Ras regulation of DNA-methylation and cancer

Experimental Cell Research

Volumn 314, Issue 6, 2008, Pages 1193-1201

  Patra, Samir Kumar ^a  

^a Cancer Epigenetics Research Nadia   (India)

Author keywords

Apoptosis; Cancer; CpG sequence; DNA demethylation; DNA methylation; Epigenetics; H Ras; K Ras; RASSF; Transcription

Indexed keywords

DNA METHYLTRANSFERASE 1; GUANOSINE TRIPHOSPHATASE; HETEROCHROMATIN PROTEIN 1; PROTEIN P53; RAS ASSOCIATION DOMAIN FAMILY PROTEIN 1A;

APOPTOSIS; CELL PROLIFERATION; CPG ISLAND; DNA METHYLATION; EPIGENETICS; GENE CONTROL; GENE EXPRESSION; GENETIC TRANSCRIPTION; NEOPLASM; ONCOGENE H RAS; ONCOGENE K RAS; ONCOGENE RAS; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; REVIEW;

MUS; VERTEBRATA;

EID: 40049111381     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yexcr.2008.01.012     Document Type: Review

References (78)

1. S.K. Patra S. Bettuzzi Epigenetic DNA-methylation regulation of genes coding for lipid raft-associated components: a role for raft proteins in cell transformation and cancer progression (Review) Oncol. Rep. 17 2007 1279 1290
2. B.E. Bernstein A. Meissner E.S. Lander The mammalian epigenome Cell 128 2007 669 681
3. E.J. Richards S.C. Elgin Epigenetic codes for heterochromatin formation and silencing: rounding up the usual suspects Cell 108 2002 489 500
4. W. Reik W. Dean J. Walter Epigenetic reprogramming in mammalian development Science 293 2001 1089 1093
5. S.K. Patra A. Patra H. Zhao R. Dahiya DNA-methyltransferase and demethylase in human prostate cancer Mol. Carcinog. 33 2002 163 167
6. S.K. Patra A. Patra R. Dahiya Histone deacetylase and DNA-methyltransferase in human prostate cancer Biochem. Biophys. Res. Commun. 287 2001 705 713
7. P.A. Jones S.B. Baylin The epigenomics of cancer Cell 128 2007 683 692
8. A.P. Feinberg B. Vogelstein Hypomethylation of ras oncogenes in primary human cancers Biochem. Biophys. Res. Commun. 111 1983 47 54
9. S.E. Goelz B. Vogelstein S.R. Hamilton A.P. Feinberg Hypomethylation of DNA from benign and malignant human colon neoplasms Science 228 1985 187 190
10. M.K. Bedford P.D. van Helden Hypomethylation of DNA in pathological conditions of the human prostate Cancer Res. 47 1987 5274 5276
11. R.A. Rupp P.B. Becker Gene regulation by histone H1: new links to DNA methylation Cell 123 2005 1199 1212
12. M.A. Surani Reprogramming of genome function through epigenetic inheritance Nature 414 2001 122 128
13. T.H. Bestor The DNA-methyltransferases of mammals Hum. Mol. Genet. 9 2000 2395 2402
14. M. Okano D.W. Bell D.A. Haber E. Li DNA-methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development Cell 99 1999 247 257
15. K. Hata M. Okano H. Lei E. Li Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice Development 129 2002 1983 1993
16. M. Esteller M. Toyota M. Sanchez-Cespedes G. Capella M.A. Peinado D.N. Watkins J.P. Issa D. Sidransky S.B. Baylin J.G. Herman Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumourigenesis Cancer Res. 60 2000 2368 2371
17. P. Wolf Y.C. Hu K. Doffek D. Sidransky S.A. Ahrendt O(6)-Methylguanine-DNA methyltransferase promoter hypermethylation shifts the p53 mutational spectrum in non-small cell lung cancer Cancer Res. 61 2001 8113 8117
18. R. Abdel-Fattah A. Glick I. Rehman P. Maiberger H. Hennings Methylation of the O6-methylguanine-DNA methyltransferase promoter suppresses expression in mouse skin tumours and varies with the tumour induction protocol Int. J. Cancer 118 2006 527 531
19. M. Menigatti M. Pedroni A.M. Verrone F. Borghi A. Scarselli P. Benatti L. Losi C. Di Gregorio P. Schär G. Marra M. Ponz de Leon L. Roncucci O6-methylguanine-DNA methyltransferase promoter hypermethylation in colorectal carcinogenesis Oncol. Rep. 17 2007 1421 1427
