-
1
-
-
0027208148
-
Fission yeast chk1 protein kinase links the rad checkpoint pathway to cdc2
-
Walworth N, Davey S, Beach D (1993) Fission yeast chk1 protein kinase links the rad checkpoint pathway to cdc2. Nature 363: 368-371.
-
(1993)
Nature
, vol.363
, pp. 368-371
-
-
Walworth, N.1
Davey, S.2
Beach, D.3
-
2
-
-
0029664616
-
rad Dependent Response of the chk1-Encoded Protein Kinase at the DNA Damage Checkpoint
-
Walworth NC, Bernards R (1996) rad Dependent Response of the chk1-Encoded Protein Kinase at the DNA Damage Checkpoint. Science 271: 353-356.
-
(1996)
Science
, vol.271
, pp. 353-356
-
-
Walworth, N.C.1
Bernards, R.2
-
3
-
-
0028198383
-
Identification and characterization of new elements involved in checkpoints and feedback controls in fission yeast
-
al-Khodairy F, Fotou E, Sheldrick KS, Griffiths DJF, Lehmann AR, et al. (1994) Identification and characterization of new elements involved in checkpoints and feedback controls in fission yeast. Molecular Biology of the Cell 5: 147-160.
-
(1994)
Molecular Biology of the Cell
, vol.5
, pp. 147-160
-
-
al-Khodairy, F.1
Fotou, E.2
Sheldrick, K.S.3
Griffiths, D.J.F.4
Lehmann, A.R.5
-
4
-
-
33751581196
-
Selective Chk1 inhibitors differentially sensitize p53-deficient cancer cells to cancer therapeutics
-
Chen Z, Xiao Z, Gu WZ, Xue J, Bui MH, et al. (2006) Selective Chk1 inhibitors differentially sensitize p53-deficient cancer cells to cancer therapeutics. Int J Cancer 119: 2784-2794.
-
(2006)
Int J Cancer
, vol.119
, pp. 2784-2794
-
-
Chen, Z.1
Xiao, Z.2
Gu, W.Z.3
Xue, J.4
Bui, M.H.5
-
5
-
-
0033975054
-
An indolocarbazole inhibitor of human checkpoint kinase (Chk1)abrogates cell cycle arrest caused by DNA damage
-
Jackson JR, Gimartin A, Imburgia C, Winkler JD, Marshall LA, et al. (2000) An indolocarbazole inhibitor of human checkpoint kinase (Chk1)abrogates cell cycle arrest caused by DNA damage. Cancer Res 60: 566-572.
-
(2000)
Cancer Res
, vol.60
, pp. 566-572
-
-
Jackson, J.R.1
Gimartin, A.2
Imburgia, C.3
Winkler, J.D.4
Marshall, L.A.5
-
6
-
-
0031438163
-
Damage and replication checkpoint control in fission yeast is ensured by interactions of Crb2, a protein with BRCT motif, with Cut5 and Chk1
-
Saka Y, Esashi F, Matsusaka T, Mochida S, Yanagida M (1997) Damage and replication checkpoint control in fission yeast is ensured by interactions of Crb2, a protein with BRCT motif, with Cut5 and Chk1. Genes and Development 11: 3387-3400.
-
(1997)
Genes and Development
, vol.11
, pp. 3387-3400
-
-
Saka, Y.1
Esashi, F.2
Matsusaka, T.3
Mochida, S.4
Yanagida, M.5
-
7
-
-
0026562544
-
DNA repair mutants defining G2 checkpoint pathways in Schizosaccharomyces pombe
-
al-Khodairy F, Carr AM (1992) DNA repair mutants defining G2 checkpoint pathways in Schizosaccharomyces pombe. EMBO Journal 11: 1343-1350.
-
(1992)
EMBO Journal
, vol.11
, pp. 1343-1350
-
-
al-Khodairy, F.1
Carr, A.M.2
-
8
-
-
0033558882
-
Association of Chk1 with 14-3-3 proteins is stimulated by DNA damage
-
Chen L, Liu T-H, Walworth NC (1999) Association of Chk1 with 14-3-3 proteins is stimulated by DNA damage. Genes and Development 13: 675-685.
-
(1999)
Genes and Development
, vol.13
, pp. 675-685
-
-
Chen, L.1
Liu, T.-H.2
Walworth, N.C.3
-
9
-
-
0026482601
-
Fission yeast genes involved in coupling mitosis to the completion of DNA replication
-
Enoch T, Carr AM, Nurse P (1992) Fission yeast genes involved in coupling mitosis to the completion of DNA replication. Genes and Development 6: 2035-2046.
