메뉴 건너뛰기




Volumn 14, Issue 2, 2008, Pages 163-173

The role of peptides in blood-brain barrier nanotechnology

Author keywords

Blood brain barrier; Nanoparticle; Nanoplatform; Nanotechnology; Peptides

Indexed keywords

ALBUMIN; ANESTHETIC AGENT; ANTICONVULSIVE AGENT; ANTINEOPLASTIC AGENT; BENZYLOXYCARBONYLASPARTYLGLUTAMYLVALYLASPARTYL FLUOROMETHYL KETONE; CONTRAST MEDIUM; DEXTRAN; DOXORUBICIN; FERUMOXTRAN 10; GADOLINIUM; GLYCOPROTEIN P; KYOTORPHIN; LEUCINE ENKEPHALIN[2 DEXTRO ALANINE 6 ARGININE]; LIPOSOME; MANNITOL; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY OX26; MRZ 2 276; NANOPARTICLE; NC 1900; PACLITAXEL; PEPTIDE DERIVATIVE; POLYMER; PRODRUG; PROTEIN DERIVATIVE; SOLID LIPID NANOPARTICLE; THIOFLAVINE; TUBOCURARINE CHLORIDE; ULTRASMALL SUPERPARAMAGNETIC IRON OXIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VASOPRESSIN DERIVATIVE;

EID: 39649113095     PISSN: 10752617     EISSN: 10991387     Source Type: Journal    
DOI: 10.1002/psc.983     Document Type: Review
Times cited : (39)

References (126)
  • 2
    • 33747749803 scopus 로고    scopus 로고
    • Blood-brain barrier genomics and proteomics: Elucidating phenotype, identifying disease targets and enabling drug delivery
    • Calabria AR, Shusta EV. Blood-brain barrier genomics and proteomics: elucidating phenotype, identifying disease targets and enabling drug delivery. Drug Discov. Today 2006; 11: 792-799.
    • (2006) Drug Discov. Today , vol.11 , pp. 792-799
    • Calabria, A.R.1    Shusta, E.V.2
  • 3
    • 26944462345 scopus 로고    scopus 로고
    • The role of nanobiotechnology in drug discovery
    • Jain KK. The role of nanobiotechnology in drug discovery. Drug Discov. Today 2005; 10: 1435-1442.
    • (2005) Drug Discov. Today , vol.10 , pp. 1435-1442
    • Jain, K.K.1
  • 6
    • 21344451667 scopus 로고    scopus 로고
    • Colloidal carriers and blood-brain barrier (BBB) translocation: A way to deliver drugs to the brain?
    • Garcia-Garcia E, Andrieux K, Gil S, Couvreur P. Colloidal carriers and blood-brain barrier (BBB) translocation: A way to deliver drugs to the brain? Int. J. Pharm. 2005; 298: 274-292.
    • (2005) Int. J. Pharm , vol.298 , pp. 274-292
    • Garcia-Garcia, E.1    Andrieux, K.2    Gil, S.3    Couvreur, P.4
  • 8
    • 0348231898 scopus 로고    scopus 로고
    • Mechanisms of diseases: The blood-brain barrier
    • Neuwelt EA, Mechanisms of diseases: the blood-brain barrier. Neurosurgery 2004; 54: 131-142.
    • (2004) Neurosurgery , vol.54 , pp. 131-142
    • Neuwelt, E.A.1
  • 9
    • 0142186830 scopus 로고    scopus 로고
    • Pain and the blood-brain barrier: Obstacles to drug delivery
    • Wolka AM, Huber JD, Davis TP. Pain and the blood-brain barrier: obstacles to drug delivery. Adv. Drug Deliv. Rev. 2003; 55: 987-1006.
    • (2003) Adv. Drug Deliv. Rev , vol.55 , pp. 987-1006
    • Wolka, A.M.1    Huber, J.D.2    Davis, T.P.3
  • 10
    • 0032754657 scopus 로고    scopus 로고
    • Microvessel organization and structure in experimental brain tumors: Microvessel populations with distinctive structural and functional properties
    • Schlageter KE, Molnar P, Lapin GD, Groothuis DR. Microvessel organization and structure in experimental brain tumors: Microvessel populations with distinctive structural and functional properties. Microvasc. Res. 1999; 58: 312-328.
    • (1999) Microvasc. Res , vol.58 , pp. 312-328
    • Schlageter, K.E.1    Molnar, P.2    Lapin, G.D.3    Groothuis, D.R.4
  • 11
    • 2342422295 scopus 로고    scopus 로고
    • Vascular microenvironment in gliomas
    • Vajkoczy P, Menger MD. Vascular microenvironment in gliomas. Cancer Treat. Res. 2004; 117: 249-262.
    • (2004) Cancer Treat. Res , vol.117 , pp. 249-262
    • Vajkoczy, P.1    Menger, M.D.2
  • 12
    • 0030026965 scopus 로고    scopus 로고
    • Targeted chemotherapy for malignant brain tumor using thermosensitive liposome and localized hyperthermia
    • Kakinuma K, tanaka R, Takahashi H, Watanabe M, Nakagawa T, Kuroki M. Targeted chemotherapy for malignant brain tumor using thermosensitive liposome and localized hyperthermia. J. Neurosurg. 1996; 84: 180-184.
    • (1996) J. Neurosurg , vol.84 , pp. 180-184
    • Kakinuma, K.1    tanaka, R.2    Takahashi, H.3    Watanabe, M.4    Nakagawa, T.5    Kuroki, M.6
  • 13
    • 0034095651 scopus 로고    scopus 로고
    • Transport of drugs from the nasal cavity to the central nervous system
    • Illum L. Transport of drugs from the nasal cavity to the central nervous system. Eur. J. Pharm. Sci. 2000; 11: 1-18.
    • (2000) Eur. J. Pharm. Sci , vol.11 , pp. 1-18
    • Illum, L.1
  • 14
    • 21344453274 scopus 로고    scopus 로고
    • Nasal drug administration: Potential for targeted central nervous system delivery
    • Graff CL, Pollack GM. Nasal drug administration: Potential for targeted central nervous system delivery. J. Pharm. Sci. 2005; 94: 1187-1195.
    • (2005) J. Pharm. Sci , vol.94 , pp. 1187-1195
    • Graff, C.L.1    Pollack, G.M.2
  • 15
    • 33645731771 scopus 로고    scopus 로고
    • Preliminary brain-targeting studies on intranasal mucoadhesive microemulsions of sumatriptan
    • Vyas TK, Babbar AK, Sharma RK, Singh S, Misra A. Preliminary brain-targeting studies on intranasal mucoadhesive microemulsions of sumatriptan. AAPS PharmSciTech 2006; 7: E8.
