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Volumn 18, Issue SUPPL. 5, 2007, Pages

Mechanisms of multidrug resistance: The potential role of microtubule-stabilizing agents

Author keywords

Epothilones; Microtubulin; P glycoprotein; Paclitaxel; Taxanes; Tubulin

Indexed keywords

ANTHRACYCLINE DERIVATIVE; ANTINEOPLASTIC AGENT; BMS 310705; DISCODERMOLIDE; DOCETAXEL; ELEUTHEROBIN; EPIPODOPHYLLOTOXIN DERIVATIVE; EPOTHILONE A; EPOTHILONE B; EPOTHILONE D; EPOTHILONE DERIVATIVE; GLYCOPROTEIN P; ISOLAULIMALIDE; IXABEPILONE; LAULIMALIDE; MICROTUBULE STABILIZING AGENT; MULTIDRUG RESISTANCE PROTEIN 1; NATURAL PRODUCT; PACLITAXEL; SARCODICTYIN A; SARCODICTYIN B; STEROID; TACCALONOLIDE A; TACCALONOLIDE E; TAXANE DERIVATIVE; TUBULIN; UNCLASSIFIED DRUG; UNINDEXED DRUG; VINBLASTINE; VINCA ALKALOID; ZK 219477; TAXOID; TUBULIN MODULATOR;

EID: 38449097524     PISSN: 09237534     EISSN: 15698041     Source Type: Journal    
DOI: 10.1093/annonc/mdm172     Document Type: Conference Paper
Times cited : (187)

References (53)
  • 1
    • 13644254794 scopus 로고    scopus 로고
    • Molecular mechanisms of drug resistance
    • Longley DB, Johnston PG. Molecular mechanisms of drug resistance. J Pathol 2005; 205: 275-292.
    • (2005) J Pathol , vol.205 , pp. 275-292
    • Longley, D.B.1    Johnston, P.G.2
  • 2
    • 0036083301 scopus 로고    scopus 로고
    • Mechanism of action of antitumor drugs that interact with microtubules and tubulin
    • Jordan MA. Mechanism of action of antitumor drugs that interact with microtubules and tubulin. Curr Med Chem Anti-Canc Agents 2002; 2: 1-17.
    • (2002) Curr Med Chem Anti-Canc Agents , vol.2 , pp. 1-17
    • Jordan, M.A.1
  • 3
    • 1942438028 scopus 로고    scopus 로고
    • Microtubules as a target for anticancer drugs
    • Jordan MA, Wilson L. Microtubules as a target for anticancer drugs. Nat Rev Cancer 2004; 4: 253-265.
    • (2004) Nat Rev Cancer , vol.4 , pp. 253-265
    • Jordan, M.A.1    Wilson, L.2
  • 4
    • 33746471989 scopus 로고    scopus 로고
    • Novel agents that target tublin and related elements
    • Rowinsky EK, Calvo E. Novel agents that target tublin and related elements. Semin Oncol 2006; 33: 421-435.
    • (2006) Semin Oncol , vol.33 , pp. 421-435
    • Rowinsky, E.K.1    Calvo, E.2
  • 5
    • 0042132423 scopus 로고
    • Expression of a multidrug-resistance gene in human tumors and tissues
    • Fojo AT, Ueda K, Slamon DJ et al. Expression of a multidrug-resistance gene in human tumors and tissues. Proc Natl Acad Sci U S A 1987; 84: 265-269.
    • (1987) Proc Natl Acad Sci U S A , vol.84 , pp. 265-269
    • Fojo, A.T.1    Ueda, K.2    Slamon, D.J.3
  • 6
    • 54449094792 scopus 로고    scopus 로고
    • 54th edition. Montvale, NJ: Medical Economics Co
    • Phsyician's Desk Reference, 54th edition. Montvale, NJ: Medical Economics Co 2001; 748-753: 1059-1067.
    • (2001) Reference , vol.748-753 , pp. 1059-1067
    • Phsyician's Desk1
  • 7
    • 0032495513 scopus 로고    scopus 로고
    • Structure of the alpha beta tubulin dimer by electron crystallography
    • Nogales E, Wolf SG, Downing KH. Structure of the alpha beta tubulin dimer by electron crystallography. Nature 1998; 391: 199-203.