20. M. Esteller J.G. Herman Generating mutations but providing chemosensitivity: the role of O6-methylguanine DNA methyltransferase in human cancer Oncogene 23 2004 1 8
21. S. Etiene-Manneville A. Hall Rho GTPases in cell biology Nature 420 2002 629 635
22. M. Barbacid Ras genes Annu. Rev. Biochem. 56 1987 779 827
23. P. Rodriguez-Viciana F. McCormick Characterization of interactions between ras family GTPases and their effectors Methods Enzymol. 407 2005 187 194
24. P.W. Sternberg J. Alberola-Ila Conspiracy theory: Ras and Raf do not act alone Cell 95 1998 447 450
25. Waf1/Cip1 Nature 394 1998 295 299
26. J. Adnane F.A. Bizouarn Y. Qian A.D. Hamilton S.M. Sebti p21(Waf1/Cip1) is upregulated by the geranylgeranyltransferase-I inhibitor GGTI-298 through a transforming growth factor b- and SP-1 responsive element: involvement of the small GTPase Rho Mol. Cell Biol. 18 1998 6962 6970
27. R.J. Jackson J. Adnane D. Coppola A. Cantor S.M. Sebti W.J. Pledger Loss of the cell cycle inhibitors p21(Cip1) and p27(Kip1) enhances tumourigenesis in knockout mouse models Oncogene. 21 2002 8486 8497
28. M. Lee G. Petrovics W.B. Anderson The synergistic activation of Raf-1 kinase by phorbol myristate acetate and hydrogen peroxide in NIH3T3 cells Biochem. Biophys. Res. Commun. 311 2003 1026 1033
29. S. Kizaka-Kondoh K. Sato K. Tamura H. Nojima H. Okayama Raf-1 protein kinase is an integral component of the oncogenic signal cascade shared by epidermal growth factor and platelet-derived growth factor Mol. Cell. Biol. 12 1992 5078 5086
30. K.I. Bland M.M. Konstadoulakis M.P. Vezeridis H.J. Wanebo Oncogene protein co-expression — value of Ha-ras, c-myc, c-fos, and p53 as prognostic discriminants for breast carcinoma Ann. Surg. 221 1995 706 720
31. T. Fukano A. Sawano Y. Ohba M. Matsuda A. Miyawaki Differential Ras activation between caveolae/raft and non-raft microdomains Cell Struct. Funct. 32 2007 9 15
32. J.F. Hancock Ras proteins: different signals from different locations Nat. Rev., Mol. Cell Biol. 4 2003 373 384
33. G.A. Gomez J.L. Daniotti H-Ras dynamically interacts with recycling endosomes in CHO-K1 cells: involvement of Rab5 and Rab11 in the trafficking of H-Ras to this pericentriolar endocytic compartment J. Biol. Chem. 280 2005 34997 35010
34. I. Arozarena D. Matallanas M.T. Berciano V. Sanz-Moreno F. Calvo M.T. Munoz G. Egea M. Lafarga P. Crespo Activation of H-Ras in the endoplasmic reticulum by the RasGRF family guanine nucleotide exchange factors Mol. Cell. Biol. 24 2004 1516 1530
35. R.G. Parton J.F. Hancock Lipid rafts and plasma membrane microorganization: insights from Ras Trends Cell Biol. 14 2004 141 147
36. S.K. Patra, Dissecting lipid raft facilitated cell signaling pathways in cancer, Biochim. Biophys. Acta (in press), doi:10.1016/j.bbcan.2007.11.002 .
37. J.S. Goodwin K.R. Drake C. Rogers L. Wright J. Lippincott-Schwartz M. R Philips A.K. Kenworthy Depalmitoylated Ras traffics to and from the Golgi complex via a nonvesicular pathway J. Cell Biol. 170 2005 261 272
38. O. Rocks A. Peyker M. Kahms P.J. Verveer C. Koerner M. Lumbierres J. Kuhlmann H. Waldmann A. Wittinghofer P.I. Bastiaens An acylation cycle regulates localization and activity of palmitoylated Ras isoforms Science 307 2005 1746 1752
39. J. Rouleau A.R. MacLeod M. Szyf Regulation of DNA-methyltransferase by the Ras-Ap-1 signaling pathway J. Biol. Chem. 270 1995 1595 1601
40. L.S.-H. Chuang H.-I. Ian T.-W. Koh H.-H. Ng G. Xu B.F.L. Li Human DNA-(cytosine-5) methyltransferase–PCNA complex as a target for p21(WAF1) Science 277 1997 1996 2000
41. P.-O. Esteve H.G. Chin S. Pradhan Human maintenance DNA (cytosine-5)-methyltransferase and p53 modulate expression of p53-repressed promoters Proc. Nat. Acad. Sci. 102 2005 1000 1005
