Dexamethasone and triamcinolone acetonide accumulation in mouse fibroblasts is differently modulated by the immunosuppressants cyclosporin A, FK506, rapamycin and their analogues, as well as by other P-glycoprotein ligands

Journal of Steroid Biochemistry and Molecular Biology

Volumn 66, Issue 1-2, 1998, Pages 11-25

  Marsaud, Véronique ^a   Mercier Bodard, Christine ^c   Fortin, Dominique ^b   Le Bihan, Stéphane ^b   Renoir, Jack Michel ^a  

^a UNIVERSITÉ PARIS SACLAY   (France)

^b INSERM   (France)

^c IFR 21   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGESTAGEN; CHLORAMPHENICOL ACETYLTRANSFERASE; CYCLOSPORIN A; CYCLOSPORIN H; DEXAMETHASONE; GLUCOCORTICOID ANTAGONIST; GLUCOCORTICOID RECEPTOR; GLYCOPROTEIN P; IMMUNOSUPPRESSIVE AGENT; L 685818; LIGAND; MIFEPRISTONE; RAPAMYCIN; RU 49 953; TACROLIMUS; TRIAMCINOLONE ACETONIDE; TRITIUM; UNCLASSIFIED DRUG; VALSPODAR; VERAPAMIL; VINBLASTINE; VINCA ALKALOID; VINCRISTINE;

ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACCUMULATION; FIBROBLAST; MOUSE; MOUSE MAMMARY TUMOR ONCOVIRUS; NONHUMAN; PROMOTER REGION; REPORTER GENE;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE; CYCLOSPORINE; DEXAMETHASONE; GENE EXPRESSION REGULATION; GENES, REPORTER; GLUCOCORTICOIDS; IMMUNOSUPPRESSIVE AGENTS; MICE; P-GLYCOPROTEIN; POLYENES; RECEPTORS, GLUCOCORTICOID; SIROLIMUS; STEROIDS; TACROLIMUS; TRANSFECTION; TRIAMCINOLONE ACETONIDE; VINCA ALKALOIDS;

ANIMALIA; MAMMARY TUMOR ONCOVIRUS; MAMMARY TUMOR VIRUS; MOUSE MAMMARY TUMOR VIRUS; ONCOVIRINAE; TRITIUM; TUMOR VIRUS; VINCA;

EID: 0032125633     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-0760(98)00008-9     Document Type: Article

References (58)

