메뉴 건너뛰기




Volumn 30, Issue 12, 2007, Pages 1635-1645

Intracerebral microdialysis technique and its application on brain pharmacokinetic-pharmacodynamic study

Author keywords

Analgesic drug; Antidepressant drug; Antiepileptic drug; Extracellular fluid; Intracerebral microdialysis; Pharmacokinetic pharmacodynamic

Indexed keywords


EID: 38049186780     PISSN: 02536269     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02977335     Document Type: Review
Times cited : (16)

References (67)
  • 2
    • 33747781409 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic profiles of the novel serotonin and norepinephrine reuptake inhibitor desvenlafaxine succinate in ovariectomized Sprague-Dawley rats
    • Alfinito, P. D., Huselton, C., Chen, X., and Deecher. D. C., Pharmacokinetic and pharmacodynamic profiles of the novel serotonin and norepinephrine reuptake inhibitor desvenlafaxine succinate in ovariectomized Sprague-Dawley rats. Brain Res., 1098, 71-78 (2006).
    • (2006) Brain Res , vol.1098 , pp. 71-78
    • Alfinito, P.D.1    Huselton, C.2    Chen, X.3    Deecher, D.C.4
  • 3
    • 15044362005 scopus 로고    scopus 로고
    • Effects of combined lamotrigine and valproate on basal and stimulated extracellular amino acids and monoamines in the hippocampus of freely moving rats
    • Ahmad, S., Fowler, L. J., and Whitton, P. S., Effects of combined lamotrigine and valproate on basal and stimulated extracellular amino acids and monoamines in the hippocampus of freely moving rats. Naunyn-Schmiedebergs. Arch. Pharmacol., 371, 1-8 (2005).
    • (2005) Naunyn-Schmiedebergs. Arch. Pharmacol , vol.371 , pp. 1-8
    • Ahmad, S.1    Fowler, L.J.2    Whitton, P.S.3
  • 4
    • 0030890279 scopus 로고    scopus 로고
    • Relevance of the application of pharmacokinetic-pharmacodynamic modeling concepts in drug development. The "Wooden Shoe" paradigm
    • Breimer, D. D. and Danhof, M., Relevance of the application of pharmacokinetic-pharmacodynamic modeling concepts in drug development. The "Wooden Shoe" paradigm. Clin. Pharmacokin., 32, 259-267 (1997).
    • (1997) Clin. Pharmacokin , vol.32 , pp. 259-267
    • Breimer, D.D.1    Danhof, M.2
  • 5
    • 33646061674 scopus 로고    scopus 로고
    • Microdialysis versus other techniques for the clinical assessment of in vivo tissue drug distribution
    • Brunner, M. and Langer, O., Microdialysis versus other techniques for the clinical assessment of in vivo tissue drug distribution. AAPS J., 8, E263-E272 (2006).
    • (2006) AAPS J , vol.8
    • Brunner, M.1    Langer, O.2
  • 6
    • 0035679267 scopus 로고    scopus 로고
    • Blood-brain barrier transport and brain distribution of morphine-6-glucuronide in relation to the antinociceptive effect in rats-pharmacokinetic/ pharmacodynamic modelling
    • Bouw, M. R., Xie, R., Tunblad, K., and Hammarlund-Udenaeas M., Blood-brain barrier transport and brain distribution of morphine-6-glucuronide in relation to the antinociceptive effect in rats-pharmacokinetic/ pharmacodynamic modelling. Br. J. Pharmacol., 134, 1796-1804 (2001).
    • (2001) Br. J. Pharmacol , vol.134 , pp. 1796-1804
    • Bouw, M.R.1    Xie, R.2    Tunblad, K.3    Hammarlund-Udenaeas, M.4
  • 7
    • 0034293553 scopus 로고    scopus 로고
    • Pharmacokinetic-pharmacodynamic modelling of morphine transport across the blood-brain barrier as a cause of the antinociceptive effect delay in rats - a microdialysis study
    • Bouw, M. R., Gardmark, M., and Hammarlund-Udenaes, M., Pharmacokinetic-pharmacodynamic modelling of morphine transport across the blood-brain barrier as a cause of the antinociceptive effect delay in rats - a microdialysis study. Pharm. Res., 17, 1220-1228 (2000).
    • (2000) Pharm. Res , vol.17 , pp. 1220-1228
    • Bouw, M.R.1    Gardmark, M.2    Hammarlund-Udenaes, M.3
  • 8
    • 0034748784 scopus 로고    scopus 로고
    • Pharmacokinetics and Pharmacodynamics of 7-Nitroindazole, a Selective Nitric Oxide Synthase Inhibitor in the Rat Hippocampus
    • Bush, M. A. and Pollack, G. M., Pharmacokinetics and Pharmacodynamics of 7-Nitroindazole, a Selective Nitric Oxide Synthase Inhibitor in the Rat Hippocampus. Pharm. Res., 18, 1607-1612 (2001).
