Tyrosine phosphorylation of netrin receptors in netrin-1 signaling

NeuroSignals

Volumn 16, Issue 2-3, 2008, Pages 235-245

  Ren, Xiu Rong ^b   Hong, Yan ^b   Feng, Zhu ^a   Yang, Hong Mei ^b   Mei, Lin ^a   Xiong, Wen Cheng ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

^b University of Alabama at Birmingham   (United States)

Author keywords

Deleted in colorectal cancer; Focal adhesion kinase; Fyn; Neogenin; Netrin 1

Indexed keywords

ABELSON KINASE; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; NEOGENIN; NETRIN 1; PROTEIN KINASE FYN; PROTEIN KINASE LCK; PROTEIN TYROSINE KINASE; RECEPTOR;

ARTICLE; CELL CULTURE; COLORECTAL CANCER; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; IMMUNOPRECIPITATION; IN VITRO STUDY; NERVE FIBER GROWTH; NONHUMAN; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE; CELLS, CULTURED; CHICKENS; FEMALE; HUMANS; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; NERVE GROWTH FACTORS; NEURONS; PHOSPHORYLATION; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEINS; TYROSINE;

EID: 39349108018     PISSN: 1424862X     EISSN: None     Source Type: Journal    
DOI: 10.1159/000111566     Document Type: Article

References (44)

