IL-12 deficiency in MRL-Faslpr mice delays nephritis and intrarenal IFN-γ expression, and diminishes systemic pathology

Journal of Immunology

Volumn 170, Issue 7, 2003, Pages 3915-3925

  Kikawada, Eriya ^a   Lenda, Deborah M ^a   Kelley, Vicki ^a,b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD INSTITUTES OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; CD4 ANTIGEN; CD8 ANTIGEN; FAS ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 18;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE DISEASE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; HISTOPATHOLOGY; HYPOTHESIS; LACRIMAL GLAND; LUNG; LUPUS ERYTHEMATOSUS NEPHRITIS; LYMPHADENOPATHY; MACROPHAGE; MOUSE; MOUSE STRAIN; NEPHRITIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SALIVARY GLAND; SKIN; T LYMPHOCYTE; WILD TYPE;

EID: 0037378016     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.170.7.3915     Document Type: Article

References (67)

1. Theofilopoulos, A. N., and F. J. Dixon. 1981. Etiopathogenesis of murine SLE. Immunol. Rev. 55:179.
2. Kelley, V. E., and J. B. Roths. 1985. Interaction of mutant lpr gene with background strain influences renal disease. Clin. Immunol. Immunopathol. 37:220.
3. Moyer, C. F., J. D. Strandberg, and C. L. Reinisch. 1987. Systemic mononuclear-cell vasculitis in MRL/Mp-lpr/lpr mice: a histologic and immunocytochemical analysis. Am. J. Pathol. 127:229.
4. lpr mice. Kidney Int. 53:1631.
5. lpr mice. J. Immunol. 163:6884.
6. lpr mice. J. Exp. Med. 190:1813.
7. Wada, T., T. Naito, R. C. Griffiths, T. M. Coffman, and V. R. Kelley. 1997. Systemic autoimmune nephritogenic components induce CSF-1 and TNF-α in MRL kidneys. Kidney Int. 52:934.
8. lpr mice. J. Immunol. 161:494.
9. Haas, C., B. Ryffel, and M. Le Hir. 1997. IFN-γ is essential for the development of autoimmune glomerulonephritis in MRL/lpr mice. J. Immunol. 158:5484.
10. Diaz Gallo, C., A. M. Jevnikar, D. C. Brennan, S. Florquin, A. Pacheco-Silva, and V. R. Kelley. 1992. Autoreactive kidney-infiltrating T-cell clones in murine lupus nephritis. Kidney Int. 42:851.
11. Manolios, N., L. Schrieber, M. Nelson, and C. L. Geczy. 1989. Enhanced interferon-γ (IFN) production by lymph node cells from autoimmune (MRL/l. MRL/n) mice. Clin. Exp. Immunol. 76:301.
12. Timoshanko, J. R., S. R. Holdsworth, A. R. Kitching, and P. G. Tipping. 2002. IFN-γ production by intrinsic renal cells and bone marrow-derived cells is required for full expression of crescentic glomerulonephritis in mice. J. Immunol. 168:4135.
13. + T cells through IL-12 produced by Listeria-induced macrophages. Science 260:547.
14. D'Andrea, A., M. Rengaraju, N. M. Valiante, J. Chehimi, M. Kubin, M. Aste, S. H. Chan, M. Kobayashi, D. Young, E. Nickbarg, et al. 1992. Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells. J. Exp. Med. 176:1387.
15. Trinchieri, G. 1993. Interleukin-12 and its role in the generation of TH1 cells. Immunol. Today 14:335.
16. Gately, M. K., B. B. Desai, A. G. Wolitzky, P. M. Quinn, C. M. Dwyer, F. J. Podlaski, P. C. Familletti, F. Sinigaglia, R. Chizonnite, U. Gubler, et al. 1991. Regulation of human lymphocyte proliferation by a heterodimeric cytokine. IL-12 (cytotoxic lymphocyte maturation factor). J. Immunol. 147:874.
17. + T lymphocytes, and NK cells. J. Immunol. 149:3495.
