Antidepressants enhance glucocorticoid receptor function in vitro by modulating the membrane steroid transporters

British Journal of Pharmacology

Volumn 134, Issue 6, 2001, Pages 1335-1343

  Pariante, Carmine M ^a   Makoff, Andrew ^a   Lovestone, Simon ^a   Feroli, Susan ^a   Heyden, Alexandra ^a   Miller, Andrew H ^b   Kerwin, Robert W ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Corticosterone; Cortisol; Dexamethasone; Glucocorticoid receptor; H 89; Hypothalamic pituitary adrenal (HPA) axis; L929 cells; Multiple drug resistance (MDR) p glycoprotein; Selective serotonin reuptake inhibitor (SSRI); Tricyclic antidepressants; Verapamil

Indexed keywords

AMITRIPTYLINE; ANTIDEPRESSANT AGENT; CARRIER PROTEIN; CITALOPRAM; CLOMIPRAMINE; CORTICOSTERONE; DESIPRAMINE; DEXAMETHASONE; FLUOXETINE; GLUCOCORTICOID RECEPTOR; HYDROCORTISONE; MEMBRANE STEROID TRANSPORTER; PAROXETINE; UNCLASSIFIED DRUG; VERAPAMIL;

ANIMAL CELL; ARTICLE; CELL STRAIN; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; GENETIC TRANSCRIPTION; IN VITRO STUDY; INTRACELLULAR TRANSPORT; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0035197083     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704368     Document Type: Article

References (51)

1. Regulation of corticosteroids receptor gene expression in depression and antidepressant action
2. DNA binding properties of glucocorticosteroid receptors bound to the steroid antagonist RU-486
3. Antidepressant drugs inhibit glucocorticoid receptor mediated gene transcription-a possible mechanism
4. Short-term treatment of mood disorders with standard antidepressants
5. Membrane permeation by multidrug-resistance-modulators and non-modulators: Effects of hydrophobicity and electric charge
6. Chronic treatment of C6 glioma cells with antidepressant drugs increases functional coupling between a G protein (Gs) and adenylyl cyclase
7. Brain corticosteroid receptor balance in health and disease
8. Increased synaptic availability of norepinephrine following desipramine is not essential for increases in GR mRNA
9. Experimental reversal of p-glycoprotein-mediated multidrug resistance by pharmacological chemosensitisers
10. Brain concentration of tricyclic antidepressants: Single-dose kinetics and relationship to plasma concentrations in chronically dosed rats
11. The effects of serotonin on glucocorticoid receptor binding in rat raphe nuclei and hippocampal cells in culture
12. Pituitary-adrenal-system regulation and psychopathology during amitriptyline treatment in elderly depressed patients and normal comparison subjects
13. The corticosteroids receptor hypothesis of depression
14. Brain distribution and kinetics of desipramine in the rat
15. Multidrug resistance p-glycoprotein hampers the access of cortisol but not corticosterone to mouse and human brain
16. Slow increase in intranuclear and cytosolic free calcium concentrations in L929 cells is important in tumour necrosis factor-alpha-mediated cell death
17. An FK 506-sensitive transporter selectively decreases intracellular levels and potency of steroid hormones
18. Multidrug resistance (MDR) in cancer. Mechanisms, reversal using modulators of MDR and the role of MDR modulators in influencing the pharmacokinetics of anticancer drugs
19. Dexamethasone and triamcinolone acetonide accumulation in mouse fibroblasts is differently modulated by the immunosuppressants cyclosporin A, FK 506, rapamycin and their analogues, as well as by other p-glycoprotein ligands
20. The molecular interaction of the high affinity reversal agent XR9576 with P-glycoprotein
21. Future therapeutic targets in mood disorders: The glucocorticoid receptor
22. Agonist-specific modulation of glucocorticoid receptor-mediated transcription by immunosuppressants
23. Penetration of dexamethasone into brain glucocorticoid targets is enhanced in mdr1A p-glycoprotein knockout mice
24. Circumvention of pleiotropic drug resistance in subcutaneous tumours in vivo with verapamil and clomipramine
25. Long-term antidepressant treatment reduces behavioural deficits in transgenic mice with impaired glucocorticoid receptor function
26. The corticotropin-releasing factor (CRF) hypothesis of depression: New findings and new directions
27. Long-term treatment with antidepressants increases glucocorticoid receptor binding and gene expression in cultured rat hippocampal neurones
28. Paroxetine binding to the rat norepinephrine transporter in vivo
29. Glucocorticoid receptors in major depression: Relevance to pathophysiology and treatment
30. Steroid-independent translocation of the glucocorticoid receptor by the antidepressant desipramine
31. The proinflammatory cytokine, interleukin-1 alpha, reduces glucocorticoid receptor translocation and function
32. The steroid receptor antagonists, RU486 and RU40555, activate glucocorticoid receptor translocation and are not excreted by the steroid hormone transporter in L929 cells
33. Increased glucocorticoid receptor gene promoter activity after antidepressant treatment
34. The effect of repeated combined treatment with nifedipine and antidepressant drugs or electroconvulsive shock on the hippocampal corticosteroid receptors in rats
35. Chronic treatment of rats with the antidepressant amitriptyline attenuates the activity of the hypothalamic-pituitary-adrenocortical system
36. Norepinephrine-independent regulation of GRII mRNA in vivo by a tricyclic antidepressant
37. Pharmacological and functional characterization of human mineralocorticoid and glucocorticoid receptor ligands
38. Potentiation of glucocorticoid receptor-mediated gene expression by heat and chemical shock
39. Structural and functional reconstitution of the glucocorticoid receptor-hsp90 complex
40. Antidepressants increase glucocorticoid and mineralocorticoid receptor mRNA expression in rat hippocampus in vivo
41. Anti-psychotic drugs reverse multidrug resistance of tumor cell lines and human AML cell ex-vivo
42. Human P-glycoprotein transports cortisol, aldosterone, and dexamethasone, but not progesterone
43. Penetration of amitriptyline, but not fluoxetine, into brain is enhanced in mice with blood-brain barrier deficiency due to Mdrla p-glycoprotein gene disruption
44. Reversal of multidrug resistance by amitriptyline in vitro
45. Regulation of glucocorticoid receptor-mRNA in human blood cells by amitriptyline and dexamethasone
46. The novel progesterone receptor antagonists RTI 3021-012 and RTI 3021-022 exhibit complex glucocorticoid receptor antagonist activities: Implications for the development of dissociated antiprogestins
47. Redox regulation of p-glycoprotein-mediated multidrug resistance in multicellular prostate tumor spheroids
48. Interaction of cyclosporin derivatives with the ATPase activity of human P-glycoprotein
49. Cell-mediated immunity and its glucocorticoid-sensitivity after clinical recovery from severe major depressive disorder
50. The antidepressants imipramine, clomipramine, and citalopram induce apoptosis in human acute myeloid leukemia HL-60 cells via caspase-3 activation
51. Cysteines 638 and 665 in the hormone binding domain of human glucocorticoid receptor define the specificity to glucocorticoids