1. 1. Pratt W. B. and Toft D. O., Steroid receptor interactions with heat shock protein and immunophilin chaperones. Endocr. Rev. 18 (1997) 306-360.
2. 2. Tai P. K. K., Maeda Y., Nakao K., Wakim N. G., Duhring J. L. and Faber L. E., A 59-kilodalton protein associated with progestin, estrogen, androgen and glucocorticoid-receptor. Biochemistry 25 (1985) 5269-5275.
3. 3. Tai P. K. K., Albers M. N., Chang H., Faber L. E. and Schreiber S. L., Association of a 59-kilodalton immunophilin with the glucocorticoid receptor complex. Science 256 (1992) 1315-1318.
4. 4. Yem A. W., Tomasselli A. G., Heinrikson R. L., Zurcher-Neely H., Ruff V. A., Johnson R. A. and Deibel M. R., The hsp56 component of steroid receptor complexes bind to immobilized FK506 and shows homology to FKBP12 and FKBP13. J. Biol. Chem. 267 (1992) 2868-2871.
5. 5. Lebeau M. C., Massol N., Herrick J., Faber L. E., Renoir J. M., Radanyi C. and Baulieu E. E., P59, an hsp 90-binding protein. Cloning and sequencing of its cDNA and preparation of a peptide-directed polyclonal antibody. J. Biol. Chem. 267 (1992) 4281-4284.
6. 6. Renoir J. M., Le Bihan S., Mercier-Bodard C., Gold A., Arjomandi M., Radanyi C. and Baulieu E. E., Effects of immunosuppressants FK506 and rapamycin on the heterooligomeric form of the progesterone receptor. J. Steroid Biochem. Mol. Biol. 48 (1994) 101-110.
7. 7. Peattie D. A., Harding M. W., Fleming M. A., De Cenzo M. T., Lippke J. A., Livingston D. J. and Benasutti M., Expression and characterization of human FKBP52, an immunophilin that associates with the 90 kDa heat shock protein and is a component of steroid receptor complexes. Proc. Natl. Acad. Sci. U.S.A. 89 (1992) 10974-10978.
8. 8. Kieffer L. J., Seng T. W., Li W., Osterman D. G., Handschumacher R. E. and Bayney R. M., Cyclophilin 40, a protein with homology to the p59 component of the steroid receptor complex. Cloning of the cDNA and further characterization. J. Biol. Chem. 268 (1993) 12303-12310.
9. 9. Ratajczak T., Carello A., Mark P. J., Warner B. J., Simpson R. J., Moritz R. L. and House A. K., The cyclophilin component of the unactivated estrogen receptor contains a tetratricopeptide repeat domain and shares identity with p59 (FKBP59). J. Biol. Chem. 268 (1993) 13187-13192.
10. 10. Ning Y. M. and Sanchez E. R., Potentiation of glucocorticoid-mediated gene expression by the immunophilin ligands FK506 and rapamycin. J. Biol. Chem. 268 (1993) 6073-6076.
11. 11. Renoir J. M., Mercier-Bodard C., Hoffmann K., Le Bihan S., Ning Y. M., Sanchez E. R., Handschumacher R. E. and Baulieu E. E., Cyclosporin A potentiates the dexamethasone-induced mouse mammary tumor virus-chloramphenicol acetyltransferase activity in LMCAT cells: A possible role for different heat shock protein-binding immunophilins in glucocorticosteroid receptor-mediated gene expression. Proc. Natl. Acad. Sci. U.S.A. 92 (1995) 4977-4981.
12. 12. Tai P. K. K., Albers M. W., McDonnell D. P., Chang H., Schreiber S. L. and Faber L. E., Potentiation of progesterone receptor-mediated transcription by the immunosuppressant FK506. Biochemistry 33 (1994) 10666-10671.
13. 13. Kralli A., Bohen S. P. and Yamamoto K. R., LEM1, an ATP-binding-cassette transporter, selectively modulates the biological potency of steroid hormones. Proc. Natl. Acad. Sci. U.S.A. 92 (1995) 4701-4705.
14. 14. Chen C. J., Chin J. E., Ueda K., Clark D. P., Pastan I., Gottesman M. M. and Roninson I. B., Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug resistant human cells. Cell 47 (1986) 381-389.
15. 15. Yang C. H., Goei De Pinho S., Greenberger L. M., Arceci R. J. and Band Horwitz S. J., Progestin interacts with P-glycoprotein in multidrug-resistant cells and the endometrium of gravid uterus. J. Biol. Chem. 264 (1989) 782-788.
16. 16. Ueda K., Okamura N., Hirai M., Tanigawara Y., Saeki T., Kioka N., Komano T. and Hori R., Human P-glycoprotein transports cortisol, aldosterone and dexamethasone but not progesterone. J. Biol. Chem. 267 (1992) 24248-24252.
