메뉴 건너뛰기




Volumn 29, Issue 4, 2008, Pages 531-537

Cytokine-induced epithelial permeability changes are regulated by the activation of the p38 mitogen-activated protein kinase pathway in cultured caco-2 cells

Author keywords

Caco 2 cells; Cytokine; ERK; JNK; NO; p38 MAPK; Permeability

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 4 (4 FLUOROPHENYL) 2 (4 NITROPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; HEAT SHOCK PROTEIN 27; INTERLEUKIN 6; INTERLEUKIN 8; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA;

EID: 40949086461     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/SHK.0b013e318150737f     Document Type: Article
Times cited : (38)

References (37)
  • 1
    • 0029983730 scopus 로고    scopus 로고
    • The p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis response to tumor necrosis factor
    • Beyaert R, Cuenda A, Vanden Berghe W, Plaisance S, Lee JC, Haegeman G, Cohen P, Fiers W: The p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis response to tumor necrosis factor. EMBO J 15:1914-1923, 1996.
    • (1996) EMBO J , vol.15 , pp. 1914-1923
    • Beyaert, R.1    Cuenda, A.2    Vanden Berghe, W.3    Plaisance, S.4    Lee, J.C.5    Haegeman, G.6    Cohen, P.7    Fiers, W.8
  • 2
    • 0043095361 scopus 로고    scopus 로고
    • Intracellular IL-1Ra type 1 inhibits IL-1-induced IL-6 and IL-8 production in Caco-2 intestinal epithelial cells through inhibition of p38 mitogen-activated protein kinase and NF-kappaB pathways
    • Garat C, Arend WP: Intracellular IL-1Ra type 1 inhibits IL-1-induced IL-6 and IL-8 production in Caco-2 intestinal epithelial cells through inhibition of p38 mitogen-activated protein kinase and NF-kappaB pathways. Cytokine 23:31-40, 2003.
    • (2003) Cytokine , vol.23 , pp. 31-40
    • Garat, C.1    Arend, W.P.2
  • 3
    • 0034657917 scopus 로고    scopus 로고
    • Modulation of STAT signaling by STAT-interacting proteins
    • Shuai K: Modulation of STAT signaling by STAT-interacting proteins. Oncogene 19:2638-2644, 2000.
    • (2000) Oncogene , vol.19 , pp. 2638-2644
    • Shuai, K.1
  • 4
    • 0029742102 scopus 로고    scopus 로고
    • Enhancement of antiproliferative activity of gamma interferon by the specific inhibition of tyrosine dephosphorylation of Stat1
    • Shuai K, Liao J, Song MM: Enhancement of antiproliferative activity of gamma interferon by the specific inhibition of tyrosine dephosphorylation of Stat1. Mol Cell Biol 16:4932-4941, 1996.
    • (1996) Mol Cell Biol , vol.16 , pp. 4932-4941
    • Shuai, K.1    Liao, J.2    Song, M.M.3
  • 5
    • 0033569905 scopus 로고    scopus 로고
    • p38 MAP kinase is required for STAT1 serine phosphorylation and transcriptional activation induced by interferons
    • Goh KC, Haque SJ, Williams BR: p38 MAP kinase is required for STAT1 serine phosphorylation and transcriptional activation induced by interferons. EMBO J 18:5601-5608, 1999.
    • (1999) EMBO J , vol.18 , pp. 5601-5608
    • Goh, K.C.1    Haque, S.J.2    Williams, B.R.3
  • 6
    • 0027245531 scopus 로고
    • IFN-gamma modulation of epithelial barrier function. Time course, reversibility, and site of cytokine binding
    • Adams RB, Planchon SM, Roche JK: IFN-gamma modulation of epithelial barrier function. Time course, reversibility, and site of cytokine binding. J Immunol 150:2356-2363, 1993.