    • (2001) Pharm. Res , vol.18 , pp. 1607-1612
    • Bush, M.A.1    Pollack, G.M.2
  • 9
    • 0030830683 scopus 로고    scopus 로고
    • Effect of citalopram on brain serotonin release in experimental hepatic encephalopathy: Implications for thymoleptic drug safety in liver insufficiency
    • Berqqvist, P. B., Wikell, C., Hjorth, S., Bergqvist, P. B., Apeldqvist, G., and Bengtsson, F., Effect of citalopram on brain serotonin release in experimental hepatic encephalopathy: implications for thymoleptic drug safety in liver insufficiency. Clin. Neuropharmacol., 20, 511-522 (1997).
    • (1997) Clin. Neuropharmacol , vol.20 , pp. 511-522
    • Berqqvist, P.B.1    Wikell, C.2    Hjorth, S.3    Bergqvist, P.B.4    Apeldqvist, G.5    Bengtsson, F.6
  • 10
    • 18844370877 scopus 로고    scopus 로고
    • The dual transporter inhibitor duloxetine: A review of its preclinical pharmacology, pharmacokinetic profile, and clinical results in depression
    • Bymaster, F. P., Lee, T. C., Knadler, M. P., Detke, M. J., and Ivenqar, S., The dual transporter inhibitor duloxetine: a review of its preclinical pharmacology, pharmacokinetic profile, and clinical results in depression. Curr. Pharm. Des., 11, 1475-1493 (2005).
    • (2005) Curr. Pharm. Des , vol.11 , pp. 1475-1493
    • Bymaster, F.P.1    Lee, T.C.2    Knadler, M.P.3    Detke, M.J.4    Ivenqar, S.5
  • 11
    • 33846871218 scopus 로고    scopus 로고
    • An integrated microdialysis rat model for multiple pharmacokinetic/pharmacodynamic investigations of serotonergic agents
    • Bundgaard, C., Jorqensen, M., and Mork, A., An integrated microdialysis rat model for multiple pharmacokinetic/pharmacodynamic investigations of serotonergic agents. J. Pharmacol. Toxicol. Methods., 55, 214-223 (2006).
    • (2006) J. Pharmacol. Toxicol. Methods , vol.55 , pp. 214-223
    • Bundgaard, C.1    Jorqensen, M.2    Mork, A.3
  • 12
    • 12344322943 scopus 로고    scopus 로고
    • How to measure drug transport across the blood-brain barrier
    • Bickel, U., How to measure drug transport across the blood-brain barrier. NeuroRx., 2, 15-26 (2005).
    • (2005) NeuroRx , vol.2 , pp. 15-26
    • Bickel, U.1
  • 13
    • 0034672637 scopus 로고    scopus 로고
    • Microdialysis in mice for drug delivery research
    • Boschi, G. and Scherrmann, J., Microdialysis in mice for drug delivery research. Adv. Drug Deliv. Rev., 45, 271-281 (2000).
    • (2000) Adv. Drug Deliv. Rev , vol.45 , pp. 271-281
    • Boschi, G.1    Scherrmann, J.2
  • 14
    • 0037280594 scopus 로고    scopus 로고
    • Intracerebral microdialysis: 30 years as a tool for the neuroscientist
    • Bourne, J. A., Intracerebral microdialysis: 30 years as a tool for the neuroscientist. Clin. Exp. Pharmacol. Physiol., 30, 16-24 (2003).
    • (2003) Clin. Exp. Pharmacol. Physiol , vol.30 , pp. 16-24
    • Bourne, J.A.1
  • 15
    • 2542462018 scopus 로고    scopus 로고
    • Simultaneous determination of vigabatrin and amino acid neurotransmitters in brain microdialysates by capillary electrophoresis with laser-induced fluorescence detection
    • Benturquia, N., Parrot, S., Sauvinet, V., Renaud, B., and Denoroy, L., Simultaneous determination of vigabatrin and amino acid neurotransmitters in brain microdialysates by capillary electrophoresis with laser-induced fluorescence detection. J. Chromatogr. B. Analyt. Technol. Biomed. Life. Sci., 806, 237-244 (2004).
    • (2004) J. Chromatogr. B. Analyt. Technol. Biomed. Life. Sci , vol.806 , pp. 237-244
    • Benturquia, N.1    Parrot, S.2    Sauvinet, V.3    Renaud, B.4    Denoroy, L.5
  • 16
    • 2942608904 scopus 로고    scopus 로고
    • Simultaneous central nervous system distribution and pharmacokinetic-pharmacodynamic modelling of the electroencephalogram effect of norfloxacin administered at a convulsant dose in rats
    • Chenel, M., Marchand, S., Dupuis, A., Lamarche, I., Paquereau, J., Pariat, C., and Couet, W., Simultaneous central nervous system distribution and pharmacokinetic-pharmacodynamic modelling of the electroencephalogram effect of norfloxacin administered at a convulsant dose in rats. Br. J. Pharmacol., 142, 323-330 (2004).
