메뉴 건너뛰기




Volumn 183, Issue 2, 1997, Pages 134-140

Multiple pathways control cell growth and transformation: Overlapping and independent activities of p53 and p21(Cip1/WAF1/Sdi1)

Author keywords

Apoptosis; Cancer; Cell cycle control; P21 Cip1 WAF1 Sdi1; p53; Prognostic markers

Indexed keywords

CYCLINE; MYOD PROTEIN; PHOSPHOTRANSFERASE; PROTEIN P21; PROTEIN P53; TRANSCRIPTION FACTOR;

EID: 0030866223     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9896(199710)183:2<134::AID-PATH960>3.0.CO;2-D     Document Type: Review
Times cited : (118)

References (66)
  • 1
    • 0030140057 scopus 로고    scopus 로고
    • Regulation of apoptosis by Bcl-2 and its related proteins: Immunochemical challenges and therapeutic implications
    • Kernohan NM, Cox LS. Regulation of apoptosis by Bcl-2 and its related proteins: immunochemical challenges and therapeutic implications. J Pathol 1996; 179: 1-3.
    • (1996) J Pathol , vol.179 , pp. 1-3
    • Kernohan, N.M.1    Cox, L.S.2
  • 2
    • 0030612980 scopus 로고    scopus 로고
    • WAF1/Cip1 expression is associated with cell differentiation but not with p53 mutations in squamous cell carcinomas of the larynx
    • WAF1/Cip1 expression is associated with cell differentiation but not with p53 mutations in squamous cell carcinomas of the larynx. J Pathol 1997; 183: 156-163.
    • (1997) J Pathol , vol.183 , pp. 156-163
    • Nadal, A.1    Jares, P.2    Cazorla, M.3
  • 3
    • 0027109075 scopus 로고
    • p53, guardian of the genome
    • Lane DP. p53, guardian of the genome. Nature 1992; 358: 15-16.
    • (1992) Nature , vol.358 , pp. 15-16
    • Lane, D.P.1
  • 4
    • 0027179908 scopus 로고
    • In vitro growth characteristics of embryo fibroblasts isolated from p53-deficient mice
    • Harvey M, Sands AT, Weiss RS, et al. In vitro growth characteristics of embryo fibroblasts isolated from p53-deficient mice. Oncogene 1993; 8: 2457-2467.
    • (1993) Oncogene , vol.8 , pp. 2457-2467
    • Harvey, M.1    Sands, A.T.2    Weiss, R.S.3
  • 6
    • 0027278584 scopus 로고
    • Immunohistochemical detection of p53 protein in mammary carcinoma: An important new independent indicator of prognosis?
    • Barnes DM, Dublin EA, Fisher CJ, Levison DA, Millis RR. Immunohistochemical detection of p53 protein in mammary carcinoma: an important new independent indicator of prognosis? Hum Pathol 1993; 24: 469-476.
    • (1993) Hum Pathol , vol.24 , pp. 469-476
    • Barnes, D.M.1    Dublin, E.A.2    Fisher, C.J.3    Levison, D.A.4    Millis, R.R.5
  • 7
    • 0026632997 scopus 로고
    • Abnormal expression of wild type p53 protein in normal cells of a cancer family patient
    • Barnes DM, Hanby AM, Gillett CE, et al. Abnormal expression of wild type p53 protein in normal cells of a cancer family patient. Lancet 1992; 340: 259-263.
    • (1992) Lancet , vol.340 , pp. 259-263
    • Barnes, D.M.1    Hanby, A.M.2    Gillett, C.E.3
  • 8
    • 0027818553 scopus 로고
    • p53 protein detected by immunohistochemical staining is not always mutant
    • MacGeoch C, Barnes DM, Newton JA, et al. p53 protein detected by immunohistochemical staining is not always mutant. Dis Markers 1993; 11: 239-250.
