Regulatory effects of G protein-coupled receptors on cardiac sarcolemmal Na+/H+ exchanger activity: Signalling and significance

Cardiovascular Research

Volumn 57, Issue 4, 2003, Pages 942-952

  Avkiran, Metin ^a   Haworth, Robert S ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Contractile function; G proteins; Hypertrophy; Ischemia; Myocytes; Na H exchanger; Receptors; Signal transduction

Indexed keywords

ADENOSINE A1 RECEPTOR; ALPHA ADRENERGIC RECEPTOR; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 2 RECEPTOR; BETA 1 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR; ENDOTHELIN RECEPTOR; G PROTEIN COUPLED RECEPTOR; HYDROGEN; LIGAND; MUSCARINIC RECEPTOR; NEUROHORMONE; PHOSPHOTRANSFERASE; PROTEIN KINASE C; S6 KINASE; SODIUM; SODIUM PROTON EXCHANGE PROTEIN; THROMBIN RECEPTOR;

DISEASE PREDISPOSITION; EXTRACELLULAR SPACE; HEART DISEASE; HEART FUNCTION; HEART HYPERTROPHY; HEART INJURY; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; HEART MUSCLE FIBER MEMBRANE; HEART MUSCLE ISCHEMIA; MECHANICAL STIMULATION; NONHUMAN; PATHOPHYSIOLOGY; PH; PRIORITY JOURNAL; PROTEIN FUNCTION; REGULATORY MECHANISM; REVIEW; RIBOSOME; SIGNAL TRANSDUCTION; STIMULATION;

GTP-BINDING PROTEINS; HUMANS; MYOCARDIAL CONTRACTION; MYOCARDIAL REPERFUSION INJURY; MYOCYTES, CARDIAC; RECEPTORS, CELL SURFACE; SARCOLEMMA; SIGNAL TRANSDUCTION; SODIUM-HYDROGEN ANTIPORTER;

EID: 0037376625     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(02)00782-4     Document Type: Review

References (103)

