Molecular mechanisms of drug addiction: Adaptations in signal transduction pathways

Molecular Psychiatry

Volumn 1, Issue 3, 1996, Pages 190-199

  Nestler, E J ^a   Berhow, M T ^a   Brodkin, E S ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alcohol; BDNF; CNTF; Cocaine; Cyclic AMP; Mesolimbic dopamine system; Morphine; Neurotrophic factors; Protein phosphorylation

Indexed keywords

MORPHINE;

ADAPTATION; ADDICTION; ANIMAL; DRUG EFFECT; REVIEW; SIGNAL TRANSDUCTION;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; MORPHINE; SIGNAL TRANSDUCTION; SUBSTANCE-RELATED DISORDERS;

EID: 0030179867     PISSN: 13594184     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (65)

1. Wise RA. The role of reward pathways in the development of drug dependence. In: Balfour DJK (ed). Psychotropic Drugs of Abuse. Pergamon Press: Oxford, 1990, pp 23-57.
2. Koob GF. Drugs of abuse: anatomy, pharmacology and function of reward pathways. Trend Pharmacol Sci 1992; 13: 177-184.
3. Self DW, Nestler EJ. Molecular mechanisms of drug reinforcement and addiction. Annu Rev Neurosci 1995; 18: 463-495.
4. Nestler EJ. Molecular mechanisms of drug addiction. J Neurosci 1992; 12: 2439-2450.
5. Nestler EJ, Hope BT, Widnell KL. Drug addiction: a model for the molecular basis of neural plasticity. Neuron 1993; 11: 995-1006.
6. Beitner-Johnson D, Nestler EJ. Morphine and cocaine exert common chronic actions on tyrosine hydroxylase in dopaminergic brain reward regions. J Neurochem 1990; 57: 344-347.
7. Hurd YL, Linefors N, Brodin E, Brené S, Persson H, Ungerstedt U, Hökfelt T. Amphetamine regulation of mesolimbic dopamine/cholecystokinin neurotransmission. Brain Res 1992; 578: 317-326.
8. Sorg BA, Chen S-Y, Kalivas PW. Time course of tyrosine hydroxylase expression after behavioral sensitization to cocaine. J Pharmacol Exp Ther 1993; 226: 424-430.
9. Vrana SL, Vrana KE, Koves TR, Smith JE, Dworkin SI. Chronic cocaine administration increases CNS tyrosine hydroxylase enzyme activity and mRNA levels and trytophan hydroxylase enzyme activity levels. J Neurochem 1993; 61: 2262-2268.
10. Ortiz J, Fitzgerald LW, Charlton M, Lane S, Trevisan L, Guitart X, Shoemaker W, Duman RS, Nestler EJ. Biochemical actions of chronic ethanol exposure in the mesolimbic dopamine system. Synapse 1995; 21: 289-298.
11. Beitner-Johnson D, Guitart X, Nestler EJ. Neurofilaments and the mesolimbic dopamine system: common regulation by chronic morphine and chronic cocaine in the rat ventral tegmental area. J Neurosci 1992; 12: 2165-2176.
12. Fitzgerald LW, Ortiz J, Hamedani Azita G, Nestler EJ. Regulation of glutamate receptor subunit expression by drugs of abuse and stress: common adaptations among cross-sensitizing agents. J Neurosci 1996; 16: 274-282.
13. Beitner-Johnson D, Guitart X, Nestler EJ. Glial fibrillary acidic protein and the mesolimbic dopamine system: regulation by chronic morphine and Lewis-Fischer strain differences in the rat ventral tegmental area. J Neurochem 1993; 61: 1766-1773.
14. Terwilliger RZ, Beitner-Johnson D, Sevarino KA, Crain SM, Nestler EJ. A general role for adaptations in G-proteins and the cyclic AMP system in mediating the chronic actions of morphine and cocaine on neuronal function. Brain Res 1991; 548: 100-110.
15. Striplin CD, Kalivas PW. Correlation between behavioral sensitization to cocaine and G protein ADP-ribosylation in the ventral tegmental area. Brain Res 1992; 579: 181-186.
16. Self DW, McClenahan AW, Beitner-Johnson D, Terwilliger RZ, Nestler EJ. Biochemical adaptations in the mesolimbic dopamine system in response to heroin self-administration. Synapse 1995; 21: 312-318.
17. Vezina P, Stewart J. Amphetamine administered to the ventral tegmental area but not to the nucleus accumbens sensitizes rats to systemic morphine: lack of conditional effects. Brain Res 1990; 516: 99-106.
18. Kalivas PW, Stewart J. Dopamine transmission in the initiation and expression of drug- and stress-induced sensitization of motor activity. Brain Res Rev 1991; 16: 223-244.
19. Cunningham ST, Kelley AE. Evidence for opiate-dopamine cross-sensitization in the nucleus accumbens: studies of conditional reward. Brain Res Bull 1993; 29: 675-680.
20. Horger BA, Giles MK, Schenk S. Preexposure to amphetamine and nicotine predisposes rats to self-administer a low dose of cocaine. Pstchopharmacology 1992; 107: 271-276.
