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Volumn 40, Issue 1-2, 1999, Pages 75-87

The size of liposomes: A factor which affects their targeting efficiency to tumors and therapeutic activity of liposomal antitumor drugs

Author keywords

Antitumor activity; Blood circulation; Drug delivery; Drug release; Pharmacokinetics; Toxicity; Tumor accumulation; Vesicle size

Indexed keywords

HEMODYNAMICS; ONCOLOGY; PHARMACOKINETICS; TOXICITY;

EID: 0032866761     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-409X(99)00041-1     Document Type: Article
Times cited : (378)

References (86)
  • 2
    • 0021741835 scopus 로고
    • Biological approaches to the controlled delivery of drugs: A critical review
    • Poznansky M.J., Juliano R.L. Biological approaches to the controlled delivery of drugs: a critical review. Pharmacol. Rev. 36:1984;277-336.
    • (1984) Pharmacol. Rev. , vol.36 , pp. 277-336
    • Poznansky, M.J.1    Juliano, R.L.2
  • 3
    • 0344758588 scopus 로고
    • Liposomes as a drug delivery system in cancer therapy
    • P.S. Sunkara. New York: Academic Press
    • Poste G., Kirsh R., Bugelski P. Liposomes as a drug delivery system in cancer therapy. Sunkara P.S. Novel Approaches to Cancer Chemotherapy. 1984;165-230 Academic Press, New York.
    • (1984) Novel Approaches to Cancer Chemotherapy , pp. 165-230
    • Poste, G.1    Kirsh, R.2    Bugelski, P.3
  • 4
    • 0019832509 scopus 로고
    • Liposome disposition in vivo III: Dose and vesicle-size effects
    • Abra R.M., Hunt C.A. Liposome disposition in vivo III: dose and vesicle-size effects. Biochim. Biophys. Acta. 666:1981;493-503.
    • (1981) Biochim. Biophys. Acta , vol.666 , pp. 493-503
    • Abra, R.M.1    Hunt, C.A.2
  • 5
    • 0020518842 scopus 로고
    • Effect of liposome size and drug release properties on pharmacokinetics of encapsulated drug in rats
    • Allen T.M., Everest J.M. Effect of liposome size and drug release properties on pharmacokinetics of encapsulated drug in rats. J. Pharmacol. Exp. Ther. 226:1983;539-544.
    • (1983) J. Pharmacol. Exp. Ther. , vol.226 , pp. 539-544
    • Allen, T.M.1    Everest, J.M.2
  • 6
    • 0030580954 scopus 로고    scopus 로고
    • Liposomal targeting and drug delivery: Kinetic consideration
    • Harashima H., Kiwada H. Liposomal targeting and drug delivery: kinetic consideration. Adv. Drug Deliv. Rev. 19:1996;425-444.
    • (1996) Adv. Drug Deliv. Rev. , vol.19 , pp. 425-444
    • Harashima, H.1    Kiwada, H.2
  • 8
    • 0026733476 scopus 로고
    • Microscopic localization of sterically stabilized liposomes in colon carcinoma-bearing mice
    • Huang S.K., Lee K.-D., Friend D.S., Papahadjopoulos D. Microscopic localization of sterically stabilized liposomes in colon carcinoma-bearing mice. Cancer Res. 52:1992;5135-5143.
    • (1992) Cancer Res. , vol.52 , pp. 5135-5143
    • Huang, S.K.1    Lee, K.-D.2    Friend, D.S.3    Papahadjopoulos, D.4
  • 9
    • 0005447282 scopus 로고
    • Extravasation and transcytosis of liposomes in Kaposi's sarcoma-like dermal lesions of transgenic mice bearing the HIV tat gene
    • Huang S.K., Martin F.J., Gilbert J., Vogel J., Papahadjopoulos D., Friend D.S. Extravasation and transcytosis of liposomes in Kaposi's sarcoma-like dermal lesions of transgenic mice bearing the HIV tat gene. Am. J. Pathol. 143:1993;10-14.
    • (1993) Am. J. Pathol. , vol.143 , pp. 10-14
    • Huang, S.K.1    Martin, F.J.2    Gilbert, J.3    Vogel, J.4    Papahadjopoulos, D.5    Friend, D.S.6
  • 10
    • 0028304405 scopus 로고
    • Microvascular permeability and interstitial penetration of sterically stabilized (Stealth) liposomes in a human tumor xenograft
    • Yuan F., Leunig M., Huang S.K., Berk D.A., Papahadjopoulos D., Jain R.K. Microvascular permeability and interstitial penetration of sterically stabilized (Stealth) liposomes in a human tumor xenograft. Cancer Res. 54:1994;3352-3356.
