Quantitative evaluation of opioid withdrawal signs in rats repeatedly treated with morphine and injected with naloxone, in the absence or presence of the antiabstinence agent clonidine

Journal of Pharmacological and Toxicological Methods

Volumn 38, Issue 3, 1997, Pages 117-131

  Pinelli, A ^a   Trivulzio, S ^a  

^a Chemotherapy and Medical Toxicology ^*  (Italy)

Author keywords

Antiwithdrawal drug; Experimental model; Opioid withdrawal syndrome; Rats; Screening

Indexed keywords

CLONIDINE; MORPHINE; NALOXONE; OPIATE; OPIATE RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; EXPERIMENTAL MODEL; FECES; JUMPING; LATENT PERIOD; MALE; METHODOLOGY; NONHUMAN; PAIN THRESHOLD; QUANTITATIVE ASSAY; RAT; RECTUM TEMPERATURE; SALIVATION; SYMPTOM; URINARY EXCRETION; URINE; WET DOG SHAKES; WITHDRAWAL SYNDROME;

ADMINISTRATION, ORAL; ADRENERGIC ALPHA-AGONISTS; ANIMALS; BEHAVIOR, ANIMAL; BODY TEMPERATURE; CLONIDINE; DEFECATION; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; MALE; MORPHINE; NALOXONE; NARCOTIC ANTAGONISTS; NARCOTICS; PAIN THRESHOLD; RATS; RATS, SPRAGUE-DAWLEY; SALIVATION; SUBSTANCE WITHDRAWAL SYNDROME; URINATION;

EID: 0031416922     PISSN: 10568719     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1056-8719(97)00050-6     Document Type: Article

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