-
(1992)
Genes and Development
, vol.6
, pp. 2035-2046
-
-
Enoch, T.1
Carr, A.M.2
Nurse, P.3
-
10
-
-
0028101138
-
14-3-3 protein homologs required for the DNA damage checkpoint in fission yeast
-
Ford JC, al-Khodairy F, Fotou E, Sheldrick KS, Griffiths DJ, et al. (1994) 14-3-3 protein homologs required for the DNA damage checkpoint in fission yeast. Science 265: 533-535.
-
(1994)
Science
, vol.265
, pp. 533-535
-
-
Ford, J.C.1
al-Khodairy, F.2
Fotou, E.3
Sheldrick, K.S.4
Griffiths, D.J.5
-
11
-
-
2442519038
-
Assaying the DNA damage checkpoint in fission yeast
-
Dunaway S, Walworth NC (2004) Assaying the DNA damage checkpoint in fission yeast. Methods 33: 260-263.
-
(2004)
Methods
, vol.33
, pp. 260-263
-
-
Dunaway, S.1
Walworth, N.C.2
-
12
-
-
0036902096
-
Phosphorylation activates Chk1 and is required for checkpoint-mediated cell cycle arrest
-
Capasso H, Palermo C, Wan S, Rao H, John UP, et al. (2002) Phosphorylation activates Chk1 and is required for checkpoint-mediated cell cycle arrest. J Cell Sci 115: 4555-4564.
-
(2002)
J Cell Sci
, vol.115
, pp. 4555-4564
-
-
Capasso, H.1
Palermo, C.2
Wan, S.3
Rao, H.4
John, U.P.5
-
13
-
-
0034967556
-
ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1
-
Zhao H, Piwnica-Worms H (2001) ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1. Molecular and Cellular Biology 21: 4129-4139.
-
(2001)
Molecular and Cellular Biology
, vol.21
, pp. 4129-4139
-
-
Zhao, H.1
Piwnica-Worms, H.2
-
15
-
-
0032535157
-
Analysis of Rad3 and Chk1 protein kinases defines different checkpoint responses
-
Martinho RG, Lindsay HD, Flaggs G, DeMaggio AJ, Hoekstra MF, et al. (1998) Analysis of Rad3 and Chk1 protein kinases defines different checkpoint responses. EMBO Journal 17: 7239-7249.
-
(1998)
EMBO Journal
, vol.17
, pp. 7239-7249
-
-
Martinho, R.G.1
Lindsay, H.D.2
Flaggs, G.3
DeMaggio, A.J.4
Hoekstra, M.F.5
-
16
-
-
0035949568
-
Serine-345 is required for Rad3-dependent phosphorylation and function of checkpoint kinase Chk1 in fission yeast
-
Lopez-Girona A, Tanaka K, Chen XB, Baber BA, McGowan CH, et al. (2001) Serine-345 is required for Rad3-dependent phosphorylation and function of checkpoint kinase Chk1 in fission yeast. Proceeding of the National Academy of Sciences 98: 11289-11294.
-
(2001)
Proceeding of the National Academy of Sciences
, vol.98
, pp. 11289-11294
-
-
Lopez-Girona, A.1
Tanaka, K.2
Chen, X.B.3
Baber, B.A.4
McGowan, C.H.5
-
17
-
-
0031035528
-
Chk1 is a weel kinase in the G2 DNA damage checkpoint inhibiting cdc2 by Y15 phosphorylation
-
O'Connell MJ, Raleigh JM, Verkade HM, Nurse P (1997) Chk1 is a weel kinase in the G2 DNA damage checkpoint inhibiting cdc2 by Y15 phosphorylation. EMBO Journal 16: 545-554.
-
(1997)
EMBO Journal
, vol.16
, pp. 545-554
-
-
O'Connell, M.J.1
Raleigh, J.M.2
Verkade, H.M.3
Nurse, P.4
-
18
-
-
0030768948
-
Cdc25 mitotic inducer targeted by Chk1 DNA damage checkpoint kinase
-
Furnari B, Rhind N, Russell P (1997) Cdc25 mitotic inducer targeted by Chk1 DNA damage checkpoint kinase. Science 277: 1495-1497.
-
(1997)
Science
, vol.277
, pp. 1495-1497
-
-
Furnari, B.1
Rhind, N.2
Russell, P.3
-
19
-
-
0025246110
-
Universal control mechanism regulating the onset of M-phase
-
Nurse P (1990) Universal control mechanism regulating the onset of M-phase. Nature 344: 503-508.
