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Volumn 121, Issue 3, 2008, Pages 231-235

Two isomers of HDTIC isolated from Astragali Radix decrease the expression of p16 in 2BS cells

Author keywords

Astragali Radix; Fibroblast; Gene expression; HDTIC; Replicative senescence

Indexed keywords

4 HYDROXY 5 HYDROXYMETHYL[1,3]DIOXOLAN 2,6' SPIRANE 5',6',7'8' TETRAHYDROINDOLIZINE 3' CARBALDEHYDE; ASTRAGALUS MEMBRANACEUS EXTRACT; CYCLIN DEPENDENT KINASE INHIBITOR 2A; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN P16; RETINOBLASTOMA PROTEIN; UNCLASSIFIED DRUG;

EID: 39049084529     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: 10.1097/00029330-200802010-00009     Document Type: Article
Times cited : (14)

References (27)
  • 1
    • 0033013980 scopus 로고    scopus 로고
    • Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts
    • Stein GH, Drullinger LF, Soulard A, Dulic V. Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts. Mol Cell Biol 1999; 19: 2109-2117.
    • (1999) Mol Cell Biol , vol.19 , pp. 2109-2117
    • Stein, G.H.1    Drullinger, L.F.2    Soulard, A.3    Dulic, V.4
  • 2
    • 0030477686 scopus 로고    scopus 로고
    • Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts
    • Alcorta DA, Xiong Y, Phelps D, Hannon G, Beach D, Barrett JC. Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts. Proc Natl Acad Sci U S A 1996; 93: 13742-13747.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 13742-13747
    • Alcorta, D.A.1    Xiong, Y.2    Phelps, D.3    Hannon, G.4    Beach, D.5    Barrett, J.C.6
  • 4
    • 0030866223 scopus 로고    scopus 로고
    • Multiple pathways control cell growth and transformation; overlapping and independent activities of p53 and p21cip1/wafl/sdil
    • Cox LS. Multiple pathways control cell growth and transformation; overlapping and independent activities of p53 and p21cip1/wafl/sdil. J Pathol 1997; 183: 134-140.
    • (1997) J Pathol , vol.183 , pp. 134-140
    • Cox, L.S.1
  • 5
    • 33750510904 scopus 로고    scopus 로고
    • Mitogenic signalling and the p161NK4a-Rb pathway cooperate to enforce irreversible cellular senescence
    • Takahashi A, Ohtani N, Yamakoshi K, Iida S-I, Tahara H, Nakayama K, et al. Mitogenic signalling and the p161NK4a-Rb pathway cooperate to enforce irreversible cellular senescence. Nat Cell Biol 2006; 8: 1291-1297.
    • (2006) Nat Cell Biol , vol.8 , pp. 1291-1297
    • Takahashi, A.1    Ohtani, N.2    Yamakoshi, K.3    Iida, S.-I.4    Tahara, H.5    Nakayama, K.6
  • 6
    • 0041966056 scopus 로고    scopus 로고
    • Reversal of human cellular senescence: Roles of the p53 and p16 pathways
    • Beausejour CM. Reversal of human cellular senescence: roles of the p53 and p16 pathways. EMBO J 2003; 22: 4212-4222.
    • (2003) EMBO J , vol.22 , pp. 4212-4222
    • Beausejour, C.M.1
  • 7
    • 0034704848 scopus 로고    scopus 로고
    • p161NK4a can initiate an autonomous senescence program
    • Dai CY, Enders GH. p161NK4a can initiate an autonomous senescence program. Oncogene 2000; 19: 1613-1622.
    • (2000) Oncogene , vol.19 , pp. 1613-1622
    • Dai, C.Y.1    Enders, G.H.2
  • 8
    • 0028946009 scopus 로고
    • Increase in expression level of p21sdi1/ cip1/waf1 with increasing division age in both normal and SV40-transfonned human fibroblasts
    • Tahara H, Sato E, Noda A, Ide T. Increase in expression level of p21sdi1/ cip1/waf1 with increasing division age in both normal and SV40-transfonned human fibroblasts. Oncogene 1995; 10: 835-840.
    • (1995) Oncogene , vol.10 , pp. 835-840
    • Tahara, H.1    Sato, E.2    Noda, A.3    Ide, T.4
  • 9
    • 0027656042 scopus 로고
    • Recent advances in studies on traditional Chinese anti-ageing medica
    • Chen K, Li C. Recent advances in studies on traditional Chinese anti-ageing medica. J Tradit Chin Med 1993; 13: 223-226.
    • (1993) J Tradit Chin Med , vol.13 , pp. 223-226
    • Chen, K.1    Li, C.2
  • 10
    • 0345490805 scopus 로고    scopus 로고
    • HDTIC-1 and HDTIC-2, two compounds extracted from Astragali Radix, delay replicative senescence of human diploid fibroblasts