1. Livesey FJ: Netrins and netrin receptors. Cell Mol Life Sci 1999;56:62-68.
2. Colavita A, Culotti JG: Suppressors of ectopic UNC-5 growth cone steering identify eight genes involved in axon guidance in Caenorhabditis elegans. Dev Biol 1998;194:72-85.
3. Kennedy TE, Serafini T, de la Torre JR, Tessier-Lavigne M: Netrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cord. Cell 1994;78:425-435.
4. Serafini T, Kennedy TE, Galko MJ, Mirzayan C, Jessell TM, Tessier-Lavigne M: The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6. Cell 1994;78:409-424.
5. Colamarino SA, Tessier-Lavigne M: The axonal chemoattractant netrin-1 is also a chemorepellent for trochlear motor axons. Cell 1995;81:621-629.
6. Keino-Masu K, Masu M, Hinck L, Leonardo ED, Chan SS, Culotti JG, Tessier-Lavigne M: Deleted in colorectal cancer (DCC) encodes a netrin receptor. Cell 1996;87:175-185.
7. Chan SS, Zheng H, Su MW, Wilk R, Killeen MT, Hedgecock EM, Culotti JG: UNC-40, a C. elegans homolog of DCC (deleted in colorectal cancer), is required in motile cells responding to UNC-6 netrin cues. Cell 1996;87:187-195.
8. Kolodziej PA, Timpe LC, Mitchell KJ, Fried SR, Goodman CS, Jan LY, Jan YN: Frazzled encodes a Drosophila member of the DCC immunoglobulin subfamily and is required for CNS and motor axon guidance. Cell 1996;87:197-204.
9. Hiramoto M, Hiromi Y, Giniger E, Hotta Y: The Drosophila netrin receptor Frazzled guides axons by controlling netrin distribution. Nature 2000;406:886-889.
10. Culotti JG, Merz DC: DCC and netrins. Curr Opin Cell Biol 1998;10:609-613.
11. Hedgecock EM, Culotti JG, Hall DH: The unc-5, unc-6, and unc-40 genes guide circumferential migrations of pioneer axons and mesodermal cells on the epidermis in C. elegans . Neuron 1990;4:61-85.
12. Hong K, Hinck L, Nishiyama M, Poo MM, Tessier-Lavigne M, Stein E: A ligand-gated association between cytoplasmic domains of UNC5 and DCC family receptors converts netrin-induced growth cone attraction to repulsion. Cell 1999;97:927-941.
13. Keleman K, Dickson BJ: Short- and long-range repulsion by the Drosophila Unc5 netrin receptor. Neuron 2001;32:605-617.
14. Ackerman SL, Kozak LP, Przyborski SA, Rund LA, Boyer BB, Knowles BB: The mouse rostral cerebellar malformation gene encodes an UNC-5-like protein. Nature 1997;386:838-842.
15. Leonardo ED, Hinck L, Masu M, Keino-Masu K, Ackerman SL, Tessier-Lavigne M: Vertebrate homologues of C. elegans UNC-5 are candidate netrin receptors. Nature 1997;386:833-838.
16. Rajagopalan S, Deitinghoff L, Davis D, Conrad S, Skutella T, Chedotal A, Mueller BK, Strittmatter SM: Neogenin mediates the action of repulsive guidance molecule. Nat Cell Biol 2004;6:756-762.
17. Matsunaga E, Tauszig-Delamasure S, Monnier PP, Mueller BK, Strittmatter SM, Mehlen P, Chedotal A: RGM and its receptor neogenin regulate neuronal survival. Nat Cell Biol 2004;6:749-755.
18. Flanagan JG, Vanderhaeghen P: The ephrins and Eph receptors in neural development. Annu Rev Neurosci 1998;21:309-345.
19. Bashaw GJ, Kidd T, Murray D, Pawson T, Goodman CS: Repulsive axon guidance: Abelson and Enabled play opposing roles downstream of the roundabout receptor. Cell 2000;101:703-715.
20. Tong J, Killeen M, Steven R, Binns KL, Culotti J, Pawson T: Netrin stimulates tyrosine phosphorylation of the UNC-5 family of netrin receptors and induces Shp2 binding to the RCM cytodomain. J Biol Chem 2001;276:40917-40925.
21. Killeen M, Tong J, Krizus A, Steven R, Scott I, Pawson T, Culotti J: UNC-5 function requires phosphorylation of cytoplasmic tyrosine 482, but its UNC-40-independent functions also require a region between the ZU-5 and death domains. Dev Biol 2002;251:348-366.
22. Chang C, Yu TW, Bargmann CI, Tessier-Lavigne M: Inhibition of netrin-mediated axon attraction by a receptor protein tyrosine phosphatase. Science 2004;305:103-106.
23. Liu G, Beggs H, Jurgensen C, Park HT, Tang H, Gorski J, Jones KR, Reichardt LF, Wu J, Rao Y: Netrin requires focal adhesion kinase and Src family kinases for axon outgrowth and attraction. Nat Neurosci 2004;7:1222-1232.
24. Ren XR, Ming GL, Xie Y, Hong Y, Sun DM, Zhao ZQ, Feng Z, Wang Q, Shim S, Chen ZF, Song HJ, Mei L, Xiong WC: Focal adhesion kinase in netrin-1 signaling. Nat Neurosci 2004;7:1204-1212.
