Serum adiponectin is reduced in acromegaly and normalized after correction of growth hormone excess

Journal of Clinical Endocrinology and Metabolism

Volumn 89, Issue 11, 2004, Pages 5448-5453

  Lam, Karen Siu Ling ^a   Xu, Aimin ^a   Tan, Kathryn Choon Beng ^a   Wong, Lai Ching ^a   Tiu, Sau Cheung ^b   Tam, Sidney ^c  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b QUEEN ELIZABETH HOSPITAL   (Hong Kong)

^c QUEEN MARY HOSPITAL   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; GROWTH HORMONE; INSULIN; MESSENGER RNA; OCTREOTIDE; SOMATOSTATIN;

ACROMEGALY; ADIPOCYTE; ADULT; ARTICLE; BODY MASS; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FIBROBLAST CULTURE; HUMAN; MALE; PRIORITY JOURNAL; TRANSSPHENOIDAL SURGERY;

3T3-L1 CELLS; ACROMEGALY; ADIPONECTIN; ADULT; AGED; ANIMALS; FEMALE; HUMAN GROWTH HORMONE; HUMANS; INSULIN; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MICE; MIDDLE AGED;

EID: 8744234072     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2003-032023     Document Type: Article

References (32)

1. Maeda N, Shimomura I, Kishida K, Nishizawa H, Matsuda M, Nagarentani H, Furuyama N, Kondo H, Takahashi M, Arita Y, Komuro R, Ouchi N, Kihara S, Tochino Y, Okutomi K, Horie M, Takeda S, Aoyama T, Funahashi S, Matsuzawa Y 2002 Diet-induced insulin resistance in mice lacking adiponectin/ACRP30. Nat Med 8:731-737
2. Yamauchi T, Kamon J, Waki H, Imai Y, Shimozawa N, Hioki KM, Uchida S, Ito Y, Takauwa K, Matsui J, Takata M, Eto K, Terauchi Y, Komeda K, Tsunoda M, Murakami K, Ohnishi Y, Naitoh T, Yamamura K, Ueyama Y, Froguel P, Kimura S, Nagai R, Kadowaki T 2003 Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis. J Biol Chem 278:2461-2468
3. Ouchi Y, Kihara S, Arita Y, Okamoto Y, Maeda K, Kuriyama H, Hotta K, Nishida M, Takahashi M, Muraguchi M, Ohmoto Y, Nakamura T, Yamashita S, Funahashi T, Matsuzawa Y 2000 Adiponectin, adipocyte-derived plasma protein, inhibits endothelial NFκB signaling through cAMP-dependent pathway. Circulation 102:1296-1301
4. Stetan N, Vozarova B, Funahashi T, Matsuzawa Y, Weyer C, Lindsay RS, Youngren JF, Havel PJ, Pratley RE, Bogardus C, Tataranni PA 2002 Plasma adiponectin concentration is associated with skeletal muscle insulin receptor tyrosine phosphorylation, and low plasma concentration and low plasma concentration precedes a decrease in whole body insulin sensitivity in humans. Diabetes 51:1884-1888
5. Haffner SM, Miettinen H 1997 Insulin resistance: implications for type II diabetes mellitus and coronary heart disease. Am J Med 103:152-162
6. Matsuzawa Y, Funahashi T, Kihara S, Shimomura I 2004 Adiponectin and metabolic syndrome. Arterioscler Thromb Vasc Biol 24:29-33
7. Xu A, Yin S, Wong LC, Chan KW, Lam KSL 2004 Adiponectin ameliorates dyslipidemia induced by the HIV protease inhibitor ritonavir in mice. Endocrinology 145:487-494
8. Kumada M, Kihara S, Sumitsuji S, Kawamoto T, Matsumoto S, Ouchi N, Arita Y, Okamoto Y, Shimomura I, Hiraoka H, Nakamura T, Matsuzawa Y 2003 Association of hypoadiponectinemia with coronary artery disease in men. Arterioscler Thromb Vasc Biol 23:85-89
9. Zoccali C, Mallamaci F, Tripepi G, Benedetto FAQ, Cutrupi S, Parlongo S, Malatino LS, Monanno G, Seminara G, Rapisarda F, Fatuzzo P, Buemi M, Nicocia G, Tanaka S, Kihara S, Funahashi T, Matsuzawa Y 2002 Adiponectin, metabolic risk factors, and cardiovascular events among patients with end-stage renal disease. J Am Soc Nephrol 13:134-141
10. Orme SM, McNally RJ, Cartwright RA, Belchtz PE 1998 Mortality and cancer incidence in acromegaly: a retrospective cohort study: United Kingdom Acomegaly Study Group. J Clin Endocrinol Metab 83:2730-2734
11. Ho KK, Jenkins AB, Furier SM, Borkman M, Chisholm DJ 1992 Impact of octreotide, a long-acting somatostatin analogue, on glucose tolerance and insulin sensitivity in acromegaly. Clin Endocrinol (Oxf) 36:271-279
12. Tan KCB, Pang RWC, Tiu SC, Lam KSL 2003 Effects of treatment with Sandostatin LAR on small dense LDL and remnant-like lipoproteins in patients with acromegaly. Clin Endocrinol (Oxf) 59:558-565
