IFN-γ mediates crescent formation and cell-mediated immune injury in murine glomerulonephritis

Journal of the American Society of Nephrology

Volumn 10, Issue 4, 1999, Pages 752-759

  Kitching, A Richard ^a   Holdsworth, Stephen R ^a   Tipping, Peter G ^a  

^a MONASH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

FIBRIN; GAMMA INTERFERON; IMMUNOGLOBULIN G2A; INTERLEUKIN 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DELAYED HYPERSENSITIVITY; DISEASE SEVERITY; HELPER CELL; IMMUNE MEDIATED INJURY; KIDNEY FUNCTION; KIDNEY INJURY; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN URINE LEVEL; RAPIDLY PROGRESSIVE GLOMERULONEPHRITIS; REGULATORY MECHANISM; URINARY EXCRETION;

EID: 0032984190     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: 10.1681/asn.v104752     Document Type: Article

References (38)

1. Rosen N, Tornroth T, Bernard DB: Membranous glomerulonephritis. In: Renal Pathology, 2nd Ed., edited by Tisher CC, Brenner BM, Philadelphia, Lippincott, 1994, pp 258-293
2. Neale TJ, Tipping PG, Carson SD, Holdsworth SR: Participation of cell-mediated immunity in deposition of fibrin in glomerulonephritis. Lancet 2: 421-424, 1988
3. Cher DJ, Mosmann TR: Two types of murine helper T cell clone. II. Delayed-type hypersensitivity is mediated by TH1 clones. J Immunol 138: 3688-3694, 1987
4. Huang XR, Tipping PG, Shuo L, Holdsworth SR: Th1 responsiveness to nephritogenic antigens determines susceptibility to crescentic glomerulonephritis in mice. Kidney Int 51: 94-103, 1997
5. Kalluri R, Danoff TM, Okada H, Neilson EG: Susceptibility to anti-glomerular basement membrane disease and Goodpasture syndrome is linked to MHC class II genes and the emergence of T cell-mediated immunity in mice. J Clin Invest 100: 2263-2275, 1997
6. Li S, Holdsworth SR, Tipping PG: Antibody independent crescentic glomerulonephritis in μ chain deficient mice. Kidney Int 51: 672-678, 1997
7. Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL: Two types of murine helper T cell clones. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 136: 2348-2357, 1986
8. Dalton DK, Pitts-Meek S, Keshav S, Figari IS, Bradley A, Stewart TA: Multiple defects of immune cell function in mice with disrupted interferon-γ genes. Science 259: 1739-1742, 1993
9. Huang S, Hendriks W, Althage A, Hemmi S, Bluethmann H, Kamijo R, Vilcek J, Zinkernagel RM, Aguet M: Immune response in mice that lack the interferon-γ receptor. Science 259: 1742-1745, 1993
10. Gudmundsson G, Hunninghake GW: Interferon-γ is necessary for the expression of hypersensitivity pneumonitis. J Clin Invest 99: 2386-2390, 1997
11. Duong TT, Finkelman FD, Singh B, Strejan GH: Effect of anti-interferon-γ monoclonal antibody treatment on the development of experimental allergic encephalomyelitis in resistant mouse strains. J Neuroimmunol 53: 101-107, 1994
12. Ferber IA, Brocke S, Taylor-Edwards C, Ridgway W, Dinisco C, Steinman, Dalton D, Fathman CG: Mice with a disrupted IFN-γ gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE). J Immunol 156: 5-7, 1996
13. Ogarra A, Steinman L, Gijbels K: CD4(+) T-cell subsets in autoimmunity. Curr Opin Immunol 9: 872-883, 1997
14. Saleem S, Konieczny BT, Lowry RP, Baddoura FK, Lakkis FG: Acute rejection of vascularized heart allografts in the absence of IFNγ. Transplantation 62: 1908-1911, 1996
15. Raisanen-Sokolowski A, Mottram PL, Glysing-Jensen T, Satoskar A, Russell ME: Heart transplants in interferon-γ, interleukin 4, and interleukin 10 knockout mice: Recipient environment alters graft rejection. J Clin Invest 100: 2449-2456, 1997
16. Huang XR, Holdsworth SR, Tipping PG: Evidence for delayed type hypersensitivity mechanisms in glomerular crescent formation. Kidney Int 46: 69-78, 1994
17. Tipping PG, Huang XR, Berndt MC, Holdsworth SR: P-selectin directs T lymphocyte-mediated injury in delayed-type hypersensitivity responses: Studies in glomerulonephritis and cutaneous delayed-type hypersensitivity. Eur J Immunol 26: 454-460, 1996