21. Henry DJ, White FJ. Repeated cocaine administration causes persistent enhancement of D1 dopamine receptor sensitivity within the nucleus accumbens. J Pharmacol Exp Ther 1991; 258: 882-890.
22. Self DW, Terwilliger RZ, Nestler EJ, Stein L. Inactivation of Gi and Go proteins in nucleus accumbens reduces both cocaine and heroin reinforcement. J Neurosci 1994; 14: 6239-6247.
23. Cunningham ST, Kelley AE. Evidence for opiate-dopamine cross-sensitization in nucleus accumbens: studies of conditioned reward. Brain Res Bull 1992; 29: 675-680.
24. Miserendino MJD, Nestler EJ. Behavioral sensitization to cocaine: modulation by the cyclic AMP system in the nucleus accumbens. Brain Res 1995; 674: 299-306.
25. Henry DJ, Greene MA, White KJ. Electrophysiological effects of cocaine in the mesoaccumbens dopamine system: repeated administration. J Pharmacol Exp Ther 1989; 251: 833-839.
26. White KJ, Hu X-T, Zhang X-F, Wolf ME. Repeated administration of cocaine or amphetamine alters neuronal responses to glutamate in the mesoaccumbens dopamine system. J Pharmacol Exp Ther 1995; 273: 445-454.
27. Beitner-Johnson D, Nestler EJ. Chronic morphine impairs axoplasmic transport in the mesolimbic dopamine system of the rat brain. NeuroReport 1993; 5: 57-60.
28. Sklair-Tavron L, Shi WX, Bunnoy BS, Nestler EJ. Morphological evidence of changes induced in the ventral tegmental area (VTA) by chronic morphine treatment. Soc Neurosci Abs 1995; 21: 1059.
29. Hyman C, Juhasz, M, Jackson C, Wright P, Ip NY, Lindsay RM. Overlapping and distinct actions of neurotrophins BDNF, NT3, and NT4/5 on cultured dopaminergic and GABAergic neurons of the ventral mesecephalon. J Neurosci 1994; 14: 335-347.
30. Loughlin SE, Fallon JH. Neurotrophic Factors. Academic Press: New York, 1993.
31. Boulton TG, Stahl N, Yancopoulous GD. Ciliary neurotrophic factor/leukemia inhibitory factor/interleukin 6/oncostatin M family of cytokines induces tyrosine phosphorylation of a common set of proteins overlapping those induced by other cytokines and growth factors. J Biol Chem 1994; 269: 11648-11655.
32. Ip NY, Yancopolous GD. Ciliary neurotrophic factor and its receptor complex. Prog Growth Factor Res 1992; 4: 139-155.
33. Berhow MT, Russell DS, Terwilliger RZ, Beitner-Johnson D, Self DW, Lindsay RM, Nestler EJ. Influence of neurotrophic factors on morphine- and cocaine-induced biochemical changes in the mesolimbic dopamine system. Neuroscience 1995; 68: 969-979.
34. Seroogy KB, Gall CM. Expression of neurotrophins by midbrain dopaminergic neurons. Exp Neurol 1993; 124: 119-128.
35. Crews CM, Erikson RL. Extracellular signals and reversible protein phosphorylation: what to MEK of it all. Cell 1993; 74: 215-217.
36. Davis RJ. The mitogen-activated protein kinase signal tranduction pathway. J Biol Chem 1993; 268: 14553-14556.
37. Ortiz J, Harris HW, Guitart X, Terwilliger RZ, Haycock JW, Nestler EJ. Extracellular signal-regulated protein kinases (ERKs) and ERK kinase (MEK) in brain. Regional distribution and regulation by chronic morphine. J Neurosci 1995; 15: 1285-1297.
38. Berhow MT, Hiroi N, Nestler EJ. Regulation of ERK (extracellular signal regulated kinase), part of the neurotrophin signal transduction cascade, in the rat mesolimbic dopamine system by chronic exposure to morphine or cocaine. J Neurosci 1996; (in press).
39. Karler R, Chaudhry IA, Calder LD, Turkanis SA. DNQX blockade of amphetamine behavioral sensitization. Brain fies 1991; 552: 295-300.
40. Schenk S, Valadez A, McNamara C, House DT, Higley D, Bankson MG, Gibbs S, Horger BA. Development and expression of sensitization to cocaine's reinforcing properties: role of NMDA receptors. Psychopharmacology 1993; 111: 332-338.
41. Wolf ME, Jeziorski M. Coadministration of MK-801 with amphetamine, cocaine or morphine prevents rather than transiently masks the development of behavioral sensitization. Brain Res 1993; 613: 291-294.
42. Ghosh A, Greenberg ME. Calcium signalling in neurons: molecular mechanisms and cellular consequences. Science 1995; 268: 239-247.
43. Ginty DD, Bonni A, Greenberg ME. Nerve growth factor activates a ras-dependent protein kinase that stimulates c-fos transcription via phosphorylation of CREB. Cell 1994; 77: 713-725.