-
(1990)
Nature
, vol.344
, pp. 503-508
-
-
Nurse, P.1
-
20
-
-
0035162304
-
Cytoplasmic occurrence of the Chk1/Cdc25 pathway and regulation of Chk1 in Xenopus oocytes
-
Oe T, Nakajo N, Katsuragi Y, Okazaki K, Sagata N (2001) Cytoplasmic occurrence of the Chk1/Cdc25 pathway and regulation of Chk1 in Xenopus oocytes. Developmental Biology 229: 250-261.
-
(2001)
Developmental Biology
, vol.229
, pp. 250-261
-
-
Oe, T.1
Nakajo, N.2
Katsuragi, Y.3
Okazaki, K.4
Sagata, N.5
-
21
-
-
0034677597
-
-
Chen P, Luo C, Deng Y, Ryan K, Register J, et al. (2000) The 1.7 Å crystal structure of human cell cycle checkpoint kinase Chk1: implications for Chk1 regulation. Cell 100: 681-692.
-
Chen P, Luo C, Deng Y, Ryan K, Register J, et al. (2000) The 1.7 Å crystal structure of human cell cycle checkpoint kinase Chk1: implications for Chk1 regulation. Cell 100: 681-692.
-
-
-
-
22
-
-
1642546298
-
Regulation of Chk1 kinase by autoinhibition and ATR-mediated phosphorylation
-
Katsuragi Y, Sagata N (2004) Regulation of Chk1 kinase by autoinhibition and ATR-mediated phosphorylation. Mol Biol Cell 15: 1680-1689.
-
(2004)
Mol Biol Cell
, vol.15
, pp. 1680-1689
-
-
Katsuragi, Y.1
Sagata, N.2
-
23
-
-
0035966005
-
Cloning and characterization of liver-specific isoform of Chk1 gene from rat
-
Shann YJ, Hsu MT (2001) Cloning and characterization of liver-specific isoform of Chk1 gene from rat. J Biol Chem 276: 48863-48870.
-
(2001)
J Biol Chem
, vol.276
, pp. 48863-48870
-
-
Shann, Y.J.1
Hsu, M.T.2
-
24
-
-
0033970743
-
Substrate specificity determinants of the checkpoint protein kinase Chk1
-
Hutchins JR, Hughes M, Clarke PR (2000) Substrate specificity determinants of the checkpoint protein kinase Chk1. FEBS Lett 466: 91-95.
-
(2000)
FEBS Lett
, vol.466
, pp. 91-95
-
-
Hutchins, J.R.1
Hughes, M.2
Clarke, P.R.3
-
25
-
-
0037013243
-
Determination of substrate motifs for human Chk1 and hCds1/Chk2 by the oriented peptide library approach
-
O'Neill T, Giarratani L, Chen P, Iyer L, Lee CH, et al. (2002) Determination of substrate motifs for human Chk1 and hCds1/Chk2 by the oriented peptide library approach. J Biol Chem 277: 16102-16115.
-
(2002)
J Biol Chem
, vol.277
, pp. 16102-16115
-
-
O'Neill, T.1
Giarratani, L.2
Chen, P.3
Iyer, L.4
Lee, C.H.5
-
26
-
-
0035177376
-
A novel genetic screen identifies checkpoint-defective alleles of Schizosaccharomyces pombe chk1
-
Wan S, Walworth NC (2001) A novel genetic screen identifies checkpoint-defective alleles of Schizosaccharomyces pombe chk1. Current Genetics 38: 299-306.
-
(2001)
Current Genetics
, vol.38
, pp. 299-306
-
-
Wan, S.1
Walworth, N.C.2
-
27
-
-
0030867582
-
Conservation of the Chk1 checkpoint pathway in mammals: Linkage of DNA damage to Cdk regulation through Cdc25
-
Sanchez Y, Wong C, Thoma RS, Richman R, Wu Z, et al. (1997) Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25. Science 277: 1497-1501.
-
(1997)
Science
, vol.277
, pp. 1497-1501
-
-
Sanchez, Y.1
Wong, C.2
Thoma, R.S.3
Richman, R.4
Wu, Z.5
-
28
-
-
0035985046
-
Fission yeast chk1 mutants show distinct responses to different types of DNA damaging treatments
-
Francesconi S, Smeets M, Grenon M, Tillit J, Blaisonneau J, et al. (2002) Fission yeast chk1 mutants show distinct responses to different types of DNA damaging treatments. Genes Cells 7: 663-673.