    • (2004) Br. J. Pharmacol , vol.142 , pp. 323-330
    • Chenel, M.1    Marchand, S.2    Dupuis, A.3    Lamarche, I.4    Paquereau, J.5    Pariat, C.6    Couet, W.7
  • 17
    • 0037470754 scopus 로고    scopus 로고
    • Synergistic interaction between felbamate and lamotrigine against seizures induced by 4-aminopyridine and pentylenetetrazole in mice
    • Cuadrado, A., Bravo, J., and Armijo, J. A., Synergistic interaction between felbamate and lamotrigine against seizures induced by 4-aminopyridine and pentylenetetrazole in mice. Eur. J. Pharmacol., 465, 43-52 (2003).
    • (2003) Eur. J. Pharmacol , vol.465 , pp. 43-52
    • Cuadrado, A.1    Bravo, J.2    Armijo, J.A.3
  • 18
    • 0033842216 scopus 로고    scopus 로고
    • The anticonvulsant lamotrigine decreases spontaneous glutamate release but increases spontaneous GABA release in the rat entorhinal cortex in vivo
    • Cunningham, M. O. and Jones, R. S., The anticonvulsant lamotrigine decreases spontaneous glutamate release but increases spontaneous GABA release in the rat entorhinal cortex in vivo. Neuropharmacology, 39, 2139-2141 (2000).
    • (2000) Neuropharmacology , vol.39 , pp. 2139-2141
    • Cunningham, M.O.1    Jones, R.S.2
  • 19
    • 0033922585 scopus 로고    scopus 로고
    • Effect of amygdala kindling on the central nervous system effects of tiagabine: Effects versus brain GABA levels
    • Cleton, A., Altorf, B. A., Voskuyl, R. A., and Danhof, M., Effect of amygdala kindling on the central nervous system effects of tiagabine: Effects versus brain GABA levels. Br. J. Pharmacol., 130, 1037-1044 (2000).
    • (2000) Br. J. Pharmacol , vol.130 , pp. 1037-1044
    • Cleton, A.1    Altorf, B.A.2    Voskuyl, R.A.3    Danhof, M.4
  • 20
    • 24944457231 scopus 로고    scopus 로고
    • Hippocampal dopamine and serotonin elevations as pharmacodynamic markers for the anticonvulsant efficacy of oxcarbazepine and 10,11-dihydro-10- hydroxycarbamazepine
    • Clinckers, R., Smolders, I., Meurs, A., Ebinger, G., and Michotte, Y., Hippocampal dopamine and serotonin elevations as pharmacodynamic markers for the anticonvulsant efficacy of oxcarbazepine and 10,11-dihydro-10- hydroxycarbamazepine. Neurosci. Lett. 390, 48-53 (2005a).
    • (2005) Neurosci. Lett , vol.390 , pp. 48-53
    • Clinckers, R.1    Smolders, I.2    Meurs, A.3    Ebinger, G.4    Michotte, Y.5
  • 21
    • 22944434897 scopus 로고    scopus 로고
    • Quantitative in vivo microdialysis study on the influence of multidrug transporters on the blood-brain barrier passage of oxcarbazepine: Conconmitant use of hippocampal monoamine as pharmacodynamic markers for the anticonvulsant activity
    • Clinckers, R., Smolders, I., Meurs, A., Ebinger, G., and Michotte, Y., Quantitative in vivo microdialysis study on the influence of multidrug transporters on the blood-brain barrier passage of oxcarbazepine: conconmitant use of hippocampal monoamine as pharmacodynamic markers for the anticonvulsant activity. J. Pharmacol. Exp. Ther., 314, 725-731 (2005b).
    • (2005) J. Pharmacol. Exp. Ther , vol.314 , pp. 725-731
    • Clinckers, R.1    Smolders, I.2    Meurs, A.3    Ebinger, G.4    Michotte, Y.5
  • 22
    • 0242412135 scopus 로고    scopus 로고
    • Separation methods that are capable of revealing blood-brain barrier permeability
    • Dash, A. K. and Elmquist, W. F., Separation methods that are capable of revealing blood-brain barrier permeability. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci., 797, 241-254 (2003).