    • (1994) Cancer Res. , vol.54 , pp. 3352-3356
    • Yuan, F.1    Leunig, M.2    Huang, S.K.3    Berk, D.A.4    Papahadjopoulos, D.5    Jain, R.K.6
  • 11
    • 0030598282 scopus 로고    scopus 로고
    • Direct measurement of extravasation of polyethyleneglycol-coated liposomes into solid tumor tissue by in vivo fluorescence microscopy
    • Unezaki S., Maruyama K., Hosoda J., Nagase I., Koyanagi Y., Nakata M., Ishida O., Iwatsuru M., Tsuchiya S. Direct measurement of extravasation of polyethyleneglycol-coated liposomes into solid tumor tissue by in vivo fluorescence microscopy. Int. J. Pharm. 144:1996;11-17.
    • (1996) Int. J. Pharm. , vol.144 , pp. 11-17
    • Unezaki, S.1    Maruyama, K.2    Hosoda, J.3    Nagase, I.4    Koyanagi, Y.5    Nakata, M.6    Ishida, O.7    Iwatsuru, M.8    Tsuchiya, S.9
  • 12
  • 13
    • 0026567096 scopus 로고
    • Role of liposome size and RES blockade in controlling biodistribution and tumor uptake of GM1-containing liposomes
    • Liu D., Mori A., Huang L. Role of liposome size and RES blockade in controlling biodistribution and tumor uptake of GM1-containing liposomes. Biochim. Biophys. Acta. 1104:1992;95-101.
    • (1992) Biochim. Biophys. Acta , vol.1104 , pp. 95-101
    • Liu, D.1    Mori, A.2    Huang, L.3
  • 14
    • 0029000870 scopus 로고
    • Effects of the size and fluidity of liposomes on their accumulation in tumors: A presumption of their interaction with tumors
    • Uchiyama K., Nagayasu A., Yamagiwa Y., Nishida T., Harashima H., Kiwada H. Effects of the size and fluidity of liposomes on their accumulation in tumors: a presumption of their interaction with tumors. Int. J. Pharm. 121:1995;195-203.
    • (1995) Int. J. Pharm. , vol.121 , pp. 195-203
    • Uchiyama, K.1    Nagayasu, A.2    Yamagiwa, Y.3    Nishida, T.4    Harashima, H.5    Kiwada, H.6
  • 15
    • 0029131680 scopus 로고
    • Real-time analysis of liposomal trafficking in tumor-bearing mice by use of positron emission tomography
    • Oku N., Tokudome Y., Tsukada H., Okada S. Real-time analysis of liposomal trafficking in tumor-bearing mice by use of positron emission tomography. Biochim. Biophys. Acta. 1238:1995;86-90.
    • (1995) Biochim. Biophys. Acta , vol.1238 , pp. 86-90
    • Oku, N.1    Tokudome, Y.2    Tsukada, H.3    Okada, S.4
  • 16
    • 0024470863 scopus 로고
    • Influence of vesicle size, lipid composition, and drug-to-lipid ratio on the biological activity of liposomal doxorubicin in mice
    • Mayer L.D., Tai L.C.L., Ko D.S.C., Masin D., Ginsberg R.S., Cullis P.R., Bally M.B. Influence of vesicle size, lipid composition, and drug-to-lipid ratio on the biological activity of liposomal doxorubicin in mice. Cancer Res. 49:1989;5922-5930.
    • (1989) Cancer Res. , vol.49 , pp. 5922-5930
    • Mayer, L.D.1    Tai, L.C.L.2    Ko, D.S.C.3    Masin, D.4    Ginsberg, R.S.5    Cullis, P.R.6    Bally, M.B.7
  • 17
    • 0026603586 scopus 로고
    • Selective tumor localization and improved therapeutic index of anthracyclines encapsulated in long-circulating liposomes
    • Gabizon A. Selective tumor localization and improved therapeutic index of anthracyclines encapsulated in long-circulating liposomes. Cancer Res. 52:1992;891-896.
    • (1992) Cancer Res. , vol.52 , pp. 891-896
    • Gabizon, A.1
  • 18
    • 0028101079 scopus 로고
    • Effects of fluidity and vesicle size on antitumor activity and myelosuppressive activity of liposomes loaded with daunorubicin
    • Nagayasu A., Shimooka T., Kinouchi Y., Uchiyama K., Takeichi Y., Kiwada H. Effects of fluidity and vesicle size on antitumor activity and myelosuppressive activity of liposomes loaded with daunorubicin. Biol. Pharm. Bull. 17:1994;935-939.
    • (1994) Biol. Pharm. Bull. , vol.17 , pp. 935-939
    • Nagayasu, A.1    Shimooka, T.2    Kinouchi, Y.3    Uchiyama, K.4    Takeichi, Y.5    Kiwada, H.6
  • 19
    • 0029006392 scopus 로고
    • Effects of vesicle size and lipid composition in the in vivo tumor selectivity and toxicity of the non-cross-resistant anthracycline annamycin incorporated in liposomes
    • Zou Y., Ling Y.-H., Reddy S., Priebe W., Perez-Soler R. Effects of vesicle size and lipid composition in the in vivo tumor selectivity and toxicity of the non-cross-resistant anthracycline annamycin incorporated in liposomes. Int. J. Cancer. 61:1995;666-671.