13. Tan KCB, Tso AWK, Lam KSL 2001 Effect of Sandostatin LAR on serum leptin levels in patients with acromegaly. Clin Endocrinol (Oxf) 54:31-35
14. Yoshida S, Inadera H, Ishikawa Y, Shinomiya M, Shirai K, Saito Y 1991 Endocrine disorders and body fat distribution. Int J Obes 15(Suppl 2):37-40
15. del Rincon JP, Hellmann P, Coschigano KT, Kopchick JJ, Thorner MO, Low circulating adiponectin/Acrp30 levels in a mouse model of acromegaly. Proc of the 85th Annual Meeting of The Endocrine Society, Philadelphia, PA, 2003, p. 1372 (Abstract P2-271)
16. Silha JV, Krsek M, Hanna V, Marek J, Jezkova J, Weiss V, Murphy LJ 2003 Perturbations in adiponectin, leptin and resistin levels in acromegaly: lack of correlation with insulin resistance. Clin Endocrinol (Oxf) 58:736-742
17. Hizuka N, Fukuda I, Ishikawa Y, Itoh E, Murakami Y, Sata A, Tsukada J, Yasumoto K, Okubo Y, Takano K, Serum adiponectin levels in patients with growth hormone deficiency and acromegaly. Proc of the 85th Annual Meeting of The Endocrine Society, Philadelphia, PA, 2003, p. 391 (Abstract P2-350)
18. Xu A, Choi KL, Keshaw H, Xu LY, Lam KSL, Cooper GJ 2003 The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice. J Clin Invest 112:91-100
19. Tan KCB, Xu A, Chow WS, Lam MCW, Ai VHG, Tam SCF, Lam KSL 2004 Hypoadiponectinemia is associated with impaired endothelium dependent vasodilation. J Clin Endocrinol Metab 89:765-769
20. Fasshauer M, Klein J, Neumann S, Eszlinger M, Paschke R 2002 Hormonal regulation of adiponectin gene expression in 3T3-L1 adipocytes. Biochem Biophys Res Commun 290:1084-1089
21. Engstom BE, Burman P, Holdstock C, Karlsson FA 2003 Effects of growth hormone (GH) on ghrelin, leptin and adiponectin in GH-deficient patients. J Clin Endocrinol Metab 88:5193-5198
22. Xu A, Wong LC, Wang Y, Xu JY, Cooper GJS, Lam KSL 2004 Chronic treatment of growth hormone stimulates adiponectin gene expression in 3T3-L1 adipocytes. FEBS Lett 572:129-134
23. Bluher M, Michael MD, Peroi OD, Ueki K, Carter N, Kahn BB, Kahn CR 2002 Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance. Dev Cell 3:25-3S
24. Mohlig M, Wegewitz U, Osterhoff M, Isken F, Ristow M, Pfeiffer AF, Spranger J 2002 Insulin decreases human adiponectin plasma levels. Horm Metab Res 34:655-658
25. Boni-Schnetzler M, Gosteli-Peter MA, Moritz W, Froesch ER, Zapf J 1996 Reduced ob mRNA in hypophysectomised rats is not restored by growth hormone (GH), but further suppressed by exogenously administered insulin-like growth factor (IGF)1. Biochem Biophys Res Commun 225:296-301
26. Yang WS, Lee WJ, Funahashi T, Tanaka S, Matsuzawa Y, Chao CL, Tai TY, Chuang LM 2002 Plasma adiponectin levels in overweight and obese Asians. Obes Res 10:1104-1110
27. Gavrilla A, Chan JA, Yiannakouris N, Kontogian M, Miller LC, Orlova C, Mantzoros CS 2003 Serum adiponectin levels are inversely associated with over all and central fat distribution but are not directly regulated by acute fasting or leptin administration in humans: cross-sectional and interventional studies. J Clin Endocrinol Metab 88:4823-4831
28. Cnop M, Havel PJ, Utzschneider KM, Carr DB, Sinha MK, Boyko EJ, Retzlaff BM, Knoop RH, Brunzell JD, Kahn SE 2003 Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent role of age and sex. Diabetologia 46:459-469
29. O'Sullivan AJ, Kelly JJ, Hoffman D, Freund J, Ho KK 1994 Body composition and energy expenditure in acromegaly. J Clin Endocrinol Metab 78:381-386
30. Hanley AJ, Connelly PW, Harris SB, Zinman B 2003 Adiponectin in a native Canadian population experiencing rapid epidemiological transition. Diabetes Care 26:3219-3225
31. Weiss R, Dufour S, Groszmann A, Petersen K, Dziura J, Taksali SE, Shulman G, Caprio S 2003 Low adiponectin levels in adolescent obesity: a marker of increased intramyocellular lipid accumulation. J Clin Endocrinol Metab 88: 2014-2018
32. Nishizawa H, Shimomura I, Kishida K, Maeda I, Kuriyama H, Nagaretani H, Matsuda M, Kondo S, Furuyama N, Kihar S, Nakamura T, Tochino Y, Funahashi T, Matsuzawa Y 2002 Androgens decrease plasma adiponectin, insulin-sensitizing adipocyte-derived protein. Diabetes 51:2734-2741