-
1
-
-
0034923502
-
DNA topoisomerases: structure function and mechanism
-
Champous J.J. DNA topoisomerases: structure function and mechanism. Annu Rev Biochem 70 (2001) 369-413
-
(2001)
Annu Rev Biochem
, vol.70
, pp. 369-413
-
-
Champous, J.J.1
-
2
-
-
0036085460
-
Cellular roles of DNA topoisomerases: a molecular perspective
-
Wang J.C. Cellular roles of DNA topoisomerases: a molecular perspective. Nat Rev Mol Cell Biol 3 (2002) 430-440
-
(2002)
Nat Rev Mol Cell Biol
, vol.3
, pp. 430-440
-
-
Wang, J.C.1
-
3
-
-
0036227720
-
Culprit and victim-DNA topoisomerase II
-
Kellner U., Sehested M., Jensen P.B., Gieseler F., and Rudolph P. Culprit and victim-DNA topoisomerase II. Lancet Oncol 3 (2002) 235-243
-
(2002)
Lancet Oncol
, vol.3
, pp. 235-243
-
-
Kellner, U.1
Sehested, M.2
Jensen, P.B.3
Gieseler, F.4
Rudolph, P.5
-
4
-
-
0028046036
-
Structure and function of type II DNA topoisomerases
-
Watt P.M., and Hickson I.D. Structure and function of type II DNA topoisomerases. Biochem J 303 (1994) 681-695
-
(1994)
Biochem J
, vol.303
, pp. 681-695
-
-
Watt, P.M.1
Hickson, I.D.2
-
5
-
-
0033628701
-
Topoisomerase II as a target for anticancer drugs: when enzymes stop being nice
-
Fortune J.M., and Osheroff N. Topoisomerase II as a target for anticancer drugs: when enzymes stop being nice. Proc Nucleic Acid Res Mol Biol 64 (2000) 221-253
-
(2000)
Proc Nucleic Acid Res Mol Biol
, vol.64
, pp. 221-253
-
-
Fortune, J.M.1
Osheroff, N.2
-
6
-
-
0037277089
-
Drugs acting on the beta isoform of human topoisomerase II
-
Gatto B., and Leo E. Drugs acting on the beta isoform of human topoisomerase II. Curr Med Chem 3 (2003) 175-185
-
(2003)
Curr Med Chem
, vol.3
, pp. 175-185
-
-
Gatto, B.1
Leo, E.2
-
7
-
-
0037470042
-
A two-drug model for etoposide action against human topoisomerase II alpha
-
Bromberg K.D., Burgin A.B., and Osheroff N. A two-drug model for etoposide action against human topoisomerase II alpha. J Biol Chem 278 (2003) 7406-7412
-
(2003)
J Biol Chem
, vol.278
, pp. 7406-7412
-
-
Bromberg, K.D.1
Burgin, A.B.2
Osheroff, N.3
-
8
-
-
34248356003
-
Cellular response to etoposide treatment
-
Montecucco A., and Biamonti G. Cellular response to etoposide treatment. Cancer Lett 252 (2007) 9-18
-
(2007)
Cancer Lett
, vol.252
, pp. 9-18
-
-
Montecucco, A.1
Biamonti, G.2
-
9
-
-
0037119491
-
Caspase 2 acts upstream of mitochondria to promote cytochrome C release during etoposide-induced apoptosis
-
Robertson J.D., Enoksson M., Suomela M., Zhivotovsky B., and Orrenius S. Caspase 2 acts upstream of mitochondria to promote cytochrome C release during etoposide-induced apoptosis. J Biol Chem 277 (2002) 29803-29809
-
(2002)
J Biol Chem
, vol.277
, pp. 29803-29809
-
-
Robertson, J.D.1
Enoksson, M.2
Suomela, M.3
Zhivotovsky, B.4
Orrenius, S.5
-
10
-
-
4644314416
-
Sequential caspase-2 and caspase-8 activation of mitochondria during ceramide and etoposide induced apoptosis
-
Lin C.F., Chen C.L., Chang W.T., Jan M.S., Hsu L.L., and Wu R.H. Sequential caspase-2 and caspase-8 activation of mitochondria during ceramide and etoposide induced apoptosis. J Biol Chem 279 (2004) 40755-40761
-
(2004)
J Biol Chem
, vol.279
, pp. 40755-40761
-
-
Lin, C.F.1
Chen, C.L.2
Chang, W.T.3
Jan, M.S.4
Hsu, L.L.5
Wu, R.H.6
-
11
-
-
0035132464
-
Reconstitution of caspase 3 sensitizes MCF-7 breast cancer cells to doxorubicin- and etoposide-induced apoptosis
-
Yang X.H., Sladek T.L., Liu X., Butler B.R., Froelich C.J., and Thor A.D. Reconstitution of caspase 3 sensitizes MCF-7 breast cancer cells to doxorubicin- and etoposide-induced apoptosis. Cancer Res 61 (2001) 348-354
-
(2001)
Cancer Res
, vol.61
, pp. 348-354
-
-
Yang, X.H.1
Sladek, T.L.2
Liu, X.3
Butler, B.R.4
Froelich, C.J.5
Thor, A.D.6
-
12
-
-
33751010123
-
Caspase 10 involvement in cytotoxic drug-induced apoptosis of tumor cells
-
Filomenko R., Prevolat L., Rebe C., Cortier M., Jeannin J.F., Solary E., et al. Caspase 10 involvement in cytotoxic drug-induced apoptosis of tumor cells. Oncogene 25 (2006) 7635-7645
-
(2006)
Oncogene
, vol.25
, pp. 7635-7645
-
-
Filomenko, R.1
Prevolat, L.2
Rebe, C.3
Cortier, M.4
Jeannin, J.F.5
Solary, E.6
-
13
-
-
0141705424
-
Synergistic interactions of chemotherapeutic drugs and tumor necrosis factor-related apoptosis-inducing ligand/Apo-2 ligand on apoptosis and on regression of breast carcinoma in vivo
-
Singh T.R., Shankar S., Chen X., Asim M., and Srivastava R.K. Synergistic interactions of chemotherapeutic drugs and tumor necrosis factor-related apoptosis-inducing ligand/Apo-2 ligand on apoptosis and on regression of breast carcinoma in vivo. Cancer Res 63 (2003) 5390-5400
-
(2003)
Cancer Res
, vol.63
, pp. 5390-5400
-
-
Singh, T.R.1
Shankar, S.2
Chen, X.3
Asim, M.4
Srivastava, R.K.5
-
14
-
-
0038045649
-
Etoposide up regulates Bax-enhancing tumor necrosis factor-related apoptosis inducing ligand-mediated apoptosis in the human hepatocellular carcinoma cell line QGY-7703
-
Miao L., Yi P., Wang Y., and Wu M. Etoposide up regulates Bax-enhancing tumor necrosis factor-related apoptosis inducing ligand-mediated apoptosis in the human hepatocellular carcinoma cell line QGY-7703. Eur J Biochem 270 (2003) 2721-2731
-
(2003)
Eur J Biochem
, vol.270
, pp. 2721-2731
-
-
Miao, L.1
Yi, P.2
Wang, Y.3
Wu, M.4
-
15
-
-
0037338271
-
Profiling of differentially expressed apoptosis-related genes by cDNA arrays in human cord blood CD34+ cells treated with etoposide
-
Tao W., Hangoc G., Hawes J.W., Si Y., Cooper S., and Broxmeyer H.E. Profiling of differentially expressed apoptosis-related genes by cDNA arrays in human cord blood CD34+ cells treated with etoposide. Exp Hematol 31 (2003) 251-260
-
(2003)
Exp Hematol
, vol.31
, pp. 251-260
-
-
Tao, W.1
Hangoc, G.2
Hawes, J.W.3
Si, Y.4
Cooper, S.5
Broxmeyer, H.E.6
-
16
-
-
0042674256
-
G2 arrest in response to topoisomerase II inhibitors: the role of p53
-
Clifford B., Beljin M., Stark G.R., and Taylor W.R. G2 arrest in response to topoisomerase II inhibitors: the role of p53. Cancer Res 63 (2003) 4074-4081
-
(2003)
Cancer Res
, vol.63
, pp. 4074-4081
-
-
Clifford, B.1
Beljin, M.2
Stark, G.R.3
Taylor, W.R.4
-
17
-
-
31044441712
-
Early G2/M checkpoint failure as a molecular mechanism underlying etoposide-induced chromosomal aberrations
-
Nakada S., Katsuki Y., Imoto I., Yokoyama T., Nagasawa M., Inazawa J., et al. Early G2/M checkpoint failure as a molecular mechanism underlying etoposide-induced chromosomal aberrations. J Clin Invest 116 (2006) 80-90
-
(2006)
J Clin Invest
, vol.116
, pp. 80-90
-
-
Nakada, S.1
Katsuki, Y.2
Imoto, I.3
Yokoyama, T.4
Nagasawa, M.5
Inazawa, J.6
-
18
-
-
0037630385
-
Phosphorylation of serine 1106 in the catalytic domain of topoisomerase II alpha regulates enzymatic activity and drug sensitivity
-
Chikamori K., Grabowski D.R., Kinter M., Willard B.B., Yadav S., Aebersold R.H., et al. Phosphorylation of serine 1106 in the catalytic domain of topoisomerase II alpha regulates enzymatic activity and drug sensitivity. J Biol Chem 278 (2003) 12696-12702
-
(2003)
J Biol Chem
, vol.278
, pp. 12696-12702
-
-
Chikamori, K.1
Grabowski, D.R.2
Kinter, M.3
Willard, B.B.4
Yadav, S.5
Aebersold, R.H.6
-
19
-
-
0141592619
-
Hypersensitivity of nonhomologous DNA end-joining mutants to VP-16 and ICRF-193: implications for the repair of topoisomerase II-mediated DNA damage
-
Adachi N., Suzuki H., Iiizumi S., and Koyama H. Hypersensitivity of nonhomologous DNA end-joining mutants to VP-16 and ICRF-193: implications for the repair of topoisomerase II-mediated DNA damage. J Biol Chem 278 (2003) 35897-35902
-
(2003)
J Biol Chem
, vol.278
, pp. 35897-35902
-
-
Adachi, N.1
Suzuki, H.2
Iiizumi, S.3
Koyama, H.4
-
20
-
-
33947386313
-
Synergism between etoposide and 17-AAG in leukemic cells: critical roles for Hsp90, FLT3, topoisomerase II, Chk1 and Rad51
-
Yao Q., Weigel B., and Kersey J. Synergism between etoposide and 17-AAG in leukemic cells: critical roles for Hsp90, FLT3, topoisomerase II, Chk1 and Rad51. Clin Cancer Res 13 (2007) 1591-1600
-
(2007)
Clin Cancer Res
, vol.13
, pp. 1591-1600
-
-
Yao, Q.1
Weigel, B.2
Kersey, J.3
-
21
-
-
0037903038
-
Hydrolytically activated etoposide prodrugs inhibit MDR-1 function and eradicate established MDR-1 multidrug-resistant T-cell leukemia
-
Schroeder U., Bernt K.M., Lange B., Wenkel J., Jikai J., Shabat D., et al. Hydrolytically activated etoposide prodrugs inhibit MDR-1 function and eradicate established MDR-1 multidrug-resistant T-cell leukemia. Blood 102 (2003) 246-253
-
(2003)
Blood
, vol.102
, pp. 246-253
-
-
Schroeder, U.1
Bernt, K.M.2
Lange, B.3
Wenkel, J.4
Jikai, J.5
Shabat, D.6
-
22
-
-
12444254792
-
Particular cutaneous side effects with etoposide-containing courses: is VP-16 or etoposide phosphate responsible?
-
Marigny K., Aubin F., Burgot G., Le Gall E., and Gandemar V. Particular cutaneous side effects with etoposide-containing courses: is VP-16 or etoposide phosphate responsible?. Cancer Chemother Pharmacol 55 (2005) 244-250
-
(2005)
Cancer Chemother Pharmacol
, vol.55
, pp. 244-250
-
-
Marigny, K.1
Aubin, F.2
Burgot, G.3
Le Gall, E.4
Gandemar, V.5
-
24
-
-
0029061892
-
A phase I study of etoposide phosphate administered as a daily 30-minute infusion for 5 days
-
Thompson D.S., Greco A., Miller A.A., Srinivas N.R., Igwemezie K.B., Hainsworth J.D., et al. A phase I study of etoposide phosphate administered as a daily 30-minute infusion for 5 days. Clin Pharmacol Ther 57 (1995) 499-507
-
(1995)
Clin Pharmacol Ther
, vol.57
, pp. 499-507
-
-
Thompson, D.S.1
Greco, A.2
Miller, A.A.3
Srinivas, N.R.4
Igwemezie, K.B.5
Hainsworth, J.D.6
-
25
-
-
0037033691
-
Safe administration of etoposide phosphate after hypersensitivity reaction to intravenous etoposide
-
Siderov J., Prasad P., DeBoer R., and Desai J. Safe administration of etoposide phosphate after hypersensitivity reaction to intravenous etoposide. Br J Cancer 86 (2002) 12-13
-
(2002)
Br J Cancer
, vol.86
, pp. 12-13
-
-
Siderov, J.1
Prasad, P.2
DeBoer, R.3
Desai, J.4
-
26
-
-
0038702510
-
Comparative pharmacokinetic study of high-dose etoposide and etoposide phosphate in patients with lymphoid malignancy receiving autologous stem cell transplantation
-
Dorr R.T., Briggs A., Kintzel P., Meyers H., Chow H.S., and List A. Comparative pharmacokinetic study of high-dose etoposide and etoposide phosphate in patients with lymphoid malignancy receiving autologous stem cell transplantation. Bone Marrow Transplant 31 (2003) 643-649
-
(2003)
Bone Marrow Transplant
, vol.31
, pp. 643-649
-
-
Dorr, R.T.1
Briggs, A.2
Kintzel, P.3
Meyers, H.4
Chow, H.S.5
List, A.6
-
27
-
-
0025718526
-
Epipodophyllotoxin-related acute myeloid
-
Pui C.H. Epipodophyllotoxin-related acute myeloid. Lancet 338 (1991) 1468
-
(1991)
Lancet
, vol.338
, pp. 1468
-
-
Pui, C.H.1
-
28
-
-
0033008437
-
Secondary leukemia or myelodysplastic syndrome after treatment with intravenous epipodophyllotoxins
-
Smith M.A., Rubenstein L., Anderson J.R., Arthur D., Catalano P.J., Friedlin B., et al. Secondary leukemia or myelodysplastic syndrome after treatment with intravenous epipodophyllotoxins. J Clin Oncol 17 (1999) 569-577
-
(1999)
J Clin Oncol
, vol.17
, pp. 569-577
-
-
Smith, M.A.1
Rubenstein, L.2
Anderson, J.R.3
Arthur, D.4
Catalano, P.J.5
Friedlin, B.6
-
29
-
-
0033641492
-
-
Anonymous. DNA topoisomerase II inhibitors. IARC Monographs on the evaluation of carcinogenic risk to humans, vol. 76; 2000. p. 175-344.
-
Anonymous. DNA topoisomerase II inhibitors. IARC Monographs on the evaluation of carcinogenic risk to humans, vol. 76; 2000. p. 175-344.