    • (1995) Int. J. Cancer , vol.61 , pp. 666-671
    • Zou, Y.1    Ling, Y.-H.2    Reddy, S.3    Priebe, W.4    Perez-Soler, R.5
  • 21
    • 0026541171 scopus 로고
    • Serum opsonins and liposomes: Their interaction and opsonophagocytosis
    • Patel H.M. Serum opsonins and liposomes: Their interaction and opsonophagocytosis. Crit. Rev. Ther. Drug Carrier Syst. 9:1992;39-90.
    • (1992) Crit. Rev. Ther. Drug Carrier Syst. , vol.9 , pp. 39-90
    • Patel, H.M.1
  • 22
    • 0030935267 scopus 로고    scopus 로고
    • The role of immunoproteins in the survival of liposomes in the circulation
    • Devine D.V., Marjan M.J. The role of immunoproteins in the survival of liposomes in the circulation. Crit. Rev. Ther. Drug Carrier Syst. 14:1997;105-131.
    • (1997) Crit. Rev. Ther. Drug Carrier Syst. , vol.14 , pp. 105-131
    • Devine, D.V.1    Marjan, M.J.2
  • 24
    • 0028326452 scopus 로고
    • Liposome-complement interactions in rat serum: Implications for liposome survival studies
    • Devine D.V., Wong K., Serrano K., Chonn A., Cullis P.R. Liposome-complement interactions in rat serum: implications for liposome survival studies. Biochim. Biophys. Acta. 1191:1994;43-51.
    • (1994) Biochim. Biophys. Acta , vol.1191 , pp. 43-51
    • Devine, D.V.1    Wong, K.2    Serrano, K.3    Chonn, A.4    Cullis, P.R.5
  • 25
    • 0029590781 scopus 로고
    • Size-dependent liposome degradation in blood: In vitro/in vivo correlation by kinetic modeling
    • Harashima H., Hiraiwa T., Ochi Y., Kiwada H. Size-dependent liposome degradation in blood: in vitro/in vivo correlation by kinetic modeling. J. Drug. Target. 3:1995;253-261.
    • (1995) J. Drug. Target. , vol.3 , pp. 253-261
    • Harashima, H.1    Hiraiwa, T.2    Ochi, Y.3    Kiwada, H.4
  • 26
    • 0030480444 scopus 로고    scopus 로고
    • Synergistic effect between size and cholesterol content in the enhanced hepatic uptake clearance of liposomes through complement activation in rats
    • Harashima H., Huong T.M., Ishida I., Manabe Y., Matsuo H., Kiwada H. Synergistic effect between size and cholesterol content in the enhanced hepatic uptake clearance of liposomes through complement activation in rats. Pharm. Res. 13:1996;1704-1709.
    • (1996) Pharm. Res. , vol.13 , pp. 1704-1709
    • Harashima, H.1    Huong, T.M.2    Ishida, I.3    Manabe, Y.4    Matsuo, H.5    Kiwada, H.6
  • 27
    • 0031935924 scopus 로고    scopus 로고
    • The interaction of liposomes with the complement system
    • Szebeni J. The interaction of liposomes with the complement system. Crit. Rev. Ther. Drug Carrier Syst. 15:1998;57-88.
    • (1998) Crit. Rev. Ther. Drug Carrier Syst. , vol.15 , pp. 57-88
    • Szebeni, J.1
  • 28
    • 0023280158 scopus 로고
    • Fate and behavior of liposomes in vivo; A review of controlling factors
    • Senior J.H. Fate and behavior of liposomes in vivo; a review of controlling factors. Crit. Rev. Ther. Drug Carrier Syst. 3:1987;123-193.
    • (1987) Crit. Rev. Ther. Drug Carrier Syst. , vol.3 , pp. 123-193
    • Senior, J.H.1
  • 29
    • 0019951707 scopus 로고
    • Stability of small unilamellar in serum and clearance from the circulation: The effect of the phospholipid and cholesterol components
    • Senior J.H., Greoriadis G. Stability of small unilamellar in serum and clearance from the circulation: the effect of the phospholipid and cholesterol components. Life Sci. 30:1982;2123-2136.
    • (1982) Life Sci. , vol.30 , pp. 2123-2136
    • Senior, J.H.1    Greoriadis, G.2
  • 30
    • 0021848043 scopus 로고
    • Tissue distribution of liposomes exhibiting long half-lives in the circulation after intravenous injection
    • Senior J., Crawley J.C.W., Gregoriadis G. Tissue distribution of liposomes exhibiting long half-lives in the circulation after intravenous injection. Biochim. Biophys. Acta. 839:1985;1-8.
    • (1985) Biochim. Biophys. Acta , vol.839 , pp. 1-8
    • Senior, J.1    Crawley, J.C.W.2    Gregoriadis, G.3
  • 31
    • 0024551243 scopus 로고
    • Liposomes with prolonged circulation times: Factors affecting uptake by reticuloendothelial and other tissues
    • Allen T.M., Hansen C., Rutledge J. Liposomes with prolonged circulation times: factors affecting uptake by reticuloendothelial and other tissues. Biochim. Biophys. Acta. 981:1989;27-35.