    • (1993) J Immunol , vol.150 , pp. 2356-2363
    • Adams, R.B.1    Planchon, S.M.2    Roche, J.K.3
  • 7
    • 0024553788 scopus 로고
    • Interferon-gamma directly affects barrier function of cultured intestinal epithelial monolayers
    • Madara JL, Stafford J: Interferon-gamma directly affects barrier function of cultured intestinal epithelial monolayers. J Clin Invest 83:724-727, 1989.
    • (1989) J Clin Invest , vol.83 , pp. 724-727
    • Madara, J.L.1    Stafford, J.2
  • 8
    • 0036320133 scopus 로고    scopus 로고
    • Interferon-gamma expression by intraepithelial lymphocytes results in a loss of epithelial barrier function in a mouse model of total parenteral nutrition
    • Yang H, Kiristioglu I, Fan Y, Forbush B, Bishop DK, Antony PA, Zhou H, Teitelbaum DH: Interferon-gamma expression by intraepithelial lymphocytes results in a loss of epithelial barrier function in a mouse model of total parenteral nutrition. Ann Surg 236:226-234, 2002.
    • (2002) Ann Surg , vol.236 , pp. 226-234
    • Yang, H.1    Kiristioglu, I.2    Fan, Y.3    Forbush, B.4    Bishop, D.K.5    Antony, P.A.6    Zhou, H.7    Teitelbaum, D.H.8
  • 9
    • 0034526788 scopus 로고    scopus 로고
    • Epithelial barrier defects in HT-29/B6 colonic cell monolayers induced by tumor necrosis factor-alpha
    • Gitter AH, Bendfeldt K, Schmitz H, Schulzke JD, Bentzel CJ, Fromm M: Epithelial barrier defects in HT-29/B6 colonic cell monolayers induced by tumor necrosis factor-alpha. Ann N Y Acad Sci 915:193-203, 2000.
    • (2000) Ann N Y Acad Sci , vol.915 , pp. 193-203
    • Gitter, A.H.1    Bendfeldt, K.2    Schmitz, H.3    Schulzke, J.D.4    Bentzel, C.J.5    Fromm, M.6
  • 11
    • 0032734162 scopus 로고    scopus 로고
    • Cytokine-induced intestinal epithelial hyperpermeability: Role of nitric oxide
    • Chavez AM, Menconi MJ, Hodin RA, Fink MP: Cytokine-induced intestinal epithelial hyperpermeability: role of nitric oxide. Crit Care Med 27:2246-2251, 1999.
    • (1999) Crit Care Med , vol.27 , pp. 2246-2251
    • Chavez, A.M.1    Menconi, M.J.2    Hodin, R.A.3    Fink, M.P.4
  • 12
    • 0141957168 scopus 로고    scopus 로고
    • Proinflammatory cytokines cause NO*-dependent and-independent changes in expression and localization of tight junction proteins in intestinal epithelial cells
    • Han X, Fink MP, Delude RL: Proinflammatory cytokines cause NO*-dependent and-independent changes in expression and localization of tight junction proteins in intestinal epithelial cells. Shock 19:229-237, 2003.
    • (2003) Shock , vol.19 , pp. 229-237
    • Han, X.1    Fink, M.P.2    Delude, R.L.3
  • 14
    • 33846224224 scopus 로고    scopus 로고
    • Heat shock stress ameliorates cytokine mixture-induced permeability by downregulating the nitric oxide and signal transducer and activator of transcription pathways in Caco-2 cells
    • Wang Q, Guo XL, Noel G, Ogle C: Heat shock stress ameliorates cytokine mixture-induced permeability by downregulating the nitric oxide and signal transducer and activator of transcription pathways in Caco-2 cells. Shock 27:179-185, 2007.
    • (2007) Shock , vol.27 , pp. 179-185
    • Wang, Q.1    Guo, X.L.2    Noel, G.3    Ogle, C.4
  • 15
    • 0034203857 scopus 로고    scopus 로고
    • Interleukin-6 signal transduction in human intestinal epithelial cells
    • Pratt SL, Ogle CK, Mao JX, Zhao W, Lovell G, Horseman ND: Interleukin-6 signal transduction in human intestinal epithelial cells. Shock 13:435-440, 2000.