18. Dialynas DP, Quan ZS, Wall KA, Pierres A, Quintans J, Loken MR, Pierres M, Fitch FW: Characterisation of the murine T cell surface molecule, designated L3T4, identified by monoclonal antibody GK1.5: Similarity of L3T4 to the human Leu-3/T4 molecule. J Immunol 131: 2445-2451, 1983
19. Tipping PG, Kitching AR, Huang XR, Mutch DA, Holdsworth SR: Immune modulation with interleukin-4 and interleukin-10 prevents crescent formation and glomerular injury in experimental glomerulonephritis. Eur J Immunol 27: 530-537, 1997
20. Snapper CM, Paul WE: Interferon-γ and B cell stimulatory factor-1 reciprocally regulate Ig isotype production. Science 236: 944-947, 1987
21. Fong TA, Mosmann TR: The role of IFN-γ in delayed-type hypersensitivity mediated by Th1 clones. J Immunol 143: 2887-2893, 1989
22. Swihart K, Fruth U, Messmer N, Hug K, Behin R, Huang S, Del Giudice G, Aguet M, Louis JA: Mice from a genetically resistant background lacking the Interferon-γ receptor are susceptible to infection with Leishmania major but mount a polarized T helper cell 1-type CD4+ T cell response. J Exp Med 181: 961-971, 1995
23. Weiser WY, Van NA, Clark SC, David JR, Remold HG: Recombinant human granulocyte/macrophage colony-stimulating factor activates intracellular killing of Leishmania donovani by human monocyte-derived macrophages. J Exp Med 166: 1436-1446, 1987
24. Onodera S, Suzuki K, Matsuno T, Kaneda K, Takagi M, Nishihira J: Macrophage migration inhibitory factor induces phagocytosis of foreign particles by macrophages in autocrine and paracrine fashion. Immunology 92: 131-137, 1997
25. Wu J, Cunha FQ, Liew FY, Weiser WY: IL-10 inhibits the synthesis of migration inhibitory factor and migration inhibitory factor-mediated macrophage activation. J Immunol 151: 4325-4332, 1993
26. Huang XR, Holdsworth SR, Tipping PG: Th2 responses induce humorally mediated injury in experimental anti-glomerular basement membrane glomerulonephritis. J Am Soc Nephrol 8: 1101-1108, 1997
27. Kitching AR, Tipping PG, Holdsworth SR: Interleukin-4 is not a crucial mediator of renal injury in Th2 prone mice with glomerulonephritis [Abstract]. Nephrology 4: A4, 1998
28. Goes N, Sims T, Urmson J, Vincent D, Ramassar V, Halloran PF: Disturbed MHC regulation in the IFN-γ knockout mouse: Evidence for three states of MHC expression with distinct roles for IFN-γ. J Immunol 155: 4559-4566, 1995
29. Li S, Kurts C, Kontgen F, Holdsworth, SR, Tipping, PG: MHC class II expression by intrinsic renal cells is required for crescentic glomerulonephritis. J Exp Med 188: 597-602, 1998
30. Tipping PG, Huang XR, Qi M, Van GY, Tang WW: Crescentic glomerulonephritis in CD4 and CD8 deficient mice: Requirement for CD4 but not CD8 cells. Am J Pathol 152: 1541-1548, 1998
31. Huang XR, Tipping PG, Apostolopoulos J, Oettinger C, D'Souza M, Milton G, Holdsworth SR: Mechanisms of T cell-induced glomerular injury in anti-glomerular basement membrane (GBM) glomerulonephritis in rats. Clin Exp Immunol 109: 134-142, 1997
32. Grandaliano G, Valente AJ, Rozek MM, Abboud HE: Gamma interferon stimulates monocyte chemotactic protein (MCP-1) in human mesangial cells. J Lab Clin Med 123: 282-289, 1994
33. Kakizaki Y, Kraft N, Atkins RC: Interferon-γ stimulates the secretion of IL-1, but not of IL-6, by glomerular mesangial cells. Clin Exp Immunol 91: 521-525, 1993
34. Haas C, Ryffel B, Le Hir M: Crescentic glomerulonephritis in interferon-γ receptor deficient mice. J Inflamm 47: 206-213, 1996
35. Haas C, Ryffel B, Le Hir M: IFN-γ is essential for the development of autoimmune glomerulonephritis in MRL/lpr mice. J Immunol 158: 5484-5491, 1997
36. Balomenos D, Rumold R, Theofilopoulos AN: Interferon-γ is required for lupus-like disease and lymphoaccumulation in MRL-lpr mice. J Clin Invest 101: 364-371, 1998
37. Machold KP, Smolen JS: Interferon-γ induced exacerbation of systemic lupus erythematosus. J Rheumatol 17: 831-832, 1990
38. Graninger WB, Hassfeld W, Pesau BB, Machold KP, Zielinski CC, Smolen JS: Induction of systemic lupus erythematosus by interferon-γ in a patient with rheumatoid arthritis. J Rheumatol 18: 1621-1622, 1991