    • (1989) Biochim. Biophys. Acta , vol.981 , pp. 27-35
    • Allen, T.M.1    Hansen, C.2    Rutledge, J.3
  • 32
    • 0016612425 scopus 로고
    • The effect of particle size and charge on the clearance of liposomes and liposome encapsulated drugs
    • Juriano R.L., Stamp D. The effect of particle size and charge on the clearance of liposomes and liposome encapsulated drugs. Biochem. Biophys. Res. Commun. 63:1975;651-658.
    • (1975) Biochem. Biophys. Res. Commun. , vol.63 , pp. 651-658
    • Juriano, R.L.1    Stamp, D.2
  • 33
    • 0019439249 scopus 로고
    • The effect of reticuloendothelial blockade on the blood clearance and tissue distribution of liposomes
    • Souhami R., Patel H.M., Ryman B.E. The effect of reticuloendothelial blockade on the blood clearance and tissue distribution of liposomes. Biochim. Biophys. Acta. 674:1981;354-371.
    • (1981) Biochim. Biophys. Acta , vol.674 , pp. 354-371
    • Souhami, R.1    Patel, H.M.2    Ryman, B.E.3
  • 34
    • 0026778635 scopus 로고
    • Association of blood proteins with large unilamellar liposomes in vivo: Relation to circulation lifetimes
    • Chonn A., Semple S.C., Cullis P.R. Association of blood proteins with large unilamellar liposomes in vivo: relation to circulation lifetimes. J. Biol. Chem. 267:1992;18759-18765.
    • (1992) J. Biol. Chem. , vol.267 , pp. 18759-18765
    • Chonn, A.1    Semple, S.C.2    Cullis, P.R.3
  • 36
    • 0023659741 scopus 로고
    • Large unilamellar liposomes with low uptake into the reticuloendothelial system
    • Allen T.M., Chonn A. Large unilamellar liposomes with low uptake into the reticuloendothelial system. FEBS Lett. 223:1987;42-46.
    • (1987) FEBS Lett. , vol.223 , pp. 42-46
    • Allen, T.M.1    Chonn, A.2
  • 37
    • 0842279809 scopus 로고
    • Liposome formulations with prolonged circulation time in blood and enhanced uptake by tumors
    • Gabizon A., Papahadjopoulos D. Liposome formulations with prolonged circulation time in blood and enhanced uptake by tumors. Proc. Natl. Acad. Sci. USA. 85:1988;6949-6953.
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 6949-6953
    • Gabizon, A.1    Papahadjopoulos, D.2
  • 38
    • 0025162391 scopus 로고
    • Effect of liposome composition and other factors on the targeting of liposomes to experimental tumors: Biodistribution and imaging studies
    • Gabizon A., Price D.C., Huberty J., Bresalier R.S., Papahadjopoulos D. Effect of liposome composition and other factors on the targeting of liposomes to experimental tumors: biodistribution and imaging studies. Cancer Res. 50:1990;6371-6378.
    • (1990) Cancer Res. , vol.50 , pp. 6371-6378
    • Gabizon, A.1    Price, D.C.2    Huberty, J.3    Bresalier, R.S.4    Papahadjopoulos, D.5
  • 39
    • 0025341615 scopus 로고
    • Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes
    • Klibanov A.L., Maruyama K., Torchilin V.P., Huang L. Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes. FEBS Lett. 268:1990;235-237.
    • (1990) FEBS Lett. , vol.268 , pp. 235-237
    • Klibanov, A.L.1    Maruyama, K.2    Torchilin, V.P.3    Huang, L.4
  • 40
    • 0025731906 scopus 로고
    • Liposomes containing synthetic lipid derivatives of poly(ethylene glycol) show prolonged circulation half-lives in vivo
    • Allen T.M., Hansen C., Martin F., Redemann C., Yau-Young A. Liposomes containing synthetic lipid derivatives of poly(ethylene glycol) show prolonged circulation half-lives in vivo. Biochim. Biophys. Acta. 1066:1991;29-36.
    • (1991) Biochim. Biophys. Acta , vol.1066 , pp. 29-36
    • Allen, T.M.1    Hansen, C.2    Martin, F.3    Redemann, C.4    Yau-Young, A.5
  • 42
    • 0002559783 scopus 로고
    • 1-O-Palmityl-D-glucuronate endows liposomes with long half-life in vivo
    • Namba Y., Sakakibara T., Masada M., Ito F., Oku N. 1-O-Palmityl-D-glucuronate endows liposomes with long half-life in vivo. Chem. Lett. 1989:1989;2145-2148.
    • (1989) Chem. Lett. , vol.1989 , pp. 2145-2148
    • Namba, Y.1    Sakakibara, T.2    Masada, M.3    Ito, F.4    Oku, N.5
  • 44
    • 0025789143 scopus 로고
    • Pharmacokinetics of Stealth versus conventional liposomes: Effect of dose
    • Allen T.M., Hansen C. Pharmacokinetics of Stealth versus conventional liposomes: effect of dose. Biochim. Biophys. Acta. 1068:1991;133-141.