    • (2000) Shock , vol.13 , pp. 435-440
    • Pratt, S.L.1    Ogle, C.K.2    Mao, J.X.3    Zhao, W.4    Lovell, G.5    Horseman, N.D.6
  • 16
    • 0028784101 scopus 로고
    • Assessment of inflammatory events in epithelial permeability: A rapid screening method using fluorescein dextrans
    • Sanders SE, Madara JL, McGuirk DK, Gelman DS, Colgan SP: Assessment of inflammatory events in epithelial permeability: a rapid screening method using fluorescein dextrans. Epithelial Cell Biol 4:25-34, 1995.
    • (1995) Epithelial Cell Biol , vol.4 , pp. 25-34
    • Sanders, S.E.1    Madara, J.L.2    McGuirk, D.K.3    Gelman, D.S.4    Colgan, S.P.5
  • 17
    • 0034830633 scopus 로고    scopus 로고
    • Intestinal permeability is reduced and IL-10 levels are increased in septic IL-6 knockout mice
    • Wang Q, Fang CH, Hasselgren PO: Intestinal permeability is reduced and IL-10 levels are increased in septic IL-6 knockout mice. Am J Physiol Regul Integr Comp Physiol 281:R1013-R1023, 2001.
    • (2001) Am J Physiol Regul Integr Comp Physiol , vol.281
    • Wang, Q.1    Fang, C.H.2    Hasselgren, P.O.3
  • 18
    • 0035066383 scopus 로고    scopus 로고
    • Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation
    • Kyriakis JM, Avruch J: Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol Rev 81:807-869, 2001.
    • (2001) Physiol Rev , vol.81 , pp. 807-869
    • Kyriakis, J.M.1    Avruch, J.2
  • 19
    • 3342918498 scopus 로고    scopus 로고
    • The p38 MAP kinase pathway as a therapeutic target in inflammatory disease
    • Saklatvala J: The p38 MAP kinase pathway as a therapeutic target in inflammatory disease. Curr Opin Pharmacol 4:372-377, 2004.
    • (2004) Curr Opin Pharmacol , vol.4 , pp. 372-377
    • Saklatvala, J.1
  • 21
    • 0033111732 scopus 로고    scopus 로고
    • Both Erk and p38 kinases are necessary for cytokine gene transcription
    • Carter AB, Monick MM, Hunninghake GW: Both Erk and p38 kinases are necessary for cytokine gene transcription. Am J Respir Cell Mol Biol 20:751-758, 1999.
    • (1999) Am J Respir Cell Mol Biol , vol.20 , pp. 751-758
    • Carter, A.B.1    Monick, M.M.2    Hunninghake, G.W.3
  • 22
    • 0038482175 scopus 로고    scopus 로고
    • Involvement of p38 MAPK, JNK, p42/p44 ERK and NF-kappaB in IL-1beta-induced chemokine release in human airway smooth muscle cells
    • Wuyts WA, Vanaudenaerde BM, Dupont LJ, Demedts MG, Verleden GM: Involvement of p38 MAPK, JNK, p42/p44 ERK and NF-kappaB in IL-1beta-induced chemokine release in human airway smooth muscle cells. Respir Med 97:811-817, 2003.
    • (2003) Respir Med , vol.97 , pp. 811-817
    • Wuyts, W.A.1    Vanaudenaerde, B.M.2    Dupont, L.J.3    Demedts, M.G.4    Verleden, G.M.5
  • 23
    • 0035986591 scopus 로고    scopus 로고
    • Inhibition of the p38 pathway upregulates macrophage JNK and ERK activities, and the ERK, JNK, and p38 MAP kinase pathways are reprogrammed during differentiation of the murine myeloid M1 cell line
    • Hall JP, Davis RJ: Inhibition of the p38 pathway upregulates macrophage JNK and ERK activities, and the ERK, JNK, and p38 MAP kinase pathways are reprogrammed during differentiation of the murine myeloid M1 cell line. J Cell Biochem 86:1-11, 2002.