17. 17. Barnes K. M., Dickstein B., Cutler G. B. Jr., Fojo T. and Bates S. E., Steroid transport, accumulation, and antagonism of P-glycoprotein in multidrug-resistant cells. Biochemistry 35 (1996) 4820-4827.
18. 18. Dayan G., Jault J. M., Baubichon-Cortay H., Renoir J. M., Baulieu E. E., Gros P. and DiPietro A., Binding of steroid modulators to recombinant cytosolic domain from mouse P-glycoprotein: Close proximity to tryptophan-696 and to ATP site. Biochemistry 36 (1997) 15208-15215.
19. 19. Kralli A. and Yamamoto K. R., An FK506-sensitive transporter selectively decreases intracellular levels and potency of steroid hormones. J. Biol. Chem. 271 (1996) 17152-17156.
20. 20. Felgner P. L., Gadek T. R., Holm M., Roman R., Chan H. W., Wenz M., Northrop J. P., Ringold G. M. and Danielsen M., Lipofectin: A highly efficient lipid-mediated DNA transfection procedure. Proc. Natl. Acad. Sci. U.S.A. 84 (1987) 7413-7447.
21. 21. Ostrowski M. C., Richard-Foy H., Wolford R. G., Berard D. S. and Hager G. L., Glucocorticoid regulation of transcription at an amplified episomal promoter. Mol. Cell. Biol. 3 (1983) 2045-2057.
22. 125I]iodoacetamide) identifies four protein bands in mouse brain membranes. J. Neurochem. 63 (1994) 1434-1438.
23. 23. Laemmli U. K., Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227 (1970) 680-685.
24. 24. Kartner N., Evernden-Porelle D., Bradley G. and Ling V., Detection of P-glycoprotein in multidrug-resistant cell lines by monoclonal antibodies. Nature 316 (1985) 820-823.
25. 25. Mechetner E. B. and Roninson I. B., Efficient inhibition of P-glycoprotein-mediated multidrug resistance with a monoclonal antibody. Proc. Natl. Acad. Sci. U.S.A. 89 (1992) 5824-5828.
26. 26. Schneider C., Newman R. A., Sutherland D. R., Asser U. and Greaves H. J., A one-step purification of membrane proteins using a high efficiency immunomatrix. J. Biol. Chem. 257 (1982) 10766-10769.
27. 27. Akiyama S.-I., Fojo A., Hanover J. A., Pastan I. and Gottesman M. M., Isolation and genetic charaterization of human KB cell lines resistant to multiple drugs. Somat. Cell Mol. Gen. 11 (1985) 117-126.
28. 28. Bradford M. M., A rapid and sensitive method for the quantitation of microgram quantities of protein using the principle of protein-dye binding. Anal. Biochem. 72 (1976) 248-254.
29. 29. Naito M., Oh-hara T., Yamazaki A., Danki T. and Tsuruo T., Reversal of multidrug resistance by an immunosuppressive agent FK506. Cancer Chemotherap. Pharmacol. 29 (1992) 195-200.
30. 30. Saeki T., Ueda K., Tanigawara Y., Hori R. and Komano T., Human P-glycoprotein transports cyclosporin A and FK506. J. Biol. Chem. 268 (1993) 6077-6080.
31. 31. Boesch D., Gavériaux C., Jachez B., Pourtier-Mauzanedo A., Bollinger P. and Loor F., In vivo circumvention of P-glycoprotein-mediated multidrug resistance of tumor cells with SDZ PSC 833. Cancer Res. 51 (1991) 4226-4233.
32. 32. Safa A. R., Photoaffinity labeling of the multidrug resistance related P-glycoprotein with photoactive analogs of verapamil. Proc. Natl. Acad. Sci. U.S.A. 85 (1988) 7187-7191.
33. 33. Tsuruo T., Lida H., Tsukagoshi S. and Sakurai Y., Overcoming of vincristine resistance in P388 leukemia in vitro and in vivo through enhanced cytotoxicity of vincristine and vinblastine by verapamil. Cancer Res. 42 (1981) 1967-1972.
34. 34. Tamai I. and Safa R., Competitive interactions of cyclosporins with the vincaalcaloïd-binding site of P-glycoprotein in multidrug resistant cells. J. Biol. Chem. 265 (1990) 16509-16513.
35. 35. Baulieu E. E., Contragestion and other clinical applications of RU 486, an antiprogesterone at the receptor. Science 245 (1989) 1351-1357.
36. 36. Gruol D. J., Zee M. C., Trotter J. and Bourgeois S., Reversal of multidrug resistance by RU486. Cancer Res. 54 (1994) 3088-3091.
37. 37. Bierer B. E., Cyclosporin A, FK506 and rapamycin: Binding to immunophilins and biological actions. Chem. Immunol. 59 (1994) 128-155.
38. 38. Galat A. M. and Metcalfe S. M., Peptidyl prolyl cis/trans isomerase. Int. Prog. Biophys. Mol. Biol. 63 (1995) 67-118.
39. 39. Fruman D. A., Burakoff S. J. and Bierer B., Immunophilins in protein folding and immunosuppression. FASEB J. 8 (1994) 391-400.
