N-methylated peptide inhibitors of β-amyloid aggregation and toxicity. Optimization of the inhibitor structure

Biochemistry

Volumn 45, Issue 32, 2006, Pages 9906-9918

  Kokkoni, Nicoleta ^a   Stott, Kelvin ^b   Amijee, Hozefa ^a,b   Mason, Jody M ^a   Doig, Andrew J ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b Babraham Research Campus   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLATION; CHROMATOGRAPHY; HYDROGEN BONDS; OLIGOMERS; STRUCTURE (COMPOSITION); TOXIC MATERIALS;

AMIDATION; HYDROPHOBIC SIDE CHAINS; PEPTIDE AGGREGATION INHIBITORS; PEPTIDE INHIBITORS;

AMINO ACIDS;

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; AMYLOID BETA PROTEIN; DEXTRO AMINO ACID; DEXTRO CYCLOHEXYLGLYCYLTYROSYLCYCLOHEXYLGLYCYLCYCLOHEXYLGLYCYLMETHYLLEUCINAMIDE; GLYCINE; LEUCINE; LYSYLLEUCYLVALYLPHENYLALANYLPHENYLALANINE; N METHYLATED PEPTIDE; OLIGOMER; POLYPEPTIDE; PROTEIN INHIBITOR; SEN 304; THIOFLAVINE; TYROSINE; UNCLASSIFIED DRUG;

ACETYLATION; AFFINITY CHROMATOGRAPHY; ALZHEIMER DISEASE; AMIDATION; AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; ASSAY; CARBOXY TERMINAL SEQUENCE; CHIRALITY; CONTROLLED STUDY; DRUG MECHANISM; ELECTRON MICROSCOPY; ENZYME ACTIVITY; HYDROGEN BOND; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN BINDING; PROTEIN METHYLATION; PROTEIN STRUCTURE; RAT; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN; ANIMALS; CHROMATOGRAPHY, AFFINITY; MOLECULAR SEQUENCE DATA; PC12 CELLS; PEPTIDE FRAGMENTS; PEPTIDE LIBRARY; PEPTIDES; PROTEIN STRUCTURE, QUATERNARY; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAZOLIUM SALTS; THIAZOLES; TOXICITY TESTS;

EID: 33747484171     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi060837s     Document Type: Article

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