IRAK-4-dependent degradation of IRAK-1 is a negative feedback signal for TLR-mediated NF-κB activation

Journal of Biochemistry

Volumn 143, Issue 3, 2008, Pages 295-302

  Kubo Murai, Miho ^a   Hazeki, Kaoru ^a   Nigorikawa, Kiyomi ^a   Omoto, Takatoshi ^a   Inoue, Norimitsu ^b   Hazeki, Osamu ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

^b OSAKA MEDICAL CENTER FOR CANCER AND CARDIOVASCULAR DISEASES   (Japan)

Author keywords

IRAK; LPS; NF B; Phosphorylation; TLR

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 1; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 4; SHORT HAIRPIN RNA; TOLL LIKE RECEPTOR;

ANIMAL CELL; ARTICLE; AUTOPHOSPHORYLATION; CONTROLLED STUDY; EMBRYO; HUMAN; HUMAN CELL; MACROPHAGE; MOUSE; NEGATIVE FEEDBACK; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STIMULATION;

ANIMALS; CELL LINE; FEEDBACK, BIOCHEMICAL; HUMANS; I-KAPPA B PROTEINS; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; NF-KAPPA B; PROTEIN PROCESSING, POST-TRANSLATIONAL; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4;

EID: 40549115966     PISSN: 0021924X     EISSN: 17562651     Source Type: Journal    
DOI: 10.1093/jb/mvm234     Document Type: Article

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