18. Chan, S. H., B. Perussia, J. W. Gupta, M. Kobayashi, M. Pospisil, H. A. Young, S. F. Wolf, D. Young, S. C. Clark, and G. Trinchieri. 1991. Induction of interferon γ production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers. J. Exp. Med. 173:869.
19. Takahashi, S., L. Fossati, M. Iwamoto. R. Merino, R. Motta, T. Kobayakawa, and S. Izui. 1996. Imbalance towards Th1 predominance is associated with acceleration of lupus-like autoimmune syndrome in MRL mice. J. Clin. Invest. 97:1597.
20. Mustafa, W., J. Zhu, G. Deng, A. Diab, H. Link, L. Frithiof, and B. Klinge. 1998. Augmented levels of macrophage and Th1 cell-related cytokine mRNA in submandibular glands of MRL/lpr mice with autoimmune sialoadenitis. Clin. Exp. Immunol. 112:389.
21. + T cells to enhance priming for interferon γ production and diminishes interleukin 4 inhibition of such priming. Proc. Natl. Acad. Sci. USA 90:10188.
22. Huang, F. P., G. J. Feng, G. Lindop, D. I. Stott, and F. Y. Liew. 1996. The role of interleukin 12 and nitric oxide in the development of spontaneous autoimmune disease in MRL?MP-lpr?lpr mice. J. Exp. Med. 183:1447.
23. Kobayashi, M., L. Fitz, M. Ryan, R. M. Hewick, S. C. Clark, S. Chan, R. Loudon, F. Sherman, B. Perussia, and G. Trinchieri. 1989. Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes. J. Exp. Med. 170:827.
24. Stern, A. S., F. J. Podlaski, J. D. Hulmes, Y. C. Pan, P. M. Quinn, A. G. Wolitzky, P. C. Familletti, D. L. Stremlo, T. Truitt, R. Chizzonite, et al. 1990. Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells. Proc. Natl. Acad. Sci. USA 87:6808.
25. Schoenhaut, D. S., A. O. Chua, A. G. Wolitzky, P. M. Quinn, C. M Dwyer, W. McComas, P. C. Familletti, M. K. Gately, and U. Gubler. 1992. Cloning and expression of murine IL-12. J. Immunol. 148:3433.
26. Wolf, S. F., P. A. Temple, M. Kobayashi, D. Young, M. Dicig, L. Lowe, R. Dzialo, L. Fitz, C. Ferenz, R. M. Hewick, et al. 1991. Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells. J. Immunol. 146:3074.
27. Gubler, U., A. O. Chua, D. S. Schoenhaut, C. M. Dwyer, W. McComas, R. Motyka, N. Nabavi, A. G. Wolitzky, P. M. Quinn, P. C. Familletti, et al. 1991. Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor. Proc. Natl. Acad. Sci. USA 88:4143.
28. Magram, J., S. E. Connaughton, R. R. Warrier, D. M. Carvajal, C. Y. Wu, J. Ferrante, C. Stewart, U. Sarmiento, D. A. Faherty, and M. K. Gately. 1996. IL-12-deficient mice are defective in IFN γ production and type 1 cytokine responses. Immunity 4:471.
29. -/- setting. Immunity 16:429.
30. Moore, K. J., T. Naito, C. Martin, and V. R. Kelley. 1996. Enhanced response of macrophages to CSF-1 in autoimmune mice: a gene transfer strategy. J. Immunol. 157:433.
31. lpr autoimmune interstitial nephritis: a negative regulatory pathway. J. Immunol. 160:4074.
32. O'Connor, K. C., K. Nguyen, and B. D. Stollar. 2001. Recognition of DNA by VH and Fv domains of an IgG anti-poly(dC) antibody with a singly mutated VH domain. J. Mol. Recognit. 14:18.
33. + T cells to lymphoproliferation and autoantibody production in MRL-lpr/lpr mice. J. Exp. Med. 167:1713.
