Focal adhesion kinase in netrin-1 signaling

Nature Neuroscience

Volumn 7, Issue 11, 2004, Pages 1204-1212

  Ren, Xiu Rong ^a   Ming, Guo Li ^b   Xie, Yi ^a   Hong, Yan ^a   Sun, Dong Mei ^a   Zhao, Zhong Qiu ^c   Feng, Zhu ^a,d   Wang, Qiang ^a,d,e   Shim, Sangwoo ^b   Chen, Zhou Feng ^c   Song, Hong Jun ^b   Mei, Lin ^a,d,e   Xiong, Wen Cheng ^a,d  

^a University of Alabama at Birmingham   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c WASHINGTON UNIVERSITY   (United States)

^d MEDICAL COLLEGE OF GEORGIA   (United States)

^e University of Alabama at Birmingham   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FOCAL ADHESION KINASE; NETRIN; NETRIN 1; NETRIN RECEPTOR; NETRIN RECEPTOR DCC; TYROSINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BRAIN DEVELOPMENT; CELL ADHESION; CELL MIGRATION; CONTROLLED STUDY; GROWTH CONE; MOUSE; NERVE CELL CULTURE; NERVE FIBER; NERVE FIBER GROWTH; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; XENOPUS LAEVIS;

ANIMALS; AXONS; BLOTTING, WESTERN; CELL COUNT; CELLS, CULTURED; CEREBRAL CORTEX; CHICK EMBRYO; COCULTURE TECHNIQUES; CULTURE MEDIA, CONDITIONED; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; EMBRYO; ENZYME ACTIVATION; ENZYME INHIBITORS; FEMALE; FOCAL ADHESION KINASE 1; FOCAL ADHESION PROTEIN-TYROSINE KINASES; GENE EXPRESSION REGULATION; GREEN FLUORESCENT PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; LAMININ; MALE; MICE; MICE, KNOCKOUT; MUCOPROTEINS; NERVE GROWTH FACTOR; NERVE GROWTH FACTORS; NEURITES; NEURONS; ONCOGENE PROTEINS V-ABL; PHOSPHORYLATION; PREGNANCY; PROTEIN-TYROSINE KINASES; RATS; RECEPTOR, TRKA; SIGNAL TRANSDUCTION; SPINAL CORD; SRC-FAMILY KINASES; TIME FACTORS; TUBULIN; TUMOR SUPPRESSOR PROTEINS; TWO-HYBRID SYSTEM TECHNIQUES; TYROSINE;

EID: 7044269185     PISSN: 10976256     EISSN: None     Source Type: Journal    
DOI: 10.1038/nn1330     Document Type: Article

References (50)

