Therapeutic potential of Na-H exchange inhibitors for the treatment of heart failure

Expert Opinion on Investigational Drugs

Volumn 10, Issue 5, 2001, Pages 835-843

  Karmazyn, M ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

Cariporide; Hypertrophy; Myocardial remodelling; NHE 1

Indexed keywords

(3 METHYLSULFONYL 4 PIPERIDINOBENZOYL)GUANIDINE METHANESULFONATE; ANGIOTENSIN; BETA ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM ION; CARIPORIDE; CARRIER PROTEIN; CYTOKINE; CYTOKINE RECEPTOR; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; ENDOTHELIN 1; ENDOTHELIN RECEPTOR ANTAGONIST; GROWTH FACTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; INOTROPIC AGENT; ISOPROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN INHIBITOR; PROTEIN KINASE C; PROTON; PROTON SODIUM EXCHANGE INHIBITOR; RECEPTOR SUBTYPE; SODIUM ION; UNCLASSIFIED DRUG; VASODILATOR AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; CELL GROWTH; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; HEART FAILURE; HEART INFARCTION; HEART INJURY; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HEART STIMULATION; HEART VENTRICLE HYPERTROPHY; HUMAN; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PH; PROTON SODIUM EXCHANGE; RAT; REGULATORY MECHANISM; REPERFUSION INJURY; REVIEW; SODIUM TRANSPORT; STOICHIOMETRY;

CARDIOMEGALY; HEART FAILURE, CONGESTIVE; HUMANS; MYOCARDIAL ISCHEMIA; SODIUM-HYDROGEN ANTIPORTER;

EID: 0035022395     PISSN: 13543784     EISSN: None     Source Type: Journal    
DOI: 10.1517/13543784.10.5.835     Document Type: Review

References (33)

1. The management of chronic heart failure
2. The hypertrophic response: Programmed cell death
3. Cardiac remodelling in congestive heart failure
4. Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study
5. Regression of left ventricular hypertrophy: New hope for dying hearts
6. Cytoplasmic signaling pathways that regulate cardiac hypertrophy
7. 2 receptors
8. + exchange in mediating effects of endothelin-1 on normal and ischemic/reperfused hearts
9. + exchanger and cardiac hypertrophy
10. + exchange: Structure, regulation and its role in heart disease
11. The myocardial sodium-hydrogen exchanger a potential therapeutic target for the prevention of myocardial ischemic and reperfusion injury and attenuation of postinfarction heart failure
12. Pharmacology and clinical assessment of cariporide for the treatment coronary artery disease
13. Mechanisms of protection of the ischemic and reperfused myocardium by sodium-hydrogen exchange inhibition
14. Rational basis for use of sodium-hydrogen exchange inhibitors in myocardial ischemia
15. + exchanger through mitogen-activated protein kinase
16. + exchanger in the rat myocardium by mitogen-activated protein kinase-dependent pathways
17. + exchange
18. + exchange inhibitors decrease neointimal formation after rat carotid injury. Effects on smooth muscle cell migration and proliferation
19. Angiotensin II mediates cell hypertrophy in vascular smooth muscle cell cultures from hypertensive Ren-2 transgenic rats by an amiloride-and furosemide-sensitive mechanism
20. Protective effects of HOE642, a selective sodium-hydrogen exchange subtype 1 inhibitor, on cardiac ischaemia and reperfusion
21. + antiporter (NHE-1) gene expression during growth, hypertrophy and proliferation of the rabbit cardiovascular system
22. Role of ion channels and exchanger in mechanical stretch-induced cardiomyocyte hypertrophy
23. Stretch-induced alkalinization of feline papillary muscle. An autocrine-paracrine system
24. + exchange in norepinephrine-induced protein synthesis in neonatal cultured cardiomyocytes
25. + exchange blocker amiloride on left ventricular remodeling after anterior myocardial infarction in rats
26. + exchange blocker, in a murine model of dilated cardiomyopathy
27. + exchange inhibition attenuates hypertrophy and heart failure in 1-wk postinfarction rat myocardium
28. + exchange inhibition reduces hypertrophy and heart failure following myocardial infarction in rats
29. + exchange inhibitor cariporide
30. + exchange on intracellular sodium and pH in working and ischemic hearts
31. Protective effects of dimethyl amiloride against postichemic myocardial dysfunction in rabbit hearts: Phosphorus 31-nuclear magnetic resonance measurements of intracellular pH and cellular energy
32. Sodium induces hypertrophy of cultured myocardial myoblasts and vascular smooth muscle cells
33. + exchange activates protein kinase C isozymes δ and ε in cultured neonatal rat cardiac myocytes