34. Sobel, E. S., T. Katagiri, K. Katagiri, S. C. Morris, P. L. Cohen, and R. A. Eisenberg. 1991. An intrinsic B cell defect is required for the production of autoantibodies in the lpr model of murine systemic autoimmunity. J. Exp. Med. 173:1441.
35. 1 and MRL/MpJ-lpr/lpr mice. J. Immunol. 151:6509.
36. Andrews, B. S., R. A. Eisenberg, A. N. Theofilopoulos, S. Izui, C. B. Wilson, P. J. McConahey, E. D. Murphy, J. B. Roths, and F. J. Dixon. 1978. Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains. J. Exp. Med. 148:1198.
37. Hoffman, R. W., M. A. Alspaugh, K. S. Waggie, J. B. Durham, and S. E. Walker. 1984. Sjogren's syndrome in MRL/l and MRL/n mice. Arthritis Rheum. 27:157.
38. Lawson, B. R., G. J. Prud'homme, Y. Chang, H. A. Gardner, J. Kuan, D. H. Kono, and A. N. Theofilopoulos. 2000. Treatment of murine lupus with cDNA encoding IFN-γR/Fc. J. Clin. Invest. 106:207.
39. Yoshimoto, T., K. Takeda, T. Tanaka, K. Ohkusu, S. Kashiwamura, H. Okamura, S. Akira, and K. Nakanishi. 1998. IL-12 up-regulates IL-18 receptor expression on T cells. Th1 cells, and B cells: synergism with IL-18 for IFN-γ production. J. Immunol. 161:3400.
40. Naito, T., H. Yokoyama, K. J. Moore, G. Dranoff, R. C. Mulligan, and V. R. Kelley. 1996. Macrophage growth factors introduced into the kidney initiate renal injury. Mol. Med. 2:297.
41. Peng, S. L., J. Moslehi, and J. Craft. 1997. Roles of interferon-γ and interleukin-4 in murine lupus. J. Clin. Invest. 99:1936.
42. Moore, K. J., K. Yeh, T. Naito, and V. R. Kelley. 1996. TNF-α enhances colony-stimulating factor-1-induced macrophage accumulation in autoimmune renal disease. J. Immunol. 157:427.
43. lpr mice: an example of disease regulation at the organ level. J. Immunol. 167:2985.
44. Bos, J. D. 1997. The skin as an organ of immunity. Clin. Exp. Immunol. 107(Suppl. 1):3.
45. Laissue, J. A., B. B. Chappuis, C. Muller, J. C. Reubi, and J. O. Gebbers. 1993. The intestinal immune system and its relation to disease. Dig. Dis. 11:298.
46. Semenzato, G., M. Bortolin, M. Facco, C. Tassinari, R. Sancetta, and C. Agostini. 1996. Lung lymphocytes: origin, biological functions, and laboratory techniques for their study in immune-mediated pulmonary disorders. Crit. Rev. Clin. Lab. Sci. 33:423.
47. Huaux, F., M. Arras, D. Tomasi, V. Barbarin, M. Delos, J. P. Coutelier, A. Vink, S. H. Phan, J. C. Renauld, and D. Lison. 2002. A profibrotic function of IL-12p40 in experimental pulmonary fibrosis. J. Immunol. 169:2653.
48. Walter, M. J., N. Kajiwara, P. Karanja, M. Castro, and M. J. Holtzman. 2001. Interleukin 12 p40 production by barrier epithelial cells during airway inflammation. J. Exp. Med. 193:339.
49. Aragane, Y., H. Riemann, R. S. Bhardwaj, A. Schwarz, Y. Sawada, H. Yamada, T. A. Luger, M. Kubin, G. Trinchieri, and T. Schwarz. 1994. IL-12 is expressed and released by human keratinocytes and epidermoid carcinoma cell lines. J. Immunol. 153:5366.
50. Kondo, S., and K. Jimbow. 1998. Dose-dependent induction of IL-12 but not IL-10 from human keratinocytes after exposure to ultraviolet light A. J. Cell. Physiol. 177:493.