25. Li W, Lee J, Vikis HG, Lee SH, Liu G, Aurandt J, Shen TL, Fearon ER, Guan JL, Han M, Rao Y, Hong K, Guan KL: Activation of FAK and Src are receptor-proximal events required for netrin signaling. Nat Neurosci 2004;7:1213-1221.
26. Meriane M, Tcherkezian J, Webber CA, Danek EI, Triki I, McFarlane S, Bloch-Gallego E, Lamarche-Vane N: Phosphorylation of DCC by Fyn mediates netrin-1 signaling in growth cone guidance. J Cell Biol 2004;167:687-698.
27. Li HS, Chen JH, Wu W, Fagaly T, Zhou L, Yuan W, Dupuis S, Jiang ZH, Nash W, Gick C, Ornitz DM, Wu JY, Rao Y: Vertebrate slit, a secreted ligand for the transmembrane protein roundabout, is a repellent for olfactory bulb axons. Cell 1999;96:807-818.
28. Tang H, Kerins DM, Hao Q, Inagami T, Vaughan DE: The urokinase-type plasminogen activator receptor mediates tyrosine phosphorylation of focal adhesion proteins and activation of mitogen-activated protein kinase in cultured endothelial cells. J Biol Chem 1998;273:18268-18272.
29. Xiong W, Parsons JT: Induction of apoptosis after expression of PYK2, a tyrosine kinase structurally related to focal adhesion kinase. J Cell Biol 1997;139:529-539.
30. Ren XR, Du QS, Huang YZ, Ao SZ, Mei L, Xiong WC: Regulation of CDC42 GTPase by proline-rich tyrosine kinase 2 interacting with PSGAP, a novel pleckstrin homology and Src homology 3 domain containing rhoGAP protein. J Cell Biol 2001;152:971-984.
31. Huang YZ, Won S, Ali DW, Wang Q, Tanowitz M, Du QS, Pelkey KA, Yang DJ, Xiong WC, Salter MW, Mei L: Regulation of neuregulin signaling by PSD-95 interacting with ErbB4 at CNS synapses. Neuron 2000;26:443-455.
32. Wong K, Ren XR, Huang YZ, Xie Y, Liu G, Saito H, Tang H, Wen L, Brady-Kalnay SM, Mei L, Wu JY, Xiong WC, Rao Y: Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway. Cell 2001;107:209-221.
33. Metin C, Deleglise D, Serafini T, Kennedy TE, Tessier-Lavigne M: A role for netrin-1 in the guidance of cortical efferents. Development 1997;124:5063-5074.
34. Braisted JE, Catalano SM, Stimac R, Kennedy TE, Tessier-Lavigne M, Shatz CJ, O'Leary DD: Netrin-1 promotes thalamic axon growth and is required for proper development of the thalamocortical projection. J Neurosci 2000;20:5792-5801.
35. Yang LT, Alexandropoulos K, Sap J: c-SRC mediates neurite outgrowth through recruitment of Crk to the scaffolding protein Sin/Efs without altering the kinetics of ERK activation. J Biol Chem 2002;277:17406-17414.
36. Sly LM, Rauh MJ, Kalesnikoff J, Buchse T, Krystal G: SHIP, SHIP2, and PTEN activities are regulated in vivo by modulation of their protein levels: SHIP is up-regulated in macrophages and mast cells by lipopolysaccharide. Exp Hematol 2003;31:1170-1181.
37. Abu-Ghazaleh R, Kabir J, Jia H, Lobo M, Zachary I: Src mediates stimulation by vascular endothelial growth factor of the phosphorylation of focal adhesion kinase at tyrosine 861, and migration and anti-apoptosis in endothelial cells. Biochem J 2001;360:255-264.
38. Calalb MB, Zhang X, Polte TR, Hanks SK: Focal adhesion kinase tyrosine-861 is a major site of phosphorylation by Src. Biochem Biophys Res Commun 1996;228:662-668.
39. Richards LJ, Koester SE, Tuttle R, O'Leary DD: Directed growth of early cortical axons is influenced by a chemoattractant released from an intermediate target. J Neurosci 1997;17:2445-2458.
40. Toutant M, Studler JM, Burgaya F, Costa A, Ezan P, Gelman M, Girault JA: Autophosphorylation of Tyr397 and its phosphorylation by Src-family kinases are altered in focal-adhesion-kinase neuronal isoforms. Biochem J 2000;348:119-128.
41. Derkinderen P, Toutant M, Kadare G, Ledent C, Parmentier M, Girault JA: Dual role of Fyn in the regulation of FAK+6,7 by cannabinoids in hippocampus. J Biol Chem 2001;276:38289-38296.
42. Kang JS, Yi MJ, Zhang W, Feinleib JL, Cole F, Krauss RS: Netrins and neogenin promote myotube formation. J Cell Biol 2004;167:493-504.
43. Polte TR, Hanks SK: Complexes of focal adhesion kinase (FAK) and Crk-associated substrate (p130(Cas)) are elevated in cytoskeleton-associated fractions following adhesion and Src transformation: requirements for Src kinase activity and FAK proline-rich motifs. J Biol Chem 1997;272:5501-5509.
44. Feller SM: Crk family adaptors-signalling complex formation and biological roles. Oncogene 2001;20:6348-6371.