    • (2003) J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci , vol.797 , pp. 241-254
    • Dash, A.K.1    Elmquist, W.F.2
  • 24
    • 24044497597 scopus 로고    scopus 로고
    • Mechanism-based pharmacokinetic/pharmacodynamic modeling - a new classification of biomarkers
    • Danhof, M., Alvan, G., Dahl, S. G., Kuhlmann, J., and Paintaud, G., Mechanism-based pharmacokinetic/pharmacodynamic modeling - a new classification of biomarkers. Pharm. Res., 22, 1432-1437 (2005).
    • (2005) Pharm. Res , vol.22 , pp. 1432-1437
    • Danhof, M.1    Alvan, G.2    Dahl, S.G.3    Kuhlmann, J.4    Paintaud, G.5
  • 26
    • 33749335206 scopus 로고    scopus 로고
    • Comparing nucleus accumbens and dorsal striatal dopamine responses to self-administered cocaine in naive rats
    • D'Souza, M. S. and Duvauchelle, C. L., Comparing nucleus accumbens and dorsal striatal dopamine responses to self-administered cocaine in naive rats. Neurosci. Lett., 408, 146-150 (2006).
    • (2006) Neurosci. Lett , vol.408 , pp. 146-150
    • D'Souza, M.S.1    Duvauchelle, C.L.2
  • 27
    • 0030806636 scopus 로고    scopus 로고
    • Methodological considerations of intracerebral microdialysis in pharmacokinetic studies on drug transport across the blood-brain barrier
    • de Lang, E. C., Danhof, M., de Boer, A.G., and Breimer, D. D., Methodological considerations of intracerebral microdialysis in pharmacokinetic studies on drug transport across the blood-brain barrier. Brain Res. Rev., 25, 27-49(1997).
    • (1997) Brain Res. Rev , vol.25 , pp. 27-49
    • de Lang, E.C.1    Danhof, M.2    de Boer, A.G.3    Breimer, D.D.4
  • 28
    • 33644812284 scopus 로고    scopus 로고
    • Toward the prediction of CNs drug-effect profiles in physiological and pathological conditions using MD and mechanism-based pharmacokinetic- pharmacodynamic modeling
    • de Lang E. C., Ravenstijn P. G., Groenendaal D., and van Steeg T. J., Toward the prediction of CNs drug-effect profiles in physiological and pathological conditions using MD and mechanism-based pharmacokinetic- pharmacodynamic modeling. AAPS J., 7, E532-E543 (2005).
    • (2005) AAPS J , vol.7
    • de Lang, E.C.1    Ravenstijn, P.G.2    Groenendaal, D.3    van Steeg, T.J.4
  • 29
    • 0027964247 scopus 로고
    • Effects of single and chronic treatment with tranylcypromine on extracellular serotonin in rat brain
    • Ferrer, A. and Artiqas, F., Effects of single and chronic treatment with tranylcypromine on extracellular serotonin in rat brain. Eur. J. Pharmacol., 263, 227-34 (1994).
    • (1994) Eur. J. Pharmacol , vol.263 , pp. 227-234
    • Ferrer, A.1    Artiqas, F.2
  • 30
    • 0027527737 scopus 로고
    • Biotransformation to nitric oxide of organic nitrates in comparison to other nitrovasodilators
    • Feelisch, M., Biotransformation to nitric oxide of organic nitrates in comparison to other nitrovasodilators. Eur. Heart J., 14, 123-132 (1993).
    • (1993) Eur. Heart J , vol.14 , pp. 123-132
    • Feelisch, M.1
  • 31
    • 0034574284 scopus 로고    scopus 로고
    • Greig, N. H., De, Micheli. E., Holloway, H. W., Yu, Q. S., Utsuki, T., Perry, T. A., Brossi, A., Ingram, D. K., Deutsch, J., Lahiri, D. K., and Soncrant, T. T., The experimental Alzheimer drug phenserine: preclinical pharmacokinetics and pharmacodynamics. Acta. Neurol. Scand. Suppl., 176, 74-84 (2000).
    • Greig, N. H., De, Micheli. E., Holloway, H. W., Yu, Q. S., Utsuki, T., Perry, T. A., Brossi, A., Ingram, D. K., Deutsch, J., Lahiri, D. K., and Soncrant, T. T., The experimental Alzheimer drug phenserine: preclinical pharmacokinetics and pharmacodynamics. Acta. Neurol. Scand. Suppl., 176, 74-84 (2000).
  • 32
    • 22244457958 scopus 로고    scopus 로고
    • High-performance liquid chromatography of nalbuphine, butorphanol and morphine in blood and brain microdialysate samples: Application to pharmacokinetic/ pharmacodynamic studies in rats
    • Groenendaal, D., Blom-Roosemalen, M. C., Danhof, M., and Lange, E. C., High-performance liquid chromatography of nalbuphine, butorphanol and morphine in blood and brain microdialysate samples: application to pharmacokinetic/ pharmacodynamic studies in rats. J. Chromatogr. B. Analyt. Technol. Biomed. Life. Sci., 822, 230-237 (2005).
