-
1
-
-
13644254794
-
Molecular mechanisms of drug resistance
-
Longley DB, Johnston PG. Molecular mechanisms of drug resistance. J Pathol 2005; 205: 275-292.
-
(2005)
J Pathol
, vol.205
, pp. 275-292
-
-
Longley, D.B.1
Johnston, P.G.2
-
2
-
-
0036083301
-
Mechanism of action of antitumor drugs that interact with microtubules and tubulin
-
Jordan MA. Mechanism of action of antitumor drugs that interact with microtubules and tubulin. Curr Med Chem Anti-Canc Agents 2002; 2: 1-17.
-
(2002)
Curr Med Chem Anti-Canc Agents
, vol.2
, pp. 1-17
-
-
Jordan, M.A.1
-
3
-
-
1942438028
-
Microtubules as a target for anticancer drugs
-
Jordan MA, Wilson L. Microtubules as a target for anticancer drugs. Nat Rev Cancer 2004; 4: 253-265.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 253-265
-
-
Jordan, M.A.1
Wilson, L.2
-
4
-
-
33746471989
-
Novel agents that target tublin and related elements
-
Rowinsky EK, Calvo E. Novel agents that target tublin and related elements. Semin Oncol 2006; 33: 421-435.
-
(2006)
Semin Oncol
, vol.33
, pp. 421-435
-
-
Rowinsky, E.K.1
Calvo, E.2
-
5
-
-
0042132423
-
Expression of a multidrug-resistance gene in human tumors and tissues
-
Fojo AT, Ueda K, Slamon DJ et al. Expression of a multidrug-resistance gene in human tumors and tissues. Proc Natl Acad Sci U S A 1987; 84: 265-269.
-
(1987)
Proc Natl Acad Sci U S A
, vol.84
, pp. 265-269
-
-
Fojo, A.T.1
Ueda, K.2
Slamon, D.J.3
-
6
-
-
54449094792
-
-
54th edition. Montvale, NJ: Medical Economics Co
-
Phsyician's Desk Reference, 54th edition. Montvale, NJ: Medical Economics Co 2001; 748-753: 1059-1067.
-
(2001)
Reference
, vol.748-753
, pp. 1059-1067
-
-
Phsyician's Desk1
-
7
-
-
0032495513
-
Structure of the alpha beta tubulin dimer by electron crystallography
-
Nogales E, Wolf SG, Downing KH. Structure of the alpha beta tubulin dimer by electron crystallography. Nature 1998; 391: 199-203.
-
(1998)
Nature
, vol.391
, pp. 199-203
-
-
Nogales, E.1
Wolf, S.G.2
Downing, K.H.3
-
8
-
-
0142040355
-
Direct analysis of tubulin expression in cancer cell lines by electrospray ionization mass spectrometry
-
Verdier-Pinard P, Wang F, Burd B et al. Direct analysis of tubulin expression in cancer cell lines by electrospray ionization mass spectrometry. Biochemistry 2003; 42: 12019-12027.
-
(2003)
Biochemistry
, vol.42
, pp. 12019-12027
-
-
Verdier-Pinard, P.1
Wang, F.2
Burd, B.3
-
9
-
-
0030709242
-
Multiple forms of tubulin: Different gene products and covalent modifications
-
Luduena RF. Multiple forms of tubulin: Different gene products and covalent modifications. Int Rev Cytol 1998; 178: 207-275.
-
(1998)
Int Rev Cytol
, vol.178
, pp. 207-275
-
-
Luduena, R.F.1
-
10
-
-
0037928490
-
Drug resistance associated with loss of p53 involves extensive alterations in microtubule composition and dynamics
-
Galmarini CM, Kamath K, Vanier-Viornery A et al. Drug resistance associated with loss of p53 involves extensive alterations in microtubule composition and dynamics. Br J Cancer 2003; 88: 1793-1799.
