Substrate channeling and domain-domain interactions in bifunctional thymidylate synthase-dihydrofolate reductase

Biochemistry

Volumn 37, Issue 35, 1998, Pages 12195-12205

  Liang, Po Huang ^a,b   Anderson, Karen S ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Smith Kline Beecham ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIHYDROFOLATE REDUCTASE; THYMIDYLATE SYNTHASE; TRYPTOPHAN SYNTHASE;

ARTICLE; CATALYSIS; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ASSAY; ENZYME KINETICS; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; LEISHMANIA MAJOR; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; BINDING SITES; CATALYSIS; ENZYME ACTIVATION; FLUORESCENCE POLARIZATION; KINETICS; LEISHMANIA MAJOR; MODELS, CHEMICAL; MULTIENZYME COMPLEXES; PROTEIN STRUCTURE, TERTIARY; SPECTROMETRY, FLUORESCENCE; SUBSTRATE SPECIFICITY; TETRAHYDROFOLATE DEHYDROGENASE; THYMIDYLATE SYNTHASE;

LEISHMANIA MAJOR; PROTOZOA;

EID: 0032167808     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9803168     Document Type: Article

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