    • (2005) J. Chromatogr. B. Analyt. Technol. Biomed. Life. Sci , vol.822 , pp. 230-237
    • Groenendaal, D.1    Blom-Roosemalen, M.C.2    Danhof, M.3    Lange, E.C.4
  • 33
    • 3042776739 scopus 로고    scopus 로고
    • Gatto, G. J. , Bohme, G. A., Caldwell, W. S., Letchworth, S. R., Traina, V. M., Obinum, M. C., Laville, M., Reibaud, M., Pradier, L., Dunbar, G., and Bencherif, M., TC-1734: an orally active neuronal nicotinic acetylcholine receptor modulator with antidepressant neuroprotective and long-lasting cognitive effects. CNS. Drug. Rev., 10, 147-166 (2004).
    • Gatto, G. J. , Bohme, G. A., Caldwell, W. S., Letchworth, S. R., Traina, V. M., Obinum, M. C., Laville, M., Reibaud, M., Pradier, L., Dunbar, G., and Bencherif, M., TC-1734: an orally active neuronal nicotinic acetylcholine receptor modulator with antidepressant neuroprotective and long-lasting cognitive effects. CNS. Drug. Rev., 10, 147-166 (2004).
  • 34
    • 0034852860 scopus 로고    scopus 로고
    • In vivo microdialysis for nonapeptides in rat brain - a practical guide
    • Horn, T. F. and Engelmann, M., In vivo microdialysis for nonapeptides in rat brain - a practical guide, Methods, 23,41-53 (2001).
    • (2001) Methods , vol.23 , pp. 41-53
    • Horn, T.F.1    Engelmann, M.2
  • 35
    • 0022975323 scopus 로고
    • A small, removable microdialysis probe
    • Hernandez, L., Stanley, B. G., and Hoebel, B. G., A small, removable microdialysis probe. Life. Sci., 39, 2629-2637 (1986).
    • (1986) Life. Sci , vol.39 , pp. 2629-2637
    • Hernandez, L.1    Stanley, B.G.2    Hoebel, B.G.3
  • 36
    • 0024655054 scopus 로고
    • Haloperidol given chronically decreases basal dopamine in the prefrontal cortex more than the striatum or nucleus accumbens as simultaneously measured by microdialysis
    • Hernandez, L. and Hoebel, B. G., Haloperidol given chronically decreases basal dopamine in the prefrontal cortex more than the striatum or nucleus accumbens as simultaneously measured by microdialysis. Brain Res. Bull., 22, 763-769 (1989).
    • (1989) Brain Res. Bull , vol.22 , pp. 763-769
    • Hernandez, L.1    Hoebel, B.G.2
  • 37
    • 4544261139 scopus 로고    scopus 로고
    • Pharmacodynamics of morphine-induced neuronal nitric oxide production and antinociceptive tolerance development
    • Heinzen, E. L. and Pollack, G. M., Pharmacodynamics of morphine-induced neuronal nitric oxide production and antinociceptive tolerance development. Brain Res., 1023, 175-184 (2004).
    • (2004) Brain Res , vol.1023 , pp. 175-184
    • Heinzen, E.L.1    Pollack, G.M.2
  • 38
    • 0030842561 scopus 로고    scopus 로고
    • Cocaine pharmacokinetics/pharmacodynamics in awake freely moving rats
    • Hedava, M. A. and Pan W. J., Cocaine pharmacokinetics/pharmacodynamics in awake freely moving rats. Pharm. Res., 14, 1099-1113 (1997).
    • (1997) Pharm. Res , vol.14 , pp. 1099-1113
    • Hedava, M.A.1    Pan, W.J.2
  • 39
    • 0032486151 scopus 로고    scopus 로고
    • Differential effects of chronic imipramine and fluoxetine on basal and amphetamine-induced extracellular dopamine levels in rat nucleus accumbens
    • Ichikawa, J., Kuroki, T., and Meltzer, H. Y., Differential effects of chronic imipramine and fluoxetine on basal and amphetamine-induced extracellular dopamine levels in rat nucleus accumbens. Eur. J. Pharmacol., 350, 159-164 (1998).
    • (1998) Eur. J. Pharmacol , vol.350 , pp. 159-164
    • Ichikawa, J.1    Kuroki, T.2    Meltzer, H.Y.3
  • 40
    • 0022404730 scopus 로고
    • Mass transfer in brain dialysis devices - a new method for the estimation of extracellular amino acids concentration
    • Jacobson, I., Sandberg, M., and Hamberger, A., Mass transfer in brain dialysis devices - a new method for the estimation of extracellular amino acids concentration. J. Neurosci. Methods, 15, 263-268 (1985).