-
(2003)
Br J Cancer
, vol.88
, pp. 1793-1799
-
-
Galmarini, C.M.1
Kamath, K.2
Vanier-Viornery, A.3
-
11
-
-
0036570207
-
Regulation of microtubule stability and mitotic progression by survivin
-
Giodini A, Kallio MJ, Wall NR et al. Regulation of microtubule stability and mitotic progression by survivin. Cancer Res 2002; 62: 2462-2467.
-
(2002)
Cancer Res
, vol.62
, pp. 2462-2467
-
-
Giodini, A.1
Kallio, M.J.2
Wall, N.R.3
-
12
-
-
0035860717
-
Molecular dissection of the microtubule depolymerizing activity of mitotic centromere-associated kinesin
-
Maney T, Wagenbach M, Wordeman L. Molecular dissection of the microtubule depolymerizing activity of mitotic centromere-associated kinesin. J Biol Chem 2001; 276: 34753-34758.
-
(2001)
J Biol Chem
, vol.276
, pp. 34753-34758
-
-
Maney, T.1
Wagenbach, M.2
Wordeman, L.3
-
13
-
-
0021686169
-
Dynamic instability of microtubule growth
-
Mitchison T, Kirschner M. Dynamic instability of microtubule growth. Nature 1984; 312: 237-242.
-
(1984)
Nature
, vol.312
, pp. 237-242
-
-
Mitchison, T.1
Kirschner, M.2
-
14
-
-
0037341343
-
Alteration of microtubule dynamic instability during preprophase band formation revealed by yellow fluorescent protein-CLIP170 microtubule plus-end labeling
-
Dhonukshe P, Gadella TW Jr. Alteration of microtubule dynamic instability during preprophase band formation revealed by yellow fluorescent protein-CLIP170 microtubule plus-end labeling. Plant Cell 2003; 15: 597-611.
-
(2003)
Plant Cell
, vol.15
, pp. 597-611
-
-
Dhonukshe, P.1
Gadella Jr., T.W.2
-
15
-
-
1842479831
-
Microtubules become more dynamic but not shorter during preprophase band formation: A possible "search-and-capture" mechanism for microtubule translocation
-
Vos JW, Dogterom M, Emons AM. Microtubules become more dynamic but not shorter during preprophase band formation: A possible "search-and-capture" mechanism for microtubule translocation. Cell Motil Cytoskeleton 2004; 57: 246-258.
-
(2004)
Cell Motil Cytoskeleton
, vol.57
, pp. 246-258
-
-
Vos, J.W.1
Dogterom, M.2
Emons, A.M.3
-
17
-
-
0028249115
-
The MDR superfamily of genes and its biological implications
-
Childs S, Ling V. The MDR superfamily of genes and its biological implications. Important Adv Oncol 1994: 21-36.
-
(1994)
Important Adv Oncol
, pp. 21-36
-
-
Childs, S.1
Ling, V.2
-
18
-
-
0037453894
-
Multidrug resistance: Can new drugs help chemotherapy score against cancer?
-
Goldman B. Multidrug resistance: Can new drugs help chemotherapy score against cancer? J Natl Cancer Inst 2003; 95: 255-257.
-
(2003)
J Natl Cancer Inst
, vol.95
, pp. 255-257
-
-
Goldman, B.1
-
19
-
-
0037358040
-
Overcoming multidrug resistance in cancer: An update on the clinical strategy of inhibiting p-glycoprotein
-
Thomas H, Coley HM. Overcoming multidrug resistance in cancer: An update on the clinical strategy of inhibiting p-glycoprotein. Cancer Control 2003; 10: 159-165.
-
(2003)
Cancer Control
, vol.10
, pp. 159-165
-
-
Thomas, H.1
Coley, H.M.2
-
21
-
-
0035918287
-
Differential binding regulation of microtubule-associated proteins MAP1A, MAP1B, and MAP2 by tubulin polyglutamylation
-
Bonnet C, Boucher D, Lazereg S et al. Differential binding regulation of microtubule-associated proteins MAP1A, MAP1B, and MAP2 by tubulin polyglutamylation. J Biol Chem 2001; 276: 12839-12848.