    • (1993) Dis Markers , vol.11 , pp. 239-250
    • MacGeoch, C.1    Barnes, D.M.2    Newton, J.A.3
  • 9
    • 0029831120 scopus 로고    scopus 로고
    • Analysis of p53 antibody response in patients with squamous cell carcinoma of the head and neck
    • Lavieille JP, Lubin R, Soussi T, Reyt E, Brambilla C, Riva C. Analysis of p53 antibody response in patients with squamous cell carcinoma of the head and neck. Anticancer Res 1996; 16: 2385-2388.
    • (1996) Anticancer Res , vol.16 , pp. 2385-2388
    • Lavieille, J.P.1    Lubin, R.2    Soussi, T.3    Reyt, E.4    Brambilla, C.5    Riva, C.6
  • 10
    • 0027332996 scopus 로고
    • Differential induction of transcriptionally active p53 following UV or ionizing radiation: Defects in chromosome instability syndromes?
    • Lu X, Lane DP. Differential induction of transcriptionally active p53 following UV or ionizing radiation: defects in chromosome instability syndromes? Cell 1993; 75: 765-778.
    • (1993) Cell , vol.75 , pp. 765-778
    • Lu, X.1    Lane, D.P.2
  • 11
    • 0031015044 scopus 로고    scopus 로고
    • Ubiquitination of p53 and p21 is differentially affected by ionizing and UV radiation
    • Maki CG, Howley PM. Ubiquitination of p53 and p21 is differentially affected by ionizing and UV radiation. Mol Cell Biol 1997; 17: 355-363.
    • (1997) Mol Cell Biol , vol.17 , pp. 355-363
    • Maki, C.G.1    Howley, P.M.2
  • 12
    • 0029315510 scopus 로고
    • Tumour suppressors, kinases and clamps: How p53 regulates the cell cycle in response to DNA damage
    • Cox LS, Lane DP. Tumour suppressors, kinases and clamps: how p53 regulates the cell cycle in response to DNA damage. BioEssays 1995; 17: 501-508.
    • (1995) BioEssays , vol.17 , pp. 501-508
    • Cox, L.S.1    Lane, D.P.2
  • 13
    • 0026448672 scopus 로고
    • Regulation of the specific DNA binding function of p53
    • Hupp TR, Meek DW, Midgley CA, Lane DP. Regulation of the specific DNA binding function of p53. Cell 1992; 71: 875-886.
    • (1992) Cell , vol.71 , pp. 875-886
    • Hupp, T.R.1    Meek, D.W.2    Midgley, C.A.3    Lane, D.P.4
  • 14
    • 0027250493 scopus 로고
    • Activation of the cryptic DNA binding function of mutant forms of p53
    • Hupp TR, Meek DW, Midgley CA, Lane DP. Activation of the cryptic DNA binding function of mutant forms of p53. Nucleic Acids Res 1993; 21: 3167-3174.
    • (1993) Nucleic Acids Res , vol.21 , pp. 3167-3174
    • Hupp, T.R.1    Meek, D.W.2    Midgley, C.A.3    Lane, D.P.4
  • 15
    • 0026786235 scopus 로고
    • Nuclear protein phosphorylation and growth control
    • Meek DW, Street AJ. Nuclear protein phosphorylation and growth control. Biochem J 1992; 287: 1-15.
    • (1992) Biochem J , vol.287 , pp. 1-15
    • Meek, D.W.1    Street, A.J.2
  • 17
    • 0026496885 scopus 로고
    • A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telengiectasia
    • Kastan MB, Zhan Q, El-Deiry WS, et al. A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telengiectasia. Cell 1992; 71: 587-597.
    • (1992) Cell , vol.71 , pp. 587-597
    • Kastan, M.B.1    Zhan, Q.2    El-Deiry, W.S.3
  • 18
    • 0028883179 scopus 로고
    • Tumour suppressor p53 is a direct transcriptional activator of the human bax gene
    • Miyashita T, Reed JC. Tumour suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 1995; 80: 293-299.
    • (1995) Cell , vol.80 , pp. 293-299
    • Miyashita, T.1    Reed, J.C.2
  • 19
    • 0027944251 scopus 로고
    • Cyclin G is a transcriptional target of the p53 tumour suppressor protein
    • Okamoto K, Beach D. Cyclin G is a transcriptional target of the p53 tumour suppressor protein. EMBO J 1994; 13: 4816-4823.
