    • Li1    Eisenach, J.C.X.2
  • 39
    • 0035696235 scopus 로고    scopus 로고
    • Protein kinases modulate the cellular adaptations associated with opioid tolerance and dependence
    • J.G. Liu, and K.J. Anand Protein kinases modulate the cellular adaptations associated with opioid tolerance and dependence Brain. Res. Brain. Res. Rev. 38 2001 1 19
    • (2001) Brain. Res. Brain. Res. Rev. , vol.38 , pp. 1-19
    • Liu1    Anand, K.J.J.G.2
  • 40
    • 0026659520 scopus 로고
    • Selective blockade by yohimbine of descending spinal inhibition from lateral reticular nucleus but not from locus coeruleus in rats
    • R.H. Liu, and Z.Q. Zhao Selective blockade by yohimbine of descending spinal inhibition from lateral reticular nucleus but not from locus coeruleus in rats Neurosci. Lett. 142 1992 65 68
    • (1992) Neurosci. Lett. , vol.142 , pp. 65-68
    • Liu1    Zhao, Z.Q.R.H.2
  • 41
    • 0024215586 scopus 로고
    • Behavioural and neurochemical effects of medetomidine, a novel veterinary sedative
    • E. MacDonald, H. Scheinin, and M. Scheinin Behavioural and neurochemical effects of medetomidine, a novel veterinary sedative Eur. J. Pharmacol. 158 1988 119 127
    • (1988) Eur. J. Pharmacol. , vol.158 , pp. 119-127
    • MacDonald, E.1    Scheinin2    Scheinin, M.H.3
  • 42
    • 0031045839 scopus 로고    scopus 로고
    • Participation of noradrenergic pathways in the expression of opiate withdrawal: Biochemical and pharmacological evidence
    • R. Maldonado Participation of noradrenergic pathways in the expression of opiate withdrawal: biochemical and pharmacological evidence Neurosci. Biobehav. Rev. 21 1997 91 104
    • (1997) Neurosci. Biobehav. Rev. , vol.21 , pp. 91-104
    • Maldonado, R.1
  • 43
    • 0035038030 scopus 로고    scopus 로고
    • Contribution of alpha(2) receptor subtypes to nerve injury-induced pain and its regulation by dexmedetomidine
    • A.B. Malmberg, L.R. Hedley, J.R. Jasper, J.C. Hunter, and A.I. Basbaum Contribution of alpha(2) receptor subtypes to nerve injury-induced pain and its regulation by dexmedetomidine Br. J. Pharmacol. 132 2001 1827 1836
    • (2001) Br. J. Pharmacol. , vol.132 , pp. 1827-1836
    • Malmberg, A.B.1    Hedley, L.R.2    Jasper, J.R.3    Hunter4    Basbaum, A.I.J.C.5
  • 44
    • 0036277865 scopus 로고    scopus 로고
    • Descending control of pain
    • M.J. Millan Descending control of pain Prog. Neurobiol. 66 2002 355 474
    • (2002) Prog. Neurobiol. , vol.66 , pp. 355-474
    • Millan, M.J.1
  • 46
    • 0034925262 scopus 로고    scopus 로고
    • An isobolographic analysis of the adrenergic modulation of diclofenac antinociception
    • H.F. Miranda, F. Sierralta, and G. Pinardi An isobolographic analysis of the adrenergic modulation of diclofenac antinociception Anesth. Analg. 93 2001 430 435
    • (2001) Anesth. Analg. , vol.93 , pp. 430-435
    • Miranda, H.F.1    Sierralta2    Pinardi, G.F.3
  • 47
    • 0037422558 scopus 로고    scopus 로고
    • Contribution of GIRK2-mediated postsynaptic signaling to opiate and alpha 2-adrenergic analgesia and analgesic sex differences
    • I. Mitrovic, M. Margeta-Mitrovic, S. Bader, M. Stoffel, L.Y. Jan, and A.I. Basbaum Contribution of GIRK2-mediated postsynaptic signaling to opiate and alpha 2-adrenergic analgesia and analgesic sex differences Proc. Natl. Acad. Sci. U. S. A. 100 2003 271 276