    • (1985) J. Neurosci. Methods , vol.15 , pp. 263-268
    • Jacobson, I.1    Sandberg, M.2    Hamberger, A.3
  • 41
    • 15244352983 scopus 로고    scopus 로고
    • Towards a mechanism-based analysis of pharmacodynamic drug-drug interactions in vivo
    • Jonker, D. M., Visser, S. A., Graaf, P. H., Voskuyl, R. A., and Danhof, M., Towards a mechanism-based analysis of pharmacodynamic drug-drug interactions in vivo. Pharmacol. Ther., 106, 1-18 (2005).
    • (2005) Pharmacol. Ther , vol.106 , pp. 1-18
    • Jonker, D.M.1    Visser, S.A.2    Graaf, P.H.3    Voskuyl, R.A.4    Danhof, M.5
  • 42
    • 0034854787 scopus 로고    scopus 로고
    • The technique of intracerebral microdialysis
    • Khan, S. H. and Shuaib, A., The technique of intracerebral microdialysis. Methods, 23, 3-9 (2001).
    • (2001) Methods , vol.23 , pp. 3-9
    • Khan, S.H.1    Shuaib, A.2
  • 43
    • 0023627577 scopus 로고
    • A microdialysis method allowing characterization of intercellular water space in humans
    • Lonnroth, P., Jansson P. A., and Smith U., A microdialysis method allowing characterization of intercellular water space in humans. Am. J. Physiol., 253, E228-E231 (1987).
    • (1987) Am. J. Physiol , vol.253
    • Lonnroth, P.1    Jansson, P.A.2    Smith, U.3
  • 44
    • 0025743370 scopus 로고
    • The use of an "internal standard" for control of the recovery in microdialysis
    • Larsson, C. I., The use of an "internal standard" for control of the recovery in microdialysis. Life Sci., 49, PL73-PL78 (1991).
    • (1991) Life Sci , vol.49
    • Larsson, C.I.1
  • 45
    • 0026802049 scopus 로고
    • Push-pull perfusion and microdialysis studies of central oxytocin and vasopressin release in freely moving rats during pregnancy, parturition, and lactation
    • Landgraf, R., Neumann, I., Russel, J. A., and Pittman, Q. J., Push-pull perfusion and microdialysis studies of central oxytocin and vasopressin release in freely moving rats during pregnancy, parturition, and lactation. Ann. N. Y. Acad. Sci., 652, 326-339 (1992).
    • (1992) Ann. N. Y. Acad. Sci , vol.652 , pp. 326-339
    • Landgraf, R.1    Neumann, I.2    Russel, J.A.3    Pittman, Q.J.4
  • 46
    • 33845316415 scopus 로고    scopus 로고
    • 125Icobrotoxin after intranasal administration to the brain: A microdialysis study in freely moving rats
    • 125Icobrotoxin after intranasal administration to the brain: A microdialysis study in freely moving rats. Int. J. Pharm., 328, 161-167 (2007).
    • (2007) Int. J. Pharm , vol.328 , pp. 161-167
    • Li, F.1    Feng, J.2    Cheng, Q.3    Zhu, W.4    Jin, Y.5
  • 47
    • 33645836476 scopus 로고    scopus 로고
    • Microdialysis as a tool in local pharmacodynamics
    • Li, Y., Peris, J., Zhong, L., and Derendorf, H., Microdialysis as a tool in local pharmacodynamics. AAPS J., 8, E222-E235 (2006).
    • (2006) AAPS J , vol.8
    • Li, Y.1    Peris, J.2    Zhong, L.3    Derendorf, H.4
  • 48
    • 12244305837 scopus 로고    scopus 로고
    • Investigation of the high partition of YM992, a novel antidepressant, in rat brain - in vitro and in vivo evidence for the high binding in brain and the high permeability at the BBB
    • Mano, Y., Hiquchi, S., and Kamimura, H., Investigation of the high partition of YM992, a novel antidepressant, in rat brain - in vitro and in vivo evidence for the high binding in brain and the high permeability at the BBB. Biopham. Drug Dispos., 23, 351-360 (2002).
    • (2002) Biopham. Drug Dispos , vol.23 , pp. 351-360
    • Mano, Y.1    Hiquchi, S.2    Kamimura, H.3
  • 49
    • 0346099204 scopus 로고    scopus 로고
    • Neuronal activity in the nucleus accumbens is necessary for performance-related in cortical acetylcholine release
    • Netigh, G. N., Arnold, H. M., Rabenstein, R. L., Sarter, M., and Bruno, J. P., Neuronal activity in the nucleus accumbens is necessary for performance-related in cortical acetylcholine release. Neuroscience, 123, 635-645 (2004).