-
-
-
-
30
-
-
0027056223
-
Acute monocytic or myelomonocytic leukemia with balanced chromosome translocations to band 11q23 after therapy with 4-epi-doxorubicin and cisplatin or cyclophosphamide for breast cancer
-
Pedersen-Bjergaard J., Sigsgaard T.C., Nielsen D., Gjedde S.B., Phillip P., Hansen M., et al. Acute monocytic or myelomonocytic leukemia with balanced chromosome translocations to band 11q23 after therapy with 4-epi-doxorubicin and cisplatin or cyclophosphamide for breast cancer. J Clin Oncol 10 (1992) 1444-1451
-
(1992)
J Clin Oncol
, vol.10
, pp. 1444-1451
-
-
Pedersen-Bjergaard, J.1
Sigsgaard, T.C.2
Nielsen, D.3
Gjedde, S.B.4
Phillip, P.5
Hansen, M.6
-
31
-
-
0027154575
-
Secondary acute myeloid leukemia in children previously treated with alkylating agents, intercalating topoisomerase II inhibitors, and irradiation
-
Sandoval C., Pui C.H., Bowman L.C., Heaton D., Hurwitz C.A., Raimondi S.C., et al. Secondary acute myeloid leukemia in children previously treated with alkylating agents, intercalating topoisomerase II inhibitors, and irradiation. J Clin Oncol 11 (1993) 1039-1045
-
(1993)
J Clin Oncol
, vol.11
, pp. 1039-1045
-
-
Sandoval, C.1
Pui, C.H.2
Bowman, L.C.3
Heaton, D.4
Hurwitz, C.A.5
Raimondi, S.C.6
-
32
-
-
0033847847
-
Potential role for DNA topoisomerase II poisons in the generation of t(11:20)(p15;q11) translocations
-
Ahuja H.G., Felxi C.A., and Aplan P.D. Potential role for DNA topoisomerase II poisons in the generation of t(11:20)(p15;q11) translocations. Genes Chromosomes Cancer 29 (2000) 96-105
-
(2000)
Genes Chromosomes Cancer
, vol.29
, pp. 96-105
-
-
Ahuja, H.G.1
Felxi, C.A.2
Aplan, P.D.3
-
33
-
-
33746508542
-
An in vitro topoisomerase II cleavage site and a DNase hypersensitivity site in t(8,21) leukaemia
-
Strissel P.L., Strick R., Rowley J.D., and Zeleznik-Le N.J. An in vitro topoisomerase II cleavage site and a DNase hypersensitivity site in t(8,21) leukaemia. Proc Natl Acad Sci 99 (1998) 3070-3075
-
(1998)
Proc Natl Acad Sci
, vol.99
, pp. 3070-3075
-
-
Strissel, P.L.1
Strick, R.2
Rowley, J.D.3
Zeleznik-Le, N.J.4
-
34
-
-
1342289580
-
Etoposide induces chimeric Mll gene fusions
-
Blanco J.G., Edick M.J., and Reiling M.V. Etoposide induces chimeric Mll gene fusions. FASEB J 18 (2004) 1173-1175
-
(2004)
FASEB J
, vol.18
, pp. 1173-1175
-
-
Blanco, J.G.1
Edick, M.J.2
Reiling, M.V.3
-
35
-
-
31344454019
-
Genotoxicity of etoposide: greater susceptibility of MLL than other target genes
-
Ng A., Taylor G.M., and Eden O.B. Genotoxicity of etoposide: greater susceptibility of MLL than other target genes. Cancer Genetics Cytogen 164 (2006) 164-167
-
(2006)
Cancer Genetics Cytogen
, vol.164
, pp. 164-167
-
-
Ng, A.1
Taylor, G.M.2
Eden, O.B.3
-
36
-
-
33747882412
-
Etoposide and illegitimate DNA double-strand break repair in the generation of MLL translocations: new insights and new questions
-
Sung P.A., Libura A., and Richardson C. Etoposide and illegitimate DNA double-strand break repair in the generation of MLL translocations: new insights and new questions. DNA Repair 5 (2006) 1109-1118
-
(2006)
DNA Repair
, vol.5
, pp. 1109-1118
-
-
Sung, P.A.1
Libura, A.2
Richardson, C.3
-
37
-
-
0035814808
-
Etoposide metabolites enhance DNA topoisomerase II cleavage near leukemia-associated MLL translocation breakpoints
-
Lovett B.D., Strumberg D., Blair I.A., Pang S., Burden D.A., Megonigal M.D., et al. Etoposide metabolites enhance DNA topoisomerase II cleavage near leukemia-associated MLL translocation breakpoints. Biochemistry 40 (2001) 1159-1170
-
(2001)
Biochemistry
, vol.40
, pp. 1159-1170
-
-
Lovett, B.D.1
Strumberg, D.2
Blair, I.A.3
Pang, S.4
Burden, D.A.5
Megonigal, M.D.6
-
38
-
-
0035859820
-
Near-precise interchromosomal recombination and functional DNA topoisomerase II cleavage sites in MLL and AF-4 genomic breakpoints in treatment-related acute lymphoblastic leukemia with t(4:11) translocation
-
Lovett B.D., Lo Nigro L., Rappaport E.F., Blair I.A., Osharoff N., Zeng N., et al. Near-precise interchromosomal recombination and functional DNA topoisomerase II cleavage sites in MLL and AF-4 genomic breakpoints in treatment-related acute lymphoblastic leukemia with t(4:11) translocation. Proc Natl Acad Sci 98 (2001) 9802-9807
-
(2001)
Proc Natl Acad Sci
, vol.98
, pp. 9802-9807
-
-
Lovett, B.D.1
Lo Nigro, L.2
Rappaport, E.F.3
Blair, I.A.4
Osharoff, N.5
Zeng, N.6
-
39
-
-
33749469891
-
Role of apoptotic nuclease caspase-activated DNase in etoposide-induced treatment related leukemia
-
Hars E.S., Lyu Y.L., Lin C.P., and Liu L.F. Role of apoptotic nuclease caspase-activated DNase in etoposide-induced treatment related leukemia. Caner Res 66 (2006) 8975-8979
-
(2006)
Caner Res
, vol.66
, pp. 8975-8979
-
-
Hars, E.S.1
Lyu, Y.L.2
Lin, C.P.3
Liu, L.F.4
-
40
-
-
33645319963
-
MLL rearrangements are induced by low doses of etoposide in human fetal hematopoietic stem cells
-
Monneypenny C.G.S., Shao J., Song Y., and Gallagher E.P. MLL rearrangements are induced by low doses of etoposide in human fetal hematopoietic stem cells. Carcinogenesis 27 (2006) 874-881
-
(2006)
Carcinogenesis
, vol.27
, pp. 874-881
-
-
Monneypenny, C.G.S.1
Shao, J.2
Song, Y.3
Gallagher, E.P.4
-
41
-
-
0033008437
-
Secondary leukemia or myelodysplastic syndrome after treatment with epipodophyllotoxins
-
Smith M.A., Rubinstein L., Anderson J.R., Arthur D., Catalano P.J., Freidlin B., et al. Secondary leukemia or myelodysplastic syndrome after treatment with epipodophyllotoxins. J Clin Oncol 17 (1999) 569-577
-
(1999)
J Clin Oncol
, vol.17
, pp. 569-577
-
-
Smith, M.A.1
Rubinstein, L.2
Anderson, J.R.3
Arthur, D.4
Catalano, P.J.5
Freidlin, B.6
-
42
-
-
2942670655
-
Secondary leukemia in refractory germ cell tumor patients undergoing autologous stem cell transplantation using high dose etoposide
-
Houck W., Abonour R., Vance G., and Einhorn L.H. Secondary leukemia in refractory germ cell tumor patients undergoing autologous stem cell transplantation using high dose etoposide. J Clin Oncol 22 (2004) 2155-2158
-
(2004)
J Clin Oncol
, vol.22
, pp. 2155-2158
-
-
Houck, W.1
Abonour, R.2
Vance, G.3
Einhorn, L.H.4
-
43
-
-
0037445124
-
Risk of secondary leukemia after a solid tumor in childhood according to the dose of epipodophyllotoxins and anthracyclines: a case-control study by the Society Francaise d'Oncologie Pediatrique
-
Le Deley M.C., Leblanc T., Shamsaldin A., Raquin M.A., Lacour B., Sommelet D., et al. Risk of secondary leukemia after a solid tumor in childhood according to the dose of epipodophyllotoxins and anthracyclines: a case-control study by the Society Francaise d'Oncologie Pediatrique. J Clin Oncol 21 (2003) 1074-1081
-
(2003)
J Clin Oncol
, vol.21
, pp. 1074-1081
-
-
Le Deley, M.C.1
Leblanc, T.2
Shamsaldin, A.3
Raquin, M.A.4
Lacour, B.5
Sommelet, D.6
-
44
-
-
0027401272
-
High frequency of etoposide (VP-16)-related secondary leukemia in children with non-Hodgkin's lymphoma
-
Sugita K., Furukawa T., Tsuchida M., et al. High frequency of etoposide (VP-16)-related secondary leukemia in children with non-Hodgkin's lymphoma. Am J Pediatr Hematol Oncol 15 (1993) 99-104
-
(1993)
Am J Pediatr Hematol Oncol
, vol.15
, pp. 99-104
-
-
Sugita, K.1
Furukawa, T.2
Tsuchida, M.3
-
45
-
-
0027403501
-
Secondary acute myeloid leukemia in children with acute lymphoblastic leukemia treated with etoposide
-
Winick N.J., McKenna R.W., Shuster J.J., Schneider N.R., Borowitz M.J., Bowman W.P., et al. Secondary acute myeloid leukemia in children with acute lymphoblastic leukemia treated with etoposide. J Clin Oncol 11 (1993) 209-217
-
(1993)
J Clin Oncol
, vol.11
, pp. 209-217
-
-
Winick, N.J.1
McKenna, R.W.2
Shuster, J.J.3
Schneider, N.R.4
Borowitz, M.J.5
Bowman, W.P.6
-
46
-
-
13144282667
-
Association of CYP3A4 genotype with treatment-related leukaemia
-
Felix C.A., Walker A.H., Lange B.J., Williams T.M., Winick N.J., Cheng N.R.V., et al. Association of CYP3A4 genotype with treatment-related leukaemia. Proc Natl Acad Sci USA 95 (1998) 13176-13181
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 13176-13181
-
-
Felix, C.A.1
Walker, A.H.2
Lange, B.J.3
Williams, T.M.4
Winick, N.J.5
Cheng, N.R.V.6
-
47
-
-
0033954510
-
Glutathione S-transferase genotypes in children who develop treatment-related acute myeloid malignancies
-
Woo M.H., Shuster J.J., Chen C., Bash R.O., Behm F.G., Camitta B., et al. Glutathione S-transferase genotypes in children who develop treatment-related acute myeloid malignancies. Leukemia 14 (2000) 232-237
-
(2000)
Leukemia
, vol.14
, pp. 232-237
-
-
Woo, M.H.1
Shuster, J.J.2
Chen, C.3
Bash, R.O.4
Behm, F.G.5
Camitta, B.6
-
48
-
-
0031884608
-
Etoposide and antimetabolite pharmacology in patients who develop secondary acute myeloid leukemia
-
Relling M.V., Yanishevski Y., Nemec J., Evans W.E., Boyett J.M., Behm F.G., et al. Etoposide and antimetabolite pharmacology in patients who develop secondary acute myeloid leukemia. Leukemia 12 (1998) 346-352
-
(1998)
Leukemia
, vol.12
, pp. 346-352
-
-
Relling, M.V.1
Yanishevski, Y.2
Nemec, J.3
Evans, W.E.4
Boyett, J.M.5
Behm, F.G.6
-
49
-
-
0033747215
-
Thioguanine substitution alters DNA cleavage mediated by topoisomerase II
-
Krynetskaia N.F., Cai X., Nitiss J.L., Krynetski E.W., and Relling M.V. Thioguanine substitution alters DNA cleavage mediated by topoisomerase II. FASEB J 14 (2000) 2339-2344
-
(2000)
FASEB J
, vol.14
, pp. 2339-2344
-
-
Krynetskaia, N.F.1
Cai, X.2
Nitiss, J.L.3
Krynetski, E.W.4
Relling, M.V.5
-
50
-
-
13344260681
-
Epipodophyllotoxin-related acute myeloid leukemia: a study of 35 cases
-
Pui C.H., Relling M.V., Rivera G.K., Hancock M.L., Raimondi S.C., Heslop H.E., et al. Epipodophyllotoxin-related acute myeloid leukemia: a study of 35 cases. Leukemia 9 (1995) 1990-1996
-
(1995)
Leukemia
, vol.9
, pp. 1990-1996
-
-
Pui, C.H.1
Relling, M.V.2
Rivera, G.K.3
Hancock, M.L.4
Raimondi, S.C.5
Heslop, H.E.6
-
51
-
-
33744485560
-
Biliary excretion of etoposide in children with cancer
-
Veal G.J., Errington J., Thomas H.D., Boddy A.W., and Lowis S. Biliary excretion of etoposide in children with cancer. Cancer Chemother Pharmacol 58 (2006) 415-417
-
(2006)
Cancer Chemother Pharmacol
, vol.58
, pp. 415-417
-
-
Veal, G.J.1
Errington, J.2
Thomas, H.D.3
Boddy, A.W.4
Lowis, S.5
-
52
-
-
0022608672
-
Pharmacokinetics of etoposide in patients with abnormal renal and hepatic function
-
D'Incalci M., Rossi C., Zucchetti M., Urso R., Cavalli F., Mangioni C., et al. Pharmacokinetics of etoposide in patients with abnormal renal and hepatic function. Cancer Res 46 (1986) 2566-2571
-
(1986)
Cancer Res
, vol.46
, pp. 2566-2571
-
-
D'Incalci, M.1
Rossi, C.2
Zucchetti, M.3
Urso, R.4
Cavalli, F.5
Mangioni, C.6
-
53
-
-
0025328966
-
Etoposide kinetics in patients with obstructive jaundice
-
Hande K.R., Wolff S.N., Greco F.A., Hainsworth J.D., Reed G., and Johnson D.H. Etoposide kinetics in patients with obstructive jaundice. J Clin Oncol 8 (1990) 1101-1107
-
(1990)
J Clin Oncol
, vol.8
, pp. 1101-1107
-
-
Hande, K.R.1
Wolff, S.N.2
Greco, F.A.3
Hainsworth, J.D.4
Reed, G.5
Johnson, D.H.6
-
54
-
-
33847358669
-
-
Wen Z, Tallman MN, Ali SY, Smith PC. UDP-glucuronosyltransferase 1A1 is the principal enzyme responsible for etoposide glucuronidation in the human liver and intestinal microsomes: structural characterization of phenolic and alcoholic glucuronides of etoposide and estimation of enzyme kinetics. Drug Metab Dispos 2007;35:371-80.
-
Wen Z, Tallman MN, Ali SY, Smith PC. UDP-glucuronosyltransferase 1A1 is the principal enzyme responsible for etoposide glucuronidation in the human liver and intestinal microsomes: structural characterization of phenolic and alcoholic glucuronides of etoposide and estimation of enzyme kinetics. Drug Metab Dispos 2007;35:371-80.