    • (1991) Biochim. Biophys. Acta , vol.1068 , pp. 133-141
    • Allen, T.M.1    Hansen, C.2
  • 45
    • 0026631584 scopus 로고
    • Tumor accumulation of novel RES-avoiding liposomes
    • Oku N., Namba Y., Okada S. Tumor accumulation of novel RES-avoiding liposomes. Biochim. Biophys. Acta. 1126:1992;255-260.
    • (1992) Biochim. Biophys. Acta , vol.1126 , pp. 255-260
    • Oku, N.1    Namba, Y.2    Okada, S.3
  • 46
    • 0028055226 scopus 로고
    • Effect of liposome size on the circulation time and intraorgan distribution of amphipathic poly(ethylene glycol)-containing liposomes
    • Litzinger D.C., Buiting A.M.J., van Rooijen N., Huang L. Effect of liposome size on the circulation time and intraorgan distribution of amphipathic poly(ethylene glycol)-containing liposomes. Biochim. Biophys. Acta. 1190:1994;99-107.
    • (1994) Biochim. Biophys. Acta , vol.1190 , pp. 99-107
    • Litzinger, D.C.1    Buiting, A.M.J.2    Van Rooijen, N.3    Huang, L.4
  • 47
    • 0026570605 scopus 로고
    • The role of surface charge and hydrophilic groups on liposome clearance in vivo
    • Gabizon A., Papahadjopoulos D. The role of surface charge and hydrophilic groups on liposome clearance in vivo. Biochim. Biophys. Acta. 1103:1992;94-100.
    • (1992) Biochim. Biophys. Acta , vol.1103 , pp. 94-100
    • Gabizon, A.1    Papahadjopoulos, D.2
  • 48
    • 0025981079 scopus 로고
    • Activity of amphipathic poly(ethylene glycol) 5000 to prolong the circulation time of liposomes depends on the liposome size and is unfavorable for immunoliposome binding to target
    • Klibanov A.L., Maruyama K., Beckerleg A.M., Torchilin V.P., Huang L. Activity of amphipathic poly(ethylene glycol) 5000 to prolong the circulation time of liposomes depends on the liposome size and is unfavorable for immunoliposome binding to target. Biochim. Biophys. Acta. 1062:1991;142-148.
    • (1991) Biochim. Biophys. Acta , vol.1062 , pp. 142-148
    • Klibanov, A.L.1    Maruyama, K.2    Beckerleg, A.M.3    Torchilin, V.P.4    Huang, L.5
  • 49
    • 0026060897 scopus 로고
    • Influence of surface hydrophilicity of liposomes on their interaction with plasma protein and clearance from the circulation: Studies with poly(ethylene glycol)-coated vesicles
    • Senior J., Delgado C., Fisher D., Tilcock C., Gregoriadis G. Influence of surface hydrophilicity of liposomes on their interaction with plasma protein and clearance from the circulation: studies with poly(ethylene glycol)-coated vesicles. Biochim. Biophys. Acta. 1062:1991;77-82.
    • (1991) Biochim. Biophys. Acta , vol.1062 , pp. 77-82
    • Senior, J.1    Delgado, C.2    Fisher, D.3    Tilcock, C.4    Gregoriadis, G.5
  • 50
    • 0026671099 scopus 로고
    • Prolonged circulation time in vivo of large unilamellar liposomes composed of distearoyl phosphatidylcholine and cholesterol containing amphipathic poly(ethylene glycol)
    • Maruyama K., Yuda T., Okamoto A., Kojima S., Suginaka A., Iwatsuru M. Prolonged circulation time in vivo of large unilamellar liposomes composed of distearoyl phosphatidylcholine and cholesterol containing amphipathic poly(ethylene glycol). Biochim. Biophys. Acta. 1128:1992;44-49.
    • (1992) Biochim. Biophys. Acta , vol.1128 , pp. 44-49
    • Maruyama, K.1    Yuda, T.2    Okamoto, A.3    Kojima, S.4    Suginaka, A.5    Iwatsuru, M.6
  • 52
    • 0029679980 scopus 로고    scopus 로고
    • In vivo trafficking of long-circulating liposomes in tumor-bearing mice determined by positron emission tomography
    • Oku N. In vivo trafficking of long-circulating liposomes in tumor-bearing mice determined by positron emission tomography. Biopharm. Drug Dispos. 17:1996;435-441.
    • (1996) Biopharm. Drug Dispos. , vol.17 , pp. 435-441
    • Oku, N.1
  • 53
    • 0023481357 scopus 로고
    • Transport of molecules across tumor vasculature
    • Jain R.K. Transport of molecules across tumor vasculature. Cancer Metastasis Rev. 6:1987;559-593.
    • (1987) Cancer Metastasis Rev. , vol.6 , pp. 559-593
    • Jain, R.K.1
  • 54
    • 0024839642 scopus 로고
    • Tumoritropic and lymphotropic principles of macromolecular drugs
    • Maeda H., Matsumura Y. Tumoritropic and lymphotropic principles of macromolecular drugs. Crit. Rev. Ther. Drug Carrier Syst. 6:1989;193-210.