    • (2006) AAPS PharmSciTech , vol.7
    • Vyas, T.K.1    Babbar, A.K.2    Sharma, R.K.3    Singh, S.4    Misra, A.5
  • 16
    • 0033795553 scopus 로고    scopus 로고
    • Enhancement of the systemic and CNS specific delivery of L-dopa by the nasal administration of its water soluble prodrugs
    • Kao HD, Traboulsi A, Itoh S, Dittert L, Hussain A. Enhancement of the systemic and CNS specific delivery of L-dopa by the nasal administration of its water soluble prodrugs. Pharm. Res. 2000; 17: 978-984.
    • (2000) Pharm. Res , vol.17 , pp. 978-984
    • Kao, H.D.1    Traboulsi, A.2    Itoh, S.3    Dittert, L.4    Hussain, A.5
  • 17
    • 0030099527 scopus 로고    scopus 로고
    • Transporting therapeutics across the blood-brain barrier
    • Abbott JN, Romero IA. Transporting therapeutics across the blood-brain barrier. Mol. Med. Today 1996; 2: 106-113.
    • (1996) Mol. Med. Today , vol.2 , pp. 106-113
    • Abbott, J.N.1    Romero, I.A.2
  • 18
    • 0036629267 scopus 로고    scopus 로고
    • Barriers to remember: Brain-targeting chemical delivery systems and Alzheimer's disease
    • Bodor N, Buchwald P. Barriers to remember: brain-targeting chemical delivery systems and Alzheimer's disease. Drug Discov. Today 2002; 7: 766-774.
    • (2002) Drug Discov. Today , vol.7 , pp. 766-774
    • Bodor, N.1    Buchwald, P.2
  • 19
    • 0036228917 scopus 로고    scopus 로고
    • Enhanced neuroprotective effects of basic fibroblast growth factor in regional brain ischemia after conjugation to a blood-brain barrier delivery vector
    • Song BW, Vinters HV, Wu D, Pardridge WM. Enhanced neuroprotective effects of basic fibroblast growth factor in regional brain ischemia after conjugation to a blood-brain barrier delivery vector. J. Pharmacol. Exp. Ther. 2002; 301: 605-610.
    • (2002) J. Pharmacol. Exp. Ther , vol.301 , pp. 605-610
    • Song, B.W.1    Vinters, H.V.2    Wu, D.3    Pardridge, W.M.4
  • 20
    • 0017832535 scopus 로고
    • Nanoparticles and nanocapsules-new dosage forms in the nanometer size range
    • Kreuter J. Nanoparticles and nanocapsules-new dosage forms in the nanometer size range. Pharm. Acta Helv. 1978; 53: 33-39.
    • (1978) Pharm. Acta Helv , vol.53 , pp. 33-39
    • Kreuter, J.1
  • 23
    • 0028939209 scopus 로고
    • Controlled drug delivery with nanoparticles. Current possibilities and future trends
    • Couvreur P, Dubernet C, Puisieux F. Controlled drug delivery with nanoparticles. Current possibilities and future trends. Eur. J. Pharm. Biopharm. 1995; 41: 2-13.
    • (1995) Eur. J. Pharm. Biopharm , vol.41 , pp. 2-13
    • Couvreur, P.1    Dubernet, C.2    Puisieux, F.3
  • 25
    • 0035838366 scopus 로고    scopus 로고
    • Poly(lactic acid)-poly(ethylene glycol) nanoparticles as new carriers for the delivery of plasmid DNA
    • Perez C, Sanchez A, Putnam D, Ting D, Langer R, Alonso MJ. Poly(lactic acid)-poly(ethylene glycol) nanoparticles as new carriers for the delivery of plasmid DNA. J. Control. Rel. 2001; 75: 211-224.
    • (2001) J. Control. Rel , vol.75 , pp. 211-224
    • Perez, C.1    Sanchez, A.2    Putnam, D.3    Ting, D.4    Langer, R.5    Alonso, M.J.6
  • 26
    • 33646701176 scopus 로고    scopus 로고
    • Green chemistry and the health implications of nanoparticles
    • Albrecht MA, Evans CW, Raston CL. Green chemistry and the health implications of nanoparticles. Green Chem. 2006; 8: 417-432.
    • (2006) Green Chem , vol.8 , pp. 417-432
    • Albrecht, M.A.1    Evans, C.W.2    Raston, C.L.3
  • 27
    • 6344229772 scopus 로고    scopus 로고
    • Toxicological hazards of inhaled nanoparticles-potential implications for drug delivery
    • Borm PJ, Kreyling W. Toxicological hazards of inhaled nanoparticles-potential implications for drug delivery. J. Nanosci. Nanotechnol. 2004; 4: 521-531.
    • (2004) J. Nanosci. Nanotechnol , vol.4 , pp. 521-531
    • Borm, P.J.1    Kreyling, W.2
  • 30
    • 84886639752 scopus 로고
    • Dilute oral iron solutions as gastrointestinal contrast agents for magnetic resonance imaging; initial clinical experience
    • Wesbey GE, Brasch RC, Goldberg HI, Engelstad BL, Moss AA. Dilute oral iron solutions as gastrointestinal contrast agents for magnetic resonance imaging; initial clinical experience. Magn Reson. Imaging 1985; 3: 57-64.
    • (1985) Magn Reson. Imaging , vol.3 , pp. 57-64
    • Wesbey, G.E.1    Brasch, R.C.2    Goldberg, H.I.3    Engelstad, B.L.4    Moss, A.A.5
  • 31
    • 0033143448 scopus 로고    scopus 로고
    • Electron microscopy study of intrahepatic ultrasmall superparamagnetic iron oxide kinetics in the rat. Relation with magnetic resonance imaging
    • Dupas B, Berreur M, Rohanizadeh R, Bonnemain B, Meflah K, Pradal G. Electron microscopy study of intrahepatic ultrasmall superparamagnetic iron oxide kinetics in the rat. Relation with magnetic resonance imaging. Biol. Cell 1999; 91: 195-208.
    • (1999) Biol. Cell , vol.91 , pp. 195-208
    • Dupas, B.1    Berreur, M.2    Rohanizadeh, R.3    Bonnemain, B.4    Meflah, K.5    Pradal, G.6
  • 32
    • 28344456922 scopus 로고    scopus 로고
    • Imaging brain tumors with ferumoxtran-10, a nanoparticle magnetic resonance contrast agent
    • Murillo TP, Sandquist C, Jacobs PM, Nesbit G, Manninger S, Neuwelt EA. Imaging brain tumors with ferumoxtran-10, a nanoparticle magnetic resonance contrast agent. Therapy 2005; 2: 871-882.