-
-
-
-
55
-
-
2442616994
-
Plasma etoposide catechol increases in pediatric patients undergoing multiple day chemotherapy with etoposide
-
Zheng N., Felix C.A., Pang S., Boston R., Moate P., Scavuzzo J., et al. Plasma etoposide catechol increases in pediatric patients undergoing multiple day chemotherapy with etoposide. Clin Cancer Res 10 (2004) 2977-2985
-
(2004)
Clin Cancer Res
, vol.10
, pp. 2977-2985
-
-
Zheng, N.1
Felix, C.A.2
Pang, S.3
Boston, R.4
Moate, P.5
Scavuzzo, J.6
-
56
-
-
0033775068
-
Population pharmacokinetics of doxorubicin, etoposide and ifosfamide in small cell lung cancer patients: results of a multicentre study
-
Freyer G., Tranchand B., Ligneau B., Ardiet C., Souquet P.J., Court-Fortune I., et al. Population pharmacokinetics of doxorubicin, etoposide and ifosfamide in small cell lung cancer patients: results of a multicentre study. Br J Clin Pharmacol 50 (2000) 315-324
-
(2000)
Br J Clin Pharmacol
, vol.50
, pp. 315-324
-
-
Freyer, G.1
Tranchand, B.2
Ligneau, B.3
Ardiet, C.4
Souquet, P.J.5
Court-Fortune, I.6
-
57
-
-
0036162384
-
Randomized crossover clinical trial to study potential pharmacokinetic interactions between cisplatin or carboplatin and etoposide
-
Thomas H.D., Porter D.J., Bartelinks I., Nobbs J.R., Cole M., Elliott S., et al. Randomized crossover clinical trial to study potential pharmacokinetic interactions between cisplatin or carboplatin and etoposide. Br J Clin Pharmacol 53 (2002) 83-91
-
(2002)
Br J Clin Pharmacol
, vol.53
, pp. 83-91
-
-
Thomas, H.D.1
Porter, D.J.2
Bartelinks, I.3
Nobbs, J.R.4
Cole, M.5
Elliott, S.6
-
58
-
-
0036032328
-
Effect of grapefruit juice intake on etoposide bioavailability
-
Reif S., Nicolson M.C., Bisset D., Reid M., Kloft C., Jaehde U., et al. Effect of grapefruit juice intake on etoposide bioavailability. Eur J Clin Pharmacol 58 (2002) 491-494
-
(2002)
Eur J Clin Pharmacol
, vol.58
, pp. 491-494
-
-
Reif, S.1
Nicolson, M.C.2
Bisset, D.3
Reid, M.4
Kloft, C.5
Jaehde, U.6
-
59
-
-
9144247069
-
Effects of prednisone and genetic polymorphisms on etoposide disposition in children with acute lymphoblastic leukemia
-
Kishi S., Yang W., Boareau B., Morand S., Das S., Chen P., et al. Effects of prednisone and genetic polymorphisms on etoposide disposition in children with acute lymphoblastic leukemia. Blood 103 (2004) 67-72
-
(2004)
Blood
, vol.103
, pp. 67-72
-
-
Kishi, S.1
Yang, W.2
Boareau, B.3
Morand, S.4
Das, S.5
Chen, P.6
-
60
-
-
0034016775
-
Effect of high-dose cyclosporine on etoposide pharmacodynamics in a trial to reverse P-glycoprotein (MDR1 gene) mediated drug resistance
-
Lum B.L., Kaubisch S., Fisher G.A., Brown B.W., and Sikic B.I. Effect of high-dose cyclosporine on etoposide pharmacodynamics in a trial to reverse P-glycoprotein (MDR1 gene) mediated drug resistance. Cancer Chemother Pharmacol 45 (2000) 305-311
-
(2000)
Cancer Chemother Pharmacol
, vol.45
, pp. 305-311
-
-
Lum, B.L.1
Kaubisch, S.2
Fisher, G.A.3
Brown, B.W.4
Sikic, B.I.5
-
61
-
-
0038239599
-
The schedule-dependent effects of etoposide in leukaemic cell lines: a function of concentration and duration
-
Liu W.M., and Joel S.P. The schedule-dependent effects of etoposide in leukaemic cell lines: a function of concentration and duration. Cancer Chemother Pharmacol 51 (2003) 291-296
-
(2003)
Cancer Chemother Pharmacol
, vol.51
, pp. 291-296
-
-
Liu, W.M.1
Joel, S.P.2
-
62
-
-
0024417601
-
A randomized trial to evaluate the effect of schedule on the activity of etoposide in small-cell lung cancer
-
Slevin M.L., Clark P.I., Joel S.P., Malik S., Osborne R.J., Gregory W.M., et al. A randomized trial to evaluate the effect of schedule on the activity of etoposide in small-cell lung cancer. J Clin Oncol 7 (1989) 1333-1340
-
(1989)
J Clin Oncol
, vol.7
, pp. 1333-1340
-
-
Slevin, M.L.1
Clark, P.I.2
Joel, S.P.3
Malik, S.4
Osborne, R.J.5
Gregory, W.M.6
-
63
-
-
2642575021
-
Pharmacokinetic optimization of treatment with oral etoposide
-
Toffoli G., Corona G., Basso B., and Boiocchi M. Pharmacokinetic optimization of treatment with oral etoposide. Clin Pharmacokinet 43 (2004) 441-466
-
(2004)
Clin Pharmacokinet
, vol.43
, pp. 441-466
-
-
Toffoli, G.1
Corona, G.2
Basso, B.3
Boiocchi, M.4
-
64
-
-
0027537102
-
Bioavailability of low-dose oral etoposide
-
Hande K.R., Krozely M.G., Greco F.A., Hainsworth J.D., Johnson D.H., and Greco F.A. Bioavailability of low-dose oral etoposide. J Clin Oncol 11 (1993) 374-377
-
(1993)
J Clin Oncol
, vol.11
, pp. 374-377
-
-
Hande, K.R.1
Krozely, M.G.2
Greco, F.A.3
Hainsworth, J.D.4
Johnson, D.H.5
Greco, F.A.6
-
65
-
-
32544458019
-
The systemic absorption of etoposide after intervaginal administration in patients with cervical intraepithelial lesions with human papillomavirus infection
-
Garcia-Lopez P., Coll M., Cervera E., Reyes-Vermot L., Torres M.A., Abrego-Perez G., et al. The systemic absorption of etoposide after intervaginal administration in patients with cervical intraepithelial lesions with human papillomavirus infection. Pharmaceutical Res 23 (2006) 378-383
-
(2006)
Pharmaceutical Res
, vol.23
, pp. 378-383
-
-
Garcia-Lopez, P.1
Coll, M.2
Cervera, E.3
Reyes-Vermot, L.4
Torres, M.A.5
Abrego-Perez, G.6
-
66
-
-
0032697303
-
Inter and intra-patient variability in etoposide kinetics with oral and intravenous drug administration
-
Hande K.R., Messenger M., Wagner J., Krozely M., and Kaul S. Inter and intra-patient variability in etoposide kinetics with oral and intravenous drug administration. Clin Cancer Res 5 (1999) 2742-2747
-
(1999)
Clin Cancer Res
, vol.5
, pp. 2742-2747
-
-
Hande, K.R.1
Messenger, M.2
Wagner, J.3
Krozely, M.4
Kaul, S.5
-
67
-
-
0037322747
-
Pharmacokinetics of etoposide with intravenous drug administration in children and adolescents
-
Kato Y., Nishimura S., Sakura N., and Ueda K. Pharmacokinetics of etoposide with intravenous drug administration in children and adolescents. Pediatr Int 45 (2003) 74-79
-
(2003)
Pediatr Int
, vol.45
, pp. 74-79
-
-
Kato, Y.1
Nishimura, S.2
Sakura, N.3
Ueda, K.4
-
68
-
-
33749028696
-
Etoposide pharmacokinetics in children treated for acute myelogenous leukemia
-
Palle J., Britt-Marie F., Goran D., Merit H., Jukka K., Eva L., et al. Etoposide pharmacokinetics in children treated for acute myelogenous leukemia. Anti-Cancer Drugs 17 (2006) 1087-1094
-
(2006)
Anti-Cancer Drugs
, vol.17
, pp. 1087-1094
-
-
Palle, J.1
Britt-Marie, F.2
Goran, D.3
Merit, H.4
Jukka, K.5
Eva, L.6
-
69
-
-
0032168167
-
Etoposide: four decades of development of a topoisomerase II inhibitor
-
Hande K.R. Etoposide: four decades of development of a topoisomerase II inhibitor. Eur J Cancer 34 (1998) 1514-1521
-
(1998)
Eur J Cancer
, vol.34
, pp. 1514-1521
-
-
Hande, K.R.1
-
70
-
-
0038175325
-
Pharmacokinetics and pharmacodynamics of oral etoposide in children with relapsed or refractory acute lymphoblastic leukemia
-
Edick M.J., Gajjar A., Mahmoud M., van de Poll M.E., Harrison P.L., Panetta J.C., et al. Pharmacokinetics and pharmacodynamics of oral etoposide in children with relapsed or refractory acute lymphoblastic leukemia. J Clin Oncol 21 (2003) 1340-1346
-
(2003)
J Clin Oncol
, vol.21
, pp. 1340-1346
-
-
Edick, M.J.1
Gajjar, A.2
Mahmoud, M.3
van de Poll, M.E.4
Harrison, P.L.5
Panetta, J.C.6
-
71
-
-
0142250391
-
Pharmacokinetic study of cisplatin and infusional etoposide phosphate in advanced breast cancer with correlation of response to topoisomerase II alpha expression
-
Braybrooke J.P., Levitt N.C., Joel S., Davis T., Madhusudan S., Tarley H., et al. Pharmacokinetic study of cisplatin and infusional etoposide phosphate in advanced breast cancer with correlation of response to topoisomerase II alpha expression. Clin Cancer Res 9 (2003) 4682-4688
-
(2003)
Clin Cancer Res
, vol.9
, pp. 4682-4688
-
-
Braybrooke, J.P.1
Levitt, N.C.2
Joel, S.3
Davis, T.4
Madhusudan, S.5
Tarley, H.6
-
72
-
-
3042813710
-
Two-weekly or 3-weekly CHOP with or without etoposide for the treatment of young patients with good prognosis aggressive lymphomas: results of NHL-B1 trial of the DSHINIL
-
Pfeundschuh M., Trumper L., Kloess M., Schmits R., Schmits R., Fellrr A.C., et al. Two-weekly or 3-weekly CHOP with or without etoposide for the treatment of young patients with good prognosis aggressive lymphomas: results of NHL-B1 trial of the DSHINIL. Blood 104 (2004) 626-633
-
(2004)
Blood
, vol.104
, pp. 626-633
-
-
Pfeundschuh, M.1
Trumper, L.2
Kloess, M.3
Schmits, R.4
Schmits, R.5
Fellrr, A.C.6
-
73
-
-
4944260679
-
Translation t(12:21) is related to in vitro cellular drug sensitivity to doxorubicin and etoposide in childhood acute lymphocytic leukemia
-
Frost B.M., Forestier E., Gustafsson G., Nygen P., Hellebostad M., Jomsson O.G., et al. Translation t(12:21) is related to in vitro cellular drug sensitivity to doxorubicin and etoposide in childhood acute lymphocytic leukemia. Blood 104 (2004) 2452-2457
-
(2004)
Blood
, vol.104
, pp. 2452-2457
-
-
Frost, B.M.1
Forestier, E.2
Gustafsson, G.3
Nygen, P.4
Hellebostad, M.5
Jomsson, O.G.6
-
74
-
-
0037452830
-
The topoisomerase II beta circular clamp arrests transcription and signals a 26S proteasome pathway
-
Xiao H., Mao Y., Desai S.D., Zhou N., Ting C.Y., Hwang J., et al. The topoisomerase II beta circular clamp arrests transcription and signals a 26S proteasome pathway. Proc Natl Acad Sci 100 (2003) 3239-3244
-
(2003)
Proc Natl Acad Sci
, vol.100
, pp. 3239-3244
-
-
Xiao, H.1
Mao, Y.2
Desai, S.D.3
Zhou, N.4
Ting, C.Y.5
Hwang, J.6
-
75
-
-
0034052314
-
Topoisomerase II cleavable complex formation within DNA loop domains
-
Lambert J.M., and Fernandez D.J. Topoisomerase II cleavable complex formation within DNA loop domains. Biochem Pharmacol 60 (2000) 101-109
-
(2000)
Biochem Pharmacol
, vol.60
, pp. 101-109
-
-
Lambert, J.M.1
Fernandez, D.J.2
-
76
-
-
0032878285
-
Topoisomerase II-mediated alterations of K562 drug resistant sub lines
-
Zhou R., Wang Y., Gruber A., Larson R., Castranos-Velez E., Lillemark E., et al. Topoisomerase II-mediated alterations of K562 drug resistant sub lines. Med Oncol 16 (1999) 191-198
-
(1999)
Med Oncol
, vol.16
, pp. 191-198
-
-
Zhou, R.1
Wang, Y.2
Gruber, A.3
Larson, R.4
Castranos-Velez, E.5
Lillemark, E.6
-
77
-
-
0035056832
-
Leukemias related to treatment with DNA topoisomerase II inhibitors
-
Felix C.A. Leukemias related to treatment with DNA topoisomerase II inhibitors. Med Pediatr Oncol 36 (2001) 525-535
-
(2001)
Med Pediatr Oncol
, vol.36
, pp. 525-535
-
-
Felix, C.A.1
-
78
-
-
0026011121
-
The chemical and biological route from podophyllotoxin glucoside to etoposide: ninth Cain memorial Award lecture
-
Stahelin H.F., and von Wartburg A. The chemical and biological route from podophyllotoxin glucoside to etoposide: ninth Cain memorial Award lecture. Cancer Res 51 (1991) 5-15
-
(1991)
Cancer Res
, vol.51
, pp. 5-15
-
-
Stahelin, H.F.1
von Wartburg, A.2
-
79
-
-
0032861990
-
Effect of cyclosporin A on protein binding of teniposide in cancer patients
-
Toffoli G., Aita P., Sorio R., Corona G., Bertola A., Colassi A.H., et al. Effect of cyclosporin A on protein binding of teniposide in cancer patients. Anticancer Drugs 10 (1999) 511-518
-
(1999)
Anticancer Drugs
, vol.10
, pp. 511-518
-
-
Toffoli, G.1
Aita, P.2
Sorio, R.3
Corona, G.4
Bertola, A.5
Colassi, A.H.6
-
80
-
-
0026515548
-
Increased teniposide clearance with concomitant anticonvulsant therapy
-
Baker D.K., Relling M.V., Pui C.H., Christensen H.L., Evans W.C., and Rodman J.H. Increased teniposide clearance with concomitant anticonvulsant therapy. J Clin Oncol 10 (1992) 311-315
-
(1992)
J Clin Oncol
, vol.10
, pp. 311-315
-
-
Baker, D.K.1
Relling, M.V.2
Pui, C.H.3
Christensen, H.L.4
Evans, W.C.5
Rodman, J.H.6
-
81
-
-
0034702552
-
Adverse effect of anticonvulsants on efficacy of chemotherapy for acute lymphoblastic leukaemia
-
Relling M.V., Pui C.H., Sandlund J.T., Rivera G.K., Hancock M.L., Boyett J.M., et al. Adverse effect of anticonvulsants on efficacy of chemotherapy for acute lymphoblastic leukaemia. Lancet 356 (2000) 285-290
-
(2000)
Lancet
, vol.356
, pp. 285-290
-
-
Relling, M.V.1
Pui, C.H.2
Sandlund, J.T.3
Rivera, G.K.4
Hancock, M.L.5
Boyett, J.M.6
-
82
-
-
0038726223
-
Interactions between antiepileptic and chemotherapeutic drugs
-
Vecht C.J., Wagner G.L., and Wilms E.B. Interactions between antiepileptic and chemotherapeutic drugs. Lancet Neurol 2 (2003) 404-409
-
(2003)
Lancet Neurol
, vol.2
, pp. 404-409
-
-
Vecht, C.J.1
Wagner, G.L.2
Wilms, E.B.3
-
83
-
-
0027936319
-
Teniposide: overview of its therapeutic potential in adult cancers.