    • (1989) Crit. Rev. Ther. Drug Carrier Syst. , vol.6 , pp. 193-210
    • Maeda, H.1    Matsumura, Y.2
  • 56
    • 0030973901 scopus 로고    scopus 로고
    • Accumulation of liposomal lipid and encapsulated doxorubicin in murine Lewis lung carcinoma: The lack of beneficial effects by coating liposomes with poly(ethylene glycol)
    • Parr M.J., Masin A., Cullis P., Bally M.B. Accumulation of liposomal lipid and encapsulated doxorubicin in murine Lewis lung carcinoma: the lack of beneficial effects by coating liposomes with poly(ethylene glycol). J. Pharmacol. Exp. Ther. 280:1997;1319-1327.
    • (1997) J. Pharmacol. Exp. Ther. , vol.280 , pp. 1319-1327
    • Parr, M.J.1    Masin, A.2    Cullis, P.3    Bally, M.B.4
  • 57
    • 0002079949 scopus 로고
    • Disposition and tumor localization of mitomycin C-dextran conjugates in mice
    • Takakura Y., Takagi A., Hashida M., Sezaki H. Disposition and tumor localization of mitomycin C-dextran conjugates in mice. Pharm. Res. 4:1987;293-300.
    • (1987) Pharm. Res. , vol.4 , pp. 293-300
    • Takakura, Y.1    Takagi, A.2    Hashida, M.3    Sezaki, H.4
  • 58
    • 0032472388 scopus 로고    scopus 로고
    • Tumor accumulation of poly(vinyl alcohol) of different sizes after intravenous injection
    • Tabata Y., Murakami Y., Ikada Y. Tumor accumulation of poly(vinyl alcohol) of different sizes after intravenous injection. J. Control. Release. 50:1998;123-133.
    • (1998) J. Control. Release , vol.50 , pp. 123-133
    • Tabata, Y.1    Murakami, Y.2    Ikada, Y.3
  • 59
    • 0031665983 scopus 로고    scopus 로고
    • Accumulation of protein-loaded long-circulating micelles and liposomes in subcutaneous Lewis lung carcinoma in mice
    • Weissig V., Whiteman K.R., Torchilin V.P. Accumulation of protein-loaded long-circulating micelles and liposomes in subcutaneous Lewis lung carcinoma in mice. Pharm. Res. 15:1998;1552-1556.
    • (1998) Pharm. Res. , vol.15 , pp. 1552-1556
    • Weissig, V.1    Whiteman, K.R.2    Torchilin, V.P.3
  • 60
    • 0027242138 scopus 로고
    • Increased microvascular permeability contributed to preferential accumulation of Stealth liposomes in tumor tissue
    • Wu N.Z., Da D., Rudoll T.L., Needham D., Whorton A.R., Dewhirst M.W. Increased microvascular permeability contributed to preferential accumulation of Stealth liposomes in tumor tissue. Cancer Res. 53:1993;3765-3770.
    • (1993) Cancer Res. , vol.53 , pp. 3765-3770
    • Wu, N.Z.1    Da, D.2    Rudoll, T.L.3    Needham, D.4    Whorton, A.R.5    Dewhirst, M.W.6
  • 61
    • 0016701895 scopus 로고
    • Vascular structures in brain tumors
    • Hirano A., Matsui T. Vascular structures in brain tumors. Hum. Pathol. 6:1975;611-621.
    • (1975) Hum. Pathol. , vol.6 , pp. 611-621
    • Hirano, A.1    Matsui, T.2
  • 62
    • 0014856890 scopus 로고
    • The ultrastructure of the microcirculation at the advancing edge of Walker 256 carcinoma
    • Warren B.A. The ultrastructure of the microcirculation at the advancing edge of Walker 256 carcinoma. Microvasc. Res. 2:1970;443-453.
    • (1970) Microvasc. Res. , vol.2 , pp. 443-453
    • Warren, B.A.1
  • 63
    • 0021858187 scopus 로고
    • The liver sieve: Considerations concerning the structure and function of endothelial fenestrae, the sinusoidal wall and the space of Disse
    • Wisse E., DeZanger R.B., Charels K., Van Der Smissen P., McCuskey R.S. The liver sieve: considerations concerning the structure and function of endothelial fenestrae, the sinusoidal wall and the space of Disse. Hepatology. 5:1985;683-692.
    • (1985) Hepatology , vol.5 , pp. 683-692
    • Wisse, E.1    Dezanger, R.B.2    Charels, K.3    Van Der Smissen, P.4    McCuskey, R.S.5
  • 66
    • 0024505574 scopus 로고
    • Delivery of novel therapeutic agents in tumors: Physiological barriers and strategies
    • Jain R.K. Delivery of novel therapeutic agents in tumors: physiological barriers and strategies. J. Natl. Cancer Inst. 81:1989;570-576.