-
(2002)
Genes Cells
, vol.7
, pp. 663-673
-
-
Francesconi, S.1
Smeets, M.2
Grenon, M.3
Tillit, J.4
Blaisonneau, J.5
-
30
-
-
0024420685
-
Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin
-
Hsiang Y-H, Lihou MG, Liu LF (1989) Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin. Cancer Research 49: 5077-5082.
-
(1989)
Cancer Research
, vol.49
, pp. 5077-5082
-
-
Hsiang, Y.-H.1
Lihou, M.G.2
Liu, L.F.3
-
31
-
-
4444298849
-
DNA damage checkpoint maintenance through sustained Chk1 activity
-
Latif C, Elzen NR, O'Connell MJ (2004) DNA damage checkpoint maintenance through sustained Chk1 activity. J Cell Sci 117: 3489-3498.
-
(2004)
J Cell Sci
, vol.117
, pp. 3489-3498
-
-
Latif, C.1
Elzen, N.R.2
O'Connell, M.J.3
-
32
-
-
0028945424
-
A kinase from fission yeast responsible for blocking mitosis in S phase
-
Murakami H, Okayama H (1995) A kinase from fission yeast responsible for blocking mitosis in S phase. Nature 374: 817-819.
-
(1995)
Nature
, vol.374
, pp. 817-819
-
-
Murakami, H.1
Okayama, H.2
-
33
-
-
0032496322
-
Replication checkpoint enforced by kinases Cds1 and Chk1
-
Boddy MN, Furnari B, Mondesert O, Russell P (1998) Replication checkpoint enforced by kinases Cds1 and Chk1. Science 280: 909-912.
-
(1998)
Science
, vol.280
, pp. 909-912
-
-
Boddy, M.N.1
Furnari, B.2
Mondesert, O.3
Russell, P.4
-
34
-
-
0032004942
-
S-phase-specific activation of Cds1 kinase defines a subpathway of the checkpoint response in Schizosaccharomyces pombe
-
Lindsay HD, Griffiths DJF, Edwards RJ, Christensen PU, Murray JM, et al. (1998) S-phase-specific activation of Cds1 kinase defines a subpathway of the checkpoint response in Schizosaccharomyces pombe. Genes and Development 12: 382-295.
-
(1998)
Genes and Development
, vol.12
, pp. 382-295
-
-
Lindsay, H.D.1
Griffiths, D.J.F.2
Edwards, R.J.3
Christensen, P.U.4
Murray, J.M.5
-
35
-
-
1942486700
-
A novel protein with similarities to Pb binding protein 2 compensates for loss of Chk1 function and affects histone modification in fission yeast
-
Ahmed S, Palermo C, Wan S, Walworth, NC (2004) A novel protein with similarities to Pb binding protein 2 compensates for loss of Chk1 function and affects histone modification in fission yeast. Mol Cell Biol 24: 3660-3669.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 3660-3669
-
-
Ahmed, S.1
Palermo, C.2
Wan, S.3
Walworth, N.C.4
-
36
-
-
0017689151
-
Temperature-sensitive lethal mutants in the structural gene for DNA ligase in the yeast Schizosaccharomyces pombe
-
Nasmyth KA (1977) Temperature-sensitive lethal mutants in the structural gene for DNA ligase in the yeast Schizosaccharomyces pombe. Cell 12: 1109-1120.
-
(1977)
Cell
, vol.12
, pp. 1109-1120
-
-
Nasmyth, K.A.1
-
37
-
-
0032773824
-
The topoisomerase I poison camptothecin generates a Chk1-dependent DNA damage checkpoint signal in fission yeast
-
Wan S, Capasso H, Walworth NC (1999) The topoisomerase I poison camptothecin generates a Chk1-dependent DNA damage checkpoint signal in fission yeast. Yeast 15: 821-828.
-
(1999)
Yeast
, vol.15
, pp. 821-828
-
-
Wan, S.1
Capasso, H.2
Walworth, N.C.3
-
38
-
-
0034312277
-
Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts
-
Guo Z, Kumagai A, Wang SX, Dunphy WC (2000) Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts. Genes Dev 14: 2745-2756.
-
(2000)
Genes Dev
, vol.14
, pp. 2745-2756
-
-
Guo, Z.1
Kumagai, A.2
Wang, S.X.3
Dunphy, W.C.4
-
39
-
-
34247257202
-
The structural determinants of checkpoint activation
-
MacDougall CA, Byun TS, Van C, Yee MC, Cimprich KA (2007) The structural determinants of checkpoint activation. Genes Dev 21: 898-903.