-
Muggia F.M. Teniposide: overview of its therapeutic potential in adult cancers. Cancer Chemother Pharmacol 34 Suppl. (1994) S127-S133
-
(1994)
Cancer Chemother Pharmacol
, vol.34
, Issue.SUPPL
-
-
Muggia, F.M.1
-
84
-
-
0036753660
-
Study of either ifosfamide or teniposide compared to a standard chemotherapy for extensive disease small cell lung cancer: an Eastern Cooperative Oncology Group randomized study
-
Ettinger D.S., Finkelstein D.M., Ritch P.S., Lincoln S.T., and Blum R.H. Study of either ifosfamide or teniposide compared to a standard chemotherapy for extensive disease small cell lung cancer: an Eastern Cooperative Oncology Group randomized study. Lung Cancer 37 (2002) 311-318
-
(2002)
Lung Cancer
, vol.37
, pp. 311-318
-
-
Ettinger, D.S.1
Finkelstein, D.M.2
Ritch, P.S.3
Lincoln, S.T.4
Blum, R.H.5
-
85
-
-
0034306120
-
Treatment of brain metastases of small-cell lung cancer: comparing teniposide and teniposide with whole-brain radiotherapy-a phase III study of the European Organization for the Research and Treatment of Cancer Lung Cancer Cooperative Group
-
Postmus P.E., Haaxma-Reiche H., Smit E.F., Groen H.J., Karnicka H., Lewinski T., et al. Treatment of brain metastases of small-cell lung cancer: comparing teniposide and teniposide with whole-brain radiotherapy-a phase III study of the European Organization for the Research and Treatment of Cancer Lung Cancer Cooperative Group. J Clin Oncol 18 (2000) 3400-3408
-
(2000)
J Clin Oncol
, vol.18
, pp. 3400-3408
-
-
Postmus, P.E.1
Haaxma-Reiche, H.2
Smit, E.F.3
Groen, H.J.4
Karnicka, H.5
Lewinski, T.6
-
86
-
-
0141576742
-
Neuro-Oncology Working Group 01 trial of nimustine plus teniposide versus nimustine plus cytarabine chemotherapy in addition to involved-field radiotherapy in the first-line treatment of malignant glioma
-
Weller M., Muller B., Koch R., Bamberg M., and Kransneck P. Neuro-Oncology Working Group 01 trial of nimustine plus teniposide versus nimustine plus cytarabine chemotherapy in addition to involved-field radiotherapy in the first-line treatment of malignant glioma. J Clin Oncol 21 (2003) 3276-3284
-
(2003)
J Clin Oncol
, vol.21
, pp. 3276-3284
-
-
Weller, M.1
Muller, B.2
Koch, R.3
Bamberg, M.4
Kransneck, P.5
-
87
-
-
0021151237
-
Adriamycin-induced DNA damage mediated by mammalian DNA topoisomerase II
-
Tewey K.M., Rowe T.C., Yang L., Halligan B.D., and Liu L.F. Adriamycin-induced DNA damage mediated by mammalian DNA topoisomerase II. Science 226 (1984) 466-468
-
(1984)
Science
, vol.226
, pp. 466-468
-
-
Tewey, K.M.1
Rowe, T.C.2
Yang, L.3
Halligan, B.D.4
Liu, L.F.5
-
88
-
-
33646394582
-
Doxorubicin-DNA adducts induce a non-topoisomerase II mediated form of cell death
-
Swift L.P., Rephaeli A., Nudelman A., Phillips D.R., and Cutts S.M. Doxorubicin-DNA adducts induce a non-topoisomerase II mediated form of cell death. Cancer Res 66 (2006) 4863-4871
-
(2006)
Cancer Res
, vol.66
, pp. 4863-4871
-
-
Swift, L.P.1
Rephaeli, A.2
Nudelman, A.3
Phillips, D.R.4
Cutts, S.M.5
-
89
-
-
0027080829
-
Helicase inhibition by anthracycline anticancer agents
-
Bachur N.R., Yu F., Johnson R., Hickey R., Wu Y., and Malkas L. Helicase inhibition by anthracycline anticancer agents. Mol Pharmacol 41 (1992) 993-998
-
(1992)
Mol Pharmacol
, vol.41
, pp. 993-998
-
-
Bachur, N.R.1
Yu, F.2
Johnson, R.3
Hickey, R.4
Wu, Y.5
Malkas, L.6
-
90
-
-
12844275026
-
Mechanism of apoptosis induced by doxorubicin through the generation of hydrogen peroxide
-
Mizutani H., Tada-Oikawa S., Hiraku Y., Koljima M., and Kawanishi S. Mechanism of apoptosis induced by doxorubicin through the generation of hydrogen peroxide. Life Sci 76 (2005) 1439-1453
-
(2005)
Life Sci
, vol.76
, pp. 1439-1453
-
-
Mizutani, H.1
Tada-Oikawa, S.2
Hiraku, Y.3
Koljima, M.4
Kawanishi, S.5
-
91
-
-
1642579534
-
Evidence that activation of nuclear factor-kappa B is essential for the cytotoxic effect of doxorubicin and its analogs
-
Ashikawa K., Shishodia S., Fokt I., Priebe W., and Aggarwal B.B. Evidence that activation of nuclear factor-kappa B is essential for the cytotoxic effect of doxorubicin and its analogs. Biochem Pharmacol 67 (2004) 353-364
-
(2004)
Biochem Pharmacol
, vol.67
, pp. 353-364
-
-
Ashikawa, K.1
Shishodia, S.2
Fokt, I.3
Priebe, W.4
Aggarwal, B.B.5
-
92
-
-
2142647373
-
Nuclear factor-kappa B mediates up-regulation of cathepsin B by doxorubicin in tumor cells
-
Bien S., Ritter C.A., Gratz M., Sperker B., Sonnemann J., Beck J.F., et al. Nuclear factor-kappa B mediates up-regulation of cathepsin B by doxorubicin in tumor cells. Mol Pharmacol 65 (2004) 1092-1102
-
(2004)
Mol Pharmacol
, vol.65
, pp. 1092-1102
-
-
Bien, S.1
Ritter, C.A.2
Gratz, M.3
Sperker, B.4
Sonnemann, J.5
Beck, J.F.6
-
93
-
-
0035883083
-
Signaling pathways activated by daunorubicin
-
Laurent G., and Jeffrezou J.P. Signaling pathways activated by daunorubicin. Blood 98 (2001) 913-924
-
(2001)
Blood
, vol.98
, pp. 913-924
-
-
Laurent, G.1
Jeffrezou, J.P.2
-
94
-
-
0037192824
-
Doxorubicin induces apoptosis and CD59 gene expression in human primary endothelial cells through a p53-dependent mechanism
-
Lorenzo E., Ruiz-Ruiz C., Quesada A.J., Hernandez G., Rodriguez A., Lopes-Rivas A., et al. Doxorubicin induces apoptosis and CD59 gene expression in human primary endothelial cells through a p53-dependent mechanism. J Biol Chem 277 (2002) 10833-10892
-
(2002)
J Biol Chem
, vol.277
, pp. 10833-10892
-
-
Lorenzo, E.1
Ruiz-Ruiz, C.2
Quesada, A.J.3
Hernandez, G.4
Rodriguez, A.5
Lopes-Rivas, A.6
-
95
-
-
33750903389
-
Requirements for pre-existing p21 to prevent doxorubicin-induced apoptosis through inhibition of caspase-3 activation
-
Tang Jj, Shen C., and Lu Y.J. Requirements for pre-existing p21 to prevent doxorubicin-induced apoptosis through inhibition of caspase-3 activation. Mol Cell Biochem 291 (2006) 139-144
-
(2006)
Mol Cell Biochem
, vol.291
, pp. 139-144
-
-
Tang Jj1
Shen, C.2
Lu, Y.J.3
-
96
-
-
33847270257
-
Doxorubicin down-regulates Kruppel-associated box domain-associated protein 1 sumoylation that relieves its transcription repression on p21WAF1/CIP1 in breast cancer MCF-7 cells
-
Lee Y.K., Thomas S.N., Yang A.J., and Ann D.K. Doxorubicin down-regulates Kruppel-associated box domain-associated protein 1 sumoylation that relieves its transcription repression on p21WAF1/CIP1 in breast cancer MCF-7 cells. J Biol Chem 282 (2007) 1595-1606
-
(2007)
J Biol Chem
, vol.282
, pp. 1595-1606
-
-
Lee, Y.K.1
Thomas, S.N.2
Yang, A.J.3
Ann, D.K.4
-
97
-
-
0035868894
-
Phase I/II study of the P-glycoprotein modulator PSC 833 in patients with acute myeloid leukemia
-
Dorr R., Karanes C., Spier C., Grogan T., Greer J., Moore J., et al. Phase I/II study of the P-glycoprotein modulator PSC 833 in patients with acute myeloid leukemia. J Clin Oncol 19 (2001) 1589-1599
-
(2001)
J Clin Oncol
, vol.19
, pp. 1589-1599
-
-
Dorr, R.1
Karanes, C.2
Spier, C.3
Grogan, T.4
Greer, J.5
Moore, J.6
-
98
-
-
19944427647
-
A phase I and pharmacologic study of the MDR converter GF120918 in combination with doxorubicin in patients with advanced solid tumors
-
Planting A.S., Sonneveld P., van der Gaast A., Sparreboom A., van der Burg M.E., Luyton G.P., et al. A phase I and pharmacologic study of the MDR converter GF120918 in combination with doxorubicin in patients with advanced solid tumors. Cancer Chemother Pharmacol 55 (2005) 91-99
-
(2005)
Cancer Chemother Pharmacol
, vol.55
, pp. 91-99
-
-
Planting, A.S.1
Sonneveld, P.2
van der Gaast, A.3
Sparreboom, A.4
van der Burg, M.E.5
Luyton, G.P.6
-
99
-
-
32644438678
-
Up regulation of MDR1 and induction of doxorubicin resistance by histone deacetylase inhibitor depsipeptide (FK228) and ATRA in acute promyelocytic leukemia cells
-
Tabe Y., Konopleva M., Contractor R., Munsell M., Shober W.D., Jin L., et al. Up regulation of MDR1 and induction of doxorubicin resistance by histone deacetylase inhibitor depsipeptide (FK228) and ATRA in acute promyelocytic leukemia cells. Blood 107 (2006) 1546-1554
-
(2006)
Blood
, vol.107
, pp. 1546-1554
-
-
Tabe, Y.1
Konopleva, M.2
Contractor, R.3
Munsell, M.4
Shober, W.D.5
Jin, L.6
-
100
-
-
12544258857
-
Nitric oxide reverts the resistance to doxorubicin in human colon cancer cells by inhibiting the drug efflux
-
Riganti C., Miraglia E., Costamanga C., Pescarmona G., Ghigo D., and Bosia A. Nitric oxide reverts the resistance to doxorubicin in human colon cancer cells by inhibiting the drug efflux. Cancer Res 65 (2005) 516-525
-
(2005)
Cancer Res
, vol.65
, pp. 516-525
-
-
Riganti, C.1
Miraglia, E.2
Costamanga, C.3
Pescarmona, G.4
Ghigo, D.5
Bosia, A.6
-
101
-
-
11844305621
-
Impact of the cyclooxygenase system on doxorubicin-induced functional multidrug resistance 1 overexpression and doxorubicin sensitivity in acute myeloid leukemia HL-60 cells
-
Puhlmann U., Ziemann C., Ruedell G., Vorwek H., Schaefer D., Langebrake C., et al. Impact of the cyclooxygenase system on doxorubicin-induced functional multidrug resistance 1 overexpression and doxorubicin sensitivity in acute myeloid leukemia HL-60 cells. J Pharmacol Exp Ther 312 (2005) 346-354
-
(2005)
J Pharmacol Exp Ther
, vol.312
, pp. 346-354
-
-
Puhlmann, U.1
Ziemann, C.2
Ruedell, G.3
Vorwek, H.4
Schaefer, D.5
Langebrake, C.6
-
102
-
-
4243907381
-
Doxorubicin-induced apoptosis: implications in cardiotoxicity
-
Kalyanaraman B., Joseph J., Kalivendi S., Wang S., Konorev E., and Kotamaju S. Doxorubicin-induced apoptosis: implications in cardiotoxicity. Mol Cell Biochem 234 (2002) 119-124
-
(2002)
Mol Cell Biochem
, vol.234
, pp. 119-124
-
-
Kalyanaraman, B.1
Joseph, J.2
Kalivendi, S.3
Wang, S.4
Konorev, E.5
Kotamaju, S.6
-
103
-
-
33845197460
-
Iron is not involved in oxidative-stress mediated cytotoxicity of doxorubicin
-
Kaiservova H., den Hartog G.J., Simunek T., Schroterova L., Kvasnickova E., and Bast A. Iron is not involved in oxidative-stress mediated cytotoxicity of doxorubicin. Br J Pharmacol 149 (2006) 920-930
-
(2006)
Br J Pharmacol
, vol.149
, pp. 920-930
-
-
Kaiservova, H.1
den Hartog, G.J.2
Simunek, T.3
Schroterova, L.4
Kvasnickova, E.5
Bast, A.6
-
104
-
-
33846194191
-
Effects of the chemotherapeutic agent doxorubicin on the protein C anticoagulant pathway
-
Woodley-Cook J., Sin L.Y., Swystun L., Caruso S., Beaudin S., and Liaw P.C. Effects of the chemotherapeutic agent doxorubicin on the protein C anticoagulant pathway. Mol Cancer Ther 5 (2006) 3303-3311
-
(2006)
Mol Cancer Ther
, vol.5
, pp. 3303-3311
-
-
Woodley-Cook, J.1
Sin, L.Y.2
Swystun, L.3
Caruso, S.4
Beaudin, S.5
Liaw, P.C.6
-
105
-
-
0036310616
-
Pharmacokinetic-pharmacodynamic relationships of the anthracycline anticancer drugs
-
Danesi R., Fogli S., Gennari A., Conte P., and del Tacca M. Pharmacokinetic-pharmacodynamic relationships of the anthracycline anticancer drugs. Clin Pharmacokinet 41 (2002) 431-444
-
(2002)
Clin Pharmacokinet
, vol.41
, pp. 431-444
-
-
Danesi, R.1
Fogli, S.2
Gennari, A.3
Conte, P.4
del Tacca, M.5
-
106
-
-
0038521374
-
Congestive heart failure in patients treated with doxorubicin: a retrospective analysis of three trials
-
Swain S.M., Whaley F.S., and Ewer M.S. Congestive heart failure in patients treated with doxorubicin: a retrospective analysis of three trials. Cancer 97 (2003) 2869-2879