    • (2005) Therapy , vol.2 , pp. 871-882
    • Murillo, T.P.1    Sandquist, C.2    Jacobs, P.M.3    Nesbit, G.4    Manninger, S.5    Neuwelt, E.A.6
  • 33
    • 32944464860 scopus 로고    scopus 로고
    • An exploratory study of ferumostran-10 nanoparticles as a blood-brain barrier imaging agent targeting phagocytic cells in CNS inflammatory lesions
    • Manninger SP, Muldoon LL, Nesbit G, Murillo T, Jacobs PM, Neuwelt EA. An exploratory study of ferumostran-10 nanoparticles as a blood-brain barrier imaging agent targeting phagocytic cells in CNS inflammatory lesions. Am. J. Neuroradiol. 2005; 26: 2290-2300.
    • (2005) Am. J. Neuroradiol , vol.26 , pp. 2290-2300
    • Manninger, S.P.1    Muldoon, L.L.2    Nesbit, G.3    Murillo, T.4    Jacobs, P.M.5    Neuwelt, E.A.6
  • 34
    • 3542995683 scopus 로고    scopus 로고
    • Nanoparticle-based in vivo investigation on blood-brain barrier permeability following ischemia and reperfusion
    • Yang CS, Chang CH, Tsai PJ, Chen WY, Tseng FG, Lo LW. Nanoparticle-based in vivo investigation on blood-brain barrier permeability following ischemia and reperfusion. Anal. Chem. 2004; 76: 4465-4471.
    • (2004) Anal. Chem , vol.76 , pp. 4465-4471
    • Yang, C.S.1    Chang, C.H.2    Tsai, P.J.3    Chen, W.Y.4    Tseng, F.G.5    Lo, L.W.6
  • 35
    • 0347626110 scopus 로고    scopus 로고
    • A multimodal nanoparticle for preoperative magnetic resonance imaging and intraoperative optical brain tumor delineation
    • Kircher MF, Mahmood U, King RS, Weissleder R, Josephson L. A multimodal nanoparticle for preoperative magnetic resonance imaging and intraoperative optical brain tumor delineation. Cancer Res. 2003; 63: 8122-8125.
    • (2003) Cancer Res , vol.63 , pp. 8122-8125
    • Kircher, M.F.1    Mahmood, U.2    King, R.S.3    Weissleder, R.4    Josephson, L.5
  • 38
    • 0037468315 scopus 로고    scopus 로고
    • Electron microscopic analysis of nanoparticles delivering thioflavin-T after intrahippocampal injection in mouse: Implications for targeting β-amyloid in Alzheimer's disease
    • Härtig W, Paulke BR, Varga C, Seeger J, Harkany T. Electron microscopic analysis of nanoparticles delivering thioflavin-T after intrahippocampal injection in mouse: implications for targeting β-amyloid in Alzheimer's disease. Neurosci. Lett. 2003; 338: 174-176.
    • (2003) Neurosci. Lett , vol.338 , pp. 174-176
    • Härtig, W.1    Paulke, B.R.2    Varga, C.3    Seeger, J.4    Harkany, T.5
  • 40
    • 32844458760 scopus 로고    scopus 로고
    • Improving the delivery of therapeutic agents to CNS neoplasms: A clinical review
    • Badruddoja MA, Black KL. Improving the delivery of therapeutic agents to CNS neoplasms: a clinical review. Front. Biosci. 2006; 11: 1466-1478.
    • (2006) Front. Biosci , vol.11 , pp. 1466-1478
    • Badruddoja, M.A.1    Black, K.L.2
  • 41
    • 0035937595 scopus 로고    scopus 로고
    • Nanoparticulate systems for brain delivery of drugs
    • Kreuter J. Nanoparticulate systems for brain delivery of drugs. Adv. Drug Deliv. Rev. 2001; 47: 65-81.
    • (2001) Adv. Drug Deliv. Rev , vol.47 , pp. 65-81
    • Kreuter, J.1
  • 42
    • 0036205158 scopus 로고    scopus 로고
    • Nanoparticle technology for drug delivery across the blood-brain barrier
    • Lockman PR, Mumper RJ, Khan MA, Allen DD. Nanoparticle technology for drug delivery across the blood-brain barrier. Drug Dev. Ind. Pharm. 2002; 28: 1-13.
    • (2002) Drug Dev. Ind. Pharm , vol.28 , pp. 1-13
    • Lockman, P.R.1    Mumper, R.J.2    Khan, M.A.3    Allen, D.D.4
  • 43
    • 0037119577 scopus 로고    scopus 로고
    • Drug targeting. Breaking down barriers
    • Miller G. Drug targeting. Breaking down barriers. Science 2002; 297: 1116-1118.
    • (2002) Science , vol.297 , pp. 1116-1118
    • Miller, G.1
  • 44
    • 6344258939 scopus 로고    scopus 로고
    • Drug delivery to the brain-realization by novel drug carriers
    • Muller RH, Keck CM. Drug delivery to the brain-realization by novel drug carriers. J. Nanosci. Nanotechnol. 2004; 4: 471-483.
    • (2004) J. Nanosci. Nanotechnol , vol.4 , pp. 471-483
    • Muller, R.H.1    Keck, C.M.2
  • 45
    • 33646673555 scopus 로고    scopus 로고
    • A review of nanocarrier-based CNS delivery systems
    • Tiwari SB, Amiji MM. A review of nanocarrier-based CNS delivery systems. Curr. Drug Deliv. 2006; 3: 219-232.
    • (2006) Curr. Drug Deliv , vol.3 , pp. 219-232
    • Tiwari, S.B.1    Amiji, M.M.2
  • 47
    • 0027070540 scopus 로고
    • Body distribution of fully biodegradable [14C]-poly(lactic acid) nanoparticles coated with albumin after parenteral administration to rats
    • Bazile DV, Ropert C, Huve P, Verrecchia T, Marland M, Frydman A, Veillard M, Spenleuhauer G. Body distribution of fully biodegradable [14C]-poly(lactic acid) nanoparticles coated with albumin after parenteral administration to rats. Biomaterials 1992; 13: 1093-1102.
    • (1992) Biomaterials , vol.13 , pp. 1093-1102
    • Bazile, D.V.1    Ropert, C.2    Huve, P.3    Verrecchia, T.4    Marland, M.5    Frydman, A.6    Veillard, M.7    Spenleuhauer, G.8
  • 49
    • 0343191443 scopus 로고    scopus 로고
    • Stealth' corona-core nanoparticles surface modified by polyethylene glycol (PEG): Influences of the corona (PEG chain length and surface density) and of the core composition on phagocytic uptake and plasma protein adsorption
    • Gref R, Luck M, Quellec P, Marchand M, Dellacherie E, Harnisch S, Blunk T, Muller RH. 'Stealth' corona-core nanoparticles surface modified by polyethylene glycol (PEG): influences of the corona (PEG chain length and surface density) and of the core composition on phagocytic uptake and plasma protein adsorption. Colloids Surf., B: Biointerfaces 2000; 18: 301-313.
