Inhibition of netrin-mediated axon attraction by a receptor protein tyrosine phosphatase

Science

Volumn 305, Issue 5680, 2004, Pages 103-106

  Chang, Chieh ^a,b   Yu, Timothy W ^b   Bargmann, Cornelia I ^b   Tessier Lavigne, Marc ^a,c  

^a STANFORD UNIVERSITY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; MODULATION; MUTAGENESIS;

AXON GUIDANCE; MICROTUBULES;

PROTEINS;

NETRIN; PROTEIN TYROSINE PHOSPHATASE; PROTEIN UNC 34; RECEPTOR; RECEPTOR PROTEIN; ROUNDABOUT RECEPTOR; UNC 40 RECEPTOR; UNCLASSIFIED DRUG;

BIOLOGY;

ALLELE; ARTICLE; CAENORHABDITIS ELEGANS; CLR 1 GENE; CONTROLLED STUDY; GENE; GENE MUTATION; MICROTUBULE; MUTATION; NERVE FIBER; NERVE FIBER GROWTH; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; SAX 3 GENE; SIGNAL TRANSDUCTION; SLT 1 GENE;

AMINO ACID SEQUENCE; ANIMALS; ANIMALS, GENETICALLY MODIFIED; AXONS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CELL ADHESION MOLECULES; CELL MOVEMENT; CUES; GENES, HELMINTH; MICROTUBULES; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; MUTATION; NERVE TISSUE PROTEINS; OPEN READING FRAMES; PHENOTYPE; PROTEIN-TYROSINE-PHOSPHATASE; RECEPTORS, IMMUNOLOGIC; SIGNAL TRANSDUCTION;

CAENORHABDITIS; CAENORHABDITIS ELEGANS; INVERTEBRATA;

EID: 3042800402     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1096983     Document Type: Article

References (35)

1. M. Tessier-Lavigne, C. S. Goodman, Science 274, 1123 (1996).
2. T. W. Yu, C. I. Bargmann, Nat. Neurosci. 4, 1169 (2001).
3. B. J. Dickson, Science 298, 1959 (2002).
4. H. J. Song, G. L. Ming, M. M. Poo, Nature 388, 275 (1997).
5. K. Hong, M. Nishiyama, J. Henley, M. Tessier-Lavigne, M. M. Poo, Nature 403, 93 (2000).
6. M. Hamelin, Y. Zhou, M. W. Su, I. M. Scot, J. G. Culotti, Nature 364, 327 (1993).
7. K. Hong et al., Cell 97, 927 (1999).
8. K. Keleman, B. J. Dickson, Neuron 32, 605 (2001).
9. E. Stein, M. Tessier-Lavigne, Science 291, 1928 (2001).
10. T. W. Yu, J. C. Hao, W. Lim, M. Tessier-Lavigne, C. I. Bargmann, Nat. Neurosci. 5, 1147 (2002).
11. C. J. Desai, J. G. Gindhart Jr., L. S. Goldstein, K. Zinn, Cell 84, 599 (1996).
12. D. Van Vactor, Curr. Opin. Cell Biol. 10, 174 (1998).
13. U. Drescher et al., Cell 82, 359 (1995).
14. M. Nakamoto et al., Cell 86, 755 (1996).
15. S. McFarlane, E. Cornel, E. Amaya, C. E. Holt, Neuron 17, 245 (1996).
16. F. S. Walsh, P. Doherty, Annu. Rev. Cell Dev. Biol. 13, 425 (1997).
17. F. B. Gertler, R. L. Bennett, M. J. Clark, F. M. Hoffmann, Cell 58, 103 (1989).
18. H. E. Beggs, P. Soriano, P. F. Maness, J. Cell Biol. 127, 825 (1994).
19. W. R. Morse, J. G. Whitesides 3rd, A. S. LaMantia, P. F. Maness, J. Neurobiol. 36, 53 (1998).
20. J. C. Hao et al., Neuron 32, 25 (2001).
21. Information on materials and methods is available on Science Online.
22. M. Kokel, C. Z. Borland, L. DeLong, H. R. Horvitz, M. J. Stern, Genes Dev. 12, 1425 (1998).
23. J. N. Andersen et al., Mol. Cell. Biol. 21, 7117 (2001).
24. E. M. Hedgecock, J. G. Culotti, D. H. Hall, Neuron 4, 61 (1990).
25. D. C. Merz, G. Alves, T. Kawano, H. Zheng, J. G. Culotti, Dev. Biol. 256, 173 (2003).
26. Z. Gitai, T. W. Yu, E. A. Lundquist, M. Tessier-Lavigne, C. I. Bargmann, Neuron 37, 53 (2003).
27. E. A. Lundquist, R. K. Herman, J. E. Shaw, C. I. Bargmann, Neuron 21, 385 (1998).
28. K. M. Thompson et al., Mol. Cell. Neurosci. 23, 681 (2003).
29. K. G. Johnson, I. W. McKinnell, A. W. Stoker, C. E. Holt, J. Neurobiol. 49, 99 (2001).
30. The egl-17 FGF and the egl-15 FGFR antagonize clr-1 function in sex myoblast migration (31). egl-17 null mutations do not affect AVM guidance, whereas egl-15 mutations partially antagonize clr-1 (fig. S4). However, this effect could be indirect, because egl-15 affects axon outgrowth by acting in the epidermis (32) and egl-15 expression in AVM did not rescue the defect (33).
31. C. Z. Borland, J. L. Schutzman, M. J. Stern, Bioessays 23, 1120 (2001).
32. H. E. Bulow, T. Boulin, O. Hobert, Neuron 42, 367 (2004).
33. C. Chang, C. I. Bargmann, M. Tessier-Lavigne, data not shown.
34. A. Colavita, J. G. Culotti, Dev. Biol. 194, 72 (1998).
35. We thank G. Garriga, S. Clark, and the Caenorhabditis Genetics Center for strains; A. Fire for vectors; M. Stern for the clr-1::GFP reporter, H. Nguyen for technical support; A. Colavita for critical reading of the manuscript; and members of the Bargmann and Tessier-Lavigne labs for helpful discussions. C.C. is an American Cancer Society Postdoctoral Fellow; T.W.Y. was a MINDS Predoctoral Fellow and a UCSF Medical Scientist Training Program student; and C.I.B. is and M.T.-L. was an Investigator with HHMI.