42. W.G. Zhu T. Hileman Y. Ke P. Wang S. Lu W. Duan Z. Dai T. Tong M.A. Villalona-Calero C. Plass G.A. Otterson 5-aza-2¢-deoxycytidine activates the p53/p21(Waf1)/Cip1 pathway to inhibit cell proliferation J. Biol. Chem. 279 2004 15161 15166
43. E. Vire C. Brenner R. Deplus L. Blanchon M. Fraga C. Didelot L. Morey A. van Eynde D. Bernard J.-M. Vanderwinden M. Bollen M. Esteller L. Di Croce Y. de Launoit F. Fuks The polycomb group protein EZH2 directly controls DNA-methylation Nature 439 2006 871 874
44. S. Varambally S.M. Dhanasekaran M. Zhou T.R. Barrette C. Kumar-Sinha M.G. Sanda D. Ghosh K.J. Pienta R.G. Sewalt A.P. Otte M.A. Rubin A.M. Chinnaiyan The polycomb group protein EZH2 is involved in progression of prostate cancer Nature 419 2002 624 629
45. P.A. Croonquist B. Van Ness The polycomb group protein enhancer of zeste homolog 2 (EZH 2) is an oncogene that influences myeloma cell growth and the mutant ras phenotype Oncogene 24 2005 6269 6280
46. X. Tang M. Milyavsky I. Shats N. Erez N. Goldfinger V. Rotter Activated p53 suppresses the histone-methyltransferase EZH2 gene Oncogene 23 2004 5759 5769
47. A. Smallwood P.-O. Esteve S. Pradhan M. Carey Functional cooperation between HP1 and DNMT1 mediates gene silencing Genes Dev. 21 2007 1169 1178
48. F. Lyko B.H. Ramsahoye H. Kashevsky M. Tudor M.-A. Mastrangelo T.L. Orr-Weaver R. Jaenisch Mammalian (cytosine-5) methyltransferases cause genomic DNA-methylation and lethality in Drosophila Nat. Genet. 23 1999 363 366
49. P. Lund K. Weißhaupt T. Mikeska D. Jammas X. Chen R.J. Kuban U. Ungethüm U. Krapfenbauer H.P. Herzel R. Schäfer J. Walter C. Sers Oncogenic H-Ras suppresses clusterin expression through promoter hypermethylation Oncogene 25 2006 4890 4903
50. A.R. MacLeod J. Rouleau M. Szyf Regulation of DNA methylation by the Ras signaling pathway J. Biol. Chem. 270 1995 11327 11337
51. J. Peli M. Schröter C. Rudaz M. Hahne C. Meyer E. Reichmann J. Tschopp Oncogenic Ras inhibits Fas ligand-mediated apoptosis by downregulating the expression of Fas EMBO J. 18 1999 1824 1831
52. K. Pruitt A.S. Ulkü K. Frantz R.J. Rojas V.M. Muniz-Medina V.M. Rangnekar C.J. Der J.M. Shields Ras-mediated loss of the pro-apoptotic response protein Par-4 is mediated by DNA hypermethylation through Raf-independent and Raf-dependent signaling cascades in epithelial cells J. Biol. Chem. 280 2005 23363 23370
53. K. Akino M. Toyota H. Suzuki H. Mita Y. Sasaki M. Ohe-Toyota J.P. Issa Y. Hinoda K. Imai T. Tokino The Ras effector RASSF2 is a novel tumour-suppressor gene in human colorectal cancer Gastroenterology 129 2005 156 169
54. F.C. Mei T.W. Young J. Liu X. Cheng RAS-mediated epigenetic inactivation of OPCML in oncogenic transformation of human ovarian surface epithelial cells FASEB J. 20 2006 497 499
55. M. van Engeland G.M. Roemen M. Brink M.M. Pachen M.P. Weijenberg A.P. de Bruïne J.W. Arends P.A. van den Brandt A.F. de Goeij J.G. Herman K-ras mutations and RASSF1A promoter methylation in colorectal cancer Oncogene 21 2002 3792 3795
56. H. Noda Y. Kato H. Yoshikawa M. Arai K. Togashi H. Nagai F. Konishi Y. Miki Frequent involvement of ras-signalling pathways in both polypoid-type and flat-type early-stage colorectal cancers J. Exp. Clin. Cancer Res. 25 2006 235 242
57. J. Reifenberger C.B. Knobbe A.A. Sterzinger B. Blaschke K.W. Schulte T. Ruzicka G. Reifenberger Frequent alterations of Ras signaling pathway genes in sporadic malignant melanomas Int. J. Cancer 109 2004 377 384
58. M. Irimia M.F. Fraga M. Sanchez-Cespedes M. Esteller CpG-island promoter hypermethylation of the Ras-effector gene NORE1A occurs in the context of a wild-type K-ras in lung cancer Oncogene 23 2004 8695 8699
59. K. Eckfeld L. Hesson M.D. Vos I. Bieche F. Latif G.J. Clark RASSF4/AD037 is a potential ras effector/tumour suppressor of the RASSF family Cancer Res. 64 2004 8688 8693