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 271-276
    • Mitrovic, I.1    Margeta-Mitrovic, M.2    Bader, S.3    Stoffel, M.4    Jan5    Basbaum, A.I.L.Y.6
  • 48
    • 0030766528 scopus 로고    scopus 로고
    • Molecular and cellular basis of addiction
    • E.J. Nestler, and K. Aghajanian Molecular and cellular basis of addiction Science 278 1997 58 63
    • (1997) Science , vol.278 , pp. 58-63
    • Nestler1    Aghajanian, K.E.J.2
  • 49
    • 0030179867 scopus 로고    scopus 로고
    • Molecular mechanisms of drug addiction: Adaptations in signal transduction pathways
    • E.J. Nestler, M.T. Berhow, and E.S. Brodkin Molecular mechanisms of drug addiction: adaptations in signal transduction pathways Mol. Psychiatry. 1 1996 190 199
    • (1996) Mol. Psychiatry. , vol.1 , pp. 190-199
    • Nestler, E.J.1    Berhow2    Brodkin, E.S.M.T.3
  • 50
    • 0024536612 scopus 로고
    • Antinociceptive interactions between alpha 2-adrenergic and opiate agonists at the spinal level in rodents
    • M.H. Ossipov, L.J. Suarez, and T.C. Spaulding Antinociceptive interactions between alpha 2-adrenergic and opiate agonists at the spinal level in rodents Anesth. Analg. 68 1989 194 200
    • (1989) Anesth. Analg. , vol.68 , pp. 194-200
    • Ossipov, M.H.1    Suarez2    Spaulding, T.C.L.J.3
  • 51
    • 0025695013 scopus 로고
    • An isobolographic analysis of the antinociceptive effect of systemically and intrathecally administered combinations of clonidine and opiates
    • M.H. Ossipov, S. Harris, P. Lloyd, and E. Messineo An isobolographic analysis of the antinociceptive effect of systemically and intrathecally administered combinations of clonidine and opiates J. Pharmacol. Exp. Ther. 255 1990 1107 1116
    • (1990) J. Pharmacol. Exp. Ther. , vol.255 , pp. 1107-1116
    • Ossipov, M.H.1    Harris, S.2    Lloyd3    Messineo, E.P.4
  • 52
    • 17344375438 scopus 로고
    • Spinal antinociceptive synergy between clonidine and morphine, U69593, and DPDPE: Isobolographic analysis
    • M.H. Ossipov, R. Lozito, E. Messineo, J. Green, S. Harris, and P. Lloyd Spinal antinociceptive synergy between clonidine and morphine, U69593, and DPDPE: isobolographic analysis Life Sci. 47 1990 PL71 PL76
    • (1990) Life Sci. , vol.47
    • Ossipov, M.H.1    Lozito, R.2    Messineo, E.3    Green, J.4    Harris5    Lloyd, P.S.6
  • 53
    • 0037462432 scopus 로고    scopus 로고
    • Influence of prazosin and clonidine on morphine analgesia, tolerance and withdrawal in mice
    • U.K. Özdoǧan, J. Lähdesmäki, and M. Scheinin Influence of prazosin and clonidine on morphine analgesia, tolerance and withdrawal in mice Eur. J. Pharmacol. 460 2003 127 134
    • (2003) Eur. J. Pharmacol. , vol.460 , pp. 127-134
    • Özdoǧan, U.K.1    Lähdesm̈ki2    Scheinin, M.J.3
  • 54
    • 0018074124 scopus 로고
    • Development of tolerance to the analgesic effect of clonidine in rats. Cross-tolerance to morphine
    • G. Paalzow Development of tolerance to the analgesic effect of clonidine in rats. Cross-tolerance to morphine Naunyn-Schmiedeberg's Arch. Pharmacol. 304 1978 1 4
    • (1978) Naunyn-Schmiedeberg's Arch. Pharmacol. , vol.304 , pp. 1-4
    • Paalzow, G.1
  • 56