    • Wang PC, Zhang ZY, Ma XF, Huang Y, Liu XW, Tu PF, et al. HDTIC-1 and HDTIC-2, two compounds extracted from Astragali Radix, delay replicative senescence of human diploid fibroblasts. Mech Ageing Dev 2003; 124: 1025-1034.
    • (2003) Mech Ageing Dev , vol.124 , pp. 1025-1034
    • Wang, P.C.1    Zhang, Z.Y.2    Ma, X.F.3    Huang, Y.4    Liu, X.W.5    Tu, P.F.6
  • 11
    • 36949026650 scopus 로고    scopus 로고
    • Aminoguanidine delays the replicative senescense of human diploid fibroblasts
    • Wang PC, Zhang ZY, Tong TJ. Aminoguanidine delays the replicative senescense of human diploid fibroblasts. Chin Med J 2007; 120: 2028-2035.
    • (2007) Chin Med J , vol.120 , pp. 2028-2035
    • Wang, P.C.1    Zhang, Z.Y.2    Tong, T.J.3
  • 12
    • 0029003790 scopus 로고
    • The proliferative response and anti-oncogene expression in old 2BS cells after growth factor stimulation
    • Li JH, Zhang ZY, Tong TJ. The proliferative response and anti-oncogene expression in old 2BS cells after growth factor stimulation. Mech Ageing Dev 1995; 80: 25-34.
    • (1995) Mech Ageing Dev , vol.80 , pp. 25-34
    • Li, J.H.1    Zhang, Z.Y.2    Tong, T.J.3
  • 13
    • 0035866353 scopus 로고    scopus 로고
    • Zhu WG, Lakshmanan RR, Beal MD, Otterson GA. DNA Methyltransferase inhibition enhances apoptosis induced by histone deacetylase inhibitors. Cancer Res 2001; 61: 1327-1333.
    • Zhu WG, Lakshmanan RR, Beal MD, Otterson GA. DNA Methyltransferase inhibition enhances apoptosis induced by histone deacetylase inhibitors. Cancer Res 2001; 61: 1327-1333.
  • 14
    • 0026546177 scopus 로고
    • Mitogenic and complement activating activities of the herbal components of juzen-taiho-to
    • Yamada H, Kiyohara H, Takemoto N, Zhao JF, Kawamura H, Komatsu Y, et al. Mitogenic and complement activating activities of the herbal components of juzen-taiho-to. Planta Med 1992; 58: 166-170.
    • (1992) Planta Med , vol.58 , pp. 166-170
    • Yamada, H.1    Kiyohara, H.2    Takemoto, N.3    Zhao, J.F.4    Kawamura, H.5    Komatsu, Y.6
  • 15
    • 0035262191 scopus 로고    scopus 로고
    • Astragali and Angelica protect the kidney againat ischemia and reperfusion injury and accelerate recovery
    • Gai Q, Li XM, Wang HY Astragali and Angelica protect the kidney againat ischemia and reperfusion injury and accelerate recovery. Chin Med J 2001; 114: 119-123.
    • (2001) Chin Med J , vol.114 , pp. 119-123
    • Gai, Q.1    Li, X.M.2    Wang, H.Y.3
  • 16
    • 0034980659 scopus 로고    scopus 로고
    • Antioxidant potential of qizhu tang, a Chinese herbal medicine, and the effect on cerebral oxidative damage after ischemia reperfusion in rats
    • Wang XJ, Haruyo I, Tetsuya K. Antioxidant potential of qizhu tang, a Chinese herbal medicine, and the effect on cerebral oxidative damage after ischemia reperfusion in rats. Biol Pharm Bull 2001; 24: 558-563.
    • (2001) Biol Pharm Bull , vol.24 , pp. 558-563
    • Wang, X.J.1    Haruyo, I.2    Tetsuya, K.3
  • 17
    • 0037077371 scopus 로고    scopus 로고
    • Chemical analysis of Astragali (Huangqi) in china: A comparison with its adulterants and seasonal variations
    • Ma XQ, Shi Q, Duan JA, Dong TT, Tsim KW. Chemical analysis of Astragali (Huangqi) in china: a comparison with its adulterants and seasonal variations. J Agric Food Chem 2002; 50: 4861-4866.
    • (2002) J Agric Food Chem , vol.50 , pp. 4861-4866
    • Ma, X.Q.1    Shi, Q.2    Duan, J.A.3    Dong, T.T.4    Tsim, K.W.5
  • 18
    • 0033564106 scopus 로고    scopus 로고
    • p16/pRb pathway alterations are required for bypassing senescence in human prostate, epithelial cells
    • Jarrard DF, Sarkar S, Shi Y, Yeager TR, Magrane G, p16/pRb pathway alterations are required for bypassing senescence in human prostate, epithelial cells. Cancer Res 1999; 59: 2957-2964.
    • (1999) Cancer Res , vol.59 , pp. 2957-2964
    • Jarrard, D.F.1    Sarkar, S.2    Shi, Y.3    Yeager, T.R.4    Magrane, G.5
  • 19
    • 0035930621 scopus 로고    scopus 로고
    • Senescence delay of human diploid fibroblast induced by anti-sense p161NK4a expression