    • (1994) EMBO J , vol.13 , pp. 4816-4823
    • Okamoto, K.1    Beach, D.2
  • 20
    • 0028228913 scopus 로고
    • Human p53 directs DNA strand reassociation and is photolabelled by 8-azido ATP
    • Brain R, Jenkins JR. Human p53 directs DNA strand reassociation and is photolabelled by 8-azido ATP. Oncogene 1994; 9: 1775-1780.
    • (1994) Oncogene , vol.9 , pp. 1775-1780
    • Brain, R.1    Jenkins, J.R.2
  • 21
    • 0027284915 scopus 로고
    • P53-catalyzed annealing of complementary single-stranded nucleic acids
    • Oberosler P, Hloch P, Ramsperger U, Stahl H. p53-catalyzed annealing of complementary single-stranded nucleic acids. EMBO J 1993; 12: 2389-2396.
    • (1993) EMBO J , vol.12 , pp. 2389-2396
    • Oberosler, P.1    Hloch, P.2    Ramsperger, U.3    Stahl, H.4
  • 22
    • 0029028158 scopus 로고
    • A direct effect of activated human p53 on eukaryotic DNA replication
    • Cox LS, Hupp T, Midgley CA, Lane DP. A direct effect of activated human p53 on eukaryotic DNA replication. EMBO J 1995; 14: 2099-2105.
    • (1995) EMBO J , vol.14 , pp. 2099-2105
    • Cox, L.S.1    Hupp, T.2    Midgley, C.A.3    Lane, D.P.4
  • 23
    • 0028124665 scopus 로고
    • High-resolution structure of the oligomerization domain of p53 by multidimensional NMR
    • Clore GM, Omichinski JG, Sakaguchi K, et al. High-resolution structure of the oligomerization domain of p53 by multidimensional NMR. Science 1994; 265: 386-391.
    • (1994) Science , vol.265 , pp. 386-391
    • Clore, G.M.1    Omichinski, J.G.2    Sakaguchi, K.3
  • 24
    • 0028965832 scopus 로고
    • Refined solution structure of the oligomerization domain of the tumour suppressor p53
    • Clore GM, Ernst J, Clubb R, et al. Refined solution structure of the oligomerization domain of the tumour suppressor p53. Nat Struct Biol 1995; 2: 321-333.
    • (1995) Nat Struct Biol , vol.2 , pp. 321-333
    • Clore, G.M.1    Ernst, J.2    Clubb, R.3
  • 25
    • 0028137084 scopus 로고
    • p53: A glimpse at the puppet behind the shadow play
    • Friend S. p53: a glimpse at the puppet behind the shadow play. Science 1994; 265: 334-335.
    • (1994) Science , vol.265 , pp. 334-335
    • Friend, S.1
  • 26
    • 0026649648 scopus 로고
    • The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
    • Momand J, Zambetti GP, Olson DC, George D, Levine AJ. The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell 1992; 69: 1237-1245.
    • (1992) Cell , vol.69 , pp. 1237-1245
    • Momand, J.1    Zambetti, G.P.2    Olson, D.C.3    George, D.4    Levine, A.J.5
  • 27
    • 0028342664 scopus 로고
    • Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen
    • Noda A, Ning Y, Venable SF, Pereira-Smith OM, Smith JR. Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen. Exp Cell Res 1994; 211: 90-98.
    • (1994) Exp Cell Res , vol.211 , pp. 90-98
    • Noda, A.1    Ning, Y.2    Venable, S.F.3    Pereira-Smith, O.M.4    Smith, J.R.5
  • 29
    • 0027359827 scopus 로고
    • WAF-1, a potential mediator of p53 tumour suppression
    • El-Deiry WS, Tokino T, Velculescu VE, et al. WAF-1, a potential mediator of p53 tumour suppression. Cell 1993; 75: 817-825.
