The Drosophila netrin receptor Frazzled guides axons by controlling Netrin distribution

Nature

Volumn 406, Issue 6798, 2000, Pages 886-889

  Hiramoto, Masaki ^a,d   Hiromi, Yasushi ^a,b   Giniger, Edward ^c   Hotta, Yoshiki ^a,b,d  

^a NATIONAL INSTITUTE OF GENETICS   (Japan)

^b GRADUATE UNIVERSITY FOR ADVANCED STUDIES   (Japan)

^c Fred Hutchinson Cancer Research Center   (United States)

^d JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

NETRIN;

ARTICLE; CENTRAL NERVOUS SYSTEM; DROSOPHILA; GENE EXPRESSION; MODEL; MOLECULAR RECOGNITION; NERVE FIBER; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN LOCALIZATION;

AMINO ACID SEQUENCE; ANIMALS; AXONS; CELL DIVISION; CELL MOVEMENT; DROSOPHILA; GROWTH CONES; MODELS, NEUROLOGICAL; MOLECULAR SEQUENCE DATA; NERVE GROWTH FACTORS; RECEPTORS, CELL SURFACE; TISSUE DISTRIBUTION; TUMOR SUPPRESSOR PROTEINS;

EID: 0034710686     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35022571     Document Type: Article

References (30)

1. Serafini, T. et al. The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6. Cell 78, 409-424 (1994).
2. de la Torre, J. R. et al. Turning of retinal growth cones in a netrin-1 gradient mediated by the netrin receptor DCC. Neuron 6, 1211-1224 (1997).
3. Kolodziej, P. A. et al. frazzled encodes a Drosophila member of the DCC immunoglobulin subfamily and is required for CNS and motor axon guidance. Cell 87, 197-204 (1996).
4. Chan, S. S. et al. UNC-40, a C. elegans homolog of DCC (Deleted in Colorectal Cancer), is required in motile cells responding to UNC-6 netrin cues. Cell 87, 187-195 (1996).
5. Keino-Masu, K. et al. Deleted in Colorectal Cancer (DCC) encodes a netrin receptor. Cell 87, 175-185 (1996).
6. Leung-Hagesteijn, C. et al. UNC-5, a transmembrane protein with immunoglobulin and thrombospondin type 1 domains, guides cell and pioneer axon migrations in C. elegans. Cell 71, 289-299 (1992).
7. Hamelin, M., Zhou, Y., Su, M. W., Scott, I. M. & Culotti, J. G. Expression of the UNC-5 guidance receptor in the touch neurons of C. elegans steers their axons dorsally. Nature 364, 327-330 (1993).
8. Ackerman, S. L. et al. The mouse rostral cerebellar malformation gene encodes an UNC-5-like protein. Nature 386, 838-842 (1997).
9. Leonardo, E. D. et al. Vertebrate homologues of C. elegans UNC-5 are candidate netrin receptors. Nature 386, 833-838 (1997).
10. Fazeli, A. et al. Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene. Nature 386, 796-804 (1997).
11. Przyborski, S. A., Knowles, B. B. & Ackerman, S. L. Embryonic phenotype of Unc5h3 mutant mice suggests chemorepulsion during the formation of the rostral cerebellar boundary. Development 125, 41-50 (1998).
12. Hong, K. et al. A ligand-gated association between cytoplasmic domains of UNC5 and DCC family receptors converts netrin-induced growth cone attraction to repulsion. Cell 97, 927-941 (1999).
13. Bashaw, G. J. & Goodman, C. S. Chimeric axon guidance receptors: the cytoplasmic domains of slit and netrin receptors specify attraction versus repulsion. Cell 97, 917-926 (1999).
14. Gong, Q., Rangarajan R., Seeger, M. & Gaul, U. The Netrin receptor Frazzled is required in the target for establishment of retinal projections in the Drosophila visual system. Development 126, 1451-1456 (1999).
15. Serafini, T. et al. Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system. Cell 87, 1001-1014 (1996).
16. Kennedy, T. E., Serafini, T., de la Torre, J. R. & Tessier-Lavigne, M. Netrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cord. Cell 78, 425-435 (1994).
17. Mitchell, K. J. et al. Genetic analysis of Netrin genes in Drosophila: Netrins guide CNS commissural axons and peripheral motor axons. Neuron 17, 203-215 (1996).
18. Harris, R., Sabatelli, L. M., & Seeger, M. A. Guidance cues at the Drosophila CNS midline: identification and characterization of two Drosophila Netrin/UNC-6 homologs. Neuron 17, 217-228 (1996).
19. Hedgecock, E. M., Culotti, J. G. & Hall, D. H. The unc-5, unc-6, and unc-40 genes guide circumferential migrations of pioneer axons and mesodermal cells on the epidermis in C. elegans. Neuron 4, 61-85 (1990).
20. Wadsworth, W. G., Bhatt, H. & Hedgecock, E. M. Neuroglia and pioneer neurons express UNC-6 to provide global and local netrin cues for guiding migrations in C. elegans. Neuron 16, 35-46 (1996).
21. Ishii, N., Wadsworth, W. G., Stern, B. D., Culotti, J. G. & Hedgecock, E. M. UNC-6, a laminin-related protein, guides cell and pioneer axon migrations in C. elegans. Neuron 9, 873-881 (1992).
22. Colamarino, S. A. & Tessier-Lavigne, M. The axonal chemoattractant netrin-1 is also a chemorepellent for trochlear motor axons. Cell 81, 621-629 (1995).
23. Brose, K. et al. Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance. Cell 96, 795-806 (1999).
24. Jacobs, J. R. & Goodman, C. S. Embryonic development of axon pathways in the Drosophila CNS. II. Behavior of pioneer growth cones. J. Neurosci. 9, 2412-2422 (1989).
25. Hidalgo, A. & Brand, A. H. Targeted neuronal ablation: the role of pioneer neurons in guidance and fasciculation in the CNS of Drosophila. Development 124, 3253-3262 (1997).
26. Ramírez-Weber, F. A. & Kornberg, T. B. Cytonemes: cellular processes that project to the principal signaling center in Drosophila imaginal discs. Cell 97, 599-607 (1999).
27. Winberg, M. L., Mitchell, K. J. & Goodman, C. S. Genetic analysis of the mechanisms controlling target selection: complementary and combinatorial functions of netrins, semaphorins, and IgCAMs. Cell 93, 581-591 (1998).
28. Brand, A. H. & Perrimon, N. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118, 401-415 (1993).
29. Ashburner, M. Drosophila, a Laboratory Manual. (CSHL, Cold Spring Harbor, 1989).
30. Fujita, S. C., Zipursky, S. L., Benzer, S., Ferrus, A. & Shotwell, S. L. Monoclonal antibodies against the Drosophila nervous system. Proc. Natl Acad. Sci. USA 79, 7929-7933 (1982).