    • (2000) Colloids Surf., B: Biointerfaces , vol.18 , pp. 301-313
    • Gref, R.1    Luck, M.2    Quellec, P.3    Marchand, M.4    Dellacherie, E.5    Harnisch, S.6    Blunk, T.7    Muller, R.H.8
  • 51
    • 0033993565 scopus 로고    scopus 로고
    • Increase of the duration of the anticonvulsive activity of a novel NMDA receptor antagonist using poly(butylcyanoacrylate) nanoparticles as a parenteral controlled release system
    • Friese A, Seiller E, Quack G, Lorenz B, Kreuter J. Increase of the duration of the anticonvulsive activity of a novel NMDA receptor antagonist using poly(butylcyanoacrylate) nanoparticles as a parenteral controlled release system. Eur. J, Pharm. Biopharm. 2000; 49: 103-109.
    • (2000) Eur. J, Pharm. Biopharm , vol.49 , pp. 103-109
    • Friese, A.1    Seiller, E.2    Quack, G.3    Lorenz, B.4    Kreuter, J.5
  • 52
    • 1542291181 scopus 로고    scopus 로고
    • Nanoparticle of biodegradable polymers for clinical administration of paclitaxel
    • Feng SS, Mu L, Win KY, Huang G. Nanoparticle of biodegradable polymers for clinical administration of paclitaxel. Curr. Med. Chem. 2004; 11: 413-424.
    • (2004) Curr. Med. Chem , vol.11 , pp. 413-424
    • Feng, S.S.1    Mu, L.2    Win, K.Y.3    Huang, G.4
  • 53
    • 0033980182 scopus 로고    scopus 로고
    • P-glycoprotein: A defense mechanism limiting oral bioavailability and CNS accumulation of drugs
    • Fromm MF. P-glycoprotein: a defense mechanism limiting oral bioavailability and CNS accumulation of drugs. Int. J. Clin. Pharmacol. Ther. 2000; 38: 69-74.
    • (2000) Int. J. Clin. Pharmacol. Ther , vol.38 , pp. 69-74
    • Fromm, M.F.1
  • 54
    • 0019957083 scopus 로고
    • Toxicity of polyalkylcyanoacrylate nanoparticles II: Doxorubicin-loaded nanoparticles
    • Couvreur P, Kante B, Grislain L, Roland M, Speiser P. Toxicity of polyalkylcyanoacrylate nanoparticles II: Doxorubicin-loaded nanoparticles. J. Pharm. Sci. 1982; 71: 790-792.
    • (1982) J. Pharm. Sci , vol.71 , pp. 790-792
    • Couvreur, P.1    Kante, B.2    Grislain, L.3    Roland, M.4    Speiser, P.5
  • 56
    • 0035886682 scopus 로고    scopus 로고
    • Conjugation of biomolecules with luminophore-doped silica nanoparticles for photostable biomarkers
    • Santra S, Zhang P, Wang K, Tapec R, Tan W. Conjugation of biomolecules with luminophore-doped silica nanoparticles for photostable biomarkers. Anal. Chem. 2001; 73: 4988-4993.
    • (2001) Anal. Chem , vol.73 , pp. 4988-4993
    • Santra, S.1    Zhang, P.2    Wang, K.3    Tapec, R.4    Tan, W.5
  • 57
    • 0037161319 scopus 로고    scopus 로고
    • The effect of poly(ethylene glycol)-poly(D,L-lactic acid) diblock copolymers on peptide acylation
    • Lucke A, Fustella E, Tessmar J, Gazzaniga A, Gopferich A. The effect of poly(ethylene glycol)-poly(D,L-lactic acid) diblock copolymers on peptide acylation. J. Control. Rel. 2002; 80: 157-168.
    • (2002) J. Control. Rel , vol.80 , pp. 157-168
    • Lucke, A.1    Fustella, E.2    Tessmar, J.3    Gazzaniga, A.4    Gopferich, A.5
  • 58
    • 0036000111 scopus 로고    scopus 로고
    • Recent advances in the stabilization of proteins encapsulated in injectable PLGA delivery systems
    • Schwendeman SP. Recent advances in the stabilization of proteins encapsulated in injectable PLGA delivery systems. Crit. Rev. Ther. Drug Carrier Syst. 2002; 19: 73-98.
    • (2002) Crit. Rev. Ther. Drug Carrier Syst , vol.19 , pp. 73-98
    • Schwendeman, S.P.1
  • 59
    • 0033635054 scopus 로고    scopus 로고
    • Protein instability in poly (lactic-co-glycolic acid) microparticles
    • Van de Weert M, Hennink WE, Jiskoot W. Protein instability in poly (lactic-co-glycolic acid) microparticles. Pharm. Res. 2000; 17: 1159-1167.
    • (2000) Pharm. Res , vol.17 , pp. 1159-1167
    • Van de Weert, M.1    Hennink, W.E.2    Jiskoot, W.3
  • 61
    • 0031918253 scopus 로고    scopus 로고
    • Stealth PLA-PEG nanoparticles as protein carriers for nasal administration
    • Tobio M, Gref R, Sanchez A, Langer R, Alonso MJ. Stealth PLA-PEG nanoparticles as protein carriers for nasal administration. Pharm. Res. 1998; 15: 270-275.
    • (1998) Pharm. Res , vol.15 , pp. 270-275
    • Tobio, M.1    Gref, R.2    Sanchez, A.3    Langer, R.4    Alonso, M.J.5
  • 62
    • 0032473386 scopus 로고    scopus 로고
    • Formulation of asparaginase-loaded poly (lactide-co-glycolide) nanoparticles: Influence of polymer properties on enzyme loading, activity and in vitro release
    • Gaspar MM, Blanco D, Cruz MEM, Alonso MJ. Formulation of asparaginase-loaded poly (lactide-co-glycolide) nanoparticles: influence of polymer properties on enzyme loading, activity and in vitro release. J. Control Rel. 1998; 52: 53-62.
    • (1998) J. Control Rel , vol.52 , pp. 53-62
    • Gaspar, M.M.1    Blanco, D.2    Cruz, M.E.M.3    Alonso, M.J.4
  • 63
    • 0031395214 scopus 로고    scopus 로고
    • Development and characterization of protein-loaded poly(lactide-co-glycolide) nanospheres
    • Blanco MD, Alonso MJ. Development and characterization of protein-loaded poly(lactide-co-glycolide) nanospheres. Eur. J. Pharm. Biopharm. 1997; 43: 287-294.
    • (1997) Eur. J. Pharm. Biopharm , vol.43 , pp. 287-294
    • Blanco, M.D.1    Alonso, M.J.2
  • 64
    • 0032863592 scopus 로고    scopus 로고
    • Why does PEG 400 coencapsulation improve NGF stability and release from PLGA biodegradable microspheres?
    • Pean JM, Boury F, Venier-Julienne MC, Menei P, Proust JE, Benoit JP. Why does PEG 400 coencapsulation improve NGF stability and release from PLGA biodegradable microspheres? Pharm. Res. 1999; 16: 1294-1299.