    • Duan JM, Zhang ZY, Tong TJ. Senescence delay of human diploid fibroblast induced by anti-sense p161NK4a expression. J Biol Chem 2001; 276: 48325-48331.
    • (2001) J Biol Chem , vol.276 , pp. 48325-48331
    • Duan, J.M.1    Zhang, Z.Y.2    Tong, T.J.3
  • 20
    • 33845676619 scopus 로고    scopus 로고
    • INK4a (inhibitor of cyclin-dependent kinase 4A) immortalizes primary human keratinocytes by maintaining cells in the stem cell compartment
    • INK4a (inhibitor of cyclin-dependent kinase 4A) immortalizes primary human keratinocytes by maintaining cells in the stem cell compartment. FASEB J 2006; 20: 1516-1518.
    • (2006) FASEB J , vol.20 , pp. 1516-1518
    • Maurelli, R.1    Zambruno, G.2    Guerra, L.3    Abbruzzese, C.4    Dimri, G.5    Gellini, M.6
  • 21
    • 7544227211 scopus 로고    scopus 로고
    • Down-regulation of p21WAF1 promotes apoptosis insenescent human fibroblasts: Involvement of retinoblastoma protein phosphorylation and delay of cellular aging
    • Huang Y, Corbley MJ, Tang Z, Peng Y, Zhang ZY, Tong TJ. Down-regulation of p21WAF1 promotes apoptosis insenescent human fibroblasts: involvement of retinoblastoma protein phosphorylation and delay of cellular aging. J Cell Physiol 2004; 201: 483-491.
    • (2004) J Cell Physiol , vol.201 , pp. 483-491
    • Huang, Y.1    Corbley, M.J.2    Tang, Z.3    Peng, Y.4    Zhang, Z.Y.5    Tong, T.J.6
  • 22
    • 0029670840 scopus 로고    scopus 로고
    • Parry b, Tahara H, Stone S, Peters G Regulation of p16 expression and its implications for cell immortalization and senescence
    • Hara E, Smith R, Parry b, Tahara H, Stone S, Peters G Regulation of p16 expression and its implications for cell immortalization and senescence. Mol Cell Biol 1996; 16: 859-867.
    • (1996) Mol Cell Biol , vol.16 , pp. 859-867
    • Hara, E.1    Smith, R.2
  • 23
    • 1842850619 scopus 로고    scopus 로고
    • Sp1 is involved in the transcriptional activation of p16(INK4) by p21(Waf1) in Hela cells
    • Xue L, Wu J, Zheng W, Wang P, Li J, Zhang ZY, et al. Sp1 is involved in the transcriptional activation of p16(INK4) by p21(Waf1) in Hela cells. FEBS Lett 2004; 564: 199-204.
    • (2004) FEBS Lett , vol.564 , pp. 199-204
    • Xue, L.1    Wu, J.2    Zheng, W.3    Wang, P.4    Li, J.5    Zhang, Z.Y.6
  • 24
    • 0036566326 scopus 로고    scopus 로고
    • Inhibition of p21-mediated ROS accumulation can rescue p21-induced senescence
    • Macip S, Igarashi M, Fang L, Chen A, Pan ZQ, Lee SW, et al. Inhibition of p21-mediated ROS accumulation can rescue p21-induced senescence. EMBO J 2002; 21: 2180-2188.
    • (2002) EMBO J , vol.21 , pp. 2180-2188
    • Macip, S.1    Igarashi, M.2    Fang, L.3    Chen, A.4    Pan, Z.Q.5    Lee, S.W.6
  • 25
    • 3843115623 scopus 로고    scopus 로고
    • Regulation of cellular senescence and p161NK4a expression by Id1 and E47 proteins in human diploid fibroblast
    • Zheng WJ, Wang HY, Xue LX, Zhang ZY, Tong TJ. Regulation of cellular senescence and p161NK4a expression by Id1 and E47 proteins in human diploid fibroblast. J Biol Chem 2004; 279: 31524-31532.
    • (2004) J Biol Chem , vol.279 , pp. 31524-31532
    • Zheng, W.J.1    Wang, H.Y.2    Xue, L.X.3    Zhang, Z.Y.4    Tong, T.J.5
  • 26
    • 0035966101 scopus 로고    scopus 로고
    • Characterization of regulatory elements on the promoter region of p16(INK4a) that contribute to overexpression of p16 in senescent fibroblasts
    • Wang W, Wu JF, Zhang ZX Tong TJ. Characterization of regulatory elements on the promoter region of p16(INK4a) that contribute to overexpression of p16 in senescent fibroblasts. J Biol Chem 2001; 216: 48655-48661.
    • (2001) J Biol Chem , vol.216 , pp. 48655-48661
    • Wang, W.1    Wu, J.F.2    Zhang, Z.X.3    Tong, T.J.4
  • 27
    • 33750030758 scopus 로고    scopus 로고
    • The regulation of INK4/ARF in cancer and aging
    • Kim WY, Sharpless NE. The regulation of INK4/ARF in cancer and aging. Cell 2006; 127: 265-275.
    • (2006) Cell , vol.127 , pp. 265-275
    • Kim, W.Y.1    Sharpless, N.E.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.