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Volumn 9, Issue 9, 2007, Pages 555-562

Apoptosis regulators as targets for cancer therapy

Author keywords

Apoptosis; Bcl 2; Caspases; Therapy; TRAIL; XIAP

Indexed keywords

4 [4 (4' CHLORO 2 BIPHENYLYLMETHYL) 1 PIPERAZINYL] N [4 [3 DIMETHYLAMINO 1 (PHENYLTHIOMETHYL)PROPYLAMINO] 3 NITROBENZENESULFONYL]BENZAMIDE; ANTIMYCIN A1; BH3 PROTEIN; CASPASE; FAS ASSOCIATED DEATH DOMAIN PROTEIN; GAMBOGIC ACID; GOSSYPOL; INHIBITOR OF APOPTOSIS PROTEIN; MAPATUMUMAB; MONOCLONAL ANTIBODY; OBATOCLAX; OBLIMERSEN; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL 2; TEMOZOLOMIDE; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND RECEPTOR; APOPTOSIS REGULATORY PROTEIN; X LINKED INHIBITOR OF APOPTOSIS;

EID: 38449096211     PISSN: 1699048X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12094-007-0103-7     Document Type: Review
Times cited : (39)

References (55)
  • 1
    • 0034641980 scopus 로고    scopus 로고
    • Apoptosis in development
    • Meier P, Finch A, Evan G (2000) Apoptosis in development. Nature 407:796-801
    • (2000) Nature , vol.407 , pp. 796-801
    • Meier, P.1    Finch, A.2    Evan, G.3
  • 2
    • 0031842949 scopus 로고    scopus 로고
    • Why neurons die: Cell death in the nervous system
    • Hutchins JB, Barger SW (1998) Why neurons die: Cell death in the nervous system. Anat Rec 253:79-90
    • (1998) Anat Rec , vol.253 , pp. 79-90
    • Hutchins, J.B.1    Barger, S.W.2
  • 4
    • 0033957359 scopus 로고    scopus 로고
    • Morphologic and biochemical hallmarks of apoptosis
    • Saraste A, Pulkki K (2000) Morphologic and biochemical hallmarks of apoptosis. Cardiovasc Res 45:528-537
    • (2000) Cardiovasc Res , vol.45 , pp. 528-537
    • Saraste, A.1    Pulkki, K.2
  • 5
    • 0028782769 scopus 로고
    • The ins and outs of programmed cell death during C. elegans development
    • Hengartner MO, Horvitz HR (1994) The ins and outs of programmed cell death during C. elegans development. Philos Trans R Soc Lond B Biol Sci 345:243-246
    • (1994) Philos Trans R Soc Lond B Biol Sci , vol.345 , pp. 243-246
    • Hengartner, M.O.1    Horvitz, H.R.2
  • 6
    • 0015383455 scopus 로고
    • Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
    • Kerr JF, Wyllie AH, Currie AR (1972) Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 26:239-257
    • (1972) Br J Cancer , vol.26 , pp. 239-257
    • Kerr, J.F.1    Wyllie, A.H.2    Currie, A.R.3
  • 7
    • 0023786047 scopus 로고
    • Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells
    • Vaux DL, Cory S, Adams JM (1988) Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature 335:440-442
    • (1988) Nature , vol.335 , pp. 440-442
    • Vaux, D.L.1    Cory, S.2    Adams, J.M.3
  • 8
    • 0023812417 scopus 로고
    • Oncogenic potential of bcl-2 demonstrated by gene transfer
    • Reed JC, Cuddy M, Slabiak T et al (1988) Oncogenic potential of bcl-2 demonstrated by gene transfer. Nature 336:259-261
    • (1988) Nature , vol.336 , pp. 259-261
    • Reed, J.C.1    Cuddy, M.2    Slabiak, T.3
  • 9
    • 0024521441 scopus 로고
    • bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation
    • McDonnell TJ, Deane N, Platt FM et al (1989) bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation. Cell 57:79-88
    • (1989) Cell , vol.57 , pp. 79-88
    • McDonnell, T.J.1    Deane, N.2    Platt, F.M.3
  • 10
    • 0027525104 scopus 로고