    • (1998) Nature , vol.391 , pp. 199-203
    • Nogales, E.1    Wolf, S.G.2    Downing, K.H.3
  • 8
    • 0142040355 scopus 로고    scopus 로고
    • Direct analysis of tubulin expression in cancer cell lines by electrospray ionization mass spectrometry
    • Verdier-Pinard P, Wang F, Burd B et al. Direct analysis of tubulin expression in cancer cell lines by electrospray ionization mass spectrometry. Biochemistry 2003; 42: 12019-12027.
    • (2003) Biochemistry , vol.42 , pp. 12019-12027
    • Verdier-Pinard, P.1    Wang, F.2    Burd, B.3
  • 9
    • 0030709242 scopus 로고    scopus 로고
    • Multiple forms of tubulin: Different gene products and covalent modifications
    • Luduena RF. Multiple forms of tubulin: Different gene products and covalent modifications. Int Rev Cytol 1998; 178: 207-275.
    • (1998) Int Rev Cytol , vol.178 , pp. 207-275
    • Luduena, R.F.1
  • 10
    • 0037928490 scopus 로고    scopus 로고
    • Drug resistance associated with loss of p53 involves extensive alterations in microtubule composition and dynamics
    • Galmarini CM, Kamath K, Vanier-Viornery A et al. Drug resistance associated with loss of p53 involves extensive alterations in microtubule composition and dynamics. Br J Cancer 2003; 88: 1793-1799.
    • (2003) Br J Cancer , vol.88 , pp. 1793-1799
    • Galmarini, C.M.1    Kamath, K.2    Vanier-Viornery, A.3
  • 11
    • 0036570207 scopus 로고    scopus 로고
    • Regulation of microtubule stability and mitotic progression by survivin
    • Giodini A, Kallio MJ, Wall NR et al. Regulation of microtubule stability and mitotic progression by survivin. Cancer Res 2002; 62: 2462-2467.
    • (2002) Cancer Res , vol.62 , pp. 2462-2467
    • Giodini, A.1    Kallio, M.J.2    Wall, N.R.3
  • 12
    • 0035860717 scopus 로고    scopus 로고
    • Molecular dissection of the microtubule depolymerizing activity of mitotic centromere-associated kinesin
    • Maney T, Wagenbach M, Wordeman L. Molecular dissection of the microtubule depolymerizing activity of mitotic centromere-associated kinesin. J Biol Chem 2001; 276: 34753-34758.
    • (2001) J Biol Chem , vol.276 , pp. 34753-34758
    • Maney, T.1    Wagenbach, M.2    Wordeman, L.3
  • 13
    • 0021686169 scopus 로고
    • Dynamic instability of microtubule growth
    • Mitchison T, Kirschner M. Dynamic instability of microtubule growth. Nature 1984; 312: 237-242.
    • (1984) Nature , vol.312 , pp. 237-242
    • Mitchison, T.1    Kirschner, M.2
  • 14
    • 0037341343 scopus 로고    scopus 로고
    • Alteration of microtubule dynamic instability during preprophase band formation revealed by yellow fluorescent protein-CLIP170 microtubule plus-end labeling
    • Dhonukshe P, Gadella TW Jr. Alteration of microtubule dynamic instability during preprophase band formation revealed by yellow fluorescent protein-CLIP170 microtubule plus-end labeling. Plant Cell 2003; 15: 597-611.
    • (2003) Plant Cell , vol.15 , pp. 597-611
    • Dhonukshe, P.1    Gadella Jr., T.W.2
  • 15
    • 1842479831 scopus 로고    scopus 로고
    • Microtubules become more dynamic but not shorter during preprophase band formation: A possible "search-and-capture" mechanism for microtubule translocation
    • Vos JW, Dogterom M, Emons AM. Microtubules become more dynamic but not shorter during preprophase band formation: A possible "search-and-capture" mechanism for microtubule translocation. Cell Motil Cytoskeleton 2004; 57: 246-258.
    • (2004) Cell Motil Cytoskeleton , vol.57 , pp. 246-258
    • Vos, J.W.1    Dogterom, M.2    Emons, A.M.3
  • 17
    • 0028249115 scopus 로고
    • The MDR superfamily of genes and its biological implications
    • Childs S, Ling V. The MDR superfamily of genes and its biological implications. Important Adv Oncol 1994: 21-36.
    • (1994) Important Adv Oncol , pp. 21-36
    • Childs, S.1    Ling, V.2
  • 18
    • 0037453894 scopus 로고    scopus 로고
    • Multidrug resistance: Can new drugs help chemotherapy score against cancer?
    • Goldman B. Multidrug resistance: Can new drugs help chemotherapy score against cancer? J Natl Cancer Inst 2003; 95: 255-257.