    • (2002) J Cell Biochem , vol.86 , pp. 1-11
    • Hall, J.P.1    Davis, R.J.2
  • 24
    • 0033987112 scopus 로고    scopus 로고
    • The role of p38 mitogen-activated protein kinase in IL-6 and IL-8 production from the TNF-alpha-or IL-1beta-stimulated rheumatoid synovial fibroblasts
    • Suzuki M, Tetsuka T, Yoshida S, Watanabe N, Kobayashi M, Matsui N, Okamoto T: The role of p38 mitogen-activated protein kinase in IL-6 and IL-8 production from the TNF-alpha-or IL-1beta-stimulated rheumatoid synovial fibroblasts. FEBS Lett 465:23-27, 2000.
    • (2000) FEBS Lett , vol.465 , pp. 23-27
    • Suzuki, M.1    Tetsuka, T.2    Yoshida, S.3    Watanabe, N.4    Kobayashi, M.5    Matsui, N.6    Okamoto, T.7
  • 26
    • 0033030207 scopus 로고    scopus 로고
    • p38 mitogen-activated protein kinase inhibitors-mechanisms and therapeutic potentials
    • Lee JC, Kassis S, Kumar S, Badger A, Adams JL: p38 mitogen-activated protein kinase inhibitors-mechanisms and therapeutic potentials. Pharmacol Ther 82:389-397, 1999.
    • (1999) Pharmacol Ther , vol.82 , pp. 389-397
    • Lee, J.C.1    Kassis, S.2    Kumar, S.3    Badger, A.4    Adams, J.L.5
  • 27
    • 0032578559 scopus 로고    scopus 로고
    • The activation state of p38 mitogen-activated protein kinase determines the efficiency of ATP competition for pyridinylimidazole inhibitor binding
    • Frantz B, Klatt T, Pang M, Parsons J, Rolando A, Williams H, Tocci MJ, O'Keefe SJ, O'Neill EA: The activation state of p38 mitogen-activated protein kinase determines the efficiency of ATP competition for pyridinylimidazole inhibitor binding. Biochemistry 37:13846-13853, 1998.
    • (1998) Biochemistry , vol.37 , pp. 13846-13853
    • Frantz, B.1    Klatt, T.2    Pang, M.3    Parsons, J.4    Rolando, A.5    Williams, H.6    Tocci, M.J.7    O'Keefe, S.J.8    O'Neill, E.A.9
  • 28
    • 0034816062 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase p38 controls the expression and posttranslational modification of tristetraprolin, a regulator of tumor necrosis factor alpha mRNA stability
    • Mahtani KR, Brook M, Dean JL, Sully G, Saklatvala J, Clark AR: Mitogen-activated protein kinase p38 controls the expression and posttranslational modification of tristetraprolin, a regulator of tumor necrosis factor alpha mRNA stability. Mol Cell Biol 21:6461-6469, 2001.
    • (2001) Mol Cell Biol , vol.21 , pp. 6461-6469
    • Mahtani, K.R.1    Brook, M.2    Dean, J.L.3    Sully, G.4    Saklatvala, J.5    Clark, A.R.6
  • 29
    • 0037255931 scopus 로고    scopus 로고
    • Inhibitors of p38 mitogen-activated protein kinase: Potential as anti-inflammatory agents in asthma?
    • Newton R, Holden N: Inhibitors of p38 mitogen-activated protein kinase: potential as anti-inflammatory agents in asthma? BioDrugs 17:113-129, 2003.
