Penetration of dexamethasone into brain glucocorticoid targets is enhanced in mdr1A P-glycoprotein knockout mice

Endocrinology

Volumn 139, Issue 4, 1998, Pages 1789-1793

  Meijer, O C ^a   De Lange, E C M ^a   Breimer, D D ^a   De Boer, A G ^a   Workel, J O ^a   De Kloet, E R ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOTROPIN; DEXAMETHASONE; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; GLYCOPROTEIN P; MESSENGER RNA; TRITIUM;

ADRENALECTOMY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BLOOD BRAIN BARRIER; BRAIN; CELL NUCLEUS; CEREBELLUM; CONTROLLED STUDY; DRUG PENETRATION; DRUG TRANSPORT; DRUG UPTAKE; HIPPOCAMPUS; IMAGE ANALYSIS; IN SITU HYBRIDIZATION; LIVER; MOUSE; NONHUMAN; PRIORITY JOURNAL; SUBCUTANEOUS DRUG ADMINISTRATION; THALAMUS MIDLINE NUCLEUS;

EID: 0031732606     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.139.4.5917     Document Type: Article

References (35)

1. McEwen BS, De Kloet ER, Rostène WH 1986 Adrenal steroid receptors and actions in the nervous system. Physiol Rev 66:1121-1188
2. Joëls M, De Kloet ER 1989 Effects of glucocorticoids and norepinephrine on the excitability in hippocampus. Science 245:1503-1505
3. De Kloet ER, Joëls M 1996 Corticosteroid hormones in neuroprotection and brain damage. Curr Opin Endocrinol Diabet 3:184-192
4. Sapolsky RM 1996 Stress, Glucocorticoids and damage to the nervous system: the current state of confusion. Stress 1:1-21
5. McEwen BS, Weiss JM, Schwartz LS 1968 Selective retention of corticosterone by limbic structures in rat brain. Nature 220:911-912
6. Gerlach JL, McEwen BS 1972 Rat brain binds adrenal steroid hormone: radioautography of hippocampus. Science 175:1133-1136
7. Stumpf WE, Heiss C, Sar M, Duncan GE, Craver CE 1989 Dexamethasone and corticosterone receptor sites: differential topographic distributions in rat hippocampus revealed by high resolution autoradiography. Histochemistry 92:201-210
8. Reul JMHM, De Kloet ER 1985 Two receptor systems for corticosterone in rat brain: microdistribution and differential occupation. Endocrinology 117:2505-2511
9. Veldhuis HD, Van Koppen C, Van Ittersum M, De Kloet ER 1982 Specificity of the adrenal steroid receptor system in rat hippocampus. Endocrinology 110:2044-2049
10. Krozowski Z, Funder JW 1983 Renal mineralocorticoid receptors and hippocampal corticosterone binding species have intrinsic steroid steroid specificity. Proc Natl Acad Sci USA 80:6056-6060
11. Van Steensel B, Van Binnendijk EP, Hornsby CD, Van der Voort HTM, Krozowski ZS, De Kloet ER, Van Driel R 1996 Partial colocalization of glucocorticoid and mineralocorticoid receptors in discrete compartments in nuclei of rat hippocampus neurons. J Cell Science 109:787-792
12. De Kloet ER, Wallach G, McEwen BS 1975 Differences in corticosterone and dexamethasone binding to rat brain and pituitary. Endocrinology 96:598-609
13. 3H]-dexamethasone uptake by immunocytochemically characterized cells of the rat anterior pituitary. Cell Tissue Res 182:347-356
14. Birmingham MK, Sar M, Stumpf W 1993 Dexamethasone target sites in the central nervous system and their potential relevance to mental illness. Cell Mol Neurobiol 13:373-386
15. Bohus B, De Kloet ER, Veldhuis HD 1982 Adrenal steroids and behavioural adaptation: relationship to brain corticosteroid receptors In: Ganten D, Pfaff DW (eds) Adrenal Actions on the Brain, Springer Verlag, NY, 108-148