1. Livesey, F.J. Netrins and netrin receptors. Cell. Mol. Life Sci. 56, 62-68 (1999).
2. Kennedy, T.E., Serafini, T., de la Torre, J.R. & Tessier-Lavigne, M. Netrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cord. Cell 78, 425-435 (1994).
3. Serafini, T. et al. The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6. Cell 78, 409-424 (1994).
4. Culotti, J.G. & Merz, D.C. DCC and netrins. Curr. Opin. Cell Biol. 10, 609-613 (1998).
5. Keino-Masu, K. et al. Deleted in Colorectal Cancer (DCC) encodes a netrin receptor. Cell 87, 175-185(1996).
6. Chan, S.S. et al. UNC-40, a C. elegans homolog of DCC (Deleted in Colorectal Cancer), is required in motile cells responding to UNC-6 netrin cues. Cell 87, 187-195 (1996).
7. Kolodziej, P.A. et al. frazzled encodes a Drosophila member of the DCC immunoglobulin subfamily and is required for CNS and motor axon guidance. Cell 87, 197-204 (1996).
8. Hiramoto, M., Hiromi, Y., Giniger, E. & Hotta, Y. The Drosophila Netrin receptor Frazzled guides axons by controlling Netrin distribution. Nature 406, 886-889 (2000).
9. Hedgecock, E.M., Culotti, J.G. & Hall, D.H. The unc-5, unc-6, and unc-40 genes guide circumferential migrations of pioneer axons and mesodermal cells on the epidermis in C. elegans. Neuron 4, 61-85 (1990).
10. Ackerman, S.L. et al. The mouse rostral cerebellar malformation gene encodes an UNC-5-like protein. Nature 386, 838-842 (1997).
11. Leonardo, E.D. et al. Vertebrate homologues of C. elegans UNC-5 are candidate netrin receptors. Nature 386, 833-838 (1997).
12. Hong, K. et al. A ligand-gated association between cytoplasmic domains of UNC5 and DCC family receptors converts netrin-induced growth cone attraction to repulsion. Cell 97, 927-941 (1999).
13. Keleman, K. & Dickson, B.J. Short- and long-range repulsion by the Drosophila Unc5 netrin receptor. Neuron 32, 605-617 (2001).
14. Stein, E. & Tessier-Lavigne, M. Hierarchical organization of guidance receptors: silencing of netrin attraction by slit through a Robo/DCC receptor complex. Science 291, 1928-1938 (2001).
15. Stein, E., Zou, Y., Poo, M. & Tessier-Lavigne, M. Binding of DCC by netrin-1 to mediate axon guidance independent of adenosine A2B receptor activation. Science 291, 1976-1982 (2001).
16. Finger, J.H. et al. The netrin 1 receptors Unc5h3 and Dec are necessary at multiple choice points for the guidance of corticospinal tract axons. J. Neurosci. 22, 10346-10356 (2002).
17. Colavita, A. & Culotti, J.G. Suppressors of ectopic UNC-5 growth cone steering identify eight genes involved in axon guidance in Caenorhabditis elegans. Dev. Biol. 194, 72-85 (1998).
18. Gitai, Z., Yu, T.W., Lundquist, E.A., Tessier-Lavigne, M. & Bargmann, C.I. The Netrin Receptor UNC-40/DCC Stimulates Axon Attraction and Outgrowth through Enabled and, in Parallel, Rac and UNC-115/AbLIM. Neuron 37, 53-65 (2003).
19. Ming, G. et al. Phospholipase Cγ and phosphoinositide 3-kinase mediate cytoplasmic signaling in nerve growth cone guidance. Neuron 23, 139-148 (1999).
20. Forcet, C. et al. Netrin-1-mediated axon outgrowth requires deleted in colorectal cancer-dependent MAPK activation. Nature 417, 443-447 (2002).
21. Li, X., Saint-Cyr-Proulx, E., Aktories, K. & Lamarche-Vane, N. Rac1 and Cdc42 but not RhoA or Rho kinase activities are required for neurite outgrowth induced by the netrin-1 receptor DCC (Deleted in Colorectal Cancer) in N1E-115 neuroblastoma cells. J. Biol. Chem. 277, 15207-15214 (2002).
22. Ming, G.L. et al. Adaptation in the chemotactic guidance of nerve growth cones. Nature 417, 411-418 (2002).
23. Shekarabi, M. & Kennedy, T.E. The netrin-1 receptor DCC promotes filopodia formation and cell spreading by activating Cdc42 and Rac1. Mol. Cell. Neurosci. 19, 1-17 (2002).
24. Campbell, D.S. & Holt, C.E. Apoptotic pathway and MAPKs differentially regulate chemotropic responses of retinal growth cones. Neuron 37, 939-952 (2003).