-
(2003)
Cancer
, vol.97
, pp. 2869-2879
-
-
Swain, S.M.1
Whaley, F.S.2
Ewer, M.S.3
-
107
-
-
0035155497
-
Anthracycline-induced clinical heart failure in a cohort of 607 children: long-term follow-up study
-
Kremer L.C., van Dalen E.C., Offringa M., Otten Kamp J., and Voute P.A. Anthracycline-induced clinical heart failure in a cohort of 607 children: long-term follow-up study. J Clin Oncol 19 (2001) 191-196
-
(2001)
J Clin Oncol
, vol.19
, pp. 191-196
-
-
Kremer, L.C.1
van Dalen, E.C.2
Offringa, M.3
Otten Kamp, J.4
Voute, P.A.5
-
108
-
-
33644695139
-
Prospective longitudinal evaluation of doxorubicin-induced cardiomyopathy in sarcoma patients: a report of the late effects of surveillance system
-
Paulides M., Kremers A., Stohr W., Bielack S., Jurgens H., Treuner J., et al. Prospective longitudinal evaluation of doxorubicin-induced cardiomyopathy in sarcoma patients: a report of the late effects of surveillance system. Pediatr Blood Cancer 46 (2006) 489-495
-
(2006)
Pediatr Blood Cancer
, vol.46
, pp. 489-495
-
-
Paulides, M.1
Kremers, A.2
Stohr, W.3
Bielack, S.4
Jurgens, H.5
Treuner, J.6
-
109
-
-
3342905435
-
Cardiac abnormalities 15 years and more after adriamycin therapy in 229 childhood survivors of a solid tumour at the Institute Gustaave Roussey
-
Pein F., Sakiroglu O., Dahan M., Lebidois J., Merlot P., Shamsaldin P., et al. Cardiac abnormalities 15 years and more after adriamycin therapy in 229 childhood survivors of a solid tumour at the Institute Gustaave Roussey. Br J Cancer 91 (2004) 37-44
-
(2004)
Br J Cancer
, vol.91
, pp. 37-44
-
-
Pein, F.1
Sakiroglu, O.2
Dahan, M.3
Lebidois, J.4
Merlot, P.5
Shamsaldin, P.6
-
110
-
-
3042698689
-
Subclinical late cardiomyopathy after doxorubicin therapy for lymphoma in adults
-
Hequet O., Le Q., Moullet J., Pauli E., Salles G., Espinhouse D., et al. Subclinical late cardiomyopathy after doxorubicin therapy for lymphoma in adults. J Clin Oncol 22 (2004) 1864-1871
-
(2004)
J Clin Oncol
, vol.22
, pp. 1864-1871
-
-
Hequet, O.1
Le, Q.2
Moullet, J.3
Pauli, E.4
Salles, G.5
Espinhouse, D.6
-
111
-
-
33745263272
-
Paclitaxel and docetaxel stimulation of doxorubicinol formation in the human heart: implications for cardiotoxicity of doxorubicin-taxane chemotherapies
-
Salvetorelli E., Menna P., Cascegna S., Liberi G., Calafiore A.M., Gianni L., et al. Paclitaxel and docetaxel stimulation of doxorubicinol formation in the human heart: implications for cardiotoxicity of doxorubicin-taxane chemotherapies. J Pharmacol Exp Ther 318 (2006) 424-433
-
(2006)
J Pharmacol Exp Ther
, vol.318
, pp. 424-433
-
-
Salvetorelli, E.1
Menna, P.2
Cascegna, S.3
Liberi, G.4
Calafiore, A.M.5
Gianni, L.6
-
112
-
-
0032983504
-
Correlation between serum levels of cardiac troponin-T and the severity of the chronic cardiomyopathy induced by doxorubicin
-
Herman E.H., Zhang J., Lipshulz S.E., Rifai N., Chadwick D., Takeda K., et al. Correlation between serum levels of cardiac troponin-T and the severity of the chronic cardiomyopathy induced by doxorubicin. J Clin Oncol 17 (1999) 2237-2243
-
(1999)
J Clin Oncol
, vol.17
, pp. 2237-2243
-
-
Herman, E.H.1
Zhang, J.2
Lipshulz, S.E.3
Rifai, N.4
Chadwick, D.5
Takeda, K.6
-
113
-
-
11844290705
-
Naturetic peptides in the monitoring of anthracycline induced reduction in left ventricular ejection fraction
-
Daugaard G., Lassen U., Bie P., Pederson R.B., Jansen K.T., Abidgaard U., et al. Naturetic peptides in the monitoring of anthracycline induced reduction in left ventricular ejection fraction. Eur J Heart Fail 7 (2005) 87-93
-
(2005)
Eur J Heart Fail
, vol.7
, pp. 87-93
-
-
Daugaard, G.1
Lassen, U.2
Bie, P.3
Pederson, R.B.4
Jansen, K.T.5
Abidgaard, U.6
-
114
-
-
0037087687
-
Doxorubicin administration by continuous infusion is not cardioprotectant: the Dana-Farber 91-01 ALL protocol
-
Lipshulz S.E., Giantris A.L., Lipsitz S.R., Kimball-Dalton V., Asselin B.L., Barr R.D., et al. Doxorubicin administration by continuous infusion is not cardioprotectant: the Dana-Farber 91-01 ALL protocol. J Clin Oncol 20 (2002) 1677-1682
-
(2002)
J Clin Oncol
, vol.20
, pp. 1677-1682
-
-
Lipshulz, S.E.1
Giantris, A.L.2
Lipsitz, S.R.3
Kimball-Dalton, V.4
Asselin, B.L.5
Barr, R.D.6
-
115
-
-
1242292932
-
Does anthracycline administration by infusion in children affect late cardiotoxicity?
-
Levitt G.A., Dorup I., Sorensen K., and Sullivan J. Does anthracycline administration by infusion in children affect late cardiotoxicity?. Br J Hematol 124 (2004) 463-468
-
(2004)
Br J Hematol
, vol.124
, pp. 463-468
-
-
Levitt, G.A.1
Dorup, I.2
Sorensen, K.3
Sullivan, J.4
-
116
-
-
0031693006
-
Dexrazoxane. A review of its use as a cardio protective agent in patients receiving anthracycline-based chemotherapy
-
Wiseman L.R., and Spencer C.M. Dexrazoxane. A review of its use as a cardio protective agent in patients receiving anthracycline-based chemotherapy. Drugs 56 (1998) 385-403
-
(1998)
Drugs
, vol.56
, pp. 385-403
-
-
Wiseman, L.R.1
Spencer, C.M.2
-
117
-
-
3042850886
-
The effect of dexrazoxane on myocardial injury in doxorubicin-treated children with acute lymphoblastic leukemia
-
Lipshulz S.E., Rifai N., Dalton V.M., Levy D.E., Silverman L.B., Lipsitz S.R., et al. The effect of dexrazoxane on myocardial injury in doxorubicin-treated children with acute lymphoblastic leukemia. N Engl J Med 351 (2004) 145-153
-
(2004)
N Engl J Med
, vol.351
, pp. 145-153
-
-
Lipshulz, S.E.1
Rifai, N.2
Dalton, V.M.3
Levy, D.E.4
Silverman, L.B.5
Lipsitz, S.R.6
-
118
-
-
0036142158
-
Liposome-encapsulated doxorubicin compared with conventional doxorubicin in a randomized multicenter trial as first-line therapy of metastatic breast carcinoma
-
Harris L., Batist G., Belt R., Rovira D., Navari R., Azarnia N., et al. Liposome-encapsulated doxorubicin compared with conventional doxorubicin in a randomized multicenter trial as first-line therapy of metastatic breast carcinoma. Cancer 94 (2002) 25-36
-
(2002)
Cancer
, vol.94
, pp. 25-36
-
-
Harris, L.1
Batist, G.2
Belt, R.3
Rovira, D.4
Navari, R.5
Azarnia, N.6
-
119
-
-
0035282073
-
Reduced cardiotoxicity and preserved antitumor efficacy of liposome-encapsulated doxorubicin and cyclophosphamide compared with conventional doxorubicin and cyclophosphamide in a randomized, multicenter trial of metastatic breast cancer
-
Batist G., Ramakrishnan G., Rao C.S., Chandraskharan A., Gutheil J., Guthrie T., et al. Reduced cardiotoxicity and preserved antitumor efficacy of liposome-encapsulated doxorubicin and cyclophosphamide compared with conventional doxorubicin and cyclophosphamide in a randomized, multicenter trial of metastatic breast cancer. J Clin Oncol 19 (2001) 1444-1454
-
(2001)
J Clin Oncol
, vol.19
, pp. 1444-1454
-
-
Batist, G.1
Ramakrishnan, G.2
Rao, C.S.3
Chandraskharan, A.4
Gutheil, J.5
Guthrie, T.6
-
120
-
-
11144357506
-
Reduced cardiotoxicity and comparable efficacy in a phase III trial of pegylated liposomal doxorubicin HCl versus conventional doxorubicin for the first line treatment of metastatic breast cancer
-
O'brien M.E., Wigler N., Imbar M., Rosso R., Santaro A., Grischke E., et al. Reduced cardiotoxicity and comparable efficacy in a phase III trial of pegylated liposomal doxorubicin HCl versus conventional doxorubicin for the first line treatment of metastatic breast cancer. Ann Oncol 15 (2004) 440-449
-
(2004)
Ann Oncol
, vol.15
, pp. 440-449
-
-
O'brien, M.E.1
Wigler, N.2
Imbar, M.3
Rosso, R.4
Santaro, A.5
Grischke, E.6
-
121
-
-
33646855548
-
Biweekly pegylated liposomal doxorubicin in patients with relapsed ovarian cancer: results of a multicenter phase-II trial
-
Seboulli J., Oskay-Ozcelik G., Kuhne J., Stange P.D., Hindenberg H.J., Klare P., et al. Biweekly pegylated liposomal doxorubicin in patients with relapsed ovarian cancer: results of a multicenter phase-II trial. Ann Oncol 17 (2006) 957-961
-
(2006)
Ann Oncol
, vol.17
, pp. 957-961
-
-
Seboulli, J.1
Oskay-Ozcelik, G.2
Kuhne, J.3
Stange, P.D.4
Hindenberg, H.J.5
Klare, P.6
-
122
-
-
0033770416
-
Palmar-plantar erythrodysesthesia syndrome associated with liposomal daunorubicin
-
Hui Y.F., and Cortes J.E. Palmar-plantar erythrodysesthesia syndrome associated with liposomal daunorubicin. Pharmacotherapy 20 (2000) 1221-1223
-
(2000)
Pharmacotherapy
, vol.20
, pp. 1221-1223
-
-
Hui, Y.F.1
Cortes, J.E.2
-
123
-
-
3242703387
-
Cardiac safety profile of prolonged (> or <6 cycles) pegylated liposomal doxorubicin administration in patients with gynecologic malignancies
-
Uyar D., Kulp B., Peterson G., Markman M., and Belinson J. Cardiac safety profile of prolonged (> or <6 cycles) pegylated liposomal doxorubicin administration in patients with gynecologic malignancies. Gynecol Oncol 94 (2004) 147-151
-
(2004)
Gynecol Oncol
, vol.94
, pp. 147-151
-
-
Uyar, D.1
Kulp, B.2
Peterson, G.3
Markman, M.4
Belinson, J.5
-
124
-
-
0034820943
-
Anthracycline-induced cardiomyopathy
-
Keefe D. Anthracycline-induced cardiomyopathy. Semin Oncol 28 s (2001) 2-4
-
(2001)
Semin Oncol
, vol.28
, Issue.SUPPL
, pp. 2-4
-
-
Keefe, D.1
-
125
-
-
33744959330
-
Defective one or two electron reduction of the anticancer agent epirubicin in human heart
-
Salvatorelli E., Guarnieri S., Menna P., Calatiori A.M., Marrigio H.A., Mordente A., et al. Defective one or two electron reduction of the anticancer agent epirubicin in human heart. J Biol Chem 281 (2006) 10990-11001
-
(2006)
J Biol Chem
, vol.281
, pp. 10990-11001
-
-
Salvatorelli, E.1
Guarnieri, S.2
Menna, P.3
Calatiori, A.M.4
Marrigio, H.A.5
Mordente, A.6
-
126
-
-
0031734394
-
Epirubicin cardiotoxicity: an analysis of 469 patients with metastatic breast cancer
-
Ryberg M., Nielsen D., Skovsgaard T., Hansen J., Jensen B.V., and Dombernowsky P. Epirubicin cardiotoxicity: an analysis of 469 patients with metastatic breast cancer. J Clin Oncol 16 (1998) 3502-3508
-
(1998)
J Clin Oncol
, vol.16
, pp. 3502-3508
-
-
Ryberg, M.1
Nielsen, D.2
Skovsgaard, T.3
Hansen, J.4
Jensen, B.V.5
Dombernowsky, P.6
-
127
-
-
0036087789
-
Evaluation of long-term cardiotoxicity after epirubicin containing adjuvant chemotherapy and local regional radiotherapy for breast cancer using various detection techniques
-
Meinari M.T., van der Graaf W.T., Gietema J.A., Van den Berg M.P., Steijfer D.T., de Vries E.C., et al. Evaluation of long-term cardiotoxicity after epirubicin containing adjuvant chemotherapy and local regional radiotherapy for breast cancer using various detection techniques. Heart 88 (2002) 81-82
-
(2002)
Heart
, vol.88
, pp. 81-82
-
-
Meinari, M.T.1
van der Graaf, W.T.2
Gietema, J.A.3
Van den Berg, M.P.4
Steijfer, D.T.5
de Vries, E.C.6
-
129
-
-
0036895164
-
Long-term enalapril therapy for left ventricular dysfunction in doxorubicin-treated survivors of childhood cancer
-
Lipshulz S.E., Lipsitz S.R., Sallon S.E., Simbre V.C., Shaikh S.L., Mone S.M., et al. Long-term enalapril therapy for left ventricular dysfunction in doxorubicin-treated survivors of childhood cancer. J Clin Oncol 20 (2002) 4517-4522
-
(2002)
J Clin Oncol
, vol.20
, pp. 4517-4522
-
-
Lipshulz, S.E.1
Lipsitz, S.R.2
Sallon, S.E.3
Simbre, V.C.4
Shaikh, S.L.5
Mone, S.M.6
-
130
-
-
33947128057
-
Adriamycin induced myocardial toxicity: new solutions for an old problem?