    • (2004) Neuroscience , vol.123 , pp. 635-645
    • Netigh, G.N.1    Arnold, H.M.2    Rabenstein, R.L.3    Sarter, M.4    Bruno, J.P.5
  • 50
    • 0027255699 scopus 로고
    • Extracellular neuroactive amino acids in the rat brain striatum during ischaemia: Comparison between penumbral conditions and ischaemia with sustained anoxic depolarisation
    • Obrenovitch, T. P., Urenjak, J., Richards, D. A., Ueda, Y., Curzon, G., and Symon, L., Extracellular neuroactive amino acids in the rat brain striatum during ischaemia: comparison between penumbral conditions and ischaemia with sustained anoxic depolarisation. J. Neurochem., 61,178-186 (1993).
    • (1993) J. Neurochem , vol.61 , pp. 178-186
    • Obrenovitch, T.P.1    Urenjak, J.2    Richards, D.A.3    Ueda, Y.4    Curzon, G.5    Symon, L.6
  • 51
    • 2442578153 scopus 로고    scopus 로고
    • Microdialysis of the brain structures: Application in behavioral research on vasopressin and oxytocin
    • Orlowska-Majdak M., Microdialysis of the brain structures: application in behavioral research on vasopressin and oxytocin. Acta. Neurobiol. Exp.(Wars), 64,177-188 (2004).
    • (2004) Acta. Neurobiol. Exp.(Wars) , vol.64 , pp. 177-188
    • Orlowska-Majdak, M.1
  • 52
    • 18044370880 scopus 로고    scopus 로고
    • Microdialysis - theoretical background and recent implementation in applied life-sciences
    • Plock, N. and Kloft, C., Microdialysis - theoretical background and recent implementation in applied life-sciences. Eur. J. Pharm. Sci., 25, 1-24 (2005).
    • (2005) Eur. J. Pharm. Sci , vol.25 , pp. 1-24
    • Plock, N.1    Kloft, C.2
  • 53
    • 0033934196 scopus 로고    scopus 로고
    • Cerebral microdialysis as a new tool for neurometabolic monitoring
    • Peerdeman, S. M., Girbes, A. R., and Vandertop, W. P., Cerebral microdialysis as a new tool for neurometabolic monitoring. Intensive Care. Med., 26, 662-669 (2000).
    • (2000) Intensive Care. Med , vol.26 , pp. 662-669
    • Peerdeman, S.M.1    Girbes, A.R.2    Vandertop, W.P.3
  • 55
    • 33646467730 scopus 로고    scopus 로고
    • Effect of the attention deficit/hyperactivity disorder drug atomoxetine on extracellular concentrations of norepinephrine and dopamine in several brain regions of the rat
    • Swanson, C. J., Perry, K. W., Koch-Krueger, S., Katner, J., Svensson, K. A., and Bvmaster, F. P., Effect of the attention deficit/hyperactivity disorder drug atomoxetine on extracellular concentrations of norepinephrine and dopamine in several brain regions of the rat. Neuropharmacology, 50, 755-760 (2006).
    • (2006) Neuropharmacology , vol.50 , pp. 755-760
    • Swanson, C.J.1    Perry, K.W.2    Koch-Krueger, S.3    Katner, J.4    Svensson, K.A.5    Bvmaster, F.P.6
  • 56
    • 0242412188 scopus 로고    scopus 로고
    • Assaying protein unbound drugs using microdialysis techniques
    • Tsai, T. H., Assaying protein unbound drugs using microdialysis techniques. J. Chromatogr. B. Analyt. Technol. Biomed. Life. Sci., 797, 161-173 (2003).
    • (2003) J. Chromatogr. B. Analyt. Technol. Biomed. Life. Sci , vol.797 , pp. 161-173
    • Tsai, T.H.1
  • 57
    • 0025994730 scopus 로고
    • Microdialysis - principles and applications for studies in animals and man
    • Ungerstedt, U., Microdialysis - principles and applications for studies in animals and man. J. Intern. Med., 230, 365-373 (1991).
    • (1991) J. Intern. Med , vol.230 , pp. 365-373
    • Ungerstedt, U.1
  • 58
    • 0016138960 scopus 로고
    • Functional correlates of dopamine neurotransmission
    • Ungerstedt, U. and Pycock, C., Functional correlates of dopamine neurotransmission. Bull. Schweiz. Akad. Med. Wiss., 30, 44-55 (1974).
    • (1974) Bull. Schweiz. Akad. Med. Wiss , vol.30 , pp. 44-55
    • Ungerstedt, U.1    Pycock, C.2
  • 59
    • 0022363313 scopus 로고
    • In vivo brain dialysis of amino acids and simultaneous EEG measurements following intrahippocampal quinolinic acid injection: Evidence for a dissociation between neurochemical changes and seizures
    • Vezzani, A., Ungerstedt, U., French, E. D., and Schwarcz, R., In vivo brain dialysis of amino acids and simultaneous EEG measurements following intrahippocampal quinolinic acid injection: evidence for a dissociation between neurochemical changes and seizures. J. Neurochem., 45, 335-344 (1985).