    • The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme
    • Yuan J, Shaham S, Ledoux S et al (1993) The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme. Cell 75:641-652
    • (1993) Cell , vol.75 , pp. 641-652
    • Yuan, J.1    Shaham, S.2    Ledoux, S.3
  • 11
    • 0030581151 scopus 로고    scopus 로고
    • Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c
    • Liu X, Kim CN, Yang J et al (1996) Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c. Cell 86:147-157
    • (1996) Cell , vol.86 , pp. 147-157
    • Liu, X.1    Kim, C.N.2    Yang, J.3
  • 12
    • 0030970085 scopus 로고    scopus 로고
    • Harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-X(L)
    • Inohara N, Ding L, Chen S et al (1997) harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-X(L). EMBO J 16:1686-1694
    • (1997) EMBO J , vol.16 , pp. 1686-1694
    • Inohara, N.1    Ding, L.2    Chen, S.3
  • 13
    • 0028809209 scopus 로고
    • Bad, a het-erodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death
    • Yang E, Zha J, Jockel J et al (1995) Bad, a het-erodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death. Cell 80:285-291
    • (1995) Cell , vol.80 , pp. 285-291
    • Yang, E.1    Zha, J.2    Jockel, J.3
  • 14
    • 0029807585 scopus 로고    scopus 로고
    • BID: A novel BH3 domain-only death agonist
    • Wang K, Yin XM, Chao DT et al (1996) BID: A novel BH3 domain-only death agonist. Genes Dev 10:2859-2869
    • (1996) Genes Dev , vol.10 , pp. 2859-2869
    • Wang, K.1    Yin, X.M.2    Chao, D.T.3
  • 15
    • 0033607006 scopus 로고    scopus 로고
    • Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis
    • Yin XM, Wang K, Gross A et al (1999) Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis. Nature 400:886-891
    • (1999) Nature , vol.400 , pp. 886-891
    • Yin, X.M.1    Wang, K.2    Gross, A.3
  • 16
    • 0033607506 scopus 로고    scopus 로고
    • Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity
    • Bouillet P, Metcalf D, Huang DC et al (1999) Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity. Science 286:1735-1738
    • (1999) Science , vol.286 , pp. 1735-1738
    • Bouillet, P.1    Metcalf, D.2    Huang, D.C.3
  • 17
    • 0029953942 scopus 로고    scopus 로고
    • Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors
    • Uren AG, Pakusch M, Hawkins CJ et al (1996) Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors. Proc Natl Acad Sci U S A 93: 4974-4978
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 4974-4978
    • Uren, A.G.1    Pakusch, M.2    Hawkins, C.J.3
  • 18
    • 15844425961 scopus 로고    scopus 로고
    • A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors
    • Duckett CS, Nava VE, Gedrich RW et al (1996) A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors. EMBO J 15:2685-2694
    • (1996) EMBO J , vol.15 , pp. 2685-2694
    • Duckett, C.S.1    Nava, V.E.2    Gedrich, R.W.3
  • 19
    • 5244224827 scopus 로고    scopus 로고
    • X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death
    • Muchmore SW, Sattler M, Liang H et al (1996) X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death. Nature 381:335-341
    • (1996) Nature , vol.381 , pp. 335-341
    • Muchmore, S.W.1    Sattler, M.2    Liang, H.3
  • 20
    • 0034691130 scopus 로고    scopus 로고
    • Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells
    • Wang JL, Liu D, Zhang ZJ et al (2000) Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells. Proc Natl Acad Sci U S A 97:7124-7129
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 7124-7129
    • Wang, J.L.1    Liu, D.2    Zhang, Z.J.3
  • 21
    • 20444486559 scopus 로고    scopus 로고
    • An inhibitor of Bcl-2 family proteins induces regression of solid tumours
    • Oltersdorf T, Elmore SW, Shoemaker AR et al (2005) An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Nature 435:677-681
    • (2005) Nature , vol.435 , pp. 677-681
    • Oltersdorf, T.1    Elmore, S.W.2    Shoemaker, A.R.3
  • 22
    • 0036728834 scopus 로고    scopus 로고
    • Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics
    • Letai A, Bassik MC, Walensky LD et al (2002) Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics. Cancer Cell 2:183-192
    • (2002) Cancer Cell , vol.2 , pp. 183-192
    • Letai, A.1    Bassik, M.C.2    Walensky, L.D.3
  • 23
    • 22244464818 scopus 로고    scopus 로고
    • Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins
    • Willis SN, Chen L, Dewson G et al (2005) Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins. Genes Dev 19:1294-1305
    • (2005) Genes Dev , vol.19 , pp. 1294-1305
    • Willis, S.N.1    Chen, L.2    Dewson, G.3
  • 24
    • 33751513394 scopus 로고    scopus 로고
    • Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies
    • Kim H, Rafiuddin-Shah M, Tu HC et al (2006) Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies. Nat Cell Biol 8:1348-1358
    • (2006) Nat Cell Biol , vol.8 , pp. 1348-1358
    • Kim, H.1    Rafiuddin-Shah, M.2    Tu, H.C.3
  • 25
    • 0344389027 scopus 로고    scopus 로고
    • Caspases: The proteases of the apoptotic pathway
    • Nunez G, Benedict M, Hu Y et al (1998) Caspases: The proteases of the apoptotic pathway. Oncogene 17:3237-3245
    • (1998) Oncogene , vol.17 , pp. 3237-3245
    • Nunez, G.1    Benedict, M.2    Hu, Y.3
  • 26
    • 0037072937 scopus 로고    scopus 로고
    • An endoplasmic reticulum stress-specific caspase cascade in apoptosis. Cytochrome c-independent activation of caspase-9 by caspase-12
    • Morishima N, Nakanishi K, Takenouchi H et al (2002) An endoplasmic reticulum stress-specific caspase cascade in apoptosis. Cytochrome c-independent activation of caspase-9 by caspase-12. J Biol Chem 277:34287-34294
    • (2002) J Biol Chem , vol.277 , pp. 34287-34294
    • Morishima, N.1    Nakanishi, K.2    Takenouchi, H.3
  • 27
    • 0037291871 scopus 로고    scopus 로고
    • A unified model for apical caspase activation
    • Boatright KM, Renatus M, Scott FL et al (2003) A unified model for apical caspase activation. Mol Cell 11:529-541
    • (2003) Mol Cell , vol.11 , pp. 529-541
    • Boatright, K.M.1    Renatus, M.2    Scott, F.L.3
  • 28
    • 33646024628 scopus 로고    scopus 로고
    • The apoptosome activates caspase-9 by dimerization
    • Pop C, Timmer J, Sperandio S et al (2006) The apoptosome activates caspase-9 by dimerization. Mol Cell 22:269-275
    • (2006) Mol Cell , vol.22 , pp. 269-275
    • Pop, C.1    Timmer, J.2    Sperandio, S.3
  • 29
  • 30
    • 22344456263 scopus 로고    scopus 로고
    • BH3-only proteins in control: Specificity regulates MCL-1 and BAK-mediated apoptosis
    • Gelinas C, White E (2005) BH3-only proteins in control: Specificity regulates MCL-1 and BAK-mediated apoptosis. Genes Dev 19:1263-1268
    • (2005) Genes Dev , vol.19 , pp. 1263-1268
    • Gelinas, C.1    White, E.2
  • 31