    • (1999) Pharm. Res , vol.16 , pp. 1294-1299
    • Pean, J.M.1    Boury, F.2    Venier-Julienne, M.C.3    Menei, P.4    Proust, J.E.5    Benoit, J.P.6
  • 65
    • 0037343587 scopus 로고    scopus 로고
    • Biodegradable micro- and nanoparticles as long-term delivery vehicles for interferon-α
    • Sanchez A, Tobio M, Gonzalez L, Fabra A, Alonso MJ. Biodegradable micro- and nanoparticles as long-term delivery vehicles for interferon-α. Eur. J. Pharm. Sci. 2003; 18: 221-229.
    • (2003) Eur. J. Pharm. Sci , vol.18 , pp. 221-229
    • Sanchez, A.1    Tobio, M.2    Gonzalez, L.3    Fabra, A.4    Alonso, M.J.5
  • 66
    • 0030630036 scopus 로고    scopus 로고
    • Protein delivery from biodegradable microspheres
    • Cleland JL. Protein delivery from biodegradable microspheres. Pharm. Biotechnol. 1997; 10: 1-43.
    • (1997) Pharm. Biotechnol , vol.10 , pp. 1-43
    • Cleland, J.L.1
  • 67
    • 0031765572 scopus 로고    scopus 로고
    • Nanoparticle technology for delivery of drugs across the blood-brain barrier
    • Schroeder U, Sommerfeld P, Ulrich S, Sabel BA. Nanoparticle technology for delivery of drugs across the blood-brain barrier. J. Pharm. Sci. 1998; 87: 1305-1307.
    • (1998) J. Pharm. Sci , vol.87 , pp. 1305-1307
    • Schroeder, U.1    Sommerfeld, P.2    Ulrich, S.3    Sabel, B.A.4
  • 68
    • 0031962120 scopus 로고    scopus 로고
    • Significant entry of tubocurarine into the brain of rats by absorption to polysorbate 80-coated polybutyl-cyanoacrylate nanoparticles: An in situ brain perfusion study
    • Alyautdin RN, Tezikov EB, Ramge P, Khakevich DA, Begley DJ, Kreuter J. Significant entry of tubocurarine into the brain of rats by absorption to polysorbate 80-coated polybutyl-cyanoacrylate nanoparticles: an in situ brain perfusion study. J. Microencapsul. 1998; 15: 67-74.
    • (1998) J. Microencapsul , vol.15 , pp. 67-74
    • Alyautdin, R.N.1    Tezikov, E.B.2    Ramge, P.3    Khakevich, D.A.4    Begley, D.J.5    Kreuter, J.6
  • 70
    • 33750010294 scopus 로고    scopus 로고
    • Improvement of cationic albumin conjugated pegylated nanoparticles holding NC-1900, a vasopressin fragment analog, in memory deficits induced by scopolamine in mice
    • Xie YL, Lu W, Jiang XG. Improvement of cationic albumin conjugated pegylated nanoparticles holding NC-1900, a vasopressin fragment analog, in memory deficits induced by scopolamine in mice. Behav. Brain Res. 2006; 173: 76-84.
    • (2006) Behav. Brain Res , vol.173 , pp. 76-84
    • Xie, Y.L.1    Lu, W.2    Jiang, X.G.3
  • 71
    • 0036889760 scopus 로고    scopus 로고
    • Targeted drug delivery via the transferrin receptor-mediated endocytosis pathway
    • Qian ZM, Li H, Sun H, Ho K. Targeted drug delivery via the transferrin receptor-mediated endocytosis pathway. Pharmacol. Rev. 2002; 4: 561-587.
    • (2002) Pharmacol. Rev , vol.4 , pp. 561-587
    • Qian, Z.M.1    Li, H.2    Sun, H.3    Ho, K.4
  • 72
  • 73
    • 0018401184 scopus 로고
    • Magnetically responsive microspheres and other carriers for the biological targeting of antitumor agents
    • Widder KJ, Senyei AE, Ranney DF. Magnetically responsive microspheres and other carriers for the biological targeting of antitumor agents. Adv. Pharmacol. Chemother. 1979; 16: 213-271.
    • (1979) Adv. Pharmacol. Chemother , vol.16 , pp. 213-271
    • Widder, K.J.1    Senyei, A.E.2    Ranney, D.F.3
  • 74
    • 0018387102 scopus 로고
    • Polycyanoacrylate nanocapsules as potential lysosomotropic carriers: Preparation, morphological and sorptive properties
    • Couvreur P, Kante B, Roland M, Guiot P, Baudhin P, Speiser P. Polycyanoacrylate nanocapsules as potential lysosomotropic carriers: preparation, morphological and sorptive properties. J. Pharm. Pharmacol. 1979; 31: 331-332.
    • (1979) J. Pharm. Pharmacol , vol.31 , pp. 331-332
    • Couvreur, P.1    Kante, B.2    Roland, M.3    Guiot, P.4    Baudhin, P.5    Speiser, P.6
  • 75
    • 0019365076 scopus 로고
    • Development of biodegradable and injectable lattices for controlled release of potent drugs
    • Gurny R, Peppas NA, Harrington DD, Banker GS. Development of biodegradable and injectable lattices for controlled release of potent drugs. Drug Dev. Ind. Pharm. 1981; 7: 1-25.
    • (1981) Drug Dev. Ind. Pharm , vol.7 , pp. 1-25
    • Gurny, R.1    Peppas, N.A.2    Harrington, D.D.3    Banker, G.S.4
  • 76
    • 0032875666 scopus 로고    scopus 로고
    • Poly (ethylene glycol)-polyethyleneimine nanogel particles: Novel drug delivery systems for antisense oligonucleotides
    • Vinogradov SV, Batrakova EV, Kabanov AV. Poly (ethylene glycol)-polyethyleneimine nanogel particles: novel drug delivery systems for antisense oligonucleotides. Colloids Surf. B: Biointerfaces 1999; 16: 291-304.
    • (1999) Colloids Surf. B: Biointerfaces , vol.16 , pp. 291-304
    • Vinogradov, S.V.1    Batrakova, E.V.2    Kabanov, A.V.3
  • 78
    • 39649083495 scopus 로고    scopus 로고
    • Synthesized polypeptides as drug delivery matrix. U.S. Pat. Appl. Publ.
    • US 2005276783 Al
    • Giralt E, Cid P, Pastor JJ, Gulin OP, Rabanal F. Synthesized polypeptides as drug delivery matrix. U.S. Pat. Appl. Publ. 2005; US 2005276783 Al.
    • (2005)
    • Giralt, E.1    Cid, P.2    Pastor, J.J.3    Gulin, O.P.4    Rabanal, F.5
  • 80
    • 0028306824 scopus 로고
    • Incorporation of basic fibroblast growth factor into methylpyrrolidinone chitosan fleeces and determination of the in vitro release characteristics
    • Berscht PC, Nies B, Liebendorfer A, Kreuter J. Incorporation of basic fibroblast growth factor into methylpyrrolidinone chitosan fleeces and determination of the in vitro release characteristics. Biomaterials 1994; 15: 593-600.