1. Leem C.H., Lagadic-Gossman D., Vaughan-Jones R.D. Characterisation of intracellular pH regulation in the guinea-pig ventricular myocyte. J Physiol. 517:(1):1999;159-180.
2. + exchange in isolated myocytes from adult rat heart. Am J Physiol. 257:1989;C207-C213.
3. + exchanger. Mol Cell Biochem. 125:1993;137-143.
4. + exchanger isoform 1 (NHE-1). J Biol Chem. 269:1994;5583-5588.
5. + exchanger NHE1 through sequence-specific interaction. Biochemistry. 36:1997;12854-12861.
6. + exchanger NHE1 in rat myocardium. Am J Physiol. 276:1999;H709-H717.
7. + exchanger isoform 1. J Biol Chem. 275:2000;7942-7949.
8. +-sensing'. Proc Natl Acad Sci. 89:1992;2424-2428.
9. 2+ exchange. Eur J Pharmacol. 186:1990;29-40.
10. 1-Adrenergic effects on intracellular pH and calcium and on myofilaments in single rat cardiac cells. J Physiol. 447:1992;275-292.
11. + exchange in cardiac myocytes. Am J Physiol. 263:1992;C1096-C1102.
12. Lagadic-Gossmann D., Vaughan-Jones R.D. Coupling of dual acid extrusion in the guinea-pig isolated ventricular myocyte to alpha1- and beta-adrenoceptors. J Physiol. 464:1993;49-73.
13. 1A-adrenoceptor subtype. Circ Res. 82:1998;1078-1085.
14. Brodde O.E., Michel M.C. Adrenergic and muscarinic receptors in the human heart. Pharm Rev. 51:1999;651-689.
15. 2+ channel current by angiotensin II in rabbit ventricular myocytes. Circ Res. 75:1994;1121-1125.
16. Matsui H., Barry W.H., Livsey C., Spitzer K.W. Angiotensin II stimulates sodium-hydrogen exchange in adult rabbit ventricular myocytes. Cardiovasc Res. 29:1995;215-221.
17. Grace A.A., Metcalfe J.C., Weissberg P.L., Bethell H.W.L., Vandenberg J.I. Angiotensin II stimulates sodium-dependent proton extrusion in perfused ferret heart. Am J Physiol. 270:1996;C1687-C1694.
18. + exchange is impaired in cardiac hypertrophy. J Clin Invest. 99:1997;125-135.
19. + exchanger activity by angiotensin II in adult rat ventricular myocytes. Circ Res. 85:1999;919-930.
20. Krämer B.K., Smith T.W., Kelly R.A. Endothelin and increased contractility in adult rat ventricular myocytes. Circ Res. 68:1991;269-279.
21. + exchange in dog cardiac Purkinje fibres. J Physiol. 471:1993;583-597.
22. 2+ modulation. Circ Res. 78:1996;302-311.
23. Brunner F., Opie L.H. Role of endothelin-A receptors in ischemic contracture and reperfusion injury. Circulation. 97:1998;391-398.
24. Coughlin S.R. Thrombin receptor function and cardiovascular disease. Trends Cardiovasc Med. 4:1994;77-83.
25. + exchanger: evidence for a receptor-mediated mechanism involving protein kinase C. Circ Res. 79:1996;705-715.
26. Vu T.K.H., Hung D.T., Wheaton V.I., Coughlin S.R. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell. 64:1991;1057-1068.
27. Connolly A.J., Ishihara H., Kahn M.L., Farese R.V., Coughlin S.R. Role of the thrombin receptor in development and evidence for a second receptor. Nature. 381:1996;516-519.
28. Ishihara H., Connolly A.J., Zeng D., et al. Protease-activated receptor 3 is a second thrombin receptor in humans. Nature. 386:1997;502-506.
29. Sabri A., Muske G., Zhang H., et al. Signaling properties and functions of two distinct cardiomyocyte protease-activated receptors. Circ Res. 86:2000;1054-1061.
30. Howard A.D., McAllister G., Feighner S.D., et al. Orphan G-protein-coupled receptors and natural ligand discovery. Trends Pharmacol Sci. 22:2001;132-140.
31. Szokodi I., Tavi P., Foldes G., et al. Apelin, the novel endogenous ligand of the orphan receptor APJ, regulates cardiac contractility. Circ Res. 91:2002;434-440.
32. Guo H., Wasserstrom J.A., Rosenthal J.E. Effect of catecholamines on intracellular pH in sheep cardiac Purkinje fibres. J Physiol. 458:1992;289-306.
33. 1-adrenergic receptors in the failing human heart. Circulation. 87:1993;652-654.
34. 2+ sensitivity in failing hearts. Am J Physiol Heart Circ Physiol. 281:2001;H637-H646.
35. + exchanger. Br J Pharmacol. 131:2000;659-662.
36. Sardet C., Counillon L., Franchi A., Pouysségur J. Growth factors induce phosphorylation of the Na/H antiporter, a glycoprotein of 110 kDa. Science. 247:1990;723-726.
37. Sardet C., Fafournoux P., Pouysségur J. α-thrombin, EGF and okadaic acid activate the Na/H exchanger, NHE1 by phosphorylating a set of common sites. J Biol Chem. 266:1991;19166-19171.
