Mechanism of Na+/H+ antiporting

Science

Volumn 317, Issue 5839, 2007, Pages 799-803

  Arkin, Isaiah T ^a,b   Xu, Huafeng ^a   Jensen, Morten Ø ^a   Arbely, Eyal ^b   Bennett, Estelle R ^b   Bowers, Kevin J ^a   Chow, Edmond ^a   Dror, Ron O ^a   Eastwood, Michael P ^a   Flitman Tene, Ravenna ^b   Gregersen, Brent A ^a   Klepeis, John L ^a   Kolossváry, István ^a   Shan, Yibing ^a   Shaw, David E ^a,c  

^a D E SHAW RESEARCH   (United States)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^c Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTIC ACID; LITHIUM; MEMBRANE PROTEIN; POTASSIUM ION; PROTEIN NHAA; PROTON; SODIUM CHLORIDE; SODIUM ION; SODIUM PROTON EXCHANGE PROTEIN; UNCLASSIFIED DRUG;

EXPERIMENTAL STUDY; HOMEOSTASIS; HYDROGEN; PH; SIMULATION; SODIUM; STOICHIOMETRY;

ANIMAL CELL; ARTICLE; BACTERIAL GROWTH; BINDING SITE; CONTROLLED STUDY; CYTOPLASM; ESCHERICHIA COLI; HOMEOSTASIS; MEMBRANE TRANSPORT; MOLECULAR DYNAMICS; MUTAGENESIS; NONHUMAN; PH MEASUREMENT; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTON SODIUM EXCHANGE; PROTON TRANSPORT; SIMULATION; SODIUM TRANSPORT; STOICHIOMETRY; STRUCTURE ANALYSIS; VALIDATION PROCESS;

ASPARTIC ACID; BINDING SITES; COMPUTER SIMULATION; CRYSTALLIZATION; CYTOPLASM; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; HYDROGEN BONDING; HYDROGEN-ION CONCENTRATION; ION TRANSPORT; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MUTAGENESIS; PERIPLASM; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PROTONS; SODIUM; SODIUM-HYDROGEN ANTIPORTER;

ESCHERICHIA COLI;

EID: 34547902820     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1142824     Document Type: Article

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31. The authors would like to thank members of the Padan laboratory for helpful discussions, experimental assistance, and reagents; F. Sacerdoti for invaluable help with computational resources; and A. Weber for editorial assistance. This research was supported in part by a grant from the Israel Science Foundation to I.T.A. A version of Desmond, the software used to perform the simulations described in this article, will be released by the end of 2007. This version will be made available by D. E. Shaw Research for noncommercial research use and by Schrödinger LLC for commercial use. Before release, the current version of Desmond will be available from the authors upon request under conditions described in the SOM. D. E. Shaw Research and Schrödinger have entered into a licensing agreement for the commercial distribution of Desmond by Schrödinger. D.E.S. has a beneficial ownership interest in D. E. Shaw Research, and R.O.D., M.P.E., J.L.K., I.K., Y.S., and D.E.S. have beneficial ownership interests in Schrödinger. Each of these authors may thus benefit financially from any resulting sales of Desmond. D.E.S. is a member of the Board of Directors of the American Association for the Advancement of Science (AAAS), the publisher of Science, and serves as treasurer of the AAAS.