    • (1989) J. Natl. Cancer Inst. , vol.81 , pp. 570-576
    • Jain, R.K.1
  • 67
    • 0026672406 scopus 로고
    • In vitro cytotoxicity of liposome-encapsulated doxorubicin: Dependence on liposome composition and drug release
    • Horowitz A.T., Barenholz Y., Gabizon A.A. In vitro cytotoxicity of liposome-encapsulated doxorubicin: dependence on liposome composition and drug release. Biochim. Biophys. Acta. 1109:1992;203-209.
    • (1992) Biochim. Biophys. Acta , vol.1109 , pp. 203-209
    • Horowitz, A.T.1    Barenholz, Y.2    Gabizon, A.A.3
  • 68
    • 0022367237 scopus 로고
    • Gangliosides reduce leakage of aqueous-space markers from liposomes in the presence of human plasma
    • Allen T.M., Ryan J.L., Papahadjopoulos D. Gangliosides reduce leakage of aqueous-space markers from liposomes in the presence of human plasma. Biochim. Biophys. Acta. 818:1985;205-210.
    • (1985) Biochim. Biophys. Acta , vol.818 , pp. 205-210
    • Allen, T.M.1    Ryan, J.L.2    Papahadjopoulos, D.3
  • 69
    • 0025053067 scopus 로고
    • Liposomes for sustained drug release in vivo
    • Blume G., Cevc G. Liposomes for sustained drug release in vivo. Biochim. Biophys. Acta. 1029:1990;91-97.
    • (1990) Biochim. Biophys. Acta , vol.1029 , pp. 91-97
    • Blume, G.1    Cevc, G.2
  • 70
    • 0027467014 scopus 로고
    • Influence of liposome charge and composition on their interaction with human blood serum proteins
    • Hernández-Caselles T., Villalaín J., Gómez-Fernández J.C. Influence of liposome charge and composition on their interaction with human blood serum proteins. Mol. Cell. Biochem. 120:1993;119-126.
    • (1993) Mol. Cell. Biochem. , vol.120 , pp. 119-126
    • Hernández-Caselles, T.1    Villalaín, J.2    Gómez-Fernández, J.C.3
  • 71
    • 0019324697 scopus 로고
    • Effect of cholesterol content of small unilamellar liposomes on their stability in vivo and in vitro
    • Kirby C., Clarke J., Greoriadis G. Effect of cholesterol content of small unilamellar liposomes on their stability in vivo and in vitro. Biochem. J. 186:1980;591-598.
    • (1980) Biochem. J. , vol.186 , pp. 591-598
    • Kirby, C.1    Clarke, J.2    Greoriadis, G.3
  • 72
    • 0029095389 scopus 로고
    • Effects of vesicle size on in vivo release of daunorubicin from hydrogenated egg phosphatidylcholine-based liposomes into blood circulation
    • Nagayasu A., Shimooka T., Kiwada H. Effects of vesicle size on in vivo release of daunorubicin from hydrogenated egg phosphatidylcholine-based liposomes into blood circulation. Biol. Pharm. Bull. 18:1995;1020-1023.
    • (1995) Biol. Pharm. Bull. , vol.18 , pp. 1020-1023
    • Nagayasu, A.1    Shimooka, T.2    Kiwada, H.3
  • 74
    • 0024468809 scopus 로고
    • Pharmacokinetics and tissue distribution of doxorubicin encapsulated in stable liposomes with long circulation times
    • Gabizon A., Shiota R., Papahadjopoulos D. Pharmacokinetics and tissue distribution of doxorubicin encapsulated in stable liposomes with long circulation times. J. Natl. Cancer Inst. 81:1989;1484-1488.
    • (1989) J. Natl. Cancer Inst. , vol.81 , pp. 1484-1488
    • Gabizon, A.1    Shiota, R.2    Papahadjopoulos, D.3
  • 75
    • 0028349925 scopus 로고
    • Prolonged circulation time and enhanced accumulation in malignant exudates of doxorubicin encapsulated in polyethylene-glycol coated liposomes
    • Gabizon A., Catane R., Uziely B., Kaufman B., Safra T., Cohen R., Martin F., Huang A., Barenholz Y. Prolonged circulation time and enhanced accumulation in malignant exudates of doxorubicin encapsulated in polyethylene-glycol coated liposomes. Cancer Res. 54:1994;987-992.
    • (1994) Cancer Res. , vol.54 , pp. 987-992
    • Gabizon, A.1    Catane, R.2    Uziely, B.3    Kaufman, B.4    Safra, T.5    Cohen, R.6    Martin, F.7    Huang, A.8    Barenholz, Y.9
  • 76
    • 0029587435 scopus 로고
    • Enhanced tumor targeting and improved antitumor activity of doxorubicin by long-circulating liposomes containing amphipathic poly(ethylene glycol)
    • Unezaki S., Maruyama K., Ishida O., Suginaka A., Hosoda J., Iwatsuru M. Enhanced tumor targeting and improved antitumor activity of doxorubicin by long-circulating liposomes containing amphipathic poly(ethylene glycol). Int. J. Pharm. 126:1995;41-48.