38. 2+/calmodulin-dependent protein kinase II. Biochem J. 282:1992;139-145.
39. + exchanger through mitogen-activated protein kinase. Biochemistry. 36:1997;9151-9158.
40. Tominaga T., Ishizaki T., Narumiya S., Barber D.L. p160ROCK mediates RhoA activation of Na-H exchange. EMBO J. 17:1998;4712-4722.
41. + exchanger isoform-1. J Biol Chem. 274:1999;20206-20214.
42. Khaled A.R., Moor A.N., Li A., et al. Trophic factor withdrawal: p38 mitogen-activated protein kinase activates NHE1, which induces intracellular alkalinization. Mol Cell Biol. 21:2001;7545-7557.
43. + exchanger NHE1 and regulates NHE1 activation by platelet-derived growth factor. J Biol Chem. 276:2001;31349-31356.
44. + exchanger in the rat myocardium by mitogen-activated protein kinase-dependent pathways. J Biol Chem. 274:1999;22985-22992.
45. Smith J.A., Poteet-Smith C.E., Malarkey K., Sturgill T.W. Identification of an extracellular signal-regulated kinase (ERK) docking site in ribosomal S6 kinase, a sequence critical for activation by ERK in vivo. J Biol Chem. 274:1999;2893-2898.
46. English J.M., Cobb M.H. Pharmacological inhibitors of MAPK pathways. Trends Pharmacol Sci. 23:2002;40-45.
47. + exchanger. Circ Res. 86:2000;214-220.
48. + exchange by hydrogen peroxide in adult rat ventricular myocytes. Cardiovasc Res. 53:2002;470-480.
49. Bianchini L., L'Allemain G., Pouysségur J. The p42/p44 mitogen-activated protein kinase cascade is determinant in mediating activation of the Na/H exchanger (NHE1 isoform) in response to growth factors. J Biol Chem. 272:1997;271-279.
50. Alessi D.R. The protein kinase C inhibitors Ro 318220 and GF 109203X are equally potent inhibitors of MAPKAP kinase-1β (rsk-2) and p70 S6 kinase. FEBS Lett. 402:1997;121-123.
51. Davies S.P., Reddy H., Caivano M., Cohen P. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 351:2000;95-105.
52. + exchange in the sheep Purkinje fibre. J Physiol. 478:1994;301-313.
53. Wakabayashi S., Shigekawa M., Pouysségur J. Molecular physiology of vertebrate Na/H exchangers. Physiol Rev. 77:1997;51-74.
54. + exchanger activity. Am J Physiol. 277:1999;C1202-C1209.
55. + exchanger in hormonal activation. J Biol Chem. 268:1993;3396-3400.
56. + exchanger isoform 1 (NHE-1) is a novel member of the calmodulin binding proteins. J Biol Chem. 269:1994;13703-13709.
57. 2+ regulation-defective. J Biol Chem. 269:1994;13710-13715.
58. + exchange. Proc Natl Acad Sci. 93:1996;12631-12636.
59. + exchangers. J Biol Chem. 276:2001;17367-17372.
60. - cotransport activity in adult rat cardiomyocytes. Am J Physiol Heart Circ Physiol. 283:2002;H2102-H2109.
61. Desilets M., Puceat M., Vassort G. Chloride dependence of pH modulation by β-adrenergic agonists in rat cardiomyocytes. Circ Res. 75:1994;862-869.
62. - exchanger by angiotensin II is mediated by endogenous endothelin. Circ Res. 86:2000;622-627.
63. Orchard C.H., Kentish J.C. Effects of changes of pH on the contractile function of cardiac muscle. Am J Physiol. 258:1990;C967-C981.
64. + pump rate in rat and rabbit ventricular myocytes. J Physiol. 539:2002;133-143.
65. 2+ in cardiac myocytes. Circ Res. 71:1992;870-882.
66. Fujii N., Tanaka M., Ohnishi J., et al. Alterations of angiotensin II receptor contents in hypertrophied hearts. Biochem Biophys Res Commun. 212:1995;326-333.
67. 2+ signalling in rabbit ventricular myocytes. Br J Pharmacol. 131:2000;638-644.
68. ATP channel. J Pharmacol Exp Ther. 294:2000;770-777.
69. 2+ transient that follow stretch of cardiac muscle: a possible explanation of the Anrep effect. Circ Res. 85:1999;716-722.
70. 2+ exchange after myocardial stretch: underlying mechanism of the slow force response. Circ Res. 88:2001;376-382.
71. Avkiran M. Sodium-hydrogen exchange in myocardial ischemia and reperfusion: a critical determinant of injury. Karmazyn M. Myocardial ischemia: mechanisms, reperfusion, protection. 1996;299-311 Birkhauser Verlag, Basel.
72. + exchange inhibitors: potential mechanisms of action. Basic Res Cardiol. 96:2001;306-311.
73. Avkiran M. Rational basis for use of sodium-hydrogen exchange inhibitors in myocardial ischemia. Am J Cardiol. 83:1999;10G-18G.
