Microdialysis as a tool in local pharmacodynamics

AAPS Journal

Volumn 8, Issue 2, 2006, Pages

  Li, Yanjun ^a   Peris, Joanna ^a   Zhong, Li ^b   Derendorf, Hartmut ^a  

^a UNIVERSITY OF FLORIDA HEALTH   (United States)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

Glucose; Hormone; Microdialysis; Neurotransmitter; Pharmacodynamics (PD)

Indexed keywords

ACAMPROSATE; ACETYLCHOLINE; ALCOHOL; AMANTADINE; AMINO ACID; ANGIOTENSIN ANTAGONIST; APOMORPHINE; ATROPINE; CATECHOLAMINE; CHOLINESTERASE INHIBITOR; COCAINE; GLUCOSE; GLYCEROL; HALOPERIDOL; INSULIN; ISOFLURANE; LACTIC ACID; LEVODOPA; NALTREXONE; NEOSTIGMINE; PEPTIDE; PROSTACYCLIN; PSYCHOