Role of the cyclic AMP response element in the bcl-2 promoter in the regulation of endogenous Bcl-2 expression and apoptosis in murine B cells

Molecular and Cellular Biology

Volumn 26, Issue 22, 2006, Pages 8599-8606

  Xiang, Hong ^a   Wang, Jinghong ^a   Boxer, Linda M ^a,b  

^a STANFORD UNIVERSITY   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; IMMUNOGLOBULIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN BCL 2;

ANIMAL CELL; APOPTOSIS; ARTICLE; B LYMPHOCYTE; CELL SURVIVAL; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; CYCLIC AMP RESPONSIVE ELEMENT; GENE TARGETING; MOUSE; NONHUMAN; PRE B LYMPHOCYTE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION;

ANIMALS; APOPTOSIS; B-LYMPHOCYTES; BINDING SITES; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; GENE EXPRESSION REGULATION; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS C-BCL-2; SPLEEN; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION;

MURINAE;

EID: 33751006438     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.01062-06     Document Type: Article

References (38)

1. +-ATPaSe inhibitor. Exp. Cell Res. 238:82-89.
2. Barton, K., N. Muthusamy, M. Chanyangam, C. Fischer, C. Clendenin, and J. M. Leiden. 1996. Defective thymocyte proliferation and IL-1 production in transgenic mice expressing a dominant-negative form of CREB. Nature 379:81-85.
3. Butscher, W. G., C. Powers, M. Olive, C. Vinson, and K. Gardner. 1998. Coordinate transactivation of the interleukin-2 CD28 response element by C-Rel and ATF-1/CREB2. J. Biol. Chem. 273:552-560.
4. Desoize, B. 1994. Anticancer drug resistance and inhibition of apoptosis. Anticancer Res. 14:2291-2294.
5. Dong, L., W. Wang, F. Wang, M. Stoner, J. C. Reed, M. Harigai, I. Samudio, M. P. Kladde, C. Vyhlidal, and S. Safe. 1999. Mechanisms of transcriptional activation of bcl-2 gene expression by 17beta-estradiol in breast cancer cells. J. Biol. Chem. 274:32099-32107.
6. Du, W., D. Thanos, and T. Maniatis. 1993. Mechanisms of transcriptional synergism between distinct virus-inducible enhancer elements. Cell 74:887-898.
7. Duan, H., C. A. Heckman, and L. M. Boxer. 2005. Histone deacetylase inhibitors down-regulate bcl-2 expression and induce apoptosis in t(14;18) lymphomas. Mol. Cell. Biol. 25:1608-1619.
8. Graninger, W. B., M. Seto, B. Boutain, P. Goldman, and S. J. Korsmeyer. 1987. Expression of bcl-2 and bcl-2-Ig fusion transcripts in normal and neoplastic cells. J. Clin. Investig. 80:1512-1515.
9. Gurfinkel, N., T. Unger, D. Givol, and J. F. Mushinski. 1987. Expression of the bcl-2 gene in mouse B lymphocytic cell lines is differentiation stage specific. Eur. J. Immunol. 17:567-570.
10. Heckman, C. A., J. W. Mehew, and L. M. Boxer. 2002. NF-κB activates bcl-2 expression in t(14;18) lymphoma cells. Oncogene 21:3898-3908.
11. Hockenbery, D. M., M. Zutter, W. Hickey, M. Nahm, and S. J. Korsmeyer. 1991. BCL2 protein is topographically restricted in tissue characterized by apoptotic cell death. Proc. Natl. Acad. Sci. USA 88:6961-6965.
12. Huang, H., J. C. Cheville, Y. Pan, P. C. Roche, L. J. Schmidt, and D. J. Tindall. 2001. PTEN induces chemosensitivity in PTEN-mutated prostate cancer cells by suppression of bcl-2 expression. J. Biol. Chem. 276:38830-38836.
13. Itzhaki, O., E. Skutelsky, T. Kaptzan, J. Sinai, M. Michowitz, M. Huszar, and J. Leibovici. 2003. Ageing-apoptosis relation in murine spleen. Mech. Ageing Dev. 124:999-1012.
14. Ji, L., E. Mochon, M. Arcinas, and L. M. Boxer. 1996. CREB proteins function as positive regulators of the translocated bcl-2 allele in t(14;18) lymphomas. J. Biol. Chem. 271:22687-22691.
15. Kaszubska, W., R. Hooft van Huijsduijnen, P. Ghersa, A. M. DeRaemy-Schenk, B. P. Chen, T. Hai, J. F. DeLamarter, and J. Whelan. 1993. Cyclic AMP-independent ATF family members interact with NF-κB and function in the activation of the E-selectin promoter in response to cytokines. Mol. Cell. Biol. 13:7180-7190.
16. Korsmeyer, S. J. 1992. Bcl-2 initiates a new category of oncogenes: regulators of cell death. Blood 80:879-886.
17. Levy, Y., and J.-C. Brouet. 1994. Interleukin-10 prevents spontaneous death of germinal center B cells by induction of the bcl-2 protein. J. Clin. Investig. 93:424-428.
18. Lewandoski, M., E. N. Meyers, and G. R. Martin. 1997. Analysis of Fgf8 gene function in vertebrate development. Cold Spring Harbor Symp. Quant. Biol. 62:159-168.