74. + exchange: structure, regulation, and its role in heart disease. Circ Res. 85:1999;777-786.
75. Théroux P., Chaitman B.R., Danchin N., et al. Inhibition of the sodium-hydrogen exchanger with cariporide to prevent myocardial infarction in high-risk ischemic situations: main results of the GUARDIAN trial. Circulation. 102:2000;3032-3038.
76. + exchange inhibitors for cardioprotective therapy: progress, problems and prospects. J Am Coll Cardiol. 39:2002;747-753.
77. Schomig A., Richardt G. Cardiac sympathetic activity in myocardial ischemia: release and effects of noradrenaline. Basic Res Cardiol. 85:1990;9-30.
78. Corr P.B., Yamada K.A., DaTorre S.D. Modulation of α-adrenergic receptors and their intracellular coupling in the ischemic heart. Basic Res Cardiol. 85:1990;31-45.
79. 1-adrenoceptor and purinoceptor agonists modulate Na-H antiport in single cardiac cells. Am J Physiol. 264:1993;H310-H319.
80. 1-adrenoceptor effects on reperfused ischaemic hearts: comparison with phorbol ester. Br J Pharmacol. 112:1994;1007-1016.
81. 1-adrenergic stimulation: a potential role for receptor-mediated activation of sarcolemmal sodium-hydrogen exchange. Cardiovasc Res. 29:1995;222-230.
82. Davies M.J., Woolf N., Robertson W.B. Pathology of acute myocardial infarction with particular reference to occlusive coronary thrombi. Br Heart J. 38:1976;659-664.
83. Wagner W.R., Hubbell J.A. Local thrombin synthesis and fibrin formation in an in vitro thrombosis model result in platelet recruitment and thrombin stabilization on collagen in heparinized blood. J Lab Clin Med. 116:1990;636-650.
84. + during myocardial ischemia. Am J Physiol. 268:1995;H1740-H1748.
85. + exchanger contributes to the arrhythmogenic action of thrombin. Circulation. 96:1997;I58. Abstract.
86. Tonnessen T., Naess P.A., Kirkboen K.A., et al. Endothelin is released from the porcine coronary circulation after short-term ischemia. J Cardiovasc Pharmacol. 22:1993;S313-S316.
87. + exchange in mediating effects of endothelin-1 on normal and ischemic/reperfused hearts. Circ Res. 75:1994;369-378.
88. 1-adenosine receptor protects intact mice against myocardial infarction. Am J Physiol Heart Circ Physiol. 282:2002;H949-H955.
89. Dorn G.W., Brown J.H. Gq signaling in cardiac adaptation and maladaptation. Trends Cardiovasc Med. 9:1999;26-34.
90. Ito H., Hirata Y., Adachi S., et al. Endothelin-1 is an autocrine/paracrine factor in the mechanism of angiotensin II-induced hypertrophy in cultured rat cardiomyocytes. J Clin Invest. 92:1993;398-403.
91. Glembotski C.C., Irons C.E., Krown K.A., et al. Myocardial α-thrombin receptor activation induces hypertrophy and increases atrial natriuretic factor gene expression. J Biol Chem. 268:1993;20646-20652.
92. 1A-adrenergic receptor subtype mediates biochemical, molecular, and morphologic features of cultured myocardial cell hypertrophy. J Biol Chem. 268:1993;15374-15380.
93. 1 receptor subtype. Circ Res. 73:1993;413-423.
94. i and creatine phosphate on α-adrenoceptor-mediated cardiac hypertrophy. J Mol Cell Cardiol. 30:1998;763-771.
95. Schafer M., Schafer C., Piper H.M., Schluter K.D. Hypertrophic responsiveness of cardiomyocytes to α- or β-adrenoceptor stimulation requires sodium-proton-exchanger-1 (NHE-1) activation but not cellular alkalinization. Eur J Heart Fail. 4:2002;249-254.
96. 1-adrenergic receptor transgenic mice. Circ Res. 90:2002;814-819.
97. Yamazaki T., Komuro I., Kudoh S., et al. Role of ion channels and exchangers in mechanical stretch-induced cardiomyocyte hypertrophy. Circ Res. 82:1998;430-437.
98. + exchange blocker amiloride on left ventricular remodeling after anterior myocardial infarction in rats. Cardiovasc Drug Ther. 9:1995;823-826.
99. + exchange inhibition attenuates hypertrophy and heart failure in 1-wk postinfarction rat myocardium. Am J Physiol Heart Circ Physiol. 278:2000;H300-H304.
100. +-exchange inhibitor cariporide in infarct-induced heart failure. Cardiovasc Res. 46:2000;102-110.
101. + exchange inhibition reduces hypertrophy and heart failure after myocardial infarction in rats. Am J Physiol. 280:2001;H738-H745.
102. + exchanger. Cardiovasc Res. 53:2002;862-868.
103. + exchange inhibitor cariporide. J Pharmacol Exp Ther. 298:2001;469-476.