40. 40. Sabatini, D. M., Pierchala, B. A., Barrow, R. K., Schell, M. J. and Snyder, S. H., The rapamycin and FKBP12 target (RAFT) displays phosphatidyl inositol 4-kinase activity, J. Biol. Chem. 1995, 270, 20875-20878.
41. 41. Beretta L., Gingras A.-C., Svitkin Y. V., Hall M. N. and Sonenberg N., Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation. EMBO J. 15 (1996) 658-664.
42. 42. Gottesman M. M. and Pastan I., Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu. Rev. Biochem. 62 (1993) 385-427.
43. 43. Sonnenvald P., Marie J. P., Huisman C., Vekholf A., Schoester M., Faussat A. M., Van Kapel J., Groenewegen A., Charnick S., Zittoun R. and Lowenberg B., Reversal of multidrug resistance by SDZ PSC 833 combined with VAD (vincristine, doxorubicin, dexamethasone) in refractory multiple myeloma. A phase I study. Leukemia 10 (1996) 1741-1750.
44. 44. Ning Y. M. and Sanchez E. R., Stabilization in vitro of the untransformed glucocorticoid receptor complex of S49 lymphocytes by the immunophilin ligand FK506. J. Steroid Biochem. Mol. Biol. 52 (1995) 187-194.
45. 45. Orti E., Mendel D. B. and Munck A., Phosphorylation of glucocorticoid receptor-associated and free forms of the 90 kDa heat shock protein before and after receptor activation. J. Biol. Chem. 264 (1989) 231-237.
46. 46. Orti E., Hu L. M. and Munck A., Kinetics of glucocortiocids receptor phosphorylation in intact cells. J. Biol. Chem. 268 (1992) 7779-7784.
47. 47. Webster J. C., Jewell C. M., Bodwell J. E., Munck A., Sar M. and Cidlowski J. A., Mouse glucocorticoid receptor phophorylation status influences multiple functions of the receptor proteins. J. Biol. Chem. 272 (1997) 9287-9293.
48. 48. Miyata Y., Radanyi C., Chambraud B., Lebeau M.-C., Renoir J.-M., Leclerc, J., Shirai R., Catelli M.-G., Yahara I. and Baulieu E. E., Phosphorylation of immunosuppressant FK506 binding protein, FKBP52 by casein kinase II (CKII): Regulation of hsp90-binding activity of FKBP-52, Proc. Natl. Acad. Sci. USA, 94, 14500-14505.
49. + transport in A6 cells. J. Biol. Chem. 271 (1996) 32468-32473.
50. 50. Nordeen S., Potentiation of glucocorticoid-mediated induction of the mouse mammary tumor virus promoter in mammary carcinoma cells by activation of protein kinase C. Biochem. Biophys. Res. Commun. 198 (1996) 1183-1188.
51. 51. Le Bihan, S., Marsaud, V., Mercier-Bodard, C., Mader, S., White, J., Baulieu, E. E. and Renoir, J.-M., Calcium/calmodulin kinases inhibitors, and immunosuppressants macrolides rapamycin and FK506, inhibit stimulation of progestin/glucocorticosteroid responsive promoters in human breast cancer T47D cells, In revision in Mol. Endocrinol.
52. 52. Denner L. A., Weigel N., Maxwell B. L., Schrader W. and O'Malley B. W., Regulation of progesterone receptor-mediated transcription by phosphorylation. Science 250 (1990) 1740-1743.
53. 53. Power R. F., Mani S. K., Codina J., Concely O. M. and O'Malley B. W., Dopaminergic and ligand-independent activation of steroid hormone receptors. Science 254 (1991) 1636-1669.
54. 2+/calmodulin-dependent protein kinase II. J. Biol. Chem. 265 (1990) 4315-4323.
55. 55. Renoir J. M., Marsaud V., Mercier-Bodard C., Le Bihan S., Radanyi C. and Baulieu E. E., Modulation of steroid-induced transcription by Cyclophilins and FKBPs. In Cyclophilin structure and function, 1996. Workshop Oct 10-12 1996, Lille, France, ed. CNRS USTL, 1996, pp. 117-127.
56. 56. DeFranco D. B., Qi M., Borror K. C., Garabedian M. J. and Brautigan D. L., Protein phosphatase types 1 and/or 2A regulate nucleocytoplasmic shuttling of glucocorticoid receptors. Mol. Endocrinol. 5 (1991) 1215-1218.
57. 57. Chen M. S., Silverstein A. M., Pratt W. B. and Chinkers M., The tetratricopeptide repeat domain of protein phosphatase 5 mediates binding to glucocorticoid receptor heterocomplexes and acts as a dominant negative mutant. J. Biol. Chem. 271 (1996) 32315-32320.
58. 58. Milad M., Sullivan W., Diehl E., Altman M., Nordeen S., Edwards D. P. and Toft D. O., Interaction of the progesterone receptor with binding proteins for FK506 and cyclosporin A. Mol. Endocrinol. 9 (1995) 838-847.