The role of the efflux transporter P-glycoprotein in brain penetration of prednisolone

Journal of Endocrinology

Volumn 175, Issue 1, 2002, Pages 251-260

  Karssen, A M ^a   Meijer, O C ^a   van der Sandt, I C J ^a   De Boer, A G ^a   De Lange, E C M ^a   De Kloet, E R ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ALDOSTERONE; CARRIER PROTEIN; CORTICOSTEROID RECEPTOR; CORTODOXONE; GLUCOCORTICOID; GLYCOPROTEIN P; MULTIDRUG RESISTANCE PROTEIN; PREDNISOLONE; PROTEIN INHIBITOR; STEROID; TRACER; ZOSUQUIDAR;

ACTIVE TRANSPORT; ADRENALECTOMY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; COGNITION; CONTROLLED STUDY; DRUG PENETRATION; DRUG TRANSPORT; DRUG UPTAKE; GENETIC TRANSFECTION; IN VITRO STUDY; IN VIVO STUDY; MALE; MONOLAYER CULTURE; MOOD; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; WILD TYPE;

ADRENALECTOMY; AFFECT; ANALYSIS OF VARIANCE; ANIMALS; BIOLOGICAL TRANSPORT; BLOOD-BRAIN BARRIER; CELL LINE; DIBENZOCYCLOHEPTENES; DRUG INTERACTIONS; EPITHELIAL CELLS; GLUCOCORTICOIDS; HUMANS; MALE; MICE; MICE, KNOCKOUT; P-GLYCOPROTEIN; PREDNISOLONE; QUINOLINES; SWINE; TRANSFECTION;

EID: 0036801475     PISSN: 00220795     EISSN: None     Source Type: Journal    
DOI: 10.1677/joe.0.1750251     Document Type: Article

References (56)