    • 0031416922 scopus 로고    scopus 로고
    • Quantitative evaluation of opioid withdrawal signs in rats repeatedly treated with morphine and injected with naloxone, in the absence or presence of the antiabstinence agent clonidine
    • A. Pinelli, and S. Trivulzio Quantitative evaluation of opioid withdrawal signs in rats repeatedly treated with morphine and injected with naloxone, in the absence or presence of the antiabstinence agent clonidine J. Pharmacol. Toxicol. Methods 38 1997 117 131
    • (1997) J. Pharmacol. Toxicol. Methods , vol.38 , pp. 117-131
    • Pinelli1    Trivulzio, S.A.2
  • 57
    • 0001886508 scopus 로고    scopus 로고
    • Opioid analgesics and antagonists
    • A.G. Gilman J.G. Hardman L.E. Limbird 9th ed. McGraw-Hill New York
    • T. Reisine, and G. Pasternak Opioid analgesics and antagonists A.G. Gilman J.G. Hardman L.E. Limbird Goodman and Gilman's The Pharmacological Basis of Therapeutics 9th ed. 1996 McGraw-Hill New York 521 555
    • (1996) Goodman and Gilman's the Pharmacological Basis of Therapeutics , pp. 521-555
    • Reisine1    Pasternak, G.T.2
  • 58
    • 0020531078 scopus 로고
    • The role of interaction between opiate receptors and alpha-adrenergic receptors in tolerance and dependence
    • L.E. Robson, R.F. Mucha, and H.W. Kosterlitz The role of interaction between opiate receptors and alpha-adrenergic receptors in tolerance and dependence Biochem. Soc. Trans. 11 1983 64 65
    • (1983) Biochem. Soc. Trans. , vol.11 , pp. 64-65
    • Robson, L.E.1    Mucha2    Kosterlitz, H.W.R.F.3
  • 59
    • 0028833111 scopus 로고
    • Decreased spinal morphine/clonidine antinociceptive synergism in morphine-tolerant mice
    • S.C. Roerig Decreased spinal morphine/clonidine antinociceptive synergism in morphine-tolerant mice Life Sci. 56 1995 L115 L122
    • (1995) Life Sci. , vol.56
    • Roerig, S.C.1
  • 60
    • 0026681672 scopus 로고
    • Spinal interactions between opioid and noradrenergic agonists in mice: Multiplicativity involves delta and alpha-2 receptors
    • S.C. Roerig, S. Lei, K. Kitto, J.K. Hylden, and G.L. Wilcox Spinal interactions between opioid and noradrenergic agonists in mice: multiplicativity involves delta and alpha-2 receptors J. Pharmacol. Exp. Ther. 262 1992 365 374
    • (1992) J. Pharmacol. Exp. Ther. , vol.262 , pp. 365-374
    • Roerig, S.C.1    Lei, S.2    Kitto, K.3    Hylden4    Wilcox, G.L.J.K.5
  • 61
    • 0026484405 scopus 로고
    • Noradrenergic mediation of spinal antinociception by 5-hydroxytryptamine: Characterization of receptor subtypes
    • J. Sawynok, and A. Reid Noradrenergic mediation of spinal antinociception by 5-hydroxytryptamine: characterization of receptor subtypes Eur. J. Pharmacol. 223 1992 49 56
    • (1992) Eur. J. Pharmacol. , vol.223 , pp. 49-56
    • Sawynok1    Reid, A.J.2
  • 62
    • 0036181218 scopus 로고    scopus 로고
    • Alpha 2-adrenoceptors in the enteric nervous system: A study in alpha 2A-adrenoceptor-deficient mice
    • J. Scheibner, A.U. Trendelenburg, L. Hein, K. Starke, and C. Blandizzi Alpha 2-adrenoceptors in the enteric nervous system: a study in alpha 2A-adrenoceptor-deficient mice Br. J. Pharmacol. 135 2002 697 704
    • (2002) Br. J. Pharmacol. , vol.135 , pp. 697-704
