Electrostatic channeling in the bifunctional enzyme dihydrofolate reductase-thymidylate synthase

Journal of Molecular Biology

Volumn 262, Issue 3, 1996, Pages 370-374

  Elcock, Adrian H ^a   Potter, Michael J ^a   Matthews, David A ^b   Knighton, Daniel R ^b   McCammon, J Andrew ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b AGOURON PHARMACEUTICALS INC   (United States)

Author keywords

Bifunctional enzymes; Brownian dynamics; Electrostatic channeling; Electrostatics

Indexed keywords

DIHYDROFOLATE REDUCTASE; PROTOZOAL PROTEIN; THYMIDYLATE SYNTHASE;

ARTICLE; BINDING SITE; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; ELECTROCHEMISTRY; METABOLISM; PROTEIN CONFORMATION;

BINDING SITES; COMPUTER SIMULATION; ELECTROCHEMISTRY; MODELS, CHEMICAL; MODELS, MOLECULAR; PROTEIN CONFORMATION; PROTOZOAN PROTEINS; TETRAHYDROFOLATE DEHYDROGENASE; THYMIDYLATE SYNTHASE;

EID: 0030603887     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1996.0520     Document Type: Article

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