    • (1985) J. Neurochem , vol.45 , pp. 335-344
    • Vezzani, A.1    Ungerstedt, U.2    French, E.D.3    Schwarcz, R.4
  • 60
    • 0028892459 scopus 로고
    • Brain microdialysis and its application for the study of animal behaviour
    • Westerink B. H., Brain microdialysis and its application for the study of animal behaviour. Behav. Brain Res., 70, 130-124 (1995).
    • (1995) Behav. Brain Res , vol.70 , pp. 130-124
    • Westerink, B.H.1
  • 61
    • 10344265982 scopus 로고    scopus 로고
    • Application of triple-probe microdialysis for fast pharmacokinetic/pharmacodynamic evaluation of dopamimetic activity of drug candidates in the rat brain
    • Weikop, P., Eqestad, B., and Kehr, J., Application of triple-probe microdialysis for fast pharmacokinetic/pharmacodynamic evaluation of dopamimetic activity of drug candidates in the rat brain. J. Neurosci. Methods, 140, 59-65 (2004).
    • (2004) J. Neurosci. Methods , vol.140 , pp. 59-65
    • Weikop, P.1    Eqestad, B.2    Kehr, J.3
  • 62
    • 0036019861 scopus 로고    scopus 로고
    • Effects on drug disposition, brain monoamines and behavior after chronic treatment with the antidepressant venlafaxine in rats with experimental hepatic encephalopathy
    • Wikell, C., Apelqvist, G., Hjorth, S., Kullingsjo, J., Bergqvist, P. B., and Bengtsson, F., Effects on drug disposition, brain monoamines and behavior after chronic treatment with the antidepressant venlafaxine in rats with experimental hepatic encephalopathy. Eur. Neuropsychopharmacol., 12, 327-336 (2002).
    • (2002) Eur. Neuropsychopharmacol , vol.12 , pp. 327-336
    • Wikell, C.1    Apelqvist, G.2    Hjorth, S.3    Kullingsjo, J.4    Bergqvist, P.B.5    Bengtsson, F.6
  • 63
    • 0035204034 scopus 로고    scopus 로고
    • Effect of halving the dose of venlafaxine to adjust for putative pharmacokinetic and pharmacodynamic changes in an animal model of chronic hepatic encephalopathy
    • Wikell, C., Kugelberg F. C., Hjorth, S., Apeldqvist, G., and Bengtsson, F., Effect of halving the dose of venlafaxine to adjust for putative pharmacokinetic and pharmacodynamic changes in an animal model of chronic hepatic encephalopathy. Clin Neuropharmacal, 24, 324-333 (2001a).
    • (2001) Clin Neuropharmacal , vol.24 , pp. 324-333
    • Wikell, C.1    Kugelberg, F.C.2    Hjorth, S.3    Apeldqvist, G.4    Bengtsson, F.5
  • 65
    • 0031684641 scopus 로고    scopus 로고
    • Duloxetine (LY 248686): An inhibitor of serotonin and noradrenaline uptake and an antidepressant drug candidate
    • Wong, D. T., Duloxetine (LY 248686): an inhibitor of serotonin and noradrenaline uptake and an antidepressant drug candidate. Expert. Opin. Investig. Drugs, 7, 1691-1699 (1998).
    • (1998) Expert. Opin. Investig. Drugs , vol.7 , pp. 1691-1699
    • Wong, D.T.1
  • 66
    • 19444384011 scopus 로고    scopus 로고
    • Pharmacokinetic- pharmacodynamic modeling of the antinociceptive effect of buprenorphine and fentanyl in rats: Role of receptor equilibration kinetics
    • Yassen, A., Olofsen, E., Dahan, A., and Danhof M., Pharmacokinetic- pharmacodynamic modeling of the antinociceptive effect of buprenorphine and fentanyl in rats: role of receptor equilibration kinetics. J. Pharmacol. Exp. Ther., 313,1136-1149 (2005).
    • (2005) J. Pharmacol. Exp. Ther , vol.313 , pp. 1136-1149
    • Yassen, A.1    Olofsen, E.2    Dahan, A.3    Danhof, M.4
  • 67
    • 33644813608 scopus 로고    scopus 로고
    • In vivo microdialysis for PK and PD studies of anticancer drugs
    • Zhou, Q. and Gallo, J. M., In vivo microdialysis for PK and PD studies of anticancer drugs. AAPS J., 7, E659-E667 (2005).
    • (2005) AAPS J , vol.7
    • Zhou, Q.1    Gallo, J.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.