    • (1994) Biomaterials , vol.15 , pp. 593-600
    • Berscht, P.C.1    Nies, B.2    Liebendorfer, A.3    Kreuter, J.4
  • 81
    • 0037358299 scopus 로고    scopus 로고
    • Poly(L-glutamic acid)-paclitaxel conjugated is a potent enhancer of tumor radiocurability
    • Milas L, Mason KA, Hunter N, Li C, Wallace S. Poly(L-glutamic acid)-paclitaxel conjugated is a potent enhancer of tumor radiocurability. Int. J. Radiat. Oncol. Biol. Phys. 2003; 55: 707-712.
    • (2003) Int. J. Radiat. Oncol. Biol. Phys , vol.55 , pp. 707-712
    • Milas, L.1    Mason, K.A.2    Hunter, N.3    Li, C.4    Wallace, S.5
  • 84
    • 33846188096 scopus 로고    scopus 로고
    • Cationic albumin-conjugated pegylated nanoparticles allow gene delivery into brain tumors via intravenous administration
    • Lu W, Sun Q, Wan J, She Z, Jiang XG. Cationic albumin-conjugated pegylated nanoparticles allow gene delivery into brain tumors via intravenous administration. Cancer Res. 2006; 66: 11878-11887.
    • (2006) Cancer Res , vol.66 , pp. 11878-11887
    • Lu, W.1    Sun, Q.2    Wan, J.3    She, Z.4    Jiang, X.G.5
  • 85
    • 6344294066 scopus 로고    scopus 로고
    • Influence of the surface properties on nanoparticle mediated transport of drugs to the brain
    • Kreuter J. Influence of the surface properties on nanoparticle mediated transport of drugs to the brain. J. Nanosci. Nanotechnol. 2004; 4: 484-488.
    • (2004) J. Nanosci. Nanotechnol , vol.4 , pp. 484-488
    • Kreuter, J.1
  • 86
    • 0037335187 scopus 로고    scopus 로고
    • Direct evidence that polysorbate-80-coated poly(butylcyanoacrylate) nanoparticles deliver drugs to the CNS via specific mechanisms requiring prior binding of drug to the nanoparticles
    • Kreuter J, Ramge P, Petrov V, hamm S, Gelperina SE, Engelhardt B, Alyautdin R, Von Briesen H, Begley DJ. Direct evidence that polysorbate-80-coated poly(butylcyanoacrylate) nanoparticles deliver drugs to the CNS via specific mechanisms requiring prior binding of drug to the nanoparticles. Pharm. Res. 2003; 20: 409-416.
    • (2003) Pharm. Res , vol.20 , pp. 409-416
    • Kreuter, J.1    Ramge, P.2    Petrov, V.3    hamm, S.4    Gelperina, S.E.5    Engelhardt, B.6    Alyautdin, R.7    Von Briesen, H.8    Begley, D.J.9
  • 87
    • 0034887157 scopus 로고    scopus 로고
    • Interaction of poly(butylcyanoacrylate) nanoparticles with the blood-brain barrier in vivo and in vitro
    • Alyaudtin RN, Reichel A, Lobenberg R, Ramge P, Kreuter J, Begley DJ. Interaction of poly(butylcyanoacrylate) nanoparticles with the blood-brain barrier in vivo and in vitro. J. Drug Target. 2001; 9: 209-221.
    • (2001) J. Drug Target , vol.9 , pp. 209-221
    • Alyaudtin, R.N.1    Reichel, A.2    Lobenberg, R.3    Ramge, P.4    Kreuter, J.5    Begley, D.J.6
  • 89
    • 0028916155 scopus 로고    scopus 로고
    • Bazile D, Prud'homme C, Bassoullet MT, Marland M, Spenlehauer G, Veillard M. Stealth Me.PEG-PLA Nanoparticles Avoid Uptake by the mononuclear phagocytes system. J. Pharm. Sci. 1995; 84: 493-498.
    • Bazile D, Prud'homme C, Bassoullet MT, Marland M, Spenlehauer G, Veillard M. Stealth Me.PEG-PLA Nanoparticles Avoid Uptake by the mononuclear phagocytes system. J. Pharm. Sci. 1995; 84: 493-498.
  • 92
    • 0033649767 scopus 로고    scopus 로고
    • 3H-labelled dalargin bound to poly (butyl cyanoacrylate) nanoparticle after I.V. injections to mice
    • 3H-labelled dalargin bound to poly (butyl cyanoacrylate) nanoparticle after I.V. injections to mice. Life Sci. 2000; 66: 495-502.
    • (2000) Life Sci , vol.66 , pp. 495-502
    • Schroeder, U.1    Schroeder, H.2    Sabel, B.A.3
  • 93
    • 21344466290 scopus 로고    scopus 로고
    • Double-coated poly (butylcyanoacrylate) nanoparticulate delivery systems for brain targeting of dalargin via oral administration
    • Das D, Lin S. Double-coated poly (butylcyanoacrylate) nanoparticulate delivery systems for brain targeting of dalargin via oral administration. J. Pharm. Sci. 2005; 94: 1343-1353.
    • (2005) J. Pharm. Sci , vol.94 , pp. 1343-1353
    • Das, D.1    Lin, S.2
  • 94
    • 0343962248 scopus 로고    scopus 로고
    • The role of PEG on the stability in digestive fluids and in vivo fate of PEG-PLA nanoparticle following oral administration
    • Tobío M, Sánchez A, Vial A, Soriano I, Evora C, Vila-Jato JL, Alonso MJ. The role of PEG on the stability in digestive fluids and in vivo fate of PEG-PLA nanoparticle following oral administration. Coll. Surf. B: Biointerf. 2000; 18: 315-323.
    • (2000) Coll. Surf. B: Biointerf , vol.18 , pp. 315-323
    • Tobío, M.1    Sánchez, A.2    Vial, A.3    Soriano, I.4    Evora, C.5    Vila-Jato, J.L.6    Alonso, M.J.7
  • 95
    • 0029950793 scopus 로고    scopus 로고
    • Influence of coating agents on the degradation of poly (lactic acid) nanoparticles in model digestive fluids (USP XXII)
    • Landry FB, Bazile DV, Spenlehauer G, Veillard M, Kreuter J. Influence of coating agents on the degradation of poly (lactic acid) nanoparticles in model digestive fluids (USP XXII). STP Pharm. Sci. 1996; 63: 195-202.