    • 33750292972 scopus 로고    scopus 로고
    • Cell death in the nervous system
    • Bredesen DE, Rao RV, Mehlen P (2006) Cell death in the nervous system. Nature 443:796-802
    • (2006) Nature , vol.443 , pp. 796-802
    • Bredesen, D.E.1    Rao, R.V.2    Mehlen, P.3
  • 32
    • 1942489867 scopus 로고    scopus 로고
    • Critical role for DP5/Harakiri, a Bcl-2 homology domain 3-only Bcl-2 family member, in axotomy-induced neuronal cell death
    • Imaizumi K, Benito A, Kiryu-Seo S et al (2004) Critical role for DP5/ Harakiri, a Bcl-2 homology domain 3-only Bcl-2 family member, in axotomy-induced neuronal cell death. J Neurosci 24:3721-3725
    • (2004) J Neurosci , vol.24 , pp. 3721-3725
    • Imaizumi, K.1    Benito, A.2    Kiryu-Seo, S.3
  • 33
    • 0842347424 scopus 로고    scopus 로고
    • Proapoptotic BH3-only Bcl-2 family member Bik/Blk/Nbk is expressed in hemopoietic and endothelial cells but is redundant for their programmed death
    • Coultas L, Bouillet P, Stanley EG et al (2004) Proapoptotic BH3-only Bcl-2 family member Bik/Blk/Nbk is expressed in hemopoietic and endothelial cells but is redundant for their programmed death. Mol Cell Biol 24:1570-1581
    • (2004) Mol Cell Biol , vol.24 , pp. 1570-1581
    • Coultas, L.1    Bouillet, P.2    Stanley, E.G.3
  • 34
    • 0037439151 scopus 로고    scopus 로고
    • Proapoptotic BID is required for myeloid homeostasis and tumor suppression
    • Zinkel SS, Ong CC, Ferguson DO et al (2003) Proapoptotic BID is required for myeloid homeostasis and tumor suppression. Genes Dev 17:229-239
    • (2003) Genes Dev , vol.17 , pp. 229-239
    • Zinkel, S.S.1    Ong, C.C.2    Ferguson, D.O.3
  • 35
    • 0042424706 scopus 로고    scopus 로고
    • Bad-deficient mice develop diffuse large B cell lymphoma
    • Ranger AM, Zha J, Harada H et al (2003) Bad-deficient mice develop diffuse large B cell lymphoma. Proc Natl Acad Sci U S A 100:9324-9329
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 9324-9329
    • Ranger, A.M.1    Zha, J.2    Harada, H.3
  • 36
    • 0242410719 scopus 로고    scopus 로고
    • p53-and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa
    • Villunger A, Michalak EM, Coultas L et al (2003) p53-and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa. Science 302:1036-1038
    • (2003) Science , vol.302 , pp. 1036-1038
    • Villunger, A.1    Michalak, E.M.2    Coultas, L.3
  • 37
    • 14844285335 scopus 로고    scopus 로고
    • Genome-wide array-based CGH for mantle cell lymphoma: Identification of homozygous deletions of the proapoptotic gene BIM
    • Tagawa H, Karnan S, Suzuki R et al (2005) Genome-wide array-based CGH for mantle cell lymphoma: Identification of homozygous deletions of the proapoptotic gene BIM. Oncogene 24:1348-1358
    • (2005) Oncogene , vol.24 , pp. 1348-1358
    • Tagawa, H.1    Karnan, S.2    Suzuki, R.3
  • 38
    • 33846010700 scopus 로고    scopus 로고
    • Homozygous deletions localize novel tumor suppressor genes in B-cell lymphomas
    • Mestre-Escorihuela C, Rubio-Moscardo F, Richter JA et al (2007) Homozygous deletions localize novel tumor suppressor genes in B-cell lymphomas. Blood 109:271-280
    • (2007) Blood , vol.109 , pp. 271-280
    • Mestre-Escorihuela, C.1    Rubio-Moscardo, F.2    Richter, J.A.3
  • 39
    • 0036097786 scopus 로고    scopus 로고
    • Keeping killers on a tight leash: Transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins
    • Puthalakath H, Strasser A (2002) Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins. Cell Death Differ 9:505-512
    • (2002) Cell Death Differ , vol.9 , pp. 505-512
    • Puthalakath, H.1    Strasser, A.2
  • 40
    • 0035341218 scopus 로고    scopus 로고
    • Interleukin 3-dependent activation of DREAM is involved in transcriptional silencing of the apoptotic Hrk gene in hematopoietic progenitor cells
    • Sanz C, Mellstrom B, Link W et al (2001) Interleukin 3-dependent activation of DREAM is involved in transcriptional silencing of the apoptotic Hrk gene in hematopoietic progenitor cells. EMBO J 20:2286-2292
    • (2001) EMBO J , vol.20 , pp. 2286-2292
    • Sanz, C.1    Mellstrom, B.2    Link, W.3
  • 41
    • 0035992688 scopus 로고    scopus 로고
    • Oblimersen Bcl-2 antisense: Facilitating apoptosis in anticancer treatment
    • Klasa RJ, Gillum AM, Klem RE et al (2002) Oblimersen Bcl-2 antisense: facilitating apoptosis in anticancer treatment. Antisense Nucleic Acid Drug Dev 12:193-213
    • (2002) Antisense Nucleic Acid Drug Dev , vol.12 , pp. 193-213
    • Klasa, R.J.1    Gillum, A.M.2    Klem, R.E.3
  • 42
    • 33745863017 scopus 로고    scopus 로고
    • Drug insight: Cancer therapy strategies based on restoration of endogenous cell death mechanisms
    • Reed JC (2006) Drug insight: Cancer therapy strategies based on restoration of endogenous cell death mechanisms. Nat Clin Pract Oncol 3:388-398
    • (2006) Nat Clin Pract Oncol , vol.3 , pp. 388-398
    • Reed, J.C.1
  • 43
    • 0035147650 scopus 로고    scopus 로고
    • Antimycin A mimics a cell-death-inducing Bcl-2 homology domains 3
    • Tzung SP, Kim KM, Basanez G et al (2001) Antimycin A mimics a cell-death-inducing Bcl-2 homology domains 3. Nat Cell Biol 3:183-191
    • (2001) Nat Cell Biol , vol.3 , pp. 183-191
    • Tzung, S.P.1    Kim, K.M.2    Basanez, G.3
  • 44
    • 7444241537 scopus 로고    scopus 로고
    • Breast cancer cells can evade apoptosis-mediated selective killing by a novel small molecule inhibitor of Bcl-2
    • Real PJ, Cao Y, Wang R et al (2004) Breast cancer cells can evade apoptosis-mediated selective killing by a novel small molecule inhibitor of Bcl-2. Cancer Res 64:7947-7953
    • (2004) Cancer Res , vol.64 , pp. 7947-7953
    • Real, P.J.1    Cao, Y.2    Wang, R.3
  • 45
    • 0141569444 scopus 로고    scopus 로고
    • Discovery, characterization, and structure-activity relationships studies of proapoptotic polyphenols targeting B-cell lymphocyte/ leukemia-2 proteins
    • Kitada S, Leone M, Sareth S et al (2003) Discovery, characterization, and structure-activity relationships studies of proapoptotic polyphenols targeting B-cell lymphocyte/leukemia-2 proteins. J Med Chem 46:4259-4264
    • (2003) J Med Chem , vol.46 , pp. 4259-4264
    • Kitada, S.1    Leone, M.2    Sareth, S.3
  • 46
    • 0024347970 scopus 로고
    • Monoclonal antibody-mediated tumor regression by induction of apoptosis
    • Trauth BC, Klas C, Peters AM et al (1989) Monoclonal antibody-mediated tumor regression by induction of apoptosis. Science 245:301-305
    • (1989) Science , vol.245 , pp. 301-305
    • Trauth, B.C.1    Klas, C.2    Peters, A.M.3
  • 47
    • 0036467427 scopus 로고    scopus 로고
    • Increased susceptibility to tumor initiation and metastasis in TNF-related apoptosis-inducing lig-and-deficient mice
    • Cretney E, Takeda K, Yagita H et al (2002) Increased susceptibility to tumor initiation and metastasis in TNF-related apoptosis-inducing lig-and-deficient mice. J Immunol 168:1356-1361