-
(2001)
J Biol Chem
, vol.276
, pp. 12839-12848
-
-
Bonnet, C.1
Boucher, D.2
Lazereg, S.3
-
22
-
-
0037444386
-
Elevated levels of microtubule destabilizing factors in a Taxol-resistant/dependent A549 cell line with an alpha-tubulin mutation
-
Martello LA, Verdier-Pinard P, Shen HJ et al. Elevated levels of microtubule destabilizing factors in a Taxol-resistant/dependent A549 cell line with an alpha-tubulin mutation. Cancer Res 2003; 63: 1207-1213.
-
(2003)
Cancer Res
, vol.63
, pp. 1207-1213
-
-
Martello, L.A.1
Verdier-Pinard, P.2
Shen, H.J.3
-
23
-
-
0024632788
-
Mechanisms by which mammalian cells acquire resistance to drugs that affect microtubule assembly
-
Cabral F, Barlow SB. Mechanisms by which mammalian cells acquire resistance to drugs that affect microtubule assembly. FASEB J 1989; 3: 1593-1599.
-
(1989)
FASEB J
, vol.3
, pp. 1593-1599
-
-
Cabral, F.1
Barlow, S.B.2
-
24
-
-
0033052777
-
Mechanisms of action of and resistance to antitubulin agents: Microtubule dynamics, drug transport, and cell death
-
Dumontet C, Sikic BI. Mechanisms of action of and resistance to antitubulin agents: Microtubule dynamics, drug transport, and cell death. J Clin Oncol 1999; 17: 1061-1070.
-
(1999)
J Clin Oncol
, vol.17
, pp. 1061-1070
-
-
Dumontet, C.1
Sikic, B.I.2
-
25
-
-
0035422780
-
Multiple microtubule alterations are associated with vinca alkaloid resistance in human leukemia cells
-
Kavallaris M, Tait AS, Walsh BJ et al. Multiple microtubule alterations are associated with vinca alkaloid resistance in human leukemia cells. Cancer Res 2001; 61: 5803-5809.
-
(2001)
Cancer Res
, vol.61
, pp. 5803-5809
-
-
Kavallaris, M.1
Tait, A.S.2
Walsh, B.J.3
-
26
-
-
0030020158
-
Mitotic block induced in HeLa cells by low concentrations of paclitaxel (Taxol) results in abnormal mitotic exit and apoptotic cell death
-
Jordan MA, Wendell K, Gardiner S et al. Mitotic block induced in HeLa cells by low concentrations of paclitaxel (Taxol) results in abnormal mitotic exit and apoptotic cell death. Cancer Res 1996; 56: 816-825.
-
(1996)
Cancer Res
, vol.56
, pp. 816-825
-
-
Jordan, M.A.1
Wendell, K.2
Gardiner, S.3
-
27
-
-
0032933622
-
Taxol suppresses dynamics of individual microtubules in living human tumor cells
-
Yvon AM, Wadsworth P, Jordan MA. Taxol suppresses dynamics of individual microtubules in living human tumor cells. Mol Biol Cell 1999; 10: 947-959.
-
(1999)
Mol Biol Cell
, vol.10
, pp. 947-959
-
-
Yvon, A.M.1
Wadsworth, P.2
Jordan, M.A.3
-
28
-
-
0030018666
-
Epothilons A and B: Antifungal and cytotoxic compounds from Sorangium cellulosum (Myxobacteria). Production, physico-chemical and biological properties
-
Gerth K, Bedorf N, Hofle G et al. Epothilons A and B: Antifungal and cytotoxic compounds from Sorangium cellulosum (Myxobacteria). Production, physico-chemical and biological properties. J Antibiot (Tokyo) 1996; 49: 560-563.