    • (1996) STP Pharm. Sci , vol.63 , pp. 195-202
    • Landry, F.B.1    Bazile, D.V.2    Spenlehauer, G.3    Veillard, M.4    Kreuter, J.5
  • 96
    • 0027491769 scopus 로고
    • Coating particles with a block copolymer (poloxamine 908) suppresses opsonization but permits the activity of dysopsonin in the serum
    • Moghini S, Muir I, illum L, Davis S, KohlBachofen V. Coating particles with a block copolymer (poloxamine 908) suppresses opsonization but permits the activity of dysopsonin in the serum. Biochem. Biophys. Acta 1993; 1179: 157-165.
    • (1993) Biochem. Biophys. Acta , vol.1179 , pp. 157-165
    • Moghini, S.1    Muir, I.2    illum, L.3    Davis, S.4    KohlBachofen, V.5
  • 97
    • 0025341615 scopus 로고
    • Amphiphatic polyethyleneglycols effectively prolong the circulation time of liposomes
    • Klibanov AL, Maruyama K, Torchilin VP, Huang L. Amphiphatic polyethyleneglycols effectively prolong the circulation time of liposomes. FEBS Lett. 1990; 268: 235-237.
    • (1990) FEBS Lett , vol.268 , pp. 235-237
    • Klibanov, A.L.1    Maruyama, K.2    Torchilin, V.P.3    Huang, L.4
  • 98
    • 0028346598 scopus 로고
    • Hipótesis: Why do polyethylene glycol-coated liposomes circulate so long?
    • Torchilin VP, Papisov MI. Hipótesis: Why do polyethylene glycol-coated liposomes circulate so long? J. Liposome Res. 1994; 4: 725-739.
    • (1994) J. Liposome Res , vol.4 , pp. 725-739
    • Torchilin, V.P.1    Papisov, M.I.2
  • 100
    • 0034844370 scopus 로고    scopus 로고
    • Receptor mediated uptake of peptides that bind the human transferrin receptor
    • Lee JH, Engler JA, Collawn JF, Moore BA. Receptor mediated uptake of peptides that bind the human transferrin receptor. Eur. J. Biochem. 2001; 268: 2004-2012.
    • (2001) Eur. J. Biochem , vol.268 , pp. 2004-2012
    • Lee, J.H.1    Engler, J.A.2    Collawn, J.F.3    Moore, B.A.4
  • 101
    • 34548162419 scopus 로고    scopus 로고
    • All-D proline-rich cell-penetrating peptides: A preliminary in vivo internalization study
    • Pujals S, Sabido E, Tarrago T, Giralt E. All-D proline-rich cell-penetrating peptides: a preliminary in vivo internalization study. Biochem. Soc. Trans. 2007; 35: 794-796.
    • (2007) Biochem. Soc. Trans , vol.35 , pp. 794-796
    • Pujals, S.1    Sabido, E.2    Tarrago, T.3    Giralt, E.4
  • 103
    • 14644394067 scopus 로고    scopus 로고
    • Using iron oxide nanoparticles as gene carrier
    • Xiang JJ, Zhu SG, Li GY. Using iron oxide nanoparticles as gene carrier. Chin. J. Cancer 2001; 20: 1-6.
    • (2001) Chin. J. Cancer , vol.20 , pp. 1-6
    • Xiang, J.J.1    Zhu, S.G.2    Li, G.Y.3
  • 108
    • 33144464804 scopus 로고    scopus 로고
    • Synthesis and screening of a small library of proline-based biodendrimers for use as delivery agents
    • Sanclimens G, Shen H, Giralt E, Albericio F, Saltzman MW, Royo M. Synthesis and screening of a small library of proline-based biodendrimers for use as delivery agents. Biopolymers 2005; 80: 800-814.
    • (2005) Biopolymers , vol.80 , pp. 800-814
    • Sanclimens, G.1    Shen, H.2    Giralt, E.3    Albericio, F.4    Saltzman, M.W.5    Royo, M.6
  • 109
    • 0035910874 scopus 로고    scopus 로고
    • The role of plasma proteins in brain targeting: Species dependent protein adsorption patterns on brain-specific lipid drug conjugate (LDC) nanoparticles
    • Gessner A, Olbrich C, Schröder W, kayser O, Müller RH. The role of plasma proteins in brain targeting: species dependent protein adsorption patterns on brain-specific lipid drug conjugate (LDC) nanoparticles. Int. J. Pharm. 2001; 214: 87-91.
    • (2001) Int. J. Pharm , vol.214 , pp. 87-91
    • Gessner, A.1    Olbrich, C.2    Schröder, W.3    kayser, O.4    Müller, R.H.5
  • 110
    • 0033427851 scopus 로고    scopus 로고
    • Indirect evidence that drug brain targeting using polysorbate 80-coated polybutylcyanoacrylate nanoparticles is related o toxicity
    • Olivier JC, Fenart L, Chauvet R, Pariat C, Cecchelli R, Couet W. Indirect evidence that drug brain targeting using polysorbate 80-coated polybutylcyanoacrylate nanoparticles is related o toxicity. Pharm. Res. 1999; 16: 1836-1842.
    • (1999) Pharm. Res , vol.16 , pp. 1836-1842
    • Olivier, J.C.1    Fenart, L.2    Chauvet, R.3    Pariat, C.4    Cecchelli, R.5    Couet, W.6
  • 111
    • 0242500461 scopus 로고    scopus 로고
    • In vivo and in vitro assessment of baseline blood-brain barrier parameters in the presence of novel nanoparticles
    • Lockman PR, Koziara J, Roder KE, Paulson J, Abbruscato TJ, Mumper RJ, Allen DD. In vivo and in vitro assessment of baseline blood-brain barrier parameters in the presence of novel nanoparticles. Pharm. Res. 2003; 20: 705-713.
    • (2003) Pharm. Res , vol.20 , pp. 705-713
    • Lockman, P.R.1    Koziara, J.2    Roder, K.E.3    Paulson, J.4    Abbruscato, T.J.5    Mumper, R.J.6    Allen, D.D.7
  • 112
    • 33846499122 scopus 로고    scopus 로고
    • Chemotherapy of brain tumor using doxorubicin bound to surfactant-coated poly(butyl cyanoacrylate) nanoparticles: Revisiting the role of surfactants
    • Petri B, Bootz A, Khalansky A, Hekmatara T, Müller R, Uhl R, Kreuter J, Gelperina S. Chemotherapy of brain tumor using doxorubicin bound to surfactant-coated poly(butyl cyanoacrylate) nanoparticles: revisiting the role of surfactants. J. Control. Rel. 2007; 117: 51-58.
    • (2007) J. Control. Rel , vol.117 , pp. 51-58
    • Petri, B.1    Bootz, A.2    Khalansky, A.3    Hekmatara, T.4    Müller, R.5    Uhl, R.6    Kreuter, J.7    Gelperina, S.8
  • 113
    • 33747607074 scopus 로고    scopus 로고
    • Inhibitors of α -synuclein oligomerization and toxicity: A future therapeutic strategy for Parkinson's disease and related disorders
    • Amer DAM, Irvine GB, El-Agnaf OMA. Inhibitors of α -synuclein oligomerization and toxicity: a future therapeutic strategy for Parkinson's disease and related disorders. Exp. Brain Res. 2006; 173: 223-233.