16. Schinkel AH, Smit JJM, Van Tellingen O, Beijnen JH, Wagenaar E, Van Deemter L, Mol CAAM, Van der Valk MA, Robanus-Maandag EC, Te Riele HPJ, Berns AJM, Borst P 1994 Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs. Cell 77:491-502
17. Schinkel AH, Wagenaar E, Van Deemter L, Mol CAAM, Borst P 1995 Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A. J Clin Invest 96:1698-1705
18. Cordon-Cardo C, O'Brien JP, Casals D, Rittman-Grauer L, Biedler JL, Melamed JL, Bertino JL 1989 Multidrug resistance gene (P-glycoprotein) is expressed by endothelial cells at blood brain barrier sites. Proc Natl Acad Science USA 86:695-698
19. Reul JMHM, De Kloet ER 1986 Anatomical resolution of two types of corticosterone receptors with in vitro autoradiography and computerized image analysis. J Steroid Biochem 24:269-272
20. McEwen BS, De Kloet ER, Wallach G 1976 Interaction in vivo and in vitro of corticoids and progesterone with cell nuclei and soluble macromolecules from rat brain regions and pituitary. Brain Res 105:129-136
21. Mezey E, Palkovits M 1982 Meningeal relation of the rat hypothalamo-hypophyseal extravascular spaces in and around the median eminence. Brain Res 250:25-30
22. De Kloet ER, Van der Vies J, De Wied D 1974 The site of the suppressive action of dexamethasone on pituitary-adrenal activity. Endocrinology 94:61-73
23. De Kloet ER 1991 Brain corticosteroid receptor balance and homeostatic control. Front Neuroendocrinol 12:95-164
24. Hornsby CD, Grootendorst J, De Kloet ER 1996 Dexamethasone does not prevent seven day ADX-induced apoptosis in the dentate gyrus of the rat hippocampus. Stress 1:51-64
25. Hassan AH, Von Rosenstiel P, Patchev VK, Holsboer F, Almeida OF 1996 Exacerbation of apoptosis in the dentate gyrus of the aged rat by dexamethasone and the protective role of corticosterone. Exp Neurol 140:43-52
26. Sloviter RS, Dean E, Neubort S 1993 Electronmicroscopic analysis of adrenalectomy-induced hippocampal granule cell degeneration in the rat: apoptosis in the adult central nervous system. J Comp Neurol 330:324-336
27. McEwen BS, Gould E 1990 Adrenal steroid influences on the survival of hippocampal neurons. Biochem Pharm 40:2393-2402
28. Devault A, Gros P 1990 Two members of the mouse mdr gene family confer overlapping but distinct drug specificities. Mol Cell Biol 10:252-263
29. Holsboer F, Von Bardeleben U, Wiedemann K, Müller OA, Stalla GK 1987 Serial assessment of corticotropin releasing hormone response after dexamethasone in depression: implication for pathophysiology of DST non-suppression. Biol Psych 22:228-234
30. Holsboer F, Barden N 1996 Antidepressants and hypothalamic-pituitary-adrenocortical regulation. Endocr Rev 17:187-205
31. Van Haarst AD, Oitzl MS, Workel JO, De Kloet ER 1996 Chronic brain glucocorticoid receptor blockade enhances the rise in circadian and stress-induced rise in pituitary-adrenal activity. Endocrinology 137:4935-4943
32. De Kloet ER, Vreugdenhil E, Oitzl MS, Joëls M 1997 Glucocorticoid feedback resistance. Trends Endocrinol Metab 8:26-33
33. Croop JM, Raymond M, Haber D, Devault A, Arceci J, Gros P, Housman DE 1989 The three mouse multidrug resistance (mdr) genes are expressed in a tissue specific manner in normal mouse tissue. Mol Cell Biol 9:1346-1350
34. Bourgeois S, Gruol DJ, Newby RF, Rajah FM 1993 Expression of an mdr gene is associated with a new form of resistance to dexamethasone-induced apoptosis. Mol Endocrinol 7:840-851
35. Kralli A, Bohen SP, Yamamoto KR 1995 LEM1, an ATP-binding-cassette transporter, selectively modulates the biological potency of steroid hormones. Proc Natl Acad Sci USA 92:4701-4705