1. Acs Z & Stark E 1975 Effect of cortexolone on the feedback action of dexamethasone. Experientia 31 1365-1366.
2. Barnes KM, Dickstein B, Cutler GB, Fojo T & Bates SE 1996 Steroid transport, accumulation, and antagonism of P-glycoprotein in multidrug-resistant cells. Biochemistry 35 4820-4827.
3. Belanoff JK, Flores BH, Kalezhan M, Sund B & Schatzberg AF 2001a Rapid reversal of psychotic depression using mifepristone. Journal of Clinical Psychopharmacology 21 516-521.
4. Belanoff JK, Gross K, Yager A & Schatzberg AF 2001b Corticosteroids and cognition. Journal of Psychiatric Research 35 127-145.
5. Birmingham MK, Sar M & Stumpf WE 1984 Localization of aldosterone and corticosterone in the central nervous system, assessed by quantitative autoradiography. Neurochemical Research 9 333-350.
6. Bourgeois S, Gruol DJ, Newby RF & Rajah FM 1993 Expression of an mdr gene is associated with a new form of resistance to dexamethasone-induced apoptosis. Molecular Endocrinology 7 840-851.
7. Cordon-Cardo C, O'Brien JP, Casals D, Rittman GL, Biedler JL, Melamed MR & Bertino JR 1989 Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites. PNAS 86 695-698.
8. 3H]aldosterone binding sites within mouse brain hippocampus. Journal of Steroid Biochemistry 28 29-34.
9. Dantzig AH, Shepard RL, Law KL, Tabas L, Pratt S, Gillespie JS, Binkley SN, Kuhfeld MT, Starling JJ & Wrighton SA 1999 Selectivity of the multidrug resistance modulator, LY 335979, for P-glycoprotein and effect on cytochrome P-450 activities. Journal of Pharmacology and Experimental Therapeutics 290 854-862.
10. De Kloet ER 1991 Brain corticosteroid receptor balance and homeostatic control. Frontiers in Neuroendocrinology 12 95-164.
11. De Kloet ER, Van der Vies J & De Wied D 1974 The site of the suppressive action of dexamethasone on pituitary-adrenal activity. Endocrinology 94 61-73.
12. De Kloet ER, Wallach G & McEwen BS 1975 Differences in corticosterone and dexamethasone binding to rat brain and pituitary. Endocrinology 96 598-609.
13. De Kloet ER, Veldhuis HD, Wagenaars JL & Bergink EW 1984 Relative binding affinity of steroids for the corticosterone receptor system in rat hippocampus. Journal of Steroid Biochemistry 21 173-178.
14. De Kloet ER, Vreugdenhil E, Oitzl MS & Joëls M 1998 Brain corticosteroid receptor balance in health and disease. Endocrine Reviews 19 269-301.
15. De Kloet ER, Oitzl MS & Joëls M 1999 Stress and cognition: are corticosteroids good or bad guys? Trends in Neurosciences 22 422-426.
16. 3H]aldosterone by the anterior pituitary and brain regions in adrenalectomized rats. Hormone and Metabolic Research 13 103-106.
17. Duncan MR & Duncan GR 1979 An in vivo study of the action of antiglucocorticoids on thymus weight ratio, antibody titre and the adrenal-pituitary-hypothalamus axis. Journal of Steroid Biochemistry 10 245-259.
18. Gaillard PJ & De Boer AG 2000 Relationship between permeability status of the blood-brain barrier and in vitro permeability coefficient of a drug. European Journal of Pharmaceutical Sciences 12 95-102.
19. Jette L, Pouliot JF, Murphy GF & Béliveau R 1995 Isoform I (mdr3) is the major form of P-glycoprotein expressed in mouse brain capillaries. Evidence for cross-reactivity of antibody C219 with an unrelated protein. Biochemical Journal 305 761-766.
20. Kaiser N & Mayer M 1980 Studies on the antiglucocorticoid action of 11-deoxysteroids in rat thymocytes: discrepancies between in vivo and in vitro effects. Journal of Steroid Biochemistry 13 729-732.
21. Karssen AM & De Kloet ER 2000 Synthetic glucocorticoids. In Encyclopedia of Stress, pp 566-570. Ed. G Fink. San Diego, CA, USA: Academic Press.
22. Karssen AM, Meijer OC, Van der Sandt ICJ, Lucassen PJ, De Lange ECM, De Boer AG & De Kloet ER 2001 Multidrug resistance P-glycoprotein hampers the access of cortisol but not of corticosterone to mouse and human brain. Endocrinology 142 2686-2694.
23. Keenan PA, Jacobson MW, Soleymani RM, Mayes MD, Stress ME & Yaldoo DT 1996 The effect on memory of chronic prednisone treatment in patients with systemic disease. Neurology 47 1396-1402.
24. Kraulis I, Foldes G, Traikov H, Dubrovsky B & Birmingham MK 1975 Distribution, metabolism and biological activity of deoxycorticosterone in the central nervous system. Brain Research 88 1-14.
25. Lan NC, Matulich DT, Morris JA & Baxter JD 1981 Mineralocorticoid receptor-like aldosterone-binding protein in cell culture. Endocrinology 109 1963-1970.
26. Lan NC, Graham B, Bartter FC & Baxter JD 1982 Binding of steroids to mineralocorticoid receptors: implications for in vivo occupancy by glucocorticoids. Journal of Clinical Endocrinology and Metabolism 54 332-342.
27. Lupien SJ & Lepage M 2001 Stress, memory, and the hippocampus: can't live with it, can't live without it. Behavioural Brain Research 127 137-158.
28. McEwen BS, Weiss JM & Schwartz LS 1968 Selective retention of corticosterone by limbic structures in rat brain. Nature 220 911-912.
29. McEwen BS, De Kloet ER & Wallach G 1976 Interactions in vivo and in vitro of corticoids and progesterone with cell nuclei and soluble macromolecules from rat brain regions and pituitary. Brain Research 105 129-136.
30. McEwen BS, De Kloet ER & Rostene W 1986 Adrenal steroid receptors and actions in the nervous system. Physiological Reviews 66 1121-1188.
31. Maipang MV & Janjindamai SH 2000 Successful combination chemotherapy (vincristine, procarbazine, etoposide, and prednisolone) in the treatment of inoperable, radioresistant low grade astrocytoma: a case report. Journal of the Medical Association of Thailand 83 1525-1529.