60. L.S. Chow K.W. Lo J. Kwong A.Y. Wong D.P. Huang Aberrant methylation of RASSF4/AD037 in nasopharyngeal carcinoma Oncol. Rep. 12 2004 781 787
61. L. van der Weyden D.J. Adams The Ras-association domain family (RASSF) members and their role in human tumourigenesis Biochim. Biophys. Acta 1776 2007 58 85
62. M. Ikeda S. Hirabayashi N. Fujiwara H. Mori A. Kawata J. Iida Y. Bao Y. Sato T. Iida H. Sugimura Y. Hata Ras-association domain family protein 6 induces apoptosis via both caspase-dependent and caspase-independent pathways Exp. Cell Res. 313 2007 1484 1495
63. M. Xia H. Land Tumour suppressor p53 restricts Ras stimulation of RhoA and cancer cell motility Nat. Struct. Mol. Biol. 14 2007 215 223
64. L. Shen Y. Kondo G.L. Rosner L. Xiao N.S. Hernandez J. Vilaythong P.S. Houlihan R.S. Krouse A.R. Prasad J.G. Einspahr J. Buckmeier D.S. Alberts S.R. Hamilton J.P. Issa MGMT promoter methylation and field defect in sporadic colorectal cancer J. Natl. Cancer Inst. 97 2005 1330 1338
65. M. Nishigaki K. Aoyagi I. Danjoh M. Fukaya K. Yanagihara H. Sakamoto T. Yoshida H. Sasaki Discovery of aberrant expression of R-RAS by cancer-linked DNA-hypomethylation in gastric cancer using microarrays Cancer Res. 65 2005 2115 2124
66. C. Kress H. Thomassin T. Grange Local DNA demethylation in vertebrates: how could it be performed and targeted? FEBS Lett. 494 2001 135 140
67. S.K. Patra, A. Patra, F. Rizzi, T.C. Ghosh, and S. Bettuzzi, Demethylation of (cytosine-5-C-methyl) DNA and regulation of transcription in the epigenetic pathways of cancer development, Cancer Metas. Rev. (in press), doi:10.1007/s10555-008-9118-y .
68. M. Szyf J. Theberge V. Bozovic Ras induces a general DNA-demethylation activity in mouse embryonal P19 cells J. Biol. Chem. 270 1995 12690 12696
69. M.A. Morgan A. Ganser C.W. Reuter Targeting the RAS signaling pathway in malignant hematologic diseases Curr. Drug Targets 8 2007 217 235
70. E. Diaz-Flores K. Shannon Targeting oncogenic Ras Genes Dev. 21 2007 1989 1992
71. M.R. Philips Methotrexate and Ras methylation: a new trick for an old drug? Sci. STKE 2004 225 2004 pe13
72. R. Lu X. Wang Z.-F. Chen D.-F. Sun X.-Q. Tian J.-Y. Fang Inhibition of extracellular signal-regulated kinase/mitogen-activated protein kinase pathway decrease DNA-methylation in colon cancer cells J. Biol Chem. 282 2007 12249 12259
73. S. Benvenuti A. Sartore-Bianchi F. Di Nicolantonio C. Zanon M. Moroni S. Veronese S. Siena A. Bardelli Oncogenic activation of the RAS/RAF signaling pathway impairs the response of metastatic colorectal cancers to anti-epidermal growth factor receptor antibody therapies Cancer Res. 67 2007 2643 2648
74. P.M. Campbell A.L. Groehler K.M. Lee M.M. Ouellette V. Khazak C.J. Der K-Ras promotes growth transformation and invasion of immortalized human pancreatic cells by Raf and phosphatidylinositol 3-kinase signaling Cancer Res. 67 2007 2098 2106
75. G. Yang J.A. Thompson B. Fang J. Liu Silencing of H-ras gene expression by retrovirus-mediated siRNA decreases transformation efficiency and tumour growth in a model of human ovarian cancer Oncogene 22 2003 5694 5701
76. Y. Zhu F. Guignard D. Zhao L. Liu D.K. Burns R.P. Mason A. Messing L.F. Parada Early inactivation of p53 tumour suppressor gene cooperating with NF1 loss induces malignant astrocytoma Cancer Cell 8 2005 119 130
77. B. Nicke J. Bastien S.J. Khanna P.H. Warne V. Cowling S.J. Cook G. Peters O. Delpuech A. Schulze K. Berns J. Mullenders R.L. Beijersbergen R. Bernards T.S. Ganesan J. Downward D.C. Hancock Involvement of MINK, a Ste20 family kinase, in Ras oncogene-induced growth arrest in human ovarian surface epithelial cells Mol. Cell 20 2005 673 685
78. M.H. Jeong J. Bae W.H. Kim S.M. Yoo J.W. Kim P.I. Song K.H. Choi p19ras interacts with and activates p73 by involving the MDM2 protein J. Biol. Chem. 281 2006 8707 8715