44. Kim KS, Tinti C, Song B, Cubells JF, Joh TH. Cyclic AMP-dependent protein kinase regulates basal and cyclic AMP-stimulated but not phorbol ester-stimulated transcription of the tyrosine hydroxylase gene. J Neurochem 1994; 63: 834-842.
45. Lazaroff M, Patankar S, Yoon SO, Chikaraishi DM. The cyclic AMP response element directs tyrosine hydroxylase expression in catecholaminergic central and peripheral nervous system cell lines from transgenic mice. J Biol Chem 1995; 270: 21579-21589.
46. Ihle JN, Kerr I, JAKs and STATs in signaling by the cytokine receptor superfamily. Trends Genet 1995; 11: 69-74.
47. Berhow MT, Hiroi N, Kobierski L, Hyman SE, Nestler EJ. Influence of cocaine on the JAK-STAT pathway in the mesolimbic dopamine system. Soc Neurosci Abs 1996; (in press).
48. Sesack SR, Pickel VM. Ultrastructural relationships between terminals immunoreactive for enkephalin, GABA, or both transmitters in the rat ventral tegmental area. Brain Res 1995; 672: 261-275.
49. Piazza PV, Maccari S, Deminiere JM, Le Moal M, Mormede P, Simon H. Corticosterone levels determine individual vulnerability to amphetamine self-administration. Proc Natl Acad Sci USA 1991; 88: 2088-2092.
50. Cole BJ, Cador M, Stinus L. Critical role of the hypothalamic pituitary adrenal axis in amphetamine-induced sensitization of behavior. Life Science 1990; 47: 1715-1720.
51. Ortiz J, DeCaprio J, Guitart X, Kosten TA, Nestler EJ. Strain-selective effects of corticosterone on locomotor sensitization to cocaine and on levels of tyrosine hydroxylase and glucocorticoid receptor in the ventral tegmental area. Neuroscience 1995; 67: 383-397.
52. Hamamura T, Fibiger HC. Enhanced stress-induced dopamine release in the prefrontal cortex of amphetamine-sensitized rats. Eur J Pharmacol 1993; 237: 65-71.
53. Sorg BA, Kalivas PW. Behavioral sensitization to stress and psychostimulants: role of dopamine and excitatory amino in the mesocorticolimbic system. Sem Neurosci 1993; 5: 343-350.
54. Goeders NE, Guerin GF. Non-contingent electric footshock facilitates the acquisition of intravenous cocaine self-administration in rats. Psychopharmacology 1994; 114: 63-70.
55. Shaham Y, Stewart J. Exposure to mild stress enhances the reinforcing efficacy of intravenous heroin self-administration. Psychopharmacology 1994; 114: 523-527.
56. Shaham Y, Alvares K, Nespor SM, Grunberg NE. Effect of stress on oral morphine and fentanyl self-administration in rats. Pharmacol Biochem Behav 1994; 41: 615-619.
57. Fahlke C, Hansen S, Engel JA, Hard E. Effects of ventral striatal 6-OHDA lesions or amphetamine sensitization on ethanol consumption in the rat. Pharmacol Biochem Behav 1994; 47: 345-349.
58. Crabbe JC, Belknap JK, Buck KJ. Genetic animal models of alcohol and drug abuse. Science 1994; 264: 1715-1723.
59. Kosten TA, Miserendino MJD, Chi S, Nestler EJ. Fischer and Lewis rat strains show differential cocaine effects in conditioned place preference and behavioral sensitization, but not in locomotor activity or conditioned taste aversion. J Pharmacol Exp Ther 1994; 269: 137-144.
60. Harris HW, Nestler EJ. Immunohistochemical studies of mesolimbic dopamine neurons in Fischer 344 and Lewis rats. Brain Res 1996; 706: 1-12.
61. Guitart X, Beitner-Johnson D, Marby D, Kosten TA, Nestler EJ. Fischer and Lewis rats strains differ in basal levels of neurofilament proteins and their regulation by chronic morphine in the mesolimbic dopamine system. Synapse 1992; 12: 242-253.
62. Guitart X, Kogan JH, Berhow M, Terwilliger RZ, Aghajanian GK, Nestler EJ. Lewis and Fischer rat strains display differences in biochemical, electrophysiological, and behavioral parameters: studies in the nucleus accumbens and locus coeruleus of drug naive and morphine-treated animals. Brain Res 1993; 611: 7-17.
63. Ortiz J, Fitzgerald LW, Lane S, Terwilliger R, Nestler EJ. Biochemical effects of repeated stress in the mesolimbic dopamine system. Neuropsychopharmacology 1996; 14: 393-402.
64. Piazza PV, Deminiere J-M, Le Moal M, Simon H. Factors that predict individual vulnerability to amphetamine self-administration. Science 1989; 1245: 1511-1513.
65. Beitner-Johnson D, Guitart X, Nestler EJ. Common intracellular actions of chronic morphine and cocaine in dopaminergic brain reward regions. Ann NY Acad Sci 1992; 684: 70-87.