    • (2002) J Immunol , vol.168 , pp. 1356-1361
    • Cretney, E.1    Takeda, K.2    Yagita, H.3
  • 48
    • 0032929520 scopus 로고    scopus 로고
    • Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo
    • Walczak H, Miller RE, Ariail K et al (1999) Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo. Nat Med 5:157-163
    • (1999) Nat Med , vol.5 , pp. 157-163
    • Walczak, H.1    Miller, R.E.2    Ariail, K.3
  • 49
    • 9244237679 scopus 로고    scopus 로고
    • TRAIL inhibits tumor growth but is nontoxic to human hepatocytes in chimeric mice
    • Hao C, Song JH, Hsi B et al (2004) TRAIL inhibits tumor growth but is nontoxic to human hepatocytes in chimeric mice. Cancer Res 64:8502-8506
    • (2004) Cancer Res , vol.64 , pp. 8502-8506
    • Hao, C.1    Song, J.H.2    Hsi, B.3
  • 50
    • 34248187996 scopus 로고    scopus 로고
    • Phase I pharmacokinetic and biologic correlative study of mapatumumab, a fully human monoclonal antibody with agonist activity to tumor necrosis factor-related apoptosis-inducing ligand receptor-1
    • Tolcher AW, Mita M, Meropol NJ et al (2007) Phase I pharmacokinetic and biologic correlative study of mapatumumab, a fully human monoclonal antibody with agonist activity to tumor necrosis factor-related apoptosis-inducing ligand receptor-1. J Clin Oncol 25:1390-1395
    • (2007) J Clin Oncol , vol.25 , pp. 1390-1395
    • Tolcher, A.W.1    Mita, M.2    Meropol, N.J.3
  • 51
    • 9144234685 scopus 로고    scopus 로고
    • Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity
    • Schimmer AD, Welsh K, Pinilla C et al (2004) Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity. Cancer Cell 5:25-35
    • (2004) Cancer Cell , vol.5 , pp. 25-35
    • Schimmer, A.D.1    Welsh, K.2    Pinilla, C.3
  • 52
    • 4444243683 scopus 로고    scopus 로고
    • A small molecule Smac mimic potentiates TRAIL-and TNFalpha-mediated cell death
    • Li L, Thomas RM, Suzuki H et al (2004) A small molecule Smac mimic potentiates TRAIL-and TNFalpha-mediated cell death. Science 305:1471-1474
    • (2004) Science , vol.305 , pp. 1471-1474
    • Li, L.1    Thomas, R.M.2    Suzuki, H.3
  • 53
    • 0037428217 scopus 로고    scopus 로고
    • Distinctive roles of PHAP proteins and prothymosin-alpha in a death regulatory pathway
    • Jiang X, Kim HE, Shu H et al (2003) Distinctive roles of PHAP proteins and prothymosin-alpha in a death regulatory pathway. Science 299:223-226
    • (2003) Science , vol.299 , pp. 223-226
    • Jiang, X.1    Kim, H.E.2    Shu, H.3
  • 54
    • 0347320714 scopus 로고    scopus 로고
    • Discovery, characterization and SAR of gambogic acid as a potent apoptosis inducer by a HTS assay
    • Zhang HZ, Kasibhatla S, Wang Y et al (2004) Discovery, characterization and SAR of gambogic acid as a potent apoptosis inducer by a HTS assay. Bioorg Med Chem 12:309-317
    • (2004) Bioorg Med Chem , vol.12 , pp. 309-317
    • Zhang, H.Z.1    Kasibhatla, S.2    Wang, Y.3
  • 55
    • 33748759801 scopus 로고    scopus 로고
    • Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy
    • Putt KS, Chen GW, Pearson JM et al (2006) Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy. Nat Chem Biol 2:543-550
    • (2006) Nat Chem Biol , vol.2 , pp. 543-550
    • Putt, K.S.1    Chen, G.W.2    Pearson, J.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.