-
(1996)
J Antibiot (Tokyo)
, vol.49
, pp. 560-563
-
-
Gerth, K.1
Bedorf, N.2
Hofle, G.3
-
29
-
-
3142704182
-
The clinical development of new mitotic inhibitors that stabilize the microtubule
-
Mani S, Macapinlac M Jr, Goel S et al. The clinical development of new mitotic inhibitors that stabilize the microtubule. Anticancer Drugs 2004; 15: 553-558.
-
(2004)
Anticancer Drugs
, vol.15
, pp. 553-558
-
-
Mani, S.1
Macapinlac Jr, M.2
Goel, S.3
-
30
-
-
0031027531
-
Activities of the microtubule-stabilizing agents epothilones A and B with purified tubulin and in cells resistant to paclitaxel (Taxol®)
-
Kowalski RJ, Giannakakou P, Hamel E. Activities of the microtubule-stabilizing agents epothilones A and B with purified tubulin and in cells resistant to paclitaxel (Taxol®). J Biol Chem 1997; 272: 2534-2541.
-
(1997)
J Biol Chem
, vol.272
, pp. 2534-2541
-
-
Kowalski, R.J.1
Giannakakou, P.2
Hamel, E.3
-
31
-
-
3843053396
-
The binding mode of epothilone A on alpha,beta-tubulin by electron crystallography
-
Nettles JH, Li H, Cornett B et al. The binding mode of epothilone A on alpha,beta-tubulin by electron crystallography. Science 2004; 305: 866-869.
-
(2004)
Science
, vol.305
, pp. 866-869
-
-
Nettles, J.H.1
Li, H.2
Cornett, B.3
-
32
-
-
0034895987
-
BMS-247550: A novel epothilone analog with a mode of action similar to paclitaxel but possessing superior antitumor efficacy
-
Lee FY, Borzilleri R, Fairchild CR et al. BMS-247550: A novel epothilone analog with a mode of action similar to paclitaxel but possessing superior antitumor efficacy. Clin Cancer Res 2001; 7: 1429-1437.
-
(2001)
Clin Cancer Res
, vol.7
, pp. 1429-1437
-
-
Lee, F.Y.1
Borzilleri, R.2
Fairchild, C.R.3
-
34
-
-
17944378190
-
Antitumor efficacy of 26-fluoroepothilone B against human prostate cancer xenografts
-
Newman RA, Yang J, Raymond M et al. Antitumor efficacy of 26-fluoroepothilone B against human prostate cancer xenografts. Cancer Chemother Pharmacol 2001; 48: 319-326.
-
(2001)
Cancer Chemother Pharmacol
, vol.48
, pp. 319-326
-
-
Newman, R.A.1
Yang, J.2
Raymond, M.3
-
35
-
-
12544259215
-
A comparison of signaling activities induced by Taxol and desoxyepothilone B
-
Bergstralh DT, Taxman DJ, Chou TC et al. A comparison of signaling activities induced by Taxol and desoxyepothilone B. J Chemother 2004; 16: 563-576.
-
(2004)
J Chemother
, vol.16
, pp. 563-576
-
-
Bergstralh, D.T.1
Taxman, D.J.2
Chou, T.C.3
-
36
-
-
0034678986
-
Epothilones and related structures - a new class of microtubule inhibitors with potent in vivo antitumor activity
-
Altmann KH, Wartmann M, O'Reilly T. Epothilones and related structures - a new class of microtubule inhibitors with potent in vivo antitumor activity. Biochim Biophys Acta 2000; 1470: M79-M91.
-
(2000)
Biochim Biophys Acta
, vol.1470
-
-
Altmann, K.H.1
Wartmann, M.2
O'Reilly, T.3
-
37
-
-
0032483019
-
Desoxyepothilone B: An efficacious microtubule-targeted antitumor agent with a promising in vivo profile relative to epothilone B
-
Chou TC, Zhang XG, Balog A et al. Desoxyepothilone B: An efficacious microtubule-targeted antitumor agent with a promising in vivo profile relative to epothilone B. Proc Natl Acad Sci U S A 1998; 95: 9642-9647.
