Paradoxical elevation of high-molecular weight adiponectin in acquired extreme insulin resistance due to insulin receptor antibodies

Diabetes

Volumn 56, Issue 6, 2007, Pages 1712-1717

  Semple, Robert K ^a   Halberg, Nils H ^b   Burling, Keith ^a   Soos, Maria A ^a   Schraw, Todd ^b   Luan, Jian'an ^c   Cochran, Elaine K ^d   Dunger, David B ^c   Wareham, Nicholas J ^e   Scherer, Philipp E ^b   Gorden, Phillip ^d   O'Rahilly, Stephen ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^e UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR ANTIBODY; METFORMIN; ROSIGLITAZONE;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; FEMALE; HUMAN; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INSULIN SENSITIVITY; MUTATION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DEFECT; PROTEIN SYNTHESIS; RECEPTOR INTRINSIC ACTIVITY; SCHOOL CHILD;

ADIPONECTIN; ADULT; AUTOANTIBODIES; CHILD; ETHNIC GROUPS; FEMALE; HUMANS; HYPERINSULINISM; INSULIN RESISTANCE; LEPTIN; LONGITUDINAL STUDIES; MIDDLE AGED; MOLECULAR WEIGHT; RECEPTOR, INSULIN; REFERENCE VALUES;

EID: 34249693131     PISSN: 00121797     EISSN: 00121797     Source Type: Journal    
DOI: 10.2337/db06-1665     Document Type: Article

References (24)

1. Scherer PE: Adipose tissue: from lipid storage compartment to endocrine organ. Diabetes 55:1537-1545, 2006
2. Lindsay RS, Funahashi T, Hanson RL, Matsuzawa Y, Tanaka S, Tataranni PA, Knowler WC, Krakoff J: Adiponectin and development of type 2 diabetes in the Pima Indian population. Lancet 360:57-58, 2002
3. Yu JG, Javorschi S, Hevener AL, Kruszynska YT, Norman RA, Sinha M, Olefsky JM: The effect of thiazolidinediones on plasma adiponectin levels in normal, obese, and type 2 diabetic subjects. Diabetes 51:2968-2974, 2002
4. Berg AH, Combs TP, Du X, Brownlee M, Scherer PE: The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat Med 7:947-953, 2001
5. Yamauchi T, Kamon J, Waki H, Terauchi Y, Kubota N, Hara K, Mori Y, Ide T, Murakami K, Tsuboyama-Kasaoka N, Ezaki O, Akanuma Y, Gavrilova O, Vinson C, Reitman ML, Kagechika H, Shudo K, Yoda M, Nakano Y, Tobe K, Nagai R, Kimura S, Tomita M, Froguel P, Kadowaki T: The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med 7:941-946, 2001
6. Shklyaev S, Aslanidi G, Tennant M, Prima V, Kohlbrenner E, Kroutov V, Campbell-Thompson M, Crawford J, Shek EW, Scarpace PJ, Zolotukhin S: Sustained peripheral expression of transgene adiponectin offsets the development of diet-induced obesity in rats. Proc Natl Acad Sci U S A 100:14217-14222, 2003
7. Semple RK, Soos MA, Luan J, Mitchell CS, Wilson JC, Gurnell M, Cochran EK, Gorden P, Chatterjee VK, Wareham NJ, O'Rahilly S: Elevated plasma adiponectin in humans with genetically defective insulin receptors. J Clin Endocrinol Metab 91:3219-3223, 2006
8. Waki H, Yamauchi T, Kamon J, Ito Y, Uchida S, Kita S, Hara K, Hada Y, Vasseur F, Froguel P, Kimura S, Nagai R, Kadowaki T: Impaired multimerization of human adiponectin mutants associated with diabetes: molecular structure and multimer formation of adiponectin. J Biol Chem 278:40352-40363, 2003
9. Arioglu E, Andewelt A, Diabo C, Bell M, Taylor SI, Gorden P: Clinical course of the syndrome of autoantibodies to the insulin receptor (type B insulin resistance): a 28-year perspective. Medicine 81:87-100, 2002
10. Coll AP, Morganstein D, Jayne D, Soos MA, O'Rahilly S, Burke J: Successful treatment of type B insulin resistance in a patient with otherwise quiescent systemic lupus erythematosus. Diabet Med 22:814-815, 2005
11. Wareham NJ, Byrne CD, Williams R, Day NE, Hales CN: Fasting proinsulin concentrations predict the development of type 2 diabetes. Diabetes Care 22:262-270, 1999
12. Schultz CJ, Konopelska-Bahu T, Dalton RN, Carroll TA, Stratton I, Gale EA, Neil A, Dunger DB, Oxford Regional Prospective Study Group: Microalbuminuria prevalence varies with age, sex, and puberty in children with type 1 diabetes followed from diagnosis in a longitudinal study. Diabetes Care 22:495-502, 1999
13. Frystyk J, Tarnow L, Hansen TK, Parving HH, Flyvbjerg A: Increased serum adiponectin levels in type 1 diabetic patients with microvascular complications. Diabetologia 48:1911-1918, 2005
14. Bluher M, Michael MD, Peroni OD, Ueki K, Carter N, Kahn BB, Kahn CR: Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance. Dev Cell 3:25-38, 2002
15. Peake PW, Kriketos AD, Campbell LV, Shen Y, Charlesworth JA: The metabolism of isoforms of human adiponectin: studies in human subjects and in experimental animals. Eur J Endocrinol 153:409-417, 2005
16. Pereira RI, Draznin B: Inhibition of the phosphatidylinositol 3′-kinase signaling pathway leads to decreased insulin-stimulated adiponectin secretion from 3T3-L1 adipocytes. Metabolism 54:1636-1643, 2005
17. Hotta K, Funahashi T, Bodkin NL, Ortmeyer HK, Arita Y, Hansen BC, Matsuzawa Y: Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys. Diabetes 50:1126-1133, 2001
18. Bogan JS, Lodish HF: Two compartments for insulin-stimulated exocytosis in 3T3-L1 adipocytes defined by endogenous ACRP30 and GLUT4. J Cell Biol 146:609-620, 1999
19. Clarke M, Ewart MA, Santy LC, Prekeris R, Gould GW: ACRP30 is secreted from 3T3-L1 adipocytes via a Rab11-dependent pathway. Biochem Biophys Res Commun 342:1361-1367, 2006
20. Merl V, Peters A, Oltmanns KM, Kern W, Born J, Fehm HL, Schultes B: Serum adiponectin concentrations during a 72-hour fast in over- and normal-weight humans. Int J Obes 29:998-1001, 2005
21. Tagami T, Satoh N, Usui T, Yamada K, Shimatsu A, Kuzuya H: Adiponectin in anorexia nervosa and bulimia nervosa. J Clin Endocrinol Metab 89:1833-1837, 2004
22. Soares AF, Guichardant M, Cozzone D, Bernoud-Hubac N, Bouzaidi-Tiali N, Lagarde M, Geloen A: Effects of oxidative stress on adiponectin secretion and lactate production in 3T3-L1 adipocytes. Free Radic Biol Med 38:882-889, 2005
23. Furukawa S, Fujita T, Shimabukuro M, Iwaki M, Yamada Y, Nakajima Y, Nakayama O, Makishima M, Matsuda M, Shimomura I: Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest 114:1752-1761, 2004
24. Park HS, Jin DK, Shin SM, Jang MK, Longo N, Park JW, Bae DS, Bae YS: Impaired generation of reactive oxygen species in leprechaunism through downregulation of Nox4. Diabetes 54:3175-3181, 2005