A novel mechanism of cell killing by anti-topoisomerase II bisdioxopiperazines

Journal of Biological Chemistry

Volumn 275, Issue 3, 2000, Pages 2137-2146

  Jensen, Lars H ^a,b   Nitiss, Karin C ^a   Rose, Angela ^a   Dong, Jiaowang ^a   Zhou, Junfang ^a   Hu, Tao ^c   Osheroff, Neil ^d   Jensen, Peter B ^b   Sehested, Maxwell ^b   Nitiss, John L ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b Rigshospitalet   (Denmark)

^c DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,3 BIS(3,5 DIOXO 1 PIPERAZINYL)BUTANE; CELL DNA; DNA TOPOISOMERASE (ATP HYDROLYSING); ETOPOSIDE; RAZOXANE;

ARTICLE; CELL GROWTH; CELL KILLING; CONTROLLED STUDY; DNA CLEAVAGE; DNA TRANSCRIPTION; DRUG MECHANISM; ENZYME INHIBITION; GROWTH INHIBITION; PRIORITY JOURNAL; PROTEIN EXPRESSION; YEAST CELL;

ALLELES; ANTINEOPLASTIC AGENTS; CELL CYCLE; DNA TOPOISOMERASES, TYPE II; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, MICROBIAL; ENZYME INHIBITORS; GENES, DOMINANT; HUMANS; MICROBIAL SENSITIVITY TESTS; MUTAGENESIS; PIPERAZINES; PROTEIN CONFORMATION; RAZOXANE; SACCHAROMYCES CEREVISIAE; TIME FACTORS; ULTRACENTRIFUGATION;

STAPHYLOCOCCUS PHAGE 187;

EID: 0034695444     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.275.3.2137     Document Type: Article

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