    • (2003) J Natl Cancer Inst , vol.95 , pp. 255-257
    • Goldman, B.1
  • 19
    • 0037358040 scopus 로고    scopus 로고
    • Overcoming multidrug resistance in cancer: An update on the clinical strategy of inhibiting p-glycoprotein
    • Thomas H, Coley HM. Overcoming multidrug resistance in cancer: An update on the clinical strategy of inhibiting p-glycoprotein. Cancer Control 2003; 10: 159-165.
    • (2003) Cancer Control , vol.10 , pp. 159-165
    • Thomas, H.1    Coley, H.M.2
  • 21
    • 0035918287 scopus 로고    scopus 로고
    • Differential binding regulation of microtubule-associated proteins MAP1A, MAP1B, and MAP2 by tubulin polyglutamylation
    • Bonnet C, Boucher D, Lazereg S et al. Differential binding regulation of microtubule-associated proteins MAP1A, MAP1B, and MAP2 by tubulin polyglutamylation. J Biol Chem 2001; 276: 12839-12848.
    • (2001) J Biol Chem , vol.276 , pp. 12839-12848
    • Bonnet, C.1    Boucher, D.2    Lazereg, S.3
  • 22
    • 0037444386 scopus 로고    scopus 로고
    • Elevated levels of microtubule destabilizing factors in a Taxol-resistant/dependent A549 cell line with an alpha-tubulin mutation
    • Martello LA, Verdier-Pinard P, Shen HJ et al. Elevated levels of microtubule destabilizing factors in a Taxol-resistant/dependent A549 cell line with an alpha-tubulin mutation. Cancer Res 2003; 63: 1207-1213.
    • (2003) Cancer Res , vol.63 , pp. 1207-1213
    • Martello, L.A.1    Verdier-Pinard, P.2    Shen, H.J.3
  • 23
    • 0024632788 scopus 로고
    • Mechanisms by which mammalian cells acquire resistance to drugs that affect microtubule assembly
    • Cabral F, Barlow SB. Mechanisms by which mammalian cells acquire resistance to drugs that affect microtubule assembly. FASEB J 1989; 3: 1593-1599.
    • (1989) FASEB J , vol.3 , pp. 1593-1599
    • Cabral, F.1    Barlow, S.B.2
  • 24
    • 0033052777 scopus 로고    scopus 로고
    • Mechanisms of action of and resistance to antitubulin agents: Microtubule dynamics, drug transport, and cell death
    • Dumontet C, Sikic BI. Mechanisms of action of and resistance to antitubulin agents: Microtubule dynamics, drug transport, and cell death. J Clin Oncol 1999; 17: 1061-1070.
    • (1999) J Clin Oncol , vol.17 , pp. 1061-1070
    • Dumontet, C.1    Sikic, B.I.2
  • 25
    • 0035422780 scopus 로고    scopus 로고
    • Multiple microtubule alterations are associated with vinca alkaloid resistance in human leukemia cells
    • Kavallaris M, Tait AS, Walsh BJ et al. Multiple microtubule alterations are associated with vinca alkaloid resistance in human leukemia cells. Cancer Res 2001; 61: 5803-5809.
    • (2001) Cancer Res , vol.61 , pp. 5803-5809
    • Kavallaris, M.1    Tait, A.S.2    Walsh, B.J.3
  • 26
    • 0030020158 scopus 로고    scopus 로고
    • Mitotic block induced in HeLa cells by low concentrations of paclitaxel (Taxol) results in abnormal mitotic exit and apoptotic cell death
    • Jordan MA, Wendell K, Gardiner S et al. Mitotic block induced in HeLa cells by low concentrations of paclitaxel (Taxol) results in abnormal mitotic exit and apoptotic cell death. Cancer Res 1996; 56: 816-825.
    • (1996) Cancer Res , vol.56 , pp. 816-825
    • Jordan, M.A.1    Wendell, K.2    Gardiner, S.3
  • 27
    • 0032933622 scopus 로고    scopus 로고
    • Taxol suppresses dynamics of individual microtubules in living human tumor cells
    • Yvon AM, Wadsworth P, Jordan MA. Taxol suppresses dynamics of individual microtubules in living human tumor cells. Mol Biol Cell 1999; 10: 947-959.