    • (2006) Exp. Brain Res , vol.173 , pp. 223-233
    • Amer, D.A.M.1    Irvine, G.B.2    El-Agnaf, O.M.A.3
  • 114
    • 33747484171 scopus 로고    scopus 로고
    • N-methylated peptide inhibitors of β-amyloid aggregation and toxicity. Optimization of the inhibitor structure
    • Kokkoni N, Stott K, Amijee H, Mason JM, Doig AJ. N-methylated peptide inhibitors of β-amyloid aggregation and toxicity. Optimization of the inhibitor structure. Biochemistry. 2006; 45: 9906-9918.
    • (2006) Biochemistry , vol.45 , pp. 9906-9918
    • Kokkoni, N.1    Stott, K.2    Amijee, H.3    Mason, J.M.4    Doig, A.J.5
  • 115
    • 25844484030 scopus 로고    scopus 로고
    • Cationic albumin-conjugated pegylated nanoparticles as novel drug carrier for brain delivery
    • Lu W, Zhang Y, Tan YZ, Hu KL, Jiang XG, Fu SK. Cationic albumin-conjugated pegylated nanoparticles as novel drug carrier for brain delivery. J. Control. Rel. 2005; 107: 428-448.
    • (2005) J. Control. Rel , vol.107 , pp. 428-448
    • Lu, W.1    Zhang, Y.2    Tan, Y.Z.3    Hu, K.L.4    Jiang, X.G.5    Fu, S.K.6
  • 116
    • 33845618661 scopus 로고    scopus 로고
    • Aclarubicin-loaded cationic albumin-conjugated pegylated nanoparticle for glioma chemotherapy in rats
    • Lu W, Wan J, Zhang Q, She Z, Jiang X. Aclarubicin-loaded cationic albumin-conjugated pegylated nanoparticle for glioma chemotherapy in rats. Int. J. Cancer 2006; 120: 420-431.
    • (2006) Int. J. Cancer , vol.120 , pp. 420-431
    • Lu, W.1    Wan, J.2    Zhang, Q.3    She, Z.4    Jiang, X.5
  • 117
    • 17644410724 scopus 로고    scopus 로고
    • Cationic albumin conjugated pegylated nanoparticles with its transcytosis ability and little toxicity against blood-brain barrier
    • Lu W, Tan YZ, Hu KL, Jiang Xg. Cationic albumin conjugated pegylated nanoparticles with its transcytosis ability and little toxicity against blood-brain barrier. Int. J. Pharm. 2005; 295: 247-260.
    • (2005) Int. J. Pharm , vol.295 , pp. 247-260
    • Lu, W.1    Tan, Y.Z.2    Hu, K.L.3    Jiang, X.4
  • 118
    • 33750306696 scopus 로고    scopus 로고
    • An attempt to directly trace polymeric nanoparticles in vivo with electrón microscopy
    • Sun W, Wang H, Xie C, Hu Y, Yang X, Xs H. An attempt to directly trace polymeric nanoparticles in vivo with electrón microscopy. J. Control. Rel. 2006; 115: 259-265.
    • (2006) J. Control. Rel , vol.115 , pp. 259-265
    • Sun, W.1    Wang, H.2    Xie, C.3    Hu, Y.4    Yang, X.5    Xs, H.6
  • 119
    • 4544240398 scopus 로고    scopus 로고
    • Paclitaxel nanoparticles for the potential treatment of brain tumors
    • Koziara JM, Lockman PR, Allen DD, Mumper RJ. Paclitaxel nanoparticles for the potential treatment of brain tumors. J. Control. Rel. 2004; 99: 259-269.
    • (2004) J. Control. Rel , vol.99 , pp. 259-269
    • Koziara, J.M.1    Lockman, P.R.2    Allen, D.D.3    Mumper, R.J.4
  • 121
  • 122
    • 0030993566 scopus 로고    scopus 로고
    • Delivery of loperamide across the blood-brain barrier with polysorbate 80-coated polybutylcyanoacrylate nanoparticles
    • Alyautdin RN, Petrov VE, Langer K, berthold A, Kharkevich DA, Kreuter J. Delivery of loperamide across the blood-brain barrier with polysorbate 80-coated polybutylcyanoacrylate nanoparticles. Pharm. Res. 1997; 14: 325-328.
    • (1997) Pharm. Res , vol.14 , pp. 325-328
    • Alyautdin, R.N.1    Petrov, V.E.2    Langer, K.3    berthold, A.4    Kharkevich, D.A.5    Kreuter, J.6
  • 123
    • 33344460518 scopus 로고    scopus 로고
    • Influence of particle size on transport of methotrexate across the blood-brain barrier by polysorbate 80-coated polybutylcyanoacrylate nanoparticles
    • Gao K, Jiang X. Influence of particle size on transport of methotrexate across the blood-brain barrier by polysorbate 80-coated polybutylcyanoacrylate nanoparticles. Int. J. Pharm. 2006; 310: 213-219.
    • (2006) Int. J. Pharm , vol.310 , pp. 213-219
    • Gao, K.1    Jiang, X.2
  • 124
    • 0034118297 scopus 로고    scopus 로고
    • Polysorbate-80 coating enhances uptake of polybutylcyanoacrylate (PBCA)-nanoparticles by human and bovine primary brain capillary endothelial cells
    • Ramge P, Unger RE, Oltrogge JB, Zenker D, begley D, Kreuter J, Von Briesen H. Polysorbate-80 coating enhances uptake of polybutylcyanoacrylate (PBCA)-nanoparticles by human and bovine primary brain capillary endothelial cells. Eur. J. Neurosci. 2000; 12: 1931-1940.
    • (2000) Eur. J. Neurosci , vol.12 , pp. 1931-1940
    • Ramge, P.1    Unger, R.E.2    Oltrogge, J.B.3    Zenker, D.4    begley, D.5    Kreuter, J.6    Von Briesen, H.7
  • 126
    • 33750512963 scopus 로고    scopus 로고
    • Effect of nanoparticulate polybutylcyanoacrylate and methylmethacrylate-sulfopropylmethacrylate on the permeability of zidovudine and lamivudine across the in vivo blood-brain barrier
    • Kuo YC, Chen HH. Effect of nanoparticulate polybutylcyanoacrylate and methylmethacrylate-sulfopropylmethacrylate on the permeability of zidovudine and lamivudine across the in vivo blood-brain barrier. Int. J. Pharm. 2006; 327: 160-169.
    • (2006) Int. J. Pharm , vol.327 , pp. 160-169
    • Kuo, Y.C.1    Chen, H.H.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.