    • Scheibner, J.1    Trendelenburg, A.U.2    Hein, L.3    Starke4    Blandizzi, C.K.5
  • 63
    • 0026570660 scopus 로고
    • Dexmedetomidine attenuates sympathoadrenal responses to tracheal intubation and reduces the need for thiopentone and perioperative fentanyl
    • B. Scheinin, L. Lindgren, T. Randell, H. Scheinin, and M. Scheinin Dexmedetomidine attenuates sympathoadrenal responses to tracheal intubation and reduces the need for thiopentone and perioperative fentanyl Br. J. Anaesth. 68 1992 126 131
    • (1992) Br. J. Anaesth. , vol.68 , pp. 126-131
    • Scheinin, B.1    Lindgren, L.2    Randell, T.3    Scheinin4    Scheinin, M.H.5
  • 64
    • 0032480233 scopus 로고    scopus 로고
    • The antinociceptive effect of moclobemide in mice is mediated noradrenergic pathways
    • S. Schreiber, V. Getslev, A. Weizman, and C.G. Pick The antinociceptive effect of moclobemide in mice is mediated noradrenergic pathways Neurosci. Lett. 253 1998 183 186
    • (1998) Neurosci. Lett. , vol.253 , pp. 183-186
    • Schreiber, S.1    Getslev, V.2    Weizman3    Pick, C.G.A.4
  • 65
    • 0032840655 scopus 로고    scopus 로고
    • The antinociceptive effect of venlafaxine in mice is mediated through opioid and adrenergic mechanisms
    • S. Schreiber, M.M. Backer, and C.G. Pick The antinociceptive effect of venlafaxine in mice is mediated through opioid and adrenergic mechanisms Neurosci. Lett. 273 1999 85 88
    • (1999) Neurosci. Lett. , vol.273 , pp. 85-88
    • Schreiber, S.1    Backer2    Pick, C.G.M.M.3
  • 66
    • 0029818157 scopus 로고    scopus 로고
    • Modification of naloxone-precipitated withdrawal symptoms in mice by drugs acting on alpha(2)-adrenoceptors
    • S.I. Sharif, and A.O. El-Kadi Modification of naloxone-precipitated withdrawal symptoms in mice by drugs acting on alpha(2)-adrenoceptors Behav. Pharmacol. 4 1996 334 340
    • (1996) Behav. Pharmacol. , vol.4 , pp. 334-340
    • Sharif1    El-Kadi, A.O.S.I.2
  • 67
    • 0029835247 scopus 로고    scopus 로고
    • Alpha-adrenoceptor and opioid receptor modulation of clonidine-induced antinociception
    • F. Sierralta, D. Naquira, G. Pinardi, and H.F. Miranda Alpha-adrenoceptor and opioid receptor modulation of clonidine-induced antinociception Br. J. Pharmacol. 119 1996 551 554
    • (1996) Br. J. Pharmacol. , vol.119 , pp. 551-554
    • Sierralta, F.1    Naquira, D.2    Pinardi3    Miranda, H.F.G.4
  • 68
    • 0030611098 scopus 로고    scopus 로고
    • The alpha2a adrenergic receptor subtype mediates spinal analgesia evoked by alpha2 agonists and is necessary for spinal adrenergic-opioid synergy
    • L.S. Stone, L.B. MacMillan, K.F. Kitto, L.E. Limbird, and G.L. Wilcox The alpha2a adrenergic receptor subtype mediates spinal analgesia evoked by alpha2 agonists and is necessary for spinal adrenergic-opioid synergy J. Neurosci. 17 1997 7157 7165
    • (1997) J. Neurosci. , vol.17 , pp. 7157-7165
    • Stone, L.S.1    MacMillan, L.B.2    Kitto, K.F.3    Limbird4    Wilcox, G.L.L.E.5
  • 69
    • 0026558047 scopus 로고
    • Evidence for the involvement of the mu but not delta opioid receptor subtype in the synergistic interaction between opioid and alpha 2 adrenergic antinociception in the rat spinal cord