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 9642-9647
-
-
Chou, T.C.1
Zhang, X.G.2
Balog, A.3
-
38
-
-
0025071180
-
Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues
-
Cordon-Cardo C, O'Brien JP, Boccia J et al. Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues. J Histochem Cytochem 1990; 38: 1277-1287.
-
(1990)
J Histochem Cytochem
, vol.38
, pp. 1277-1287
-
-
Cordon-Cardo, C.1
O'Brien, J.P.2
Boccia, J.3
-
39
-
-
0037177229
-
Epothilone and paclitaxel: Unexpected differences in promoting the assembly and stabilization of yeast microtubules
-
Bode CJ, Gupta ML Jr, Reiff EA et al. Epothilone and paclitaxel: unexpected differences in promoting the assembly and stabilization of yeast microtubules. Biochemistry 2002; 41: 3870-3874.
-
(2002)
Biochemistry
, vol.41
, pp. 3870-3874
-
-
Bode, C.J.1
Gupta Jr, M.L.2
Reiff, E.A.3
-
40
-
-
0036853788
-
Five new discodermolide analogues from the marine sponge Discodermia species
-
Gunasekera SP, Paul GK, Longley RE et al. Five new discodermolide analogues from the marine sponge Discodermia species. J Nat Prod 2002; 65: 1643-1648.
-
(2002)
J Nat Prod
, vol.65
, pp. 1643-1648
-
-
Gunasekera, S.P.1
Paul, G.K.2
Longley, R.E.3
-
41
-
-
0025942924
-
-
Longley RE, Caddigan D, Harmody D et al. Discodermolide - a new, marine-derived immunosuppressive compound. I. In vitro studies. Transplantation 1991; 52: 650-656.
-
Longley RE, Caddigan D, Harmody D et al. Discodermolide - a new, marine-derived immunosuppressive compound. I. In vitro studies. Transplantation 1991; 52: 650-656.
-
-
-
-
42
-
-
0030039669
-
Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than Taxol
-
ter Haar E, Kowalski RJ, Hamel E et al. Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than Taxol. Biochemistry 1996; 35: 243-250.
-
(1996)
Biochemistry
, vol.35
, pp. 243-250
-
-
ter Haar, E.1
Kowalski, R.J.2
Hamel, E.3
-
43
-
-
0030761586
-
The microtubule-stabilizing agent discodermolide competitively inhibits the binding of paclitaxel (Taxol) to tubulin polymers, enhances tubulin nucleation reactions more potently than paclitaxel, and inhibits the growth of paclitaxel-resistant cells
-
Kowalski RJ, Giannakakou P, Gunasekera SP et al. The microtubule-stabilizing agent discodermolide competitively inhibits the binding of paclitaxel (Taxol) to tubulin polymers, enhances tubulin nucleation reactions more potently than paclitaxel, and inhibits the growth of paclitaxel-resistant cells. Mol Pharmacol 1997; 52: 613-622.
-
(1997)
Mol Pharmacol
, vol.52
, pp. 613-622
-
-
Kowalski, R.J.1
Giannakakou, P.2
Gunasekera, S.P.3
-
44
-
-
18844469806
-
Taxol and discodermolide represent a synergistic drug combination in human carcinoma cell lines
-
Martello LA, McDaid HM, Regl DL et al. Taxol and discodermolide represent a synergistic drug combination in human carcinoma cell lines. Clin Cancer Res 2000; 6: 1978-1987.
-
(2000)
Clin Cancer Res
, vol.6
, pp. 1978-1987
-
-
Martello, L.A.1
McDaid, H.M.2
Regl, D.L.3
-
45
-
-
21744449331
-
The microtubule stabilizing agent discodermolide is a potent inducer of accelerated cell senescence
-
Klein LE, Freeze BS, Smith AB III, Horwitz SB. The microtubule stabilizing agent discodermolide is a potent inducer of accelerated cell senescence. Cell Cycle 2005; 4: 501-507.