    • (1999) Mol Biol Cell , vol.10 , pp. 947-959
    • Yvon, A.M.1    Wadsworth, P.2    Jordan, M.A.3
  • 28
    • 0030018666 scopus 로고    scopus 로고
    • Epothilons A and B: Antifungal and cytotoxic compounds from Sorangium cellulosum (Myxobacteria). Production, physico-chemical and biological properties
    • Gerth K, Bedorf N, Hofle G et al. Epothilons A and B: Antifungal and cytotoxic compounds from Sorangium cellulosum (Myxobacteria). Production, physico-chemical and biological properties. J Antibiot (Tokyo) 1996; 49: 560-563.
    • (1996) J Antibiot (Tokyo) , vol.49 , pp. 560-563
    • Gerth, K.1    Bedorf, N.2    Hofle, G.3
  • 29
    • 3142704182 scopus 로고    scopus 로고
    • The clinical development of new mitotic inhibitors that stabilize the microtubule
    • Mani S, Macapinlac M Jr, Goel S et al. The clinical development of new mitotic inhibitors that stabilize the microtubule. Anticancer Drugs 2004; 15: 553-558.
    • (2004) Anticancer Drugs , vol.15 , pp. 553-558
    • Mani, S.1    Macapinlac Jr, M.2    Goel, S.3
  • 30
    • 0031027531 scopus 로고    scopus 로고
    • Activities of the microtubule-stabilizing agents epothilones A and B with purified tubulin and in cells resistant to paclitaxel (Taxol®)
    • Kowalski RJ, Giannakakou P, Hamel E. Activities of the microtubule-stabilizing agents epothilones A and B with purified tubulin and in cells resistant to paclitaxel (Taxol®). J Biol Chem 1997; 272: 2534-2541.
    • (1997) J Biol Chem , vol.272 , pp. 2534-2541
    • Kowalski, R.J.1    Giannakakou, P.2    Hamel, E.3
  • 31
    • 3843053396 scopus 로고    scopus 로고
    • The binding mode of epothilone A on alpha,beta-tubulin by electron crystallography
    • Nettles JH, Li H, Cornett B et al. The binding mode of epothilone A on alpha,beta-tubulin by electron crystallography. Science 2004; 305: 866-869.
    • (2004) Science , vol.305 , pp. 866-869
    • Nettles, J.H.1    Li, H.2    Cornett, B.3
  • 32
    • 0034895987 scopus 로고    scopus 로고
    • BMS-247550: A novel epothilone analog with a mode of action similar to paclitaxel but possessing superior antitumor efficacy
    • Lee FY, Borzilleri R, Fairchild CR et al. BMS-247550: A novel epothilone analog with a mode of action similar to paclitaxel but possessing superior antitumor efficacy. Clin Cancer Res 2001; 7: 1429-1437.
    • (2001) Clin Cancer Res , vol.7 , pp. 1429-1437
    • Lee, F.Y.1    Borzilleri, R.2    Fairchild, C.R.3
  • 34
    • 17944378190 scopus 로고    scopus 로고
    • Antitumor efficacy of 26-fluoroepothilone B against human prostate cancer xenografts
    • Newman RA, Yang J, Raymond M et al. Antitumor efficacy of 26-fluoroepothilone B against human prostate cancer xenografts. Cancer Chemother Pharmacol 2001; 48: 319-326.
    • (2001) Cancer Chemother Pharmacol , vol.48 , pp. 319-326
    • Newman, R.A.1    Yang, J.2    Raymond, M.3
  • 35
    • 12544259215 scopus 로고    scopus 로고
    • A comparison of signaling activities induced by Taxol and desoxyepothilone B
    • Bergstralh DT, Taxman DJ, Chou TC et al. A comparison of signaling activities induced by Taxol and desoxyepothilone B. J Chemother 2004; 16: 563-576.
    • (2004) J Chemother , vol.16 , pp. 563-576
    • Bergstralh, D.T.1    Taxman, D.J.2    Chou, T.C.3
  • 36
    • 0034678986 scopus 로고    scopus 로고
    • Epothilones and related structures - a new class of microtubule inhibitors with potent in vivo antitumor activity
    • Altmann KH, Wartmann M, O'Reilly T. Epothilones and related structures - a new class of microtubule inhibitors with potent in vivo antitumor activity. Biochim Biophys Acta 2000; 1470: M79-M91.