51. Mikloska, Z., A. M. Kesson, M. E. Penfold, and A. L. Cunningham. 1996. Herpes simplex virus protein targets for CD4 and CD8 lymphocyte cytotoxicity in cultured epidermal keratinocytes treated with interferon-γ. J. Infect. Dis. 173:7.
52. Neurath, M. F., I. Fuss, B. L. Kelsall, E. Stuber, and W. Strober. 1995. Antibodies to interleukin 12 abrogate established experimental colitis in mice. J. Exp. Med. 182:1281.
53. Balomenos, D., R. Rumold, and A. N. Theofilopoulos. 1998. Interferon-γ is required for lupus-like disease and lymphoaccumulation in MRL-lpr mice. J. Clin. Invest. 101:364.
54. lpr mice with renal injury. Kidney Int. 51:79.
55. Okamura, H., H. Tsutsi, T. Komatsu, M. Yutsudo, A. Hakura, T. Tanimoto, K. Torigoe, T. Okura, Y. Nukada, K. Hattori, et al. 1995. Cloning of a new cytokine that induces IFN-γ production by T cells. Nature 378:88.
56. lpr mice with autoimmune lupus nephritis. Arthritis Rheum. 46:3083.
57. Esfandiari, E., I. B. McInnes G. Lindop, F. P. Huang, M. Field, M. Komai-Koma, X. Wei, and F. Y. Liew. 2001. A proinflammatory role of IL-18 in the development of spontaneous autoimmune disease. J. Immunol. 167:5338.
58. Robinson, D., K. Shibuya, A. Mui, F. Zonin, E. Murphy, T. Sana, S. B. Hartley, S. Menon, R. Kastelein, F. Bazan, et al. 1997. IGIF does not drive Th1 development but synergizes with IL-12 for interferon-3, production and activates 1RAK and NFκB. Immunity 7:571.
59. Kohno, K., J. Kataoka, T. Ohtsuki, Y. Suemoto, I. Okamoto, M. M. Ikeda, and M. Kurimoto. 1997. IFN-γ-inducing factor (IGIF) is a costimulatory factor on the activation of Th1 but not Th2 cells and exerts its effect independently of IL-12. J. Immunol. 158:1541.
60. Nakamura, S., T. Otani, Y. Ijiri, R. Motoda, M. Kurimoto, and K. Orita. 2000. IFN-γ-dependent and -independent mechanisms in adverse effects caused by concomitant administration of IL-18 and IL-12. J. Immunol. 164:3330.
61. Takeda, K., H. Tsutsui, T. Yoshimoto, O. Adachi, N. Yoshida, T. Kishimoto, H. Okamura, K. Nakanishi, and S. Akira. 1998. Defective NK cell activity and Th1 response in IL-18-deficient mice. Immunity 8:383.
62. lpr/lpr mice are hyperresponsive to IL-18 and overexpress the IL-18 receptor accessory chain. J. Immunol. 166:3757.
63. Carvalho-Pinto, C. E., M. I. Garcia, M. Mellado, J. M. Rodriguez-Frade, J. Martin-Caballero, J. Flores, A. C. Martinez, and D. Balomenos. 2002. Autocrine production of IFN-γ by macrophages controls their recruitment to kidney and the development of glomerulonephritis in MRL/lpr mice. J. Immunol. 169:1058.
64. Ring, G. H., Z. Dai, S. Saleem, F. K. Baddoura, and F. G. Lakkis. 1999. Increased susceptibility to immunologically mediated glomerulonephritis in IFN-γ-deficient mice. J. Immunol. 163:2243.
65. Diaz-Gallo, C., and V. R. Kelley. 1993. Self-regulation of autoreactive kidney-infiltrating T cells in MRL-lpr nephritis. Kidney Int. 44:692.
66. Nakajima, A., S. Hirose, H. Yagita, and K. Okumura. 1997. Roles of IL-4 and IL-12 in the development of lupus in NZB/W F1 mice. J. Immunol. 158:1466.
67. lpreg mice. Cell Immunol. 210:77.