Ones, thiones, and N-oxides: An eercise in imidazole chemistry

Angewandte Chemie - International Edition

Volumn 41, Issue 13, 2002, Pages 2290-2293

  Laufer, Stefan ^a   Wagner, Gerd ^a   Kotschenreuther, Dunja ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Drug design; Inhibitors; Medicinal chemistry; Nitrogen heterocycles; Synthetic methods

Indexed keywords

DRUG PRODUCTS; ENZYME INHIBITION; NITROGEN COMPOUNDS;

ANTI INFLAMMATORY DRUGS;

NITROGEN OXIDES;

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTIINFLAMMATORY AGENT; CYTOCHROME P 450 ENZYME SYSTEM; CYTOCHROME P450; ENZYME INHIBITOR; IMIDAZOLE; IMIDAZOLE DERIVATIVE; ISOPROTEIN; KETONE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASES; MITOGEN-ACTIVATED PROTEIN KINASE P38; ML 3163; OXIDE;

ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ACTIVITY; DRUG EFFICACY; DRUG INHIBITION; DRUG SYNTHESIS; IC 50; METHODOLOGY; SYNTHESIS; DRUG ANTAGONISM;

CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INHIBITORS; IMIDAZOLES; INHIBITORY CONCENTRATION 50; MITOGEN-ACTIVATED PROTEIN KINASES; MOLECULAR STRUCTURE; PROTEIN ISOFORMS; SUPPORT, NON-U.S. GOV'T; P38 MITOGEN-ACTIVATED PROTEIN KINASES;

EID: 0037007829     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-3773(20020703)41:13<2290::AID-ANIE2290>3.0.CO;2-R     Document Type: Article

References (22)