-
Outomuro D., Grana D., Azzato R., and Milei J. Adriamycin induced myocardial toxicity: new solutions for an old problem?. Int J Cardiol 117 (2007) 6-15
-
(2007)
Int J Cardiol
, vol.117
, pp. 6-15
-
-
Outomuro, D.1
Grana, D.2
Azzato, R.3
Milei, J.4
-
131
-
-
0042914714
-
Risk of acute leukemia following epirubicin-based adjuvant chemotherapy: a report from the National Cancer Institute of Canada Clinical Trials Group
-
Crump M., Tu D., Shepherd L., Levine M., and Bramwell V. Risk of acute leukemia following epirubicin-based adjuvant chemotherapy: a report from the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol 21 (2003) 3066-3071
-
(2003)
J Clin Oncol
, vol.21
, pp. 3066-3071
-
-
Crump, M.1
Tu, D.2
Shepherd, L.3
Levine, M.4
Bramwell, V.5
-
132
-
-
23044482675
-
Risk of acute myeloid leukemia and myelodysplastic syndrome in trials of adjuvant epirubicin for early breast cancer: correlation with doses of epirubicin and doxorubicin
-
Praga C., Bergh J., Bliss J., Bonneterre J., Cesana B., Coomlies R.C., et al. Risk of acute myeloid leukemia and myelodysplastic syndrome in trials of adjuvant epirubicin for early breast cancer: correlation with doses of epirubicin and doxorubicin. J Clin Oncol 23 (2005) 4179-4191
-
(2005)
J Clin Oncol
, vol.23
, pp. 4179-4191
-
-
Praga, C.1
Bergh, J.2
Bliss, J.3
Bonneterre, J.4
Cesana, B.5
Coomlies, R.C.6
-
133
-
-
0031950286
-
Anthracyclines in haematology: pharmacokinetics and clinical studies
-
Johnson S.A., and Richardson D.S. Anthracyclines in haematology: pharmacokinetics and clinical studies. Blood Rev 12 (1998) 52-71
-
(1998)
Blood Rev
, vol.12
, pp. 52-71
-
-
Johnson, S.A.1
Richardson, D.S.2
-
134
-
-
1942488208
-
Factors affecting pharmacokinetic variability following doxorubicin and doxetaxel-based therapy
-
Rudek M.A., Sparreboom A., Garrett-Mayer E.S., Armstrong D.K., Wolff A.C., Verweji J., et al. Factors affecting pharmacokinetic variability following doxorubicin and doxetaxel-based therapy. Eur J Cancer 40 (2004) 1170-1178
-
(2004)
Eur J Cancer
, vol.40
, pp. 1170-1178
-
-
Rudek, M.A.1
Sparreboom, A.2
Garrett-Mayer, E.S.3
Armstrong, D.K.4
Wolff, A.C.5
Verweji, J.6
-
135
-
-
0037680647
-
The effect of age on the early disposition of doxorubicin
-
Li J., and Gwilt P.R. The effect of age on the early disposition of doxorubicin. Cancer Chemother Pharmacol 51 (2003) 395-402
-
(2003)
Cancer Chemother Pharmacol
, vol.51
, pp. 395-402
-
-
Li, J.1
Gwilt, P.R.2
-
136
-
-
33845332087
-
A joint analysis of two EORTC studies to evaluate the role of pegylated doxorubicin (Caelyx) in the treatment of elderly patients with metastatic breast cancer
-
Buganzoli L., Coleman R., Minisini A., Hamilton A., Aapro M., Therasse P., et al. A joint analysis of two EORTC studies to evaluate the role of pegylated doxorubicin (Caelyx) in the treatment of elderly patients with metastatic breast cancer. Crit Rev Oncol Hematol 61 (2007) 84-89
-
(2007)
Crit Rev Oncol Hematol
, vol.61
, pp. 84-89
-
-
Buganzoli, L.1
Coleman, R.2
Minisini, A.3
Hamilton, A.4
Aapro, M.5
Therasse, P.6
-
137
-
-
33847664734
-
Doxorubicin levels in the serum and ascites of patients with ovarian cancer
-
Gotlieb W.H., Bruchim I., Ben-Baruch G., Davidson B., Zettser A., Anderson A., et al. Doxorubicin levels in the serum and ascites of patients with ovarian cancer. Eur J Surg Oncol 33 (2007) 213-215
-
(2007)
Eur J Surg Oncol
, vol.33
, pp. 213-215
-
-
Gotlieb, W.H.1
Bruchim, I.2
Ben-Baruch, G.3
Davidson, B.4
Zettser, A.5
Anderson, A.6
-
138
-
-
0032480583
-
Daunorubicin cardiotoxicity in childhood cancer
-
Samuel L., Cummings J., and Shaw P. Daunorubicin cardiotoxicity in childhood cancer. Lancet 352 (1998) 1150
-
(1998)
Lancet
, vol.352
, pp. 1150
-
-
Samuel, L.1
Cummings, J.2
Shaw, P.3
-
139
-
-
0037681850
-
Pharmacokinetics of pegylated liposomal doxorubicin: review of animal and human studies
-
Gabizon A., Shmeeda H., Barenholz Y., and Barenholz Y. Pharmacokinetics of pegylated liposomal doxorubicin: review of animal and human studies. Clin Pharmacokinet 42 (2003) 419-436
-
(2003)
Clin Pharmacokinet
, vol.42
, pp. 419-436
-
-
Gabizon, A.1
Shmeeda, H.2
Barenholz, Y.3
Barenholz, Y.4
-
140
-
-
0035164058
-
A comparison of liposomal formulations of doxorubicin with drug administered in free form
-
Waterhouse D.N., Tardi P.G., Mayer L.D., Bally M.B., et al. A comparison of liposomal formulations of doxorubicin with drug administered in free form. Drug Safety 24 (2001) 903-920
-
(2001)
Drug Safety
, vol.24
, pp. 903-920
-
-
Waterhouse, D.N.1
Tardi, P.G.2
Mayer, L.D.3
Bally, M.B.4
-
141
-
-
11144336676
-
Pharmacokinetics of liposomal doxorubicin (TLC-D99;Myocet) in patients with solid tumors: an open-label, single dose study
-
Mross K., Niemann B., Massing U., Drews J., Unger C., Bhamra R., et al. Pharmacokinetics of liposomal doxorubicin (TLC-D99;Myocet) in patients with solid tumors: an open-label, single dose study. Cancer Chemother Pharmacol 54 (2004) 514-524
-
(2004)
Cancer Chemother Pharmacol
, vol.54
, pp. 514-524
-
-
Mross, K.1
Niemann, B.2
Massing, U.3
Drews, J.4
Unger, C.5
Bhamra, R.6
-
142
-
-
34447638919
-
Pegylated liposomal doxorubicin treatment in recurrent gynecologic cancer patients with renal dysfunction
-
Li Y., Finkel K.W., Hu W., Fu S., Liu J., Coleman R., et al. Pegylated liposomal doxorubicin treatment in recurrent gynecologic cancer patients with renal dysfunction. Gynecol Oncol 106 (2007) 375-380
-
(2007)
Gynecol Oncol
, vol.106
, pp. 375-380
-
-
Li, Y.1
Finkel, K.W.2
Hu, W.3
Fu, S.4
Liu, J.5
Coleman, R.6
-
143
-
-
0036649205
-
A phase I dose-escalating study of daunoxome, liposomal daunorubicin in metastatic breast cancer
-
Obyrne K.J., Thomas A.L., Sharma R.A., DeCartis M., Shields F., Beare S., et al. A phase I dose-escalating study of daunoxome, liposomal daunorubicin in metastatic breast cancer. Br J Cancer 87 (2002) 15-20
-
(2002)
Br J Cancer
, vol.87
, pp. 15-20
-
-
Obyrne, K.J.1
Thomas, A.L.2
Sharma, R.A.3
DeCartis, M.4
Shields, F.5
Beare, S.6
-
144
-
-
0034924032
-
Pharmacokinetics of liposomal daunorubicin (daunoxome) during a phase I-II study in children with relapsed leukemia
-
Belloff R., Auvrignon A., Leblanc T., Perel Y., Gandemer V., Bertrand Y., et al. Pharmacokinetics of liposomal daunorubicin (daunoxome) during a phase I-II study in children with relapsed leukemia. Cancer Chemother Pharmacol 47 (2001) 15-21
-
(2001)
Cancer Chemother Pharmacol
, vol.47
, pp. 15-21
-
-
Belloff, R.1
Auvrignon, A.2
Leblanc, T.3
Perel, Y.4
Gandemer, V.5
Bertrand, Y.6
-
145
-
-
0032873140
-
Pharmacokinetic optimization of treatment schedules for anthracyclines and paclitaxel in patients with cancer
-
Danesi R., Conte P.F., and Del Tacca M. Pharmacokinetic optimization of treatment schedules for anthracyclines and paclitaxel in patients with cancer. Clin Pharmacokinet 37 (1999) 195-211
-
(1999)
Clin Pharmacokinet
, vol.37
, pp. 195-211
-
-
Danesi, R.1
Conte, P.F.2
Del Tacca, M.3
-
146
-
-
0035871446
-
Clinical and pharmacologic study of the epirubicin and paclitaxel combination in women with metastatic breast cancer
-
Grasselli G., Vigano L., Capri G., Locatelli A., Tarenzi E., Spreafico C., et al. Clinical and pharmacologic study of the epirubicin and paclitaxel combination in women with metastatic breast cancer. J Clin Oncol 19 (2001) 2222-2231
-
(2001)
J Clin Oncol
, vol.19
, pp. 2222-2231
-
-
Grasselli, G.1
Vigano, L.2
Capri, G.3
Locatelli, A.4
Tarenzi, E.5
Spreafico, C.6
-
147
-
-
0035029212
-
Epirubicin glucuronidation is catalyzed by human UDP-glucuronyl-transferase 2B7
-
Innocenti F., Iyr L., Ramirez J., Green M.D., and Ratain M.J. Epirubicin glucuronidation is catalyzed by human UDP-glucuronyl-transferase 2B7. Drug Metab Dispos 29 (2001) 686-692
-
(2001)
Drug Metab Dispos
, vol.29
, pp. 686-692
-
-
Innocenti, F.1
Iyr, L.2
Ramirez, J.3
Green, M.D.4
Ratain, M.J.5
-
148
-
-
33751540127
-
Epirubicin glucuronidation and UGT2B7 developmental expression
-
Zaya M.J., Hines R.N., and Stevens J.C. Epirubicin glucuronidation and UGT2B7 developmental expression. Drug Metab Dispos 34 (2006) 2097-2101
-
(2006)
Drug Metab Dispos
, vol.34
, pp. 2097-2101
-
-
Zaya, M.J.1
Hines, R.N.2
Stevens, J.C.3
-
149
-
-
33749523057
-
Safety of epirubicin adjuvant chemotherapy in a breast cancer patient with chronic renal failure undergoing hemodialytic treatment
-
Gori S., Rulli A., Mosconi A.M., Sidoni A., Colozza M., and Crino L. Safety of epirubicin adjuvant chemotherapy in a breast cancer patient with chronic renal failure undergoing hemodialytic treatment. Tumori 92 (2006) 364-365
-
(2006)
Tumori
, vol.92
, pp. 364-365
-
-
Gori, S.1
Rulli, A.2
Mosconi, A.M.3
Sidoni, A.4
Colozza, M.5
Crino, L.6
-
150
-
-
34247208633
-
Plasma and tissue pharmacokinetic of epirubicin and paclitaxel in patients receiving neoadjuvant chemotherapy for locally advanced breast cancer
-
Hunz M., Jetter A., Warm M., Pantke E., Tuscher M., Hempel J., et al. Plasma and tissue pharmacokinetic of epirubicin and paclitaxel in patients receiving neoadjuvant chemotherapy for locally advanced breast cancer. Clin Pharmacol Ther 81 (2007) 659-668
-
(2007)
Clin Pharmacol Ther
, vol.81
, pp. 659-668
-
-
Hunz, M.1
Jetter, A.2
Warm, M.3
Pantke, E.4
Tuscher, M.5
Hempel, J.6
-
151
-
-
33748182877
-
Doxorubicin pharmacokinetics is correlated to the effect of induction therapy in children with acute myeloid leukemia
-
Palle J., Frost B.M., Peterson C., Gustafsson B., Hellebostad D., Kanerva J., et al. Doxorubicin pharmacokinetics is correlated to the effect of induction therapy in children with acute myeloid leukemia. Anti-Cancer Drugs 17 (2006) 385-392
-
(2006)
Anti-Cancer Drugs
, vol.17
, pp. 385-392
-
-
Palle, J.1
Frost, B.M.2
Peterson, C.3
Gustafsson, B.4
Hellebostad, D.5
Kanerva, J.6
-
152
-
-
0030713362
-
Anthracyclines in the treatment of cancer. An overview
-
Hortobagyi G.N. Anthracyclines in the treatment of cancer. An overview. Drugs 54 Suppl. 4 (1997) 1-7
-
(1997)
Drugs
, vol.54
, Issue.SUPPL. 4
, pp. 1-7
-
-
Hortobagyi, G.N.1
-
154
-
-
0842285393
-
New oral drugs in older patients: a review of idarubicin in elderly patients
-
Crivellari D., Lombardi D., Spazzapam S., Veronesi A., and Toffoli G. New oral drugs in older patients: a review of idarubicin in elderly patients. Crit Rev Oncol Hematol 49 (2004) 153-163
-
(2004)
Crit Rev Oncol Hematol
, vol.49
, pp. 153-163
-
-
Crivellari, D.1
Lombardi, D.2
Spazzapam, S.3
Veronesi, A.4
Toffoli, G.5
-
155
-
-
1042292052
-
Unexpected toxicities in elderly patients treated with oral idarubicin in metastatic breast cancer
-
Freyer G., Lortholary A., Delcambre C., Delozier T., Pilot T., Genin F., et al. Unexpected toxicities in elderly patients treated with oral idarubicin in metastatic breast cancer. Clin Oncol 16 (2004) 17-23
-
(2004)
Clin Oncol
, vol.16
, pp. 17-23
-
-
Freyer, G.1
Lortholary, A.2
Delcambre, C.3
Delozier, T.4
Pilot, T.5
Genin, F.6
-
156
-
-
0141465129
-
Phase II study of pegylated liposomal doxorubicin in combination with gemcitabine in patients with metastatic breast cancer
-
Rivera E., Valero V., Arun B., Royce M., Adinin R., Hoelzer K., et al. Phase II study of pegylated liposomal doxorubicin in combination with gemcitabine in patients with metastatic breast cancer. J Clin Oncol 21 (2003) 3249-3254
-
(2003)
J Clin Oncol
, vol.21
, pp. 3249-3254
-
-
Rivera, E.1
Valero, V.2
Arun, B.3
Royce, M.4
Adinin, R.5
Hoelzer, K.6
-
157
-
-
33745227713
-
The clinical benefit of pegylated doxorubicin in patients with metastatic breast cancer previously treated with conventional anthracyclines: a multicentre phase II trial
-