    • (2000) Biochim Biophys Acta , vol.1470
    • Altmann, K.H.1    Wartmann, M.2    O'Reilly, T.3
  • 37
    • 0032483019 scopus 로고    scopus 로고
    • Desoxyepothilone B: An efficacious microtubule-targeted antitumor agent with a promising in vivo profile relative to epothilone B
    • Chou TC, Zhang XG, Balog A et al. Desoxyepothilone B: An efficacious microtubule-targeted antitumor agent with a promising in vivo profile relative to epothilone B. Proc Natl Acad Sci U S A 1998; 95: 9642-9647.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 9642-9647
    • Chou, T.C.1    Zhang, X.G.2    Balog, A.3
  • 38
    • 0025071180 scopus 로고
    • Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues
    • Cordon-Cardo C, O'Brien JP, Boccia J et al. Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues. J Histochem Cytochem 1990; 38: 1277-1287.
    • (1990) J Histochem Cytochem , vol.38 , pp. 1277-1287
    • Cordon-Cardo, C.1    O'Brien, J.P.2    Boccia, J.3
  • 39
    • 0037177229 scopus 로고    scopus 로고
    • Epothilone and paclitaxel: Unexpected differences in promoting the assembly and stabilization of yeast microtubules
    • Bode CJ, Gupta ML Jr, Reiff EA et al. Epothilone and paclitaxel: unexpected differences in promoting the assembly and stabilization of yeast microtubules. Biochemistry 2002; 41: 3870-3874.
    • (2002) Biochemistry , vol.41 , pp. 3870-3874
    • Bode, C.J.1    Gupta Jr, M.L.2    Reiff, E.A.3
  • 40
    • 0036853788 scopus 로고    scopus 로고
    • Five new discodermolide analogues from the marine sponge Discodermia species
    • Gunasekera SP, Paul GK, Longley RE et al. Five new discodermolide analogues from the marine sponge Discodermia species. J Nat Prod 2002; 65: 1643-1648.
    • (2002) J Nat Prod , vol.65 , pp. 1643-1648
    • Gunasekera, S.P.1    Paul, G.K.2    Longley, R.E.3
  • 41
    • 0025942924 scopus 로고    scopus 로고
    • Longley RE, Caddigan D, Harmody D et al. Discodermolide - a new, marine-derived immunosuppressive compound. I. In vitro studies. Transplantation 1991; 52: 650-656.
    • Longley RE, Caddigan D, Harmody D et al. Discodermolide - a new, marine-derived immunosuppressive compound. I. In vitro studies. Transplantation 1991; 52: 650-656.
  • 42
    • 0030039669 scopus 로고    scopus 로고
    • Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than Taxol
    • ter Haar E, Kowalski RJ, Hamel E et al. Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than Taxol. Biochemistry 1996; 35: 243-250.
    • (1996) Biochemistry , vol.35 , pp. 243-250
    • ter Haar, E.1    Kowalski, R.J.2    Hamel, E.3
  • 43
    • 0030761586 scopus 로고    scopus 로고
    • The microtubule-stabilizing agent discodermolide competitively inhibits the binding of paclitaxel (Taxol) to tubulin polymers, enhances tubulin nucleation reactions more potently than paclitaxel, and inhibits the growth of paclitaxel-resistant cells
    • Kowalski RJ, Giannakakou P, Gunasekera SP et al. The microtubule-stabilizing agent discodermolide competitively inhibits the binding of paclitaxel (Taxol) to tubulin polymers, enhances tubulin nucleation reactions more potently than paclitaxel, and inhibits the growth of paclitaxel-resistant cells. Mol Pharmacol 1997; 52: 613-622.
    • (1997) Mol Pharmacol , vol.52 , pp. 613-622
    • Kowalski, R.J.1    Giannakakou, P.2    Gunasekera, S.P.3
  • 44
    • 18844469806 scopus 로고    scopus 로고
    • Taxol and discodermolide represent a synergistic drug combination in human carcinoma cell lines
    • Martello LA, McDaid HM, Regl DL et al. Taxol and discodermolide represent a synergistic drug combination in human carcinoma cell lines. Clin Cancer Res 2000; 6: 1978-1987.
    • (2000) Clin Cancer Res , vol.6 , pp. 1978-1987
    • Martello, L.A.1    McDaid, H.M.2    Regl, D.L.3
  • 45
    • 21744449331 scopus 로고    scopus 로고
    • The microtubule stabilizing agent discodermolide is a potent inducer of accelerated cell senescence
    • Klein LE, Freeze BS, Smith AB III, Horwitz SB. The microtubule stabilizing agent discodermolide is a potent inducer of accelerated cell senescence. Cell Cycle 2005; 4: 501-507.
