Regiospecific and highly flexible synthesis of 1,4,5-trisubstituted 2-sulfanylimidazoles from structurally diverse ethanone precursors

Synthesis

Volumn , Issue 2, 2008, Pages 253-266

  Laufer, Stefan A ^a   Hauser, Dominik R J ^a   Liedtke, Andy J ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Heterocycles; Medicinal chemistry; Nucleophilic aromatic substitutions; p38 MAP kinase inhibitors; Regioselectivity; Ring closure

Indexed keywords

HETEROCYCLES; MEDICINAL CHEMISTRY; NUCLEOPHILIC AROMATIC SUBSTITUTIONS; RING CLOSURE;

DATABASE SYSTEMS; PROTEINS; REGIOSELECTIVITY; SYNTHESIS (CHEMICAL);

AROMATIC COMPOUNDS;

1 (4 FLUOROPHENYL) 2 (2 FLUORO 4 PYRIDYL) 2 [(2 METHOXYETHYL)ETHANONE; 1 (4 FLUOROPHENYL) 2 (2 FLUORO 4 PYRIDYL)ETHANE 1,2 DIONE 1 OXIME; 1 (4 FLUOROPHENYL) 2 (METHYLAMINO)ETHANONE; 2 (2 FLUORO 4 PYRIDYL) 2 (2 METHOXYETHYLAMINO) 1 [3 (TRIFLUOROMETHYL)PHENYL]ETHANONE; 2 (4 FLUOROPHENYL) 1 (2 FLUORO 4 PYRIDYL)ETHANONE; 2 [4 [4 (4 FLUOROPHENYL) 1 (2 METHOXYETHYL) 2 (METHYLSULFANYL) 1H IMIDAZOL 5 YL] 2 PYRIDYLAMINO]PROPAN 1 OL; 2 BROMO 2 (2 FLUORO 4 PYRIDYL) 1 [3 (TRIFLUOROMETHYL)PHENYL]ETHANONE; 2 FLUORO 4 [4 (4 FLUOROPHENYL) 1 (2 METHOXYETHYL) 2 (METHYLSULFANYL) 1H IMIDAZOL 5 YL]PYRIDINE; 2 FLUORO 4 [4 (4 FLUOROPHENYL) 1 (2 METHOXYETHYL) 3 OXIDO 1H IMIDAZOL 5 YL]PYRIDINE; 2 FLUORO 4 [4 (4 FLUOROPHENYL) 1 METHYL 2 (METHYLSULFANYL) 1H IMIDAZOL 5 YL]PYRIDINE; 2 SULFANYLIMIDAZOLE DERIVATIVE; 3 [4 (4 FLUOROPHENYL) 5 (2 FLUORO 4 PYRIDYL) 1 (2 METHOXYETHYL) 1H IMIDAZOL 2 YLSULFANYL]PROPANE 1,2 DIOL; 4 (4 FLUOROPHENYL) 1 METHYL 1,3 DIHYDRO 2H IMIDAZOLE 2 THIONE; 4 (4 FLUOROPHENYL) 1 METHYL 2 (METHYLSULFANYL) 1H IMIDAZOLE; 4 (4 FLUOROPHENYL) 1 METHYL 2 (METHYLSULFANYL) 5 (3 TOLYL) 1H IMIDAZOLE; 4 (4 FLUOROPHENYL) 5 (2 FLUORO 4 PYRIDYL) 1 (2 METHOXYETHYL) 1,3 DIHYDRO 2H IMIDAZOLE 2 THIONE; 4 [2(BENZYLSULFANYL) 4 (4 FLUOROPHENYL) 1 (2 METHOXYETHYL) 1H IMIDAZOL 5 YL] 2 FLUOROPYRIDINE; 4 [4 (4 FLUOROPHENYL) 2 (METHYLSULFANYL) 1H IMIDAZOL 5 YL] 2 (PHENYLSULFANYL)PYRIDINE; 4 [4 (4 FLUOROPHENYL) 2 (METHYLSULFANYL) 1H IMIDAZOL 5 YL] 2 (THIENYLMETHOXY)PYRIDINE; 4 [4 [4 (4 FLUOROPHENYL) 1 (2 METHOXYETHYL) 2 (METHYLSULFANYL) 1H IMIDAZOL 5 YL] 2 PYRIDYLAMINO]CYCLOHEXANOL; 5 BROMO 4 (4 FLUOROPHENYL) 1 METHYL 2 (METHYLSULFANYL) 1H IMIDAZOLE; [4 [4 (4 FLUOROPHENYL) 1 (2 METHOXYETHYL) 2 (METHYLSULFANYL) 1H IMIDAZOL 5 YL] 2 PYRIDYL]PHENYLAMINE; [4 [4 (4 FLUOROPHENYL) 1 METHYL 2 (METHYLSULFANYL) 1H IMIDAZOL 5 YL] 2 PYRIDYL][1 PHENYLETHYL]AMINE; [4 [4 (4 FLUOROPHENYL) 2 (METHYLSULFANYL) 1H IMIDAZOL 5 YL] 2 PYRIDYL](TETRAHYDRO 2H PYRAN 4 YL)AMINE; ETHANONE; IMIDAZOLE DERIVATIVE; KETONE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; BROMINATION; CHEMICAL STRUCTURE; DRUG SYNTHESIS; FLUORINATION; SUBSTITUTION REACTION; SUZUKI REACTION;

EID: 38849171708     PISSN: 00397881     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-1000852     Document Type: Article

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