    • (2003) BioDrugs , vol.17 , pp. 113-129
    • Newton, R.1    Holden, N.2
  • 30
    • 0035229054 scopus 로고    scopus 로고
    • Evolution of an immune suppressive macrophage phenotype as a product of P38 MAPK activation in polymicrobial sepsis
    • Song GY, Chung CS, Jarrar D, Chaudry IH, Ayala A: Evolution of an immune suppressive macrophage phenotype as a product of P38 MAPK activation in polymicrobial sepsis. Shock 15:42-48, 2001.
    • (2001) Shock , vol.15 , pp. 42-48
    • Song, G.Y.1    Chung, C.S.2    Jarrar, D.3    Chaudry, I.H.4    Ayala, A.5
  • 31
    • 0034889851 scopus 로고    scopus 로고
    • MAPK p38 antagonism as a novel method of inhibiting lymphoid immune suppression in polymicrobial sepsis
    • Song GY, Chung CS, Chaudry IH, Ayala A: MAPK p38 antagonism as a novel method of inhibiting lymphoid immune suppression in polymicrobial sepsis. Am J Physiol Cell Physiol 281:C662-C669, 2001.
    • (2001) Am J Physiol Cell Physiol , vol.281
    • Song, G.Y.1    Chung, C.S.2    Chaudry, I.H.3    Ayala, A.4
  • 32
    • 0030426902 scopus 로고    scopus 로고
    • Pharmacological profile of SB 203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function
    • Badger AM, Bradbeer JN, Votta B, Lee JC, Adams JL, Griswold DE: Pharmacological profile of SB 203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function. J Pharmacol Exp Ther 279:1453-1461, 1996.
    • (1996) J Pharmacol Exp Ther , vol.279 , pp. 1453-1461
    • Badger, A.M.1    Bradbeer, J.N.2    Votta, B.3    Lee, J.C.4    Adams, J.L.5    Griswold, D.E.6
  • 33
    • 0037394607 scopus 로고    scopus 로고
    • The p38 mitogen-activated protein kinase regulates interleukin-1beta-induced IL-8 expression via an effect on the IL-8 promoter in intestinal epithelial cells
    • Parhar K, Ray A, Steinbrecher U, Nelson C, Salh B: The p38 mitogen-activated protein kinase regulates interleukin-1beta-induced IL-8 expression via an effect on the IL-8 promoter in intestinal epithelial cells. Immunology 108:502-512, 2003.
    • (2003) Immunology , vol.108 , pp. 502-512
    • Parhar, K.1    Ray, A.2    Steinbrecher, U.3    Nelson, C.4    Salh, B.5
  • 34
    • 0032900218 scopus 로고    scopus 로고
    • Cytokine induction of inducible nitric oxide synthase in an oligodendrocyte cell line: Role of p38 mitogen-activated protein kinase activation
    • Bhat NR, Zhang P, Bhat AN: Cytokine induction of inducible nitric oxide synthase in an oligodendrocyte cell line: role of p38 mitogen-activated protein kinase activation. J Neurochem 72:472-478, 1999.
    • (1999) J Neurochem , vol.72 , pp. 472-478
    • Bhat, N.R.1    Zhang, P.2    Bhat, A.N.3
  • 35
    • 0038054073 scopus 로고    scopus 로고
    • Signalling pathways regulating inducible nitric oxide synthase expression in human kidney epithelial cells
    • Poljakovic M, Nygren JM, Persson K: Signalling pathways regulating inducible nitric oxide synthase expression in human kidney epithelial cells. Eur J Pharmacol 469:21-28, 2003.
    • (2003) Eur J Pharmacol , vol.469 , pp. 21-28
    • Poljakovic, M.1    Nygren, J.M.2    Persson, K.3
  • 36
    • 0026782385 scopus 로고
    • IL-6 increases endothelial permeability in vitro
    • Maruo N, Morita I, Shirao M, Murota S: IL-6 increases endothelial permeability in vitro. Endocrinology 131:710-714, 1992.
    • (1992) Endocrinology , vol.131 , pp. 710-714
    • Maruo, N.1    Morita, I.2    Shirao, M.3    Murota, S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.