Localization of mRNA expression of P-glycoprotein at the blood-brain barrier and in the hippocampus

Annals of the New York Academy of Sciences

Volumn 1032, Issue , 2004, Pages 308-311

  Karssen, A M ^a,b   Meijer, O C ^a   Pons, D ^a   De Kloet, E R ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Blood brain barrier; Hippocampus; Immunohistochemistry; In situ hybridization; Mdr; P glycoprotein

Indexed keywords

GLYCOPROTEIN P; KAINIC ACID; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 1;

ANIMAL MODEL; BLOOD BRAIN BARRIER; CONFERENCE PAPER; DENTATE GYRUS; GRANULE CELL; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; NONHUMAN; PROTEIN EXPRESSION; RAT; SEIZURE;

EID: 14544303537     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1314.048     Document Type: Conference Paper

References (14)

1. SCHINKEL, A.H. 1999. P-glycoprotein, a gatekeeper in the blood-brain barrier. Adv. Drug Delivery Rev. 36: 179-194.
2. MEIJER, O.C., E.C.M. DE LANGE, D.D. BREMER, et al. 1998. Penetration of dexamethasone into brain glucocorticoid targets is enhanced in mdr1a P-glycoprotein knockout mice. Endocrinology 139: 1789-1793.
3. KARSSEN, A.M., O.C. MEIJER, I.C.J. VAN DER SANDT, et al. 2002. The role of the efflux transporter P-glycoprotein in brain penetration of prednisolone J. Endocrinol. 175: 251-260.
4. KARSSEN, A.M., O.C. MEIJER, M. VISSER, et al. 2003. Exclusion of dexamethasone from the brain leads to a selective central hypocorticosteroid state. Thesis, A.M. Karssen, Ch. 5, Leiden University.: 95-114. http://www.etcl.nl/diss/med/2003/002/ Karssen.htm
5. KARSSEN, A.M., O.C. MEIJER, I.C.J. VAN DER SANDT, et al. 2001. Multidrug resistance P-glycoprotein hampers the access of cortisol but not of corticosterone to mouse and human brain. Endocrinology 142: 2686-2694.
6. CORDON-CARDO, C., J.P. O'BRIEN, D. CASALS, et al. 1989. Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites. Proc. Natl. Acad. Sci. USA 86: 695-698.
7. KARSSEN, A.M., O.C. MEIJER, D. PONS, et al. 2003. mRNA expression of multidrug resistance P-glycoprotein in brain. Thesis, A.M. Karssen, Ch 2. Leiden University. :45-58. http://www.etcl.nl/diss/med/2003/002/Karssen.htm
8. BEAULIEU, E., M. DEMEULE, L. GHITESCU, et al. 1997. P-glycoprotein is strongly expressed in the luminal membranes of the endothelium of blood vessels in the brain. Biochem. J. 326 (Pt 2): 539-544.
9. WEBSTER, M.J., M.B. KNABLE, J. GRADY, et al. 2002. Regional specificity of brain glucocorticoid receptor mRNA alterations in subjects with schizophrenia and mood disorders. Mol. Psychiatry 7: 985-994.
10. KRALLI, A. & K.R. YAMAMOTO. 1996. An FK506-sensitive transporter selectively decreases intracellular levels and potency of steroid hormones. J. Biol. Chem. 271: 17152-17156.
11. ZHANG, L., W.Y. ONG & T. LEE. 1999. Induction of P-glycoprotein expression in astrocytes following intracerebroventricular kainate injections. Exp. Brain Res. 126: 509-516.
12. SEEGERS, U., H. POTSCHKA & W. LOSCHER. 2002. Transient increase of P-glycoprotein expression in endothelium and parenchyma of limbic brain regions in the kainate model of temporal lobe epilepsy. Epilepsy Res. 51: 257-268.
13. VOLK, H.A., K. BURKHARDT, H. POTSCHKA, et al. 2004. Neuronal expression of the drug efflux transporter P-glycoprotein in the rat hippocampus after limbic seizures. Neuroscience 123: 751-759.
14. SPERK, G. 1994. Kainic acid seizures in the rat. Prog. Neurobiol. 42: 1-32.