    • A.F. Sullivan, E.A. Kalso, H.J. McQuay, and A.H. Dickenson Evidence for the involvement of the mu but not delta opioid receptor subtype in the synergistic interaction between opioid and alpha 2 adrenergic antinociception in the rat spinal cord Neurosci. Lett. 139 1992 65 68
    • (1992) Neurosci. Lett. , vol.139 , pp. 65-68
    • Sullivan, A.F.1    Kalso, E.A.2    McQuay3    Dickenson, A.H.H.J.4
  • 70
    • 0035087457 scopus 로고    scopus 로고
    • Unifying perspectives of the mechanisms underlying the development of tolerance and physical dependence to opioids
    • D.A. Taylor, and W.W. Fleming Unifying perspectives of the mechanisms underlying the development of tolerance and physical dependence to opioids J. Pharmacol. Exp. Ther. 297 2001 11 18
    • (2001) J. Pharmacol. Exp. Ther. , vol.297 , pp. 11-18
    • Taylor1    Fleming, W.W.D.A.2
  • 71
    • 0035055204 scopus 로고    scopus 로고
    • Diversity and specificity in the regulated endocytic membrane trafficking of G- protein-coupled receptors
    • P.I. Tsao, and M. von Zastrow Diversity and specificity in the regulated endocytic membrane trafficking of G- protein-coupled receptors Pharmacol. Ther. 89 2001 139 147
    • (2001) Pharmacol. Ther. , vol.89 , pp. 139-147
    • Tsao1    Von Zastrow, M.P.I.2
  • 72
    • 0034681439 scopus 로고    scopus 로고
    • Cross-tolerance between analgesia produced by xylazine and selective opioid receptor subtype treatments
    • T.D. Ware, and D. Paul Cross-tolerance between analgesia produced by xylazine and selective opioid receptor subtype treatments Eur. J. Pharmacol. 389 2000 181 185
    • (2000) Eur. J. Pharmacol. , vol.389 , pp. 181-185
    • Ware1    Paul, D.T.D.2
  • 73
    • 0014518317 scopus 로고
    • Simultaneous quantitative assessment of morphine tolerance and physical dependence
    • E.L. Way, H.H. Loh, and F.H. Shen Simultaneous quantitative assessment of morphine tolerance and physical dependence J. Pharmacol. Exp. Ther. 167 1969 1 8
    • (1969) J. Pharmacol. Exp. Ther. , vol.167 , pp. 1-8
    • Way, E.L.1    Loh2    Shen, F.H.H.H.3
  • 74
    • 0035214481 scopus 로고    scopus 로고
    • Reduced development of tolerance to the analgesic effects of morphine and clonidine in PKC gamma mutant mice
    • K.P. Zeitz, A.B. Malmberg, H. Gilbert, and A.I. Basbaum Reduced development of tolerance to the analgesic effects of morphine and clonidine in PKC gamma mutant mice Pain 94 2001 245 253
    • (2001) Pain , vol.94 , pp. 245-253
    • Zeitz, K.P.1    Malmberg, A.B.2    Gilbert3    Basbaum, A.I.H.4
  • 75
    • 0032983162 scopus 로고    scopus 로고
    • Alpha 2-adrenoreceptor subtypes regulate ACTH and beta-endorphin secretions during stress in the rat
    • D. Zelena, D.T. Kiem, I. Barna, and G.B. Makara Alpha 2-adrenoreceptor subtypes regulate ACTH and beta-endorphin secretions during stress in the rat Psychoneuroendocrinology 24 1999 333 343
    • (1999) Psychoneuroendocrinology , vol.24 , pp. 333-343
    • Zelena, D.1    Kiem, D.T.2    Barna3    Makara, G.B.I.4
  • 76
    • 0032587931 scopus 로고    scopus 로고
    • Alpha1-adrenoceptor subtypes
    • H. Zhong, and K.P. Minneman Alpha1-adrenoceptor subtypes Eur. J. Pharmacol. 375 1999 261 276
    • (1999) Eur. J. Pharmacol. , vol.375 , pp. 261-276
    • Zhong1    Minneman, K.P.H.2


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