    • (1995) Int. J. Pharm. , vol.126 , pp. 41-48
    • Unezaki, S.1    Maruyama, K.2    Ishida, O.3    Suginaka, A.4    Hosoda, J.5    Iwatsuru, M.6
  • 78
    • 0026718957 scopus 로고
    • Selective in vivo localization of daunorubicin small unilamellar vesicles in solid tumors
    • Forssen E.A., Coulter D.M., Proffitt R.T. Selective in vivo localization of daunorubicin small unilamellar vesicles in solid tumors. Cancer Res. 52:1992;3255-3261.
    • (1992) Cancer Res. , vol.52 , pp. 3255-3261
    • Forssen, E.A.1    Coulter, D.M.2    Proffitt, R.T.3
  • 79
    • 0028040403 scopus 로고
    • Therapeutic effect of adriamycin encapsulated in long-circulating liposomes on Meth-A-sarcoma-bearing mice
    • Oku N., Doi K., Namba Y., Okada S. Therapeutic effect of adriamycin encapsulated in long-circulating liposomes on Meth-A-sarcoma-bearing mice. Int. J. Cancer. 58:1994;415-419.
    • (1994) Int. J. Cancer , vol.58 , pp. 415-419
    • Oku, N.1    Doi, K.2    Namba, Y.3    Okada, S.4
  • 80
    • 0030042023 scopus 로고    scopus 로고
    • Liposome longevity and stability in circulation: Effects on the in vivo delivery to tumors and therapeutic efficacy of encapsulated anthracyclines
    • Gabizon A., Chemla M., Tzemach D., Horowitz A.T., Goren D. Liposome longevity and stability in circulation: effects on the in vivo delivery to tumors and therapeutic efficacy of encapsulated anthracyclines. J. Drug Target. 3:1996;391-398.
    • (1996) J. Drug Target. , vol.3 , pp. 391-398
    • Gabizon, A.1    Chemla, M.2    Tzemach, D.3    Horowitz, A.T.4    Goren, D.5
  • 81
    • 0013333534 scopus 로고    scopus 로고
    • Kinetic study on the optimization of tumor delivery of antitumor agents by liposomes: Simulation study based on the physiological modeling [in Japanese]
    • Urakami Y., Harashima H., Iida S., Nagayasu A., Kiwada H. Kinetic study on the optimization of tumor delivery of antitumor agents by liposomes: simulation study based on the physiological modeling [in Japanese]. Drug Deliv. Syst. 12:1997;403-408.
    • (1997) Drug Deliv. Syst. , vol.12 , pp. 403-408
    • Urakami, Y.1    Harashima, H.2    Iida, S.3    Nagayasu, A.4    Kiwada, H.5
  • 82
    • 0025103345 scopus 로고
    • Liposomal vincristine preparations which exhibit decreased drug toxicity and increased activity against murine L1210 and P388 tumors
    • Mayer L.D., Bally M.B., Loughrey H., Masin D., Cullis P.R. Liposomal vincristine preparations which exhibit decreased drug toxicity and increased activity against murine L1210 and P388 tumors. Cancer Res. 50:1990;575-579.
    • (1990) Cancer Res. , vol.50 , pp. 575-579
    • Mayer, L.D.1    Bally, M.B.2    Loughrey, H.3    Masin, D.4    Cullis, P.R.5
  • 84
    • 0028204863 scopus 로고
    • DaunoXome treatment of solid tumors: Preclinical and clinical investigations
    • Forssen E.A., Ross M.E. DaunoXome treatment of solid tumors: preclinical and clinical investigations. J. Liposome Res. 4:1994;481-512.
    • (1994) J. Liposome Res. , vol.4 , pp. 481-512
    • Forssen, E.A.1    Ross, M.E.2
  • 85
    • 0028324859 scopus 로고
    • Pharmacokinetics, biodistribution and therapeutic efficacy of doxorubicin encapsulated in Stealth liposomes (Doxil)
    • Working P.K., Newman M.S., Huang S.K., Mayhew E., Vaage J., Lasic D.D. Pharmacokinetics, biodistribution and therapeutic efficacy of doxorubicin encapsulated in Stealth liposomes (Doxil). J. Liposome Res. 4:1994;667-687.
    • (1994) J. Liposome Res. , vol.4 , pp. 667-687
    • Working, P.K.1    Newman, M.S.2    Huang, S.K.3    Mayhew, E.4    Vaage, J.5    Lasic, D.D.6
  • 86
    • 0031886983 scopus 로고    scopus 로고
    • Mechanism of transient dyspnea induced by pegylated-liposomal doxorubicin (Doxil™)
    • Skubitz K.M., Skubitz A.P.N. Mechanism of transient dyspnea induced by pegylated-liposomal doxorubicin (Doxil™). Anti-Cancer Drugs. 9:1998;45-50.
    • (1998) Anti-Cancer Drugs , vol.9 , pp. 45-50
    • Skubitz, K.M.1    Skubitz, A.P.N.2


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