Al-Batan S.E., Bischoff J., von Minckwitz G., Atmaca A., Kleeberg U., Meuthen I., et al. The clinical benefit of pegylated doxorubicin in patients with metastatic breast cancer previously treated with conventional anthracyclines: a multicentre phase II trial. Br J Cancer 94 (2006) 1615-1620
-
(2006)
Br J Cancer
, vol.94
, pp. 1615-1620
-
-
Al-Batan, S.E.1
Bischoff, J.2
von Minckwitz, G.3
Atmaca, A.4
Kleeberg, U.5
Meuthen, I.6
-
158
-
-
0033999408
-
Phase I study of Caelyx (doxorubicin HCL, pegylated liposomal) in recurrent or metastatic head and neck cancer
-
Caponigro F., Comella P., Bryce J., Avallone A., De Rosa V., Budillon A., et al. Phase I study of Caelyx (doxorubicin HCL, pegylated liposomal) in recurrent or metastatic head and neck cancer. Ann Oncol 11 (2000) 339-342
-
(2000)
Ann Oncol
, vol.11
, pp. 339-342
-
-
Caponigro, F.1
Comella, P.2
Bryce, J.3
Avallone, A.4
De Rosa, V.5
Budillon, A.6
-
159
-
-
34447570846
-
Randomized phase III trial of gemcitabine compared with pegylated
-
Mutch D.G., Orlando M., Goss T., Teneriello M.G., Gordon A.N., McMeekin S.D., et al. Randomized phase III trial of gemcitabine compared with pegylated liposomal doxorubicin in patients with platinum resistant ovarian cancer. J Clin Oncol 25 (2007) 2811-2818
-
(2007)
J Clin Oncol
, vol.25
, pp. 2811-2818
-
-
Mutch, D.G.1
Orlando, M.2
Goss, T.3
Teneriello, M.G.4
Gordon, A.N.5
McMeekin, S.D.6
-
160
-
-
4143049229
-
Prospective randomized phase II trial of pegylated doxorubicin in the management of symptomatic hormone-refractory prostate cancer
-
Hedenreich A., Sommer F., Ohlmann C., Schader A., Obert P., Goecke J., and Engelmann U.H. Prospective randomized phase II trial of pegylated doxorubicin in the management of symptomatic hormone-refractory prostate cancer. Cancer 101 (2004) 948-956
-
(2004)
Cancer
, vol.101
, pp. 948-956
-
-
Hedenreich, A.1
Sommer, F.2
Ohlmann, C.3
Schader, A.4
Obert, P.5
Goecke, J.6
Engelmann, U.H.7
-
161
-
-
0033638112
-
Phase II study of pegylated liposomal doxorubicin: inactive in recurrent small-cell lung cancer. A Hellenic Cooperative Oncology Group Study
-
Samantas E., Kalofonos H., Linardou H., Nicolaides C., Mylonakis N., Fountzilas G., et al. Phase II study of pegylated liposomal doxorubicin: inactive in recurrent small-cell lung cancer. A Hellenic Cooperative Oncology Group Study. Ann Oncol 11 (2000) 1395-1397
-
(2000)
Ann Oncol
, vol.11
, pp. 1395-1397
-
-
Samantas, E.1
Kalofonos, H.2
Linardou, H.3
Nicolaides, C.4
Mylonakis, N.5
Fountzilas, G.6
-
162
-
-
0033950350
-
A phase II study of pegylated liposomal doxorubicin for treatment of advanced hepatocellular carcinoma
-
Halm U., Etzrodt G., Schiefke I., Schmidt F., Witzigmann H., Mossner J., et al. A phase II study of pegylated liposomal doxorubicin for treatment of advanced hepatocellular carcinoma. Ann Oncol 11 (2000) 113-114
-
(2000)
Ann Oncol
, vol.11
, pp. 113-114
-
-
Halm, U.1
Etzrodt, G.2
Schiefke, I.3
Schmidt, F.4
Witzigmann, H.5
Mossner, J.6
-
163
-
-
0036569847
-
Phase II trial of pegylated liposomal doxorubicin in previously treated metastatic endometrial cancer. A GOG study
-
Muggia F.M., Blessing J.A., Sorosky J., and Reid G.C. Phase II trial of pegylated liposomal doxorubicin in previously treated metastatic endometrial cancer. A GOG study. J Clin Oncol 20 (2002) 2360-2364
-
(2002)
J Clin Oncol
, vol.20
, pp. 2360-2364
-
-
Muggia, F.M.1
Blessing, J.A.2
Sorosky, J.3
Reid, G.C.4
-
164
-
-
0035182901
-
A phase II study evaluating the tolerability and efficacy of CAELYX 1 liposomal doxorubicin, Doxill in the treatment of unresectable pancreatic carcinoma
-
Halford S., Yip D., Karapetic C.S., Strickland A.H., Steger A., Khawaja H.T., et al. A phase II study evaluating the tolerability and efficacy of CAELYX 1 liposomal doxorubicin, Doxill in the treatment of unresectable pancreatic carcinoma. Ann Oncol 12 (2001) 1399-1402
-
(2001)
Ann Oncol
, vol.12
, pp. 1399-1402
-
-
Halford, S.1
Yip, D.2
Karapetic, C.S.3
Strickland, A.H.4
Steger, A.5
Khawaja, H.T.6
-
165
-
-
0034841139
-
A phase II study of calyx, liposomal doxorubicin: lack of activity in patients with advanced gastric cancer
-
Thomas A.L., O'Byne K., Furber L., Jeffery K., Steward W., et al. A phase II study of calyx, liposomal doxorubicin: lack of activity in patients with advanced gastric cancer. Cancer Chemother Pharmacol 48 (2001) 266-268
-
(2001)
Cancer Chemother Pharmacol
, vol.48
, pp. 266-268
-
-
Thomas, A.L.1
O'Byne, K.2
Furber, L.3
Jeffery, K.4
Steward, W.5
-
166
-
-
0035117953
-
Phase II study of liposomal doxorubicin in patients with advanced colorectal cancer
-
Shields A.F., Lange L.M., and Zalupski M.M. Phase II study of liposomal doxorubicin in patients with advanced colorectal cancer. Am J Clin Oncol 24 (2001) 96-98
-
(2001)
Am J Clin Oncol
, vol.24
, pp. 96-98
-
-
Shields, A.F.1
Lange, L.M.2
Zalupski, M.M.3
-
167
-
-
33947212925
-
Phase I study of inhaled doxorubicin for patients with metastatic tumors to the lungs
-
Otterson G.A., Villalona-Calero M.A., Sharma S., Kris M.G., Imondi A., Gerber M., et al. Phase I study of inhaled doxorubicin for patients with metastatic tumors to the lungs. Clin Cancer Res 13 (2007) 1246-1252
-
(2007)
Clin Cancer Res
, vol.13
, pp. 1246-1252
-
-
Otterson, G.A.1
Villalona-Calero, M.A.2
Sharma, S.3
Kris, M.G.4
Imondi, A.5
Gerber, M.6
-
168
-
-
0026127460
-
Mitoxantrone. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in the chemotherapy of cancer
-
Faulds D., Balfour J.A., Chrisp P., and Langtry H.D. Mitoxantrone. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in the chemotherapy of cancer. Drugs 41 (1991) 400-449
-
(1991)
Drugs
, vol.41
, pp. 400-449
-
-
Faulds, D.1
Balfour, J.A.2
Chrisp, P.3
Langtry, H.D.4
-
169
-
-
0034682798
-
Topoisomerase II is required for mitoxantrone to signal NFkB activation in HL60 cells
-
Boland M.P., Fitzgerald K.A., and O'Neill L.A. Topoisomerase II is required for mitoxantrone to signal NFkB activation in HL60 cells. J Biol Chem 275 (2000) 25231-25238
-
(2000)
J Biol Chem
, vol.275
, pp. 25231-25238
-
-
Boland, M.P.1
Fitzgerald, K.A.2
O'Neill, L.A.3
-
170
-
-
10644241965
-
Activation of mitochondiral apoptotic pathway in mantel cell lymphoma: high sensitivity to mitoxantrone in cases with functional DNA-damage response genes
-
Ferrer A., Marce S., Bellosillo B., Villamor N., Bosch F., Lopes-Guillermo A., et al. Activation of mitochondiral apoptotic pathway in mantel cell lymphoma: high sensitivity to mitoxantrone in cases with functional DNA-damage response genes. Oncogene 23 (2004) 8941-8949
-
(2004)
Oncogene
, vol.23
, pp. 8941-8949
-
-
Ferrer, A.1
Marce, S.2
Bellosillo, B.3
Villamor, N.4
Bosch, F.5
Lopes-Guillermo, A.6
-
171
-
-
0033104367
-
Multiple mechanisms confer drug resistance to mitoxantrone in the human 8226 myeloma cell line
-
Hazlehurst L.A., Foley N.E., Gleason-Guzman M.C., Hacker M.P., Cress A.E., Greenberger L.W., et al. Multiple mechanisms confer drug resistance to mitoxantrone in the human 8226 myeloma cell line. Cancer Res 59 (1999) 1021-1028
-
(1999)
Cancer Res
, vol.59
, pp. 1021-1028
-
-
Hazlehurst, L.A.1
Foley, N.E.2
Gleason-Guzman, M.C.3
Hacker, M.P.4
Cress, A.E.5
Greenberger, L.W.6
-
172
-
-
0032404092
-
A human placenta-specific ATP-binding cassette gene (ABCP) on chromosome 4q22 that is involved in multidrug resistance
-
Allikmets R., Schriml L.M., Hutchinson A., Romano-Spica V., Dean M., et al. A human placenta-specific ATP-binding cassette gene (ABCP) on chromosome 4q22 that is involved in multidrug resistance. Cancer Res 58 (1998) 5337-5339
-
(1998)
Cancer Res
, vol.58
, pp. 5337-5339
-
-
Allikmets, R.1
Schriml, L.M.2
Hutchinson, A.3
Romano-Spica, V.4
Dean, M.5
-
173
-
-
18744421466
-
Breast cancer resistance protein is localized at the plasma membrane in mitoxantrone- and topotecan-resistant cell lines
-
Scheffer G.L., Maliepaard M., Pijnenborg A.C., van Gastelen M.A., de Jong M.C., Schroeijers A.B., et al. Breast cancer resistance protein is localized at the plasma membrane in mitoxantrone- and topotecan-resistant cell lines. Cancer Res 60 (2000) 2589-2593
-
(2000)
Cancer Res
, vol.60
, pp. 2589-2593
-
-
Scheffer, G.L.1
Maliepaard, M.2
Pijnenborg, A.C.3
van Gastelen, M.A.4
de Jong, M.C.5
Schroeijers, A.B.6
-
174
-
-
0036100195
-
Increased expression of the breast cancer resistance protein (BCRP) in relapsed or refractory acute myeloid leukemia (AML)
-
van den Heuvel-Eibrink M.M., Wiemer E.A., Prins A., Meijerink J.P., Vossebeld J.M., van der Holt B., et al. Increased expression of the breast cancer resistance protein (BCRP) in relapsed or refractory acute myeloid leukemia (AML). Leukemia 16 (2002) 833-839
-
(2002)
Leukemia
, vol.16
, pp. 833-839
-
-
van den Heuvel-Eibrink, M.M.1
Wiemer, E.A.2
Prins, A.3
Meijerink, J.P.4
Vossebeld, J.M.5
van der Holt, B.6
-
175
-
-
33744462358
-
Cyclosporin A, tacrolimus and sirolimus are potent inhibitors of the human breast cancer resistance protein (ABCG2) and reverse resistance to mitoxantrone and topotecan
-
Gupta A., Dai Y., Vethananayagam R.R., Hebert M.F., Thummel K.F., and Unadkat J.D. Cyclosporin A, tacrolimus and sirolimus are potent inhibitors of the human breast cancer resistance protein (ABCG2) and reverse resistance to mitoxantrone and topotecan. Cancer Chemother Pharmacol 58 (2006) 374-383
-
(2006)
Cancer Chemother Pharmacol
, vol.58
, pp. 374-383
-
-
Gupta, A.1
Dai, Y.2
Vethananayagam, R.R.3
Hebert, M.F.4
Thummel, K.F.5
Unadkat, J.D.6
-
176
-
-
2142711101
-
Flavinoids are inhibitors of breast cancer resistance protein (ABCG2)-mediated transport
-
Zhang S., Yang X., and Morris M.E. Flavinoids are inhibitors of breast cancer resistance protein (ABCG2)-mediated transport. Mol Pharmacol 65 (2004) 1208-1216
-
(2004)
Mol Pharmacol
, vol.65
, pp. 1208-1216
-
-
Zhang, S.1
Yang, X.2
Morris, M.E.3
-
177
-
-
33644777840
-
Multi-drug resistance protein 1 (MRP1, ABCC1) mediates resistance to mitoxantrone via glutathione-dependent drug efflux
-
Morrow C.S., Peklak-Scott C., Bishwokarma B., Kute T.E., Smitherman P.K., and Townsend A.J. Multi-drug resistance protein 1 (MRP1, ABCC1) mediates resistance to mitoxantrone via glutathione-dependent drug efflux. Mol Pharmacol 69 (2006) 1499-1505
-
(2006)
Mol Pharmacol
, vol.69
, pp. 1499-1505
-
-
Morrow, C.S.1
Peklak-Scott, C.2
Bishwokarma, B.3
Kute, T.E.4
Smitherman, P.K.5
Townsend, A.J.6
-
178
-
-
0021880217
-
Disposition of mitoxantrone in cancer patients
-
Alberts D.S., Peng Y.M., Leigh S., Davis T.P., and Woodward D.L. Disposition of mitoxantrone in cancer patients. Cancer Res 45 (1985) 1879-1884
-
(1985)
Cancer Res
, vol.45
, pp. 1879-1884
-
-
Alberts, D.S.1
Peng, Y.M.2
Leigh, S.3
Davis, T.P.4
Woodward, D.L.5
-
179
-
-
0025255167
-
Pharmacokinetics and metabolism of mitoxantrone. A review
-
Ehninger G., Schuler U., Proksch B., Zeller K.P., and Blanz J. Pharmacokinetics and metabolism of mitoxantrone. A review. Clin Pharmacokinet 18 (1990) 365-380
-
(1990)
Clin Pharmacokinet
, vol.18
, pp. 365-380
-
-
Ehninger, G.1
Schuler, U.2
Proksch, B.3
Zeller, K.P.4
Blanz, J.5
-
180
-
-
18444401419
-
Pharmacokinetic interactions of cyclosporin with etoposide and mitoxantrone in children with acute myelogenous leukemia
-
LaCayo N.J., Lum B., Becton D.L., Weinstein H., Ravindranath Y., Chang M.N., et al. Pharmacokinetic interactions of cyclosporin with etoposide and mitoxantrone in children with acute myelogenous leukemia. Leukemia 16 (2002) 920-927
-
(2002)
Leukemia
, vol.16
, pp. 920-927
-
-
LaCayo, N.J.1
Lum, B.2
Becton, D.L.3
Weinstein, H.4
Ravindranath, Y.5
Chang, M.N.6
-
181
-
-
0021883906
-
Mitoxantrone: an overview of safety and toxicity
-