-
(2005)
Cell Cycle
, vol.4
, pp. 501-507
-
-
Klein, L.E.1
Freeze, B.S.2
Smith III, A.B.3
Horwitz, S.B.4
-
46
-
-
0034826406
-
The relationship between Taxol and (+)- discodermolide: Synthetic analogs and modeling studies
-
Martello LA, LaMarche MJ, He L et al. The relationship between Taxol and (+)- discodermolide: Synthetic analogs and modeling studies. Chem Biol 2001; 8: 843-855.
-
(2001)
Chem Biol
, vol.8
, pp. 843-855
-
-
Martello, L.A.1
LaMarche, M.J.2
He, L.3
-
47
-
-
3142723291
-
Synergistic suppression of microtubule dynamics by discodermolide and paclitaxel in non-small cell lung carcinoma cells
-
Honore S, Kamath K, Braguer D et al. Synergistic suppression of microtubule dynamics by discodermolide and paclitaxel in non-small cell lung carcinoma cells. Cancer Res 2004; 64: 4957-4964.
-
(2004)
Cancer Res
, vol.64
, pp. 4957-4964
-
-
Honore, S.1
Kamath, K.2
Braguer, D.3
-
48
-
-
31544473618
-
A phase I pharmacokinetic (PK) of AAA296A (Discodermolide) administered every 3 weeks in adult patients with advanced solid tumors
-
Abstr 2025
-
Mita A, Lockhart A, Chen T. A phase I pharmacokinetic (PK) of AAA296A (Discodermolide) administered every 3 weeks in adult patients with advanced solid tumors. Proc Am Soc Clin Oncol 2004; 23: 133 (Abstr 2025).
-
(2004)
Proc Am Soc Clin Oncol
, vol.23
, pp. 133
-
-
Mita, A.1
Lockhart, A.2
Chen, T.3
-
49
-
-
0033609037
-
The coral-derived natural products eleutherobin and sarcodictyins A and B: Effects on the assembly of purified tubulin with and without microtubule-associated proteins and binding at the polymer taxoid site
-
Hamel E, Sackett DL, Vourloumis D, Nicolaou KC. The coral-derived natural products eleutherobin and sarcodictyins A and B: Effects on the assembly of purified tubulin with and without microtubule-associated proteins and binding at the polymer taxoid site. Biochemistry 1999; 38: 5490-5498.
-
(1999)
Biochemistry
, vol.38
, pp. 5490-5498
-
-
Hamel, E.1
Sackett, D.L.2
Vourloumis, D.3
Nicolaou, K.C.4
-
50
-
-
0033083045
-
Laulimalide and isolaulimalide, new paclitaxel-like microtubule-stabilizing agents
-
Mooberry SL, Tien G, Hernandez AH et al. Laulimalide and isolaulimalide, new paclitaxel-like microtubule-stabilizing agents. Cancer Res 1999; 59: 653-660.
-
(1999)
Cancer Res
, vol.59
, pp. 653-660
-
-
Mooberry, S.L.1
Tien, G.2
Hernandez, A.H.3
-
51
-
-
0037731512
-
Taccalonolides E and A: Plant-derived steroids with microtubule-stabilizing activity
-
Tinley TL, Randall-Hlubek DA, Leal RM et al. Taccalonolides E and A: plant-derived steroids with microtubule-stabilizing activity. Cancer Res 2003; 63: 3211-3220.
-
(2003)
Cancer Res
, vol.63
, pp. 3211-3220
-
-
Tinley, T.L.1
Randall-Hlubek, D.A.2
Leal, R.M.3
-
52
-
-
0032925417
-
The dolastatins, a family of promising antineoplastic agents
-
Poncet J. The dolastatins, a family of promising antineoplastic agents. Curr Pharm Des 1999; 5: 139-162.
-
(1999)
Curr Pharm Des
, vol.5
, pp. 139-162
-
-
Poncet, J.1
|