32. Medh RD, Lay RH & Schmidt TJ 1998 Agonist-specific modulation of glucocorticoid receptor-mediated transcription by immunosuppressants. Molecular and Cellular Endocrinology 138 11-23.
33. Meijer OC, De Lange ECM, Breimer DD, De Boer AG, Workel JO & De Kloet ER 1998 Penetration of dexamethasone into brain glucocorticoid targets is enhanced in mdr1a P-glycoprotein knockout mice. Endocrinology 139 1789-1793.
34. Oitzl MS & De Kloet ER 1992 Selective corticosteroid antagonists modulate specific aspects of spatial orientation learning. Behavioral Neuroscience 106 62-71.
35. Pariante CM, Makoff A, Lovestone S, Feroli S, Heyden A, Miller AH & Kerwin RW 2001 Antidepressants enhance glucocorticoid receptor function in vitro by modulating the membrane steroid transporters. British Journal of Pharmacology 134 1335-1343.
36. 3H]dexamethasone in the rat brain and pituitary. In Anatomical Neuroendocrinology, pp 262-269. Eds WE Stumpf & L Grant. Basel: S Karger.
37. Regina A, Demeule M, Laplante A, Jodoin J, Dagenais C, Berthelet F, Moghrabi A & Beliveau R 2001 Multidrug resistance in brain tumors: roles of the blood-brain barrier. Cancer and Metastasis Reviews 20 13-25.
38. Robson AC, Leckie CM, Seckl JR & Holmes MC 1998 11[beta]-Hydroxysteroid dehydrogenase type 2 in the postnatal and adult rat brain. Molecular Brain Research 61 1-10.
39. Schinkel AH 1999 P-glycoprotein, a gatekeeper in the blood-brain barrier. Advanced Drug Delivery Reviews 36 179-194.
40. Schinkel AH, Smit JJ, Van Tellingen O, Beijnen JH, Wagenaar E, Van Deemter L, Mol CAAM, Van der Valk MA, Robanus Maandag EC, Te Riele HP, Berns AJM & Borst P 1994 Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs. Cell 77 491-502.
41. Schinkel AH, Wagenaar E, Van Deemter L, Mol CAAM & Borst P 1995 Absence of the mdr1a P-glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A. Journal of Clinical Investigation 96 1698-1705.
42. Schmidt TJ & Davidson CJ 1987 The antiglucocorticoid, cortexolone, fails to promote in vitro activation of cytoplasmic glucocorticoid receptors from the human leukemic cell line CEM-C7. Journal of Steroid Biochemistry 26 329-336.
43. Seckl JR 1997 11β-Hydroxysteroid dehydrogenase in the brain: a novel regulator of glucocorticoid action? Frontiers in Neuroendocrinology 18 49-99.
44. Shibamoto Y, Sasai K, Oya N & Hiraoka M 1999 Systemic chemotherapy with vincristine, cyclophosphamide, doxorubicin and prednisolone following radiotherapy for primary central nervous system lymphoma: a phase II study. Journal of Neuro-Oncology 42 161-167.
45. Starling JJ, Shepard RL, Cao J, Law KL, Norman BH, Kroin JS, Ehlhardt WJ, Baughman TM, Winter MA, Bell MG, Shih C, Gruber J, Elmquist WF & Dantzig AH 1997 Pharmacological characterization of LY 335979: a potent cyclopropyldibenzosuberane modulator of P-glycoprotein. Advances in Enzyme Regulation 37 335-347.
46. Thiebaut F, Tsuruo T, Hamada H, Gottesman MM, Pastan I & Willingham MC 1989 Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: evidence for localization in brain capillaries and crossreactivity of one antibody with a muscle protein. Journal of Histochemistry and Cytochemistry 37 159-164.
47. Ueda K, Okamura N, Hirai M, Tanigawara Y, Saeki T, Kioka N, Komano T & Hori R 1992 Human P-glycoprotein transports cortisol, aldosterone, and dexamethasone, but not progesterone. Journal of Biological Chemistry 267 24248-24252.
48. Ueda K, Kino K, Taguchi Y, Yamada K, Saeki T, Tanigawara Y & Komano T 1996 Role of P-glycoprotein in the transport of hormones and peptides. In Multidrug Resistance in Cancer Cells: Molecular, Biochemical, Physiological, and Biological Aspects, pp 303-319. Eds S Gupta & T Tsuruo. Chichester, UK: John Wiley.
49. Van Acker SABE, Oitzl MS, Fluttert MF & De Kloet ER 2002 Centrally regulated blood pressure response to vasoactive peptides is modulated by corticosterone. Journal of Neuroendocrinology, 14 56-63.
50. Van de Vrie W, Marquet RL, Stoter G, De Bruijn EA & Eggermont AM 1998 In vivo model systems in P-glycoprotein-mediated multidrug resistance. Critical Reviews in Clinical Laboratory Sciences 35 1-57.
51. Van Eekelen JAM, Kiss JZ, Westphal HM & De Kloet ER 1987 Immunocytochemical study on the intracellular localization of the type 2 glucocorticoid receptor in the rat brain. Brain Research 436 120-128.
52. Van Eekelen JAM, Jiang W, De Kloet ER & Bohn MC 1988 Distribution of the mineralocorticoid and the glucocorticoid receptor mRNAs in the rat hippocampus. Journal of Neuroscience Research 21 88-94.
53. Veldhuis HD, Van Koppen C, Van Ittersum M & De Kloet ER 1982 Specificity of the adrenal steroid receptor system in rat hippocampus. Endocrinology 110 2044-2051.
54. Wu HG, Kim IH, Ha SW, Park CI, Bang YJ & Huh DS 1999 Survival improvement with combined radio-chemotherapy in the primary central nervous system lymphomas. Journal of Korean Medical Science 14 565-570.
55. Yamazaki M, Neway WE, Ohe T, Chen I, Rowe JF, Hochman JH, Chiba M & Lin JH 2001 In vitro substrate identification studies for P-glycoprotein-mediated transport: species difference and predictability of in vivo results. Journal of Pharmacology and Experimental Therapeutics 296 723-735.
56. Yongue BG & Roy EJ 1987 Endogenous aldosterone and corticosterone in brain cell nuclei of adrenal-intact rats: regional distribution and effects of physiological variations in serum steroids. Brain Research 436 49-61.