    • (1993) Cell , vol.75 , pp. 817-825
    • El-Deiry, W.S.1    Tokino, T.2    Velculescu, V.E.3
  • 30
    • 0029802591 scopus 로고    scopus 로고
    • p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells
    • Chen X, Ko LJ, Jayaraman L, Prives C. p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells. Genes Dev 1996; 10: 2438-2451.
    • (1996) Genes Dev , vol.10 , pp. 2438-2451
    • Chen, X.1    Ko, L.J.2    Jayaraman, L.3    Prives, C.4
  • 31
    • 0028986639 scopus 로고
    • Cip1 in muscle and other terminally differentiating cells
    • Cip1 in muscle and other terminally differentiating cells. Science 1995; 267: 1024-1027.
    • (1995) Science , vol.267 , pp. 1024-1027
    • Parker, S.B.1    Eichele, G.2    Zhang, P.3
  • 32
    • 0028898203 scopus 로고
    • Potential role of WAF1/Cip1/p21 as a mediator of TGF-beta cytoinhibitory effect
    • Li CY, Suardet L, Little JB. Potential role of WAF1/Cip1/p21 as a mediator of TGF-beta cytoinhibitory effect. J Biol Chem 1995; 270: 4971-4974.
    • (1995) J Biol Chem , vol.270 , pp. 4971-4974
    • Li, C.Y.1    Suardet, L.2    Little, J.B.3
  • 33
    • 0029730636 scopus 로고    scopus 로고
    • Induction of p21 mediated by reactive oxygen species formed during the metabolism of aziridinylbenzoquinones by HCT116 cells
    • Qiu X, Forman HJ, Schonthal AH, Cadenas E. Induction of p21 mediated by reactive oxygen species formed during the metabolism of aziridinylbenzoquinones by HCT116 cells. J Biol Chem 1996; 271: 31915-31921.
    • (1996) J Biol Chem , vol.271 , pp. 31915-31921
    • Qiu, X.1    Forman, H.J.2    Schonthal, A.H.3    Cadenas, E.4
  • 34
    • 0030199843 scopus 로고    scopus 로고
    • Effects of 1, 25-dihydroxyvitamin D3 and its analogues on induction of apoptosis in breast cancer cells
    • James SY, Mackay AG, Colston KW. Effects of 1, 25-dihydroxyvitamin D3 and its analogues on induction of apoptosis in breast cancer cells. J Steroid Biochem Mol Biol 1996; 58: 395-401.
    • (1996) J Steroid Biochem Mol Biol , vol.58 , pp. 395-401
    • James, S.Y.1    Mackay, A.G.2    Colston, K.W.3
  • 35
    • 0029782220 scopus 로고    scopus 로고
    • Paradoxical tumor inhibitory effect of p53 loss in transgenic mice expressing epidermal-targeted v-rasHa, v-fos, or human transforming growth factor alpha
    • Greenhalgh DA, Wang XJ, Donehower LA, Roop DR. Paradoxical tumor inhibitory effect of p53 loss in transgenic mice expressing epidermal-targeted v-rasHa, v-fos, or human transforming growth factor alpha. Cancer Res 1996; 56: 4413-4423.
    • (1996) Cancer Res , vol.56 , pp. 4413-4423
    • Greenhalgh, D.A.1    Wang, X.J.2    Donehower, L.A.3    Roop, D.R.4
  • 36
    • 0028941483 scopus 로고
    • Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by MyoD
    • Halevy O, Novitch BG, Spicer DB, et al. Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by MyoD. Science 1995; 267: 1018-1021.
    • (1995) Science , vol.267 , pp. 1018-1021
    • Halevy, O.1    Novitch, B.G.2    Spicer, D.B.3
  • 37
    • 0029658148 scopus 로고    scopus 로고
    • WAF1/Cip1 is induced through a p300-dependent mechanism during NGF-mediated neuronal differentiation of PC12 cells
    • WAF1/Cip1 is induced through a p300-dependent mechanism during NGF-mediated neuronal differentiation of PC12 cells. Oncogene 1996; 13: 2047-2054.
    • (1996) Oncogene , vol.13 , pp. 2047-2054
    • Billon, N.1    Van Grunsven, L.A.2    Rudkin, B.B.3
  • 38
    • 0029670422 scopus 로고    scopus 로고
    • Regulation of p21WAF1/Cip1 expression by p53-independent pathways
    • Zeng YX, El-Deiry WS. Regulation of p21WAF1/Cip1 expression by p53-independent pathways. Oncogene 1996; 12: 1557-1564.
    • (1996) Oncogene , vol.12 , pp. 1557-1564
    • Zeng, Y.X.1    El-Deiry, W.S.2
  • 39
    • 0029665943 scopus 로고    scopus 로고
    • WAF1 immunohistochemical expression in breast carcinoma: Correlations with clinicopathological data, oestrogen receptor status, MIB1 expression, p53 gene and protein alterations and relapse-free survival
    • WAF1 immunohistochemical expression in breast carcinoma: correlations with clinicopathological data, oestrogen receptor status, MIB1 expression, p53 gene and protein alterations and relapse-free survival. Br J Cancer 1996; 74: 208-215.
    • (1996) Br J Cancer , vol.74 , pp. 208-215
    • Barbareschi, M.1    Caffo, O.2    Doglioni, C.3
  • 40
    • 0028970946 scopus 로고
    • p53-independent expression of the cyclin-dependent kinase inhibitor p21 in pancreatic carcinoma
    • DiGiuseppe JA, Redston MS, Yeo CJ, Kern SE, Hruban RH. p53-independent expression of the cyclin-dependent kinase inhibitor p21 in pancreatic carcinoma. Am J Pathol 1995; 47: 884-888.
    • (1995) Am J Pathol , vol.47 , pp. 884-888
    • DiGiuseppe, J.A.1    Redston, M.S.2    Yeo, C.J.3    Kern, S.E.4    Hruban, R.H.5
  • 41
    • 0029746230 scopus 로고    scopus 로고
    • Relation between infection with human papilloma viruses and expression of p21 and p53 oncoproteins in patients with cancer of the uterine cervix
    • Bar JK, Markowska J, Harlozinska A, Sedlaczek P, Nowak M, Roszak A. Relation between infection with human papilloma viruses and expression of p21 and p53 oncoproteins in patients with cancer of the uterine cervix. Eur J Gynaecol Oncol 1996; 17: 283-285.
    • (1996) Eur J Gynaecol Oncol , vol.17 , pp. 283-285
    • Bar, J.K.1    Markowska, J.2    Harlozinska, A.3    Sedlaczek, P.4    Nowak, M.5    Roszak, A.6
  • 42
    • 0028988585 scopus 로고
    • Inhibitors of mammalian G1 cyclin-dependent kinases
    • Sherr CJ, Roberts JM. Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev 1995; 9: 1149-1163.
    • (1995) Genes Dev , vol.9 , pp. 1149-1163
    • Sherr, C.J.1    Roberts, J.M.2
  • 43
    • 0027440552 scopus 로고
    • Proliferating cell nuclear antigen and p21 are components of multiple cell cycle kinase complexes
    • Zhang H, Xiong Y, Beach D. Proliferating cell nuclear antigen and p21 are components of multiple cell cycle kinase complexes. Mol Biol Cell 1993; 4: 897-906.
    • (1993) Mol Biol Cell , vol.4 , pp. 897-906
    • Zhang, H.1    Xiong, Y.2    Beach, D.3
  • 44
    • 0028169236 scopus 로고
    • p21-containing cyclin kinases exist in both active and inactive states
    • Zhang H, Hannon GJ, Beach D. p21-containing cyclin kinases exist in both active and inactive states. Genes Dev 1994; 8: 1750-1758.
    • (1994) Genes Dev , vol.8 , pp. 1750-1758
    • Zhang, H.1    Hannon, G.J.2    Beach, D.3
  • 46
    • 0028910392 scopus 로고
    • No point mutation but a codon 31ser→arg polymorphism of the WAF-1/CIP-1/p21 tumor suppressor gene in nasopharyngeal carcinoma (NPC): The polymorphism distinguishes Caucasians from Chinese
    • Sun Y, Hildesheim A, Li H, et al. No point mutation but a codon 31ser→arg polymorphism of the WAF-1/CIP-1/p21 tumor suppressor gene in nasopharyngeal carcinoma (NPC): the polymorphism distinguishes Caucasians from Chinese. Cancer Epidemiol Biomarkers Prev 1995; 4: 261-267.
    • (1995) Cancer Epidemiol Biomarkers Prev , vol.4 , pp. 261-267
    • Sun, Y.1    Hildesheim, A.2    Li, H.3
  • 47
    • 0028928540 scopus 로고
    • A mutant p21 cyclin-dependent kinase inhibitor isolated from a Burkitt's lymphoma
    • Bhatia K, Fan S, Spangler G, et al. A mutant p21 cyclin-dependent kinase inhibitor isolated from a Burkitt's lymphoma. Cancer Res 1995; 55: 1431-1435.
    • (1995) Cancer Res , vol.55 , pp. 1431-1435
    • Bhatia, K.1    Fan, S.2    Spangler, G.3
  • 48
    • 0027940495 scopus 로고
    • Absence of WAF1 mutations in a variety of human malignancies
    • Shiohara M, el Deiry WS, Wada M, et al. Absence of WAF1 mutations in a variety of human malignancies. Blood 1994; 84: 3781-3784.
    • (1994) Blood , vol.84 , pp. 3781-3784
    • Shiohara, M.1    El Deiry, W.S.2    Wada, M.3
  • 49
    • 0028978183 scopus 로고
    • WAF1 undergo normal development, but are defective in G1 checkpoint control
    • WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell 1995; 82: 675-684.
    • (1995) Cell , vol.82 , pp. 675-684
    • Deng, C.1    Zhang, P.2    Harper, J.W.3    Elledge, S.J.4    Leder, P.5
  • 50
    • 0028849274 scopus 로고
    • p21 is necessary for the p53-mediated G1 arrest in human cancer cells
    • Waldman T, Kinzler KW, Vogelstein B. p21 is necessary for the p53-mediated G1 arrest in human cancer cells. Cancer Res 1995; 55: 5187-5190.
    • (1995) Cancer Res , vol.55 , pp. 5187-5190
    • Waldman, T.1    Kinzler, K.W.2    Vogelstein, B.3
  • 51
    • 0030011128 scopus 로고    scopus 로고
    • Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21
    • Waldman T, Lengauer C, Kinzler KW, Vogelstein B. Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21. Nature 1996; 381: 713-716.
    • (1996) Nature , vol.381 , pp. 713-716
    • Waldman, T.1    Lengauer, C.2    Kinzler, K.W.3    Vogelstein, B.4
  • 53
    • 0028074603 scopus 로고
    • Differential effects by the p21 CDK inhibitor on PCNA-dependent DNA replication and repair
    • Li R, Waga S, Hannon GJ, Beach D, Stillman B. Differential effects by the p21 CDK inhibitor on PCNA-dependent DNA replication and repair. Nature 1994; 371: 534-537.
    • (1994) Nature , vol.371 , pp. 534-537
    • Li, R.1    Waga, S.2    Hannon, G.J.3    Beach, D.4    Stillman, B.5
  • 54
    • 0028675510 scopus 로고
    • Cip1 inhibits DNA replication but not PCNA-dcpcndent nucleotide excision repair
    • Shivji MKK, Grey SJ, Strausfeld UP, Wood RD, Blow JJ. Cip1 inhibits DNA replication but not PCNA-dcpcndent nucleotide excision repair. Curr Biol 1994; 4: 1062-1068.
    • (1994) Curr Biol , vol.4 , pp. 1062-1068
    • Shivji, M.K.K.1    Grey, S.J.2    Strausfeld, U.P.3    Wood, R.D.4    Blow, J.J.5
  • 55
    • 0030913166 scopus 로고    scopus 로고
    • Cip1 compete for binding to the same site on PCNA: A possible mechanism for regulation of DNA replication
    • Cip1 compete for binding to the same site on PCNA: a possible mechanism for regulation of DNA replication. Oncogene 14: 2313-2321.
    • Oncogene , vol.14 , pp. 2313-2321
    • Warbrick, E.1    Lane, D.P.2    Glover, D.M.3    Cox, L.S.4
  • 56
    • 0028820762 scopus 로고
    • The p21 cyclindependent kinase inhibitor suppresses tumorigenicity in vivo
    • Yang ZY, Perkins ND, Ohno T, Nabel EG, Nabel GJ. The p21 cyclindependent kinase inhibitor suppresses tumorigenicity in vivo. Nat Med 1995; 1: 1052-1056.
    • (1995) Nat Med , vol.1 , pp. 1052-1056
    • Yang, Z.Y.1    Perkins, N.D.2    Ohno, T.3    Nabel, E.G.4    Nabel, G.J.5
  • 57
    • 0029808931 scopus 로고    scopus 로고
    • Effects of ectopic overexpression of p21(WAF1/CIP1) on aneuploidy and the malignant phenotype of human brain tumor cells
    • Chen J, Willingham T, Shuford M, et al. Effects of ectopic overexpression of p21(WAF1/CIP1) on aneuploidy and the malignant phenotype of human brain tumor cells. Oncogene 1996; 13: 1395-1403.
    • (1996) Oncogene , vol.13 , pp. 1395-1403
    • Chen, J.1    Willingham, T.2    Shuford, M.3
  • 60
    • 8944259437 scopus 로고    scopus 로고
    • Interference with p53 protein inhibits hematopoietic and muscle differentiation
    • Soddu S, Blandino G, Scardigli R, et al. Interference with p53 protein inhibits hematopoietic and muscle differentiation. J Cell Biol 1996; 134: 193-204.
    • (1996) J Cell Biol , vol.134 , pp. 193-204
    • Soddu, S.1    Blandino, G.2    Scardigli, R.3
  • 61
    • 0028834902 scopus 로고
    • Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53
    • Jones SN, Roe AE, Donehower LA, Bradley A. Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53. Nature 1995; 378: 206-208.
    • (1995) Nature , vol.378 , pp. 206-208
    • Jones, S.N.1    Roe, A.E.2    Donehower, L.A.3    Bradley, A.4
  • 62
    • 0030021748 scopus 로고    scopus 로고
    • Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant
    • Rowan S, Ludwig RL, Haupt Y, et al. Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant. EMBO J 1996; 15: 827-838.
    • (1996) EMBO J , vol.15 , pp. 827-838
    • Rowan, S.1    Ludwig, R.L.2    Haupt, Y.3
  • 63
    • 0029742781 scopus 로고    scopus 로고
    • Differential activation of target cellular promoters by p53 mutants with impaired apoptotic function
    • Ludwig RL, Bates S, Vousden KH. Differential activation of target cellular promoters by p53 mutants with impaired apoptotic function. Mol Cell Biol 1996; 16: 4952-4960.
    • (1996) Mol Cell Biol , vol.16 , pp. 4952-4960
    • Ludwig, R.L.1    Bates, S.2    Vousden, K.H.3
  • 64
    • 0029811984 scopus 로고    scopus 로고
    • Genetic determinants of p53-induced apoptosis and growth arrest
    • Polyak K, Waldman T, He TC, Kinzler KW, Vogelstein B. Genetic determinants of p53-induced apoptosis and growth arrest. Genes Dev 1996; 10: 1945-1952.
    • (1996) Genes Dev , vol.10 , pp. 1945-1952
    • Polyak, K.1    Waldman, T.2    He, T.C.3    Kinzler, K.W.4    Vogelstein, B.5
  • 65
    • 0029980043 scopus 로고    scopus 로고
    • p53 in growth control and neoplasia
    • Gottlieb MT, Oren M. p53 in growth control and neoplasia. Biochim Biophys Acta 1996; 1287: 77-102.
    • (1996) Biochim Biophys Acta , vol.1287 , pp. 77-102
    • Gottlieb, M.T.1    Oren, M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.