    • (2005) Cell Cycle , vol.4 , pp. 501-507
    • Klein, L.E.1    Freeze, B.S.2    Smith III, A.B.3    Horwitz, S.B.4
  • 46
    • 0034826406 scopus 로고    scopus 로고
    • The relationship between Taxol and (+)- discodermolide: Synthetic analogs and modeling studies
    • Martello LA, LaMarche MJ, He L et al. The relationship between Taxol and (+)- discodermolide: Synthetic analogs and modeling studies. Chem Biol 2001; 8: 843-855.
    • (2001) Chem Biol , vol.8 , pp. 843-855
    • Martello, L.A.1    LaMarche, M.J.2    He, L.3
  • 47
    • 3142723291 scopus 로고    scopus 로고
    • Synergistic suppression of microtubule dynamics by discodermolide and paclitaxel in non-small cell lung carcinoma cells
    • Honore S, Kamath K, Braguer D et al. Synergistic suppression of microtubule dynamics by discodermolide and paclitaxel in non-small cell lung carcinoma cells. Cancer Res 2004; 64: 4957-4964.
    • (2004) Cancer Res , vol.64 , pp. 4957-4964
    • Honore, S.1    Kamath, K.2    Braguer, D.3
  • 48
    • 31544473618 scopus 로고    scopus 로고
    • A phase I pharmacokinetic (PK) of AAA296A (Discodermolide) administered every 3 weeks in adult patients with advanced solid tumors
    • Abstr 2025
    • Mita A, Lockhart A, Chen T. A phase I pharmacokinetic (PK) of AAA296A (Discodermolide) administered every 3 weeks in adult patients with advanced solid tumors. Proc Am Soc Clin Oncol 2004; 23: 133 (Abstr 2025).
    • (2004) Proc Am Soc Clin Oncol , vol.23 , pp. 133
    • Mita, A.1    Lockhart, A.2    Chen, T.3
  • 49
    • 0033609037 scopus 로고    scopus 로고
    • The coral-derived natural products eleutherobin and sarcodictyins A and B: Effects on the assembly of purified tubulin with and without microtubule-associated proteins and binding at the polymer taxoid site
    • Hamel E, Sackett DL, Vourloumis D, Nicolaou KC. The coral-derived natural products eleutherobin and sarcodictyins A and B: Effects on the assembly of purified tubulin with and without microtubule-associated proteins and binding at the polymer taxoid site. Biochemistry 1999; 38: 5490-5498.
    • (1999) Biochemistry , vol.38 , pp. 5490-5498
    • Hamel, E.1    Sackett, D.L.2    Vourloumis, D.3    Nicolaou, K.C.4
  • 50
    • 0033083045 scopus 로고    scopus 로고
    • Laulimalide and isolaulimalide, new paclitaxel-like microtubule-stabilizing agents
    • Mooberry SL, Tien G, Hernandez AH et al. Laulimalide and isolaulimalide, new paclitaxel-like microtubule-stabilizing agents. Cancer Res 1999; 59: 653-660.
    • (1999) Cancer Res , vol.59 , pp. 653-660
    • Mooberry, S.L.1    Tien, G.2    Hernandez, A.H.3
  • 51
    • 0037731512 scopus 로고    scopus 로고
    • Taccalonolides E and A: Plant-derived steroids with microtubule-stabilizing activity
    • Tinley TL, Randall-Hlubek DA, Leal RM et al. Taccalonolides E and A: plant-derived steroids with microtubule-stabilizing activity. Cancer Res 2003; 63: 3211-3220.
    • (2003) Cancer Res , vol.63 , pp. 3211-3220
    • Tinley, T.L.1    Randall-Hlubek, D.A.2    Leal, R.M.3
  • 52
    • 0032925417 scopus 로고    scopus 로고
    • The dolastatins, a family of promising antineoplastic agents
    • Poncet J. The dolastatins, a family of promising antineoplastic agents. Curr Pharm Des 1999; 5: 139-162.
    • (1999) Curr Pharm Des , vol.5 , pp. 139-162
    • Poncet, J.1
  • 53
    • 0035744348 scopus 로고    scopus 로고
    • Anticancer therapy with novel tubulin-interacting drugs
    • Kavallaris M, Verrills NM, Hill BT. Anticancer therapy with novel tubulin-interacting drugs. Drug Resist Updat 2001; 4: 392-401.
    • (2001) Drug Resist Updat , vol.4 , pp. 392-401
    • Kavallaris, M.1    Verrills, N.M.2    Hill, B.T.3


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