19. Liu, Y.-J., D. Y. Mason, G. D. Johnson, S. Abbot, C. D. Gregory, D. L. Hardie, J. Gordon, and I. C. M. MacLennan. 1991. Germinal center cells express bcl-2 protein after activation by signals which prevent their entry into apoptosis. Eur. J. Immunol. 21:1905-1910.
20. Lu, L., and D. G. Osmond. 1997. Apoptosis during B lymphopoiesis in the mouse bone marrow. J. Immunol. 158:5136-5145.
21. Maraskovsky, E., J. J. Peschon, H. McKenna, M. Teepe, and A. Strasser. 1998. Overexpression of Bcl-2 does not rescue impaired B lymphopoiesis in IL-7 receptor-deficient mice but can enhance survival of mature B cells. Int. Immunol. 10:1367-1375.
22. Marsden, V. S., and A. Strasser. 2003. Control point of apoptosis in the immune system: bcl-2, BH3-only protein and more. Annu. Rev. Immunol. 21:71-105.
23. Mehrhof, F. B., F. U. Muller, M. W. Bergmann, P. Li, Y. Wang, W. Schmitz, R. Dietz, and R. von Harsdorf. 2001. In cardiomyocyte hypoxia, insulin-like growth factor-I-induced antiapoptotic signaling requires phosphatidylinositol-3- OH-kinase-dependent and mitogen-activated protein kinase-dependent activation of the transcription factor cAMP response element-binding protein. Circulation 104:2088-2094.
24. Menendez, P., A. Vargas, C. Bueno, S. Barrena, J. Almeida, M. de Santiago, A. Lopez, S. Roa, J. F. San Miguel, and A. Orfao. 2004. Quantitative analysis of bcl-2 expression in normal and leukemic human B-cell differentiation. Leukemia 18:491-498.
25. Merino, R., L. Ding, D. J. Veis, S. J. Korsmeyer, and G. Nunez. 1994. Developmental regulation of the Bcl-2 protein and susceptibility to cell death in B lymphocytes. EMBO J. 13:683-691.
26. Nakayama, K., I. Negishi, K. Kuida, H. Sawa, and D. Y. Loh. 1994. Targeted disruption of Bcl-2 αβ in mice: occurrence of gray hair, polycystic kidney disease and lymphocytopenia. Proc. Natl. Acad. Sci. USA 91:3700-3704.
27. Ning, Z.-Q., J. D. Norton, D. Johnson, and J. J. Murphy. 1995. Early gene signalling-dependent and -independent induction of apoptosis in Ramos human B cells can be inhibited by over-expression of bcl-2. Biochem. Biophys. Res. Commun. 215:23-29.
28. Opferman, J. T., A. Letai, C. Beard, M. D. Sorcinelli, C. C. Ong, and S. J. Korsmeyer. 2003. Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1. Nature 426:671-676.
29. Pugazhenthi, S., E. Miller, C. Sable, K. A. Heidenreich, L. M. Boxer, and J. E. B. Reusch. 1999. Insulin-like growth factor induces bcl-2 promoter through the transcription factor cAMP-response element-binding protein. J. Biol. Chem. 274:27529-27535.
30. Pugazhenthi, S., A. Nesterova, C. Sable, K. A. Heidenreich, L. M. Boxer, L. E. Heasley, and J. E. B. Reusch. 2000. Akt/protein kinase B up-regulates bcl-2 expression through cAMP-response element-binding protein. J. Biol. Chem. 275:10761-10766.
31. Rathmell, J. C., and C. B. Thompson. 1999. The central effectors of cell death in the immune system. Annu. Rev. Immunol. 17:781-828.
32. Reed, J. C., S. Kitada, S. Takayama, and T. Miyashita. 1994. Regulation of chemoresistance by the bcl-2 oncoprotein in non-Hodgkin's lymphoma and lymphocytic leukemia cell lines. Ann. Oncol. 5(Suppl. 1):S61-S65.
33. Riccio, A., S. Ahn, C. M. Davenport, J. A. Blendy, and D. D. Ginty. 1999. Mediation by a CREB family transcription factor of NGF-dependent survival of sympathetic neurons. Science 286:2358-2361.
34. Veis, D. J., C. M. Sorenson, J. R. Shutter, and S. J. Korsmeyer. 1993. Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair. Cell 75:229-240.
35. Whitley, M. Z., D. Thanos, M. A. Read, T. Maniatis, and T. Collins. 1994. A striking similarity in the organization of the E-selectin and beta interferon gene promoters. Mol. Cell. Biol. 14:6464-6475.
36. Wilson, B. E., E. Mochon, and L. M. Boxer. 1996. Induction of bcl-2 expression by phosphorylated CREB proteins during B-cell activation and rescue from apoptosis. Mol. Cell. Biol. 16:5546-5556.
37. Zhang, C., Y.-L. Wu, and L. M. Boxer. 2002. Impaired proliferation and survival of activated B cells in transgenic mice that express a dominant-negative cAMP-response element-binding protein transcription factor in B cells. J. Biol. Chem. 277:48359-48365.
38. Zhang, F., M. Rincon, R. A. Flavell, and T. M. Aune. 2000. Defective Th function induced by a dominant-negative cAMP response element binding protein mutation is reversed by bcl-2. J. Immunol. 165:1762-1770.