25. Parsons, J.T., Martin, K.H., Slack, J.K., Taylor, J.M. & Weed, S.A. Focal adhesion kinase: a regulator of focal adhesion dynamics and cell movement. Oncogene 19, 5606-5613 (2000).
26. Ilic, D. et al. Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice. Nature 377, 539-544 (1995).
27. Cary, L.A., Chang, J.F. & Guan, J.L. Stimulation of cell migration by overexpression of focal adhesion kinase and its association with Src and Fyn. J. Cell Sci. 109, 1787-1794 (1996).
28. Richardson, A., Malik, R.K., Hildebrand, J.D. & Parsons, J.T. Inhibition of cell spreading by expression of the C-terminal domain of focal adhesion kinase (FAK) is rescued by coexpression of Src or catalytically inactive FAK: a role for paxillin tyrosine phosphorylation. Mol. Cell. Biol. 17, 6906-6914 (1997).
29. Girault, J.A., Costa, A., Derkinderen, P., Studler, J.M. & Toutant, M. FAK and PYK2/CAKβ in the nervous system: a link between neuronal activity, plasticity and survival? Trends Neurosci. 22, 257-263 (1999).
30. Brown, M.C., Curtis, M.S. & Turner, C.E. Paxillin LD motifs may define a new family of protein recognition domains. Nat. Struct. Biol. 5, 677-678 (1998).
31. Bouchard, J-F. et al. Protein kinase A activation promotes plasma membrane insertion of DCC from an intracellular pool: a novel mechanism regulating commissural axon extension. J. Neurosci. 24, 3040-3050 (2004).
32. Schaller, M.D. et al. Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src. Mol. Cell. Biol. 14, 1680-1688 (1994).
33. Calalb, M.B., Polte, T.R. & Hanks, S.K. Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases. Mol. Cell. Biol. 15, 954-963 (1995).
34. Guan, J.L. & Shalloway, D. Regulation of focal adhesion-associated protein tyrosine kinase by both cellular adhesion and oncogenic transformation. Nature 358, 690-692 (1992).
35. 5 in vascular endothelial growth factor signaling. J. Cell Biol. 157, 149-160 (2002).
36. Metin, C., Deleglise, D., Serafini, T., Kennedy, T.E. & Tessier-Lavigne, M. A role for netrin-1 in the guidance of cortical efferents. Development 124, 5063-5074 (1997).
37. Zhang, X. et al. Focal adhesion kinase promotes phospholipase Cγ1 activity. Proc. Natl Acad. Sci. USA 96, 9021-9026 (1999).
38. Chen, H.C. et al. Interaction of focal adhesion kinase with cytoskeletal protein talin. J. Biol. Chem. 270, 16995-16999 (1995).
39. Ren, X.R. et al. Regulation of CDC42 GTPase by proline-rich tyrosine kinase 2 interacting with PSGAP, a novel pleckstrin homology and Src homology 3 domain containing rhoGAP protein. J. Cell Biol. 152, 971-984 (2001).
40. Cas. Proc. Natl Acad. Sci. USA 92, 10678-10682 (1995).
41. fyn. J. Biol. Chem. 272, 8310-8319 (1997).
42. Hopker, V.H., Shewan, D., Tessier-Lavigne, M., Poo, M. & Holt, C. Growth-cone attraction to netrin-1 is converted to repulsion by laminin-1. Nature 401, 69-73 (1999).
43. Pasterkamp, R.J., Peschon, J.J., Spriggs, M.K. & Kolodkin, A.L. Semaphorin 7A promotes axon outgrowth through integrins and MAPKs. Nature 424, 398-405 (2003).
44. 1 regulates epithelial cell adhesion and migration. Dev. Cell 5, 695-707 (2003).
45. Liu, G. et al. Netrin requires the focal adhesion kinase and the Src family kinases to induce axon outgrowth and to attract axons. Nat. Neurosci. 7, 1222-1232 (2004).
46. Li, W. et al. Activation of FAK and Src are receptor proximal events required for netrin signaling. Nat. Neurosci. 7, 1213-1221 (2004).
47. Kornberg, L.J., Earp, H.S., Turner, C.E., Prockop, C. & Juliano, R.J. Signal transduction by integrins: increased protein tyrosine phosphorylation caused by clustering of β1 integrins. Proc. Natl Acad. Sci. USA 88, 8392-8396 (1991).
48. Rodriguez-Fernandez, J.L. Why do so many stimuli induce tyrosine phosphorylation of FAK? Bioessays 21, 1069-1075 (1999).
49. Fazeli, A. et al, Phenotype of mice lacking functional Deleted in colorectal cancer (Dec) gene. Nature 386, 796-804 (1997).
50. Huang, Y.Z. et al. Regulation of neuregulin signaling by PSD-95 interacting with ErbB4 at CNS synapses. Neuron 26, 443-455 (2000).