Posner L.E., Dukart G., Goldberg J., Bernstein T., and Cartwright K. Mitoxantrone: an overview of safety and toxicity. Invest New Drugs 3 (1985) 123-132
-
(1985)
Invest New Drugs
, vol.3
, pp. 123-132
-
-
Posner, L.E.1
Dukart, G.2
Goldberg, J.3
Bernstein, T.4
Cartwright, K.5
-
182
-
-
0037167538
-
Cardiac adverse events associated with mitoxantrone therapy in patients with MS
-
Ghalie R.G., Edan G., Laurent M., Mauch E., Eiseman S., Hartung H.F., et al. Cardiac adverse events associated with mitoxantrone therapy in patients with MS. Neurology 59 (2002) 909-913
-
(2002)
Neurology
, vol.59
, pp. 909-913
-
-
Ghalie, R.G.1
Edan, G.2
Laurent, M.3
Mauch, E.4
Eiseman, S.5
Hartung, H.F.6
-
183
-
-
1542329054
-
Cummulative incidence and risk factors of mitoxantrone-induced cardiotoxicity in children: a systematic review
-
van Dalen E.C., van der Pal H., Bakker P.J., Caron H., and Kremer L.C. Cummulative incidence and risk factors of mitoxantrone-induced cardiotoxicity in children: a systematic review. Eur J Cancer 40 (2004) 643-652
-
(2004)
Eur J Cancer
, vol.40
, pp. 643-652
-
-
van Dalen, E.C.1
van der Pal, H.2
Bakker, P.J.3
Caron, H.4
Kremer, L.C.5
-
184
-
-
33846912251
-
Anthracyclines, mitoxantrone, radiotherapy and granulocyte colony-stimulating factor: risk factors for leukemia and myelodysplastic syndrome after breast cancer
-
Le Deley M.C., Suzan F., Cutulli B., Delaloge S., Shamsaldin A., Linassier C., et al. Anthracyclines, mitoxantrone, radiotherapy and granulocyte colony-stimulating factor: risk factors for leukemia and myelodysplastic syndrome after breast cancer. J Clin Oncol 25 (2007) 292-300
-
(2007)
J Clin Oncol
, vol.25
, pp. 292-300
-
-
Le Deley, M.C.1
Suzan, F.2
Cutulli, B.3
Delaloge, S.4
Shamsaldin, A.5
Linassier, C.6
-
185
-
-
0034079462
-
Secondary myelodysplastic syndrome/acute myeloid leukaemia following mitoxantrone-based therapy for breast carcinoma
-
Saso R., Kulkarni S., Mitchell P., Treleaven J., Swansbury G.J., Mehta J., et al. Secondary myelodysplastic syndrome/acute myeloid leukaemia following mitoxantrone-based therapy for breast carcinoma. Br J Cancer 83 (2000) 91-94
-
(2000)
Br J Cancer
, vol.83
, pp. 91-94
-
-
Saso, R.1
Kulkarni, S.2
Mitchell, P.3
Treleaven, J.4
Swansbury, G.J.5
Mehta, J.6
-
186
-
-
0036783808
-
A study of therapy-related acute leukaemia after mitoxantrone therapy for multiple sclerosis
-
Ghalie R.G., Mauch E., Edan G., Hartung H.P., Gonsette R.E., Eisenmann S., et al. A study of therapy-related acute leukaemia after mitoxantrone therapy for multiple sclerosis. Mult Sclerosis 8 (2002) 441-445
-
(2002)
Mult Sclerosis
, vol.8
, pp. 441-445
-
-
Ghalie, R.G.1
Mauch, E.2
Edan, G.3
Hartung, H.P.4
Gonsette, R.E.5
Eisenmann, S.6
-
187
-
-
0037868159
-
Therapy-related acute promyelocytic leukemia
-
Beaumont M., Sanz M., Carli P., Maloisel F., Thomas X., Detourmignies L., et al. Therapy-related acute promyelocytic leukemia. J Clin Oncol 21 (2003) 2123-2137
-
(2003)
J Clin Oncol
, vol.21
, pp. 2123-2137
-
-
Beaumont, M.1
Sanz, M.2
Carli, P.3
Maloisel, F.4
Thomas, X.5
Detourmignies, L.6
-
188
-
-
20144388623
-
DNA topoisomerase II in therapy-related acute promyelocytic leukemia
-
Mitstry A., Felix C., Whitmarsh B., Mason A., Reiter A., Cassinat B., et al. DNA topoisomerase II in therapy-related acute promyelocytic leukemia. N Engl J Med 352 (2005) 1529-1538
-
(2005)
N Engl J Med
, vol.352
, pp. 1529-1538
-
-
Mitstry, A.1
Felix, C.2
Whitmarsh, B.3
Mason, A.4
Reiter, A.5
Cassinat, B.6
-
189
-
-
0025786929
-
Randomized trial of doxorubicin, bisantrene, and mitoxantrone in advanced breast cancer: a Southwest Oncology Group study
-
Cowan J.D., Neidhart J., McClure S., Coltman C.A., Gumbart C., Martino S., et al. Randomized trial of doxorubicin, bisantrene, and mitoxantrone in advanced breast cancer: a Southwest Oncology Group study. J Natl Cancer Inst 83 (1991) 1077-1084
-
(1991)
J Natl Cancer Inst
, vol.83
, pp. 1077-1084
-
-
Cowan, J.D.1
Neidhart, J.2
McClure, S.3
Coltman, C.A.4
Gumbart, C.5
Martino, S.6
-
190
-
-
0036892524
-
Outcome after induction chemotherapy for older patients with acute myeloid leukemia is not improved with mitoxantrone and etoposide compared to cytarabine and daunorubicin: a Southwest Oncology Group study
-
Anderson J.E., Kopecky K.J., Willman C.L., Head D., O'Donnell M.R., Luthardt F.W., et al. Outcome after induction chemotherapy for older patients with acute myeloid leukemia is not improved with mitoxantrone and etoposide compared to cytarabine and daunorubicin: a Southwest Oncology Group study. Blood 100 (2002) 3869-3876
-
(2002)
Blood
, vol.100
, pp. 3869-3876
-
-
Anderson, J.E.1
Kopecky, K.J.2
Willman, C.L.3
Head, D.4
O'Donnell, M.R.5
Luthardt, F.W.6
-
191
-
-
0042386631
-
Mitoxantrone and cytarabine induction, high-dose cytarabine, and etoposide intensification for pediatric patients with relapsed or refractory acute myeloid leukemia: Children's Cancer Group Study 2951
-
Wells R.J., Adams M.T., Alonzo T.A., Arceci J., Buckley J., Buxton A.B., et al. Mitoxantrone and cytarabine induction, high-dose cytarabine, and etoposide intensification for pediatric patients with relapsed or refractory acute myeloid leukemia: Children's Cancer Group Study 2951. J Clin Oncol 21 (2003) 2940-2947
-
(2003)
J Clin Oncol
, vol.21
, pp. 2940-2947
-
-
Wells, R.J.1
Adams, M.T.2
Alonzo, T.A.3
Arceci, J.4
Buckley, J.5
Buxton, A.B.6
-
192
-
-
28444470149
-
Therapeutic role of mitoxantrone in multiple sclerosis
-
Neuhaus O., Kieseier B.C., and Hartung H.P. Therapeutic role of mitoxantrone in multiple sclerosis. Pharmacol Ther 109 (2006) 198-209
-
(2006)
Pharmacol Ther
, vol.109
, pp. 198-209
-
-
Neuhaus, O.1
Kieseier, B.C.2
Hartung, H.P.3
-
193
-
-
0034695444
-
A novel mechanism of cell killing by anti-topoisomerase II bisdioxopiperazines
-
Jensen L.H., Nitiss K.C., Rose A., Dong J., Zhou J., Hu T., et al. A novel mechanism of cell killing by anti-topoisomerase II bisdioxopiperazines. J Biol Chem 275 (2000) 2137-2146
-
(2000)
J Biol Chem
, vol.275
, pp. 2137-2146
-
-
Jensen, L.H.1
Nitiss, K.C.2
Rose, A.3
Dong, J.4
Zhou, J.5
Hu, T.6
-
194
-
-
0034664936
-
Novel triterpenoids inhibit both DNA polymerase and DNA topoisomerase
-
Mizushina Y., Iida A., Ohta K., Sugawara F., and Sakaguchi K. Novel triterpenoids inhibit both DNA polymerase and DNA topoisomerase. Biochem J 350 (2000) 757-763
-
(2000)
Biochem J
, vol.350
, pp. 757-763
-
-
Mizushina, Y.1
Iida, A.2
Ohta, K.3
Sugawara, F.4
Sakaguchi, K.5
-
195
-
-
0033899555
-
F 11782, a dual inhibitor of topoisomerases I and II with an original mechanism of action in vitro, and markedly superior in vivo antitumor activity, relative to three other dual topoisomerase inhibitors, intoplicin, aclarubicin and TAS-103
-
Etievant C., Kruczynski A., Barret J.M., Perrin D., van Hille B., Guminsky Y., et al. F 11782, a dual inhibitor of topoisomerases I and II with an original mechanism of action in vitro, and markedly superior in vivo antitumor activity, relative to three other dual topoisomerase inhibitors, intoplicin, aclarubicin and TAS-103. Cancer Chemother Pharmacol 46 (2000) 101-113
-
(2000)
Cancer Chemother Pharmacol
, vol.46
, pp. 101-113
-
-
Etievant, C.1
Kruczynski, A.2
Barret, J.M.3
Perrin, D.4
van Hille, B.5
Guminsky, Y.6
-
196
-
-
0035936547
-
DNA topoisomerase II as the target for the anticancer drug TOP-53: mechanistic basis for drug action
-
Byl J.A., Cline S.D., Utsugi T., Kobunai T., Yamada Y., Osheroff N., et al. DNA topoisomerase II as the target for the anticancer drug TOP-53: mechanistic basis for drug action. Biochemistry 40 (2001) 712-718
-
(2001)
Biochemistry
, vol.40
, pp. 712-718
-
-
Byl, J.A.1
Cline, S.D.2
Utsugi, T.3
Kobunai, T.4
Yamada, Y.5
Osheroff, N.6
-
197
-
-
0035300677
-
Phase 1 clinical and pharmacogenetic study of weekly TAS-103 in patient with advanced cancer
-
Ewesuedo R.B., Iyer L., Das S., Koenig A., Mani S., Vogelzang N.J., et al. Phase 1 clinical and pharmacogenetic study of weekly TAS-103 in patient with advanced cancer. J Clin Oncol 19 (2001) 2084-2090
-
(2001)
J Clin Oncol
, vol.19
, pp. 2084-2090
-
-
Ewesuedo, R.B.1
Iyer, L.2
Das, S.3
Koenig, A.4
Mani, S.5
Vogelzang, N.J.6
-
198
-
-
34247334648
-
Analogs of the marine alkaloid makaluvamines: synthesis topoisomerase II inhibition and anticancer activity
-
Shinkre B.A., Raisch K.P., Fan L., and Velu SE. Analogs of the marine alkaloid makaluvamines: synthesis topoisomerase II inhibition and anticancer activity. Bioorg Med Chem Lett 17 (2007) 2890-2893
-
(2007)
Bioorg Med Chem Lett
, vol.17
, pp. 2890-2893
-
-
Shinkre, B.A.1
Raisch, K.P.2
Fan, L.3
Velu SE4
-
199
-
-
34249317605
-
Bioflavonoids as poisons of human topoisomerase II alpha and II beta
-
Bandele O.J., and Osheroff N. Bioflavonoids as poisons of human topoisomerase II alpha and II beta. Biochemistry 46 (2007) 6097-6108
-
(2007)
Biochemistry
, vol.46
, pp. 6097-6108
-
-
Bandele, O.J.1
Osheroff, N.2
-
200
-
-
34249310604
-
Thanatop: a novel 5-nitrofuran that is a highly active, cell-permeable inhibitor of topoisomerase II
-
Polycarpou-Schwarz M., Muller K., Denger S., Riddell A., Gannon F., et al. Thanatop: a novel 5-nitrofuran that is a highly active, cell-permeable inhibitor of topoisomerase II. Cancer Res 67 (2007) 4451-4458
-
(2007)
Cancer Res
, vol.67
, pp. 4451-4458
-
-
Polycarpou-Schwarz, M.1
Muller, K.2
Denger, S.3
Riddell, A.4
Gannon, F.5
-
201
-
-
33845886112
-
A phase 1 trial of XK469: toxicity profile of a selective topoisomerase II beta inhibitor
-
Alousi A.M., Bionpally P., Wiegand R., Parchment R., Gadgeel S., Heilbrun L., et al. A phase 1 trial of XK469: toxicity profile of a selective topoisomerase II beta inhibitor. Invest New Drugs 25 (2007) 147-154
-
(2007)
Invest New Drugs
, vol.25
, pp. 147-154
-
-
Alousi, A.M.1
Bionpally, P.2
Wiegand, R.3
Parchment, R.4
Gadgeel, S.5
Heilbrun, L.6
-
202
-
-
33750033278
-
The HSP90 and DNA topoisomerase VI inhibitor radicol also inhibits type II DNA topoisomerase
-
Gadelle D., Graille M., and Forterre P. The HSP90 and DNA topoisomerase VI inhibitor radicol also inhibits type II DNA topoisomerase. Biochem Pharmacol 72 (2006) 1207-1216
-
(2006)
Biochem Pharmacol
, vol.72
, pp. 1207-1216
-
-
Gadelle, D.1
Graille, M.2
Forterre, P.3
-
203
-
-
0035266310
-
Pharmacological and toxicological aspects of 4-demethoxy-3-deamino-3-aziridinyl-4-methylsulphonyl-daunorubicin (PNU-159548): a novel antineoplastic agent
-
Geroni C., Ripamonti M., Arrigoni C., Fiorentini F., Capolongo L., Moneta D., et al. Pharmacological and toxicological aspects of 4-demethoxy-3-deamino-3-aziridinyl-4-methylsulphonyl-daunorubicin (PNU-159548): a novel antineoplastic agent. Cancer Res 61 (2001) 1983-1990
-
(2001)
Cancer Res
, vol.61
, pp. 1983-1990
-
-
Geroni, C.1
Ripamonti, M.2
Arrigoni, C.3
Fiorentini, F.4
Capolongo, L.5
Moneta, D.6
-
204
-
-
34248578176
-
Ethonafide-induced cytotoxicity is mediated by topoisomerase II inhibition in prostate cancer cells
-
Pupa A., Landowshi T.H., and Dorr R.T. Ethonafide-induced cytotoxicity is mediated by topoisomerase II inhibition in prostate cancer cells. J Pharmacol Exp Ther 321 (2007) 1109-1117
-
(2007)
J Pharmacol Exp Ther
, vol.321
, pp. 1109-1117
-
-
Pupa, A.1
Landowshi, T.H.2
Dorr, R.T.3
-
205
-
-
33745511197
-
Pharmacokinetics of amrubicin and its active metabolite amrubicinol in lung cancer patients
-
Yusuke M., Hamada A., Okamoto I., Sasaki J., Moriyama E., Kishi H., et al. Pharmacokinetics of amrubicin and its active metabolite amrubicinol in lung cancer patients. Ther Drug Monit 28 (2006) 76-82
-
(2006)
Ther Drug Monit
, vol.28
, pp. 76-82
-
-
Yusuke, M.1
Hamada, A.2
Okamoto, I.3
Sasaki, J.4
Moriyama, E.5
Kishi, H.6
|