-
(2007)
Genes Dev
, vol.21
, pp. 898-903
-
-
MacDougall, C.A.1
Byun, T.S.2
Van, C.3
Yee, M.C.4
Cimprich, K.A.5
-
40
-
-
0033634679
-
Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts
-
Kumagai A, Dunphy WG (2000) Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts. Molecular Cell 6: 839-849.
-
(2000)
Molecular Cell
, vol.6
, pp. 839-849
-
-
Kumagai, A.1
Dunphy, W.G.2
-
41
-
-
33846636785
-
Chk1 is required for spindle checkpoint function
-
Zachos G, Black EJ, Walker M, Scott MT, Vagnarelli P, et al. (2007) Chk1 is required for spindle checkpoint function. Dev Cell 12: 247-260.
-
(2007)
Dev Cell
, vol.12
, pp. 247-260
-
-
Zachos, G.1
Black, E.J.2
Walker, M.3
Scott, M.T.4
Vagnarelli, P.5
-
42
-
-
0030987176
-
Functional transitions in myosin: Role of highly conserved Gly and Glu residues in the active site
-
Onishi H, Morales MF, Kojima S, Katoh K, Fujiwara K (1997) Functional transitions in myosin: role of highly conserved Gly and Glu residues in the active site. Biochemistry 36: 3767-3772.
-
(1997)
Biochemistry
, vol.36
, pp. 3767-3772
-
-
Onishi, H.1
Morales, M.F.2
Kojima, S.3
Katoh, K.4
Fujiwara, K.5
-
43
-
-
0035449355
-
Cell cycle checkpoint signaling through the ATM and ATR kinases
-
Abraham RT (2001) Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev 15: 2177-2196.
-
(2001)
Genes Dev
, vol.15
, pp. 2177-2196
-
-
Abraham, R.T.1
-
44
-
-
0035253615
-
ATM and ATR: Networking cellular responses to DNA damage
-
Shiloh Y (2001) ATM and ATR: networking cellular responses to DNA damage. Curr Opin Genet Dev 11: 71-77.
-
(2001)
Curr Opin Genet Dev
, vol.11
, pp. 71-77
-
-
Shiloh, Y.1
-
45
-
-
0030740937
-
Isolation and characterization of the Schizosaccharomyces pombe rhp9 gene: A gene required for the DNA damage checkpoint but not the replication checkpoint
-
Willson J, Wilson S, Warr N, Watts FZ (1997) Isolation and characterization of the Schizosaccharomyces pombe rhp9 gene: a gene required for the DNA damage checkpoint but not the replication checkpoint. Nucleic Acids Research 25: 2138-2146.
-
(1997)
Nucleic Acids Research
, vol.25
, pp. 2138-2146
-
-
Willson, J.1
Wilson, S.2
Warr, N.3
Watts, F.Z.4
-
46
-
-
33645516584
-
Site-specific phosphorylation of a checkpoint mediator protein controls its responses to different DNA structures
-
Yoo HY, Jeong SY, Dunphy WG (2006) Site-specific phosphorylation of a checkpoint mediator protein controls its responses to different DNA structures. Genes Dev 20: 772-783.
-
(2006)
Genes Dev
, vol.20
, pp. 772-783
-
-
Yoo, H.Y.1
Jeong, S.Y.2
Dunphy, W.G.3
-
47
-
-
0027174153
-
Two new multi-purpose multicopy Schizosaccharomyces pombe shuttle vectors, pSP1 and pSP2
-
Cottarel G, Beach D, Deuschle U (1993) Two new multi-purpose multicopy Schizosaccharomyces pombe shuttle vectors, pSP1 and pSP2. Current Genetics 23: 547-548.
-
(1993)
Current Genetics
, vol.23
, pp. 547-548
-
-
Cottarel, G.1
Beach, D.2
Deuschle, U.3
-
48
-
-
0027390036
-
Thiamine-repressible expression vectors pREP and pRIP for fission yeast
-
Maundrell K (1993) Thiamine-repressible expression vectors pREP and pRIP for fission yeast. Gene 123: 127-130.
-
(1993)
Gene
, vol.123
, pp. 127-130
-
-
Maundrell, K.1
-
49
-
-
0026025891
-
Molecular genetic analysis of fission yeast Schizosaccharomyces pombe
-
Moreno S, Klar A, Nurse P (1991) Molecular genetic analysis of fission yeast Schizosaccharomyces pombe. Methods in Enzymology 194: 795-823.
-
(1991)
Methods in Enzymology
, vol.194
, pp. 795-823
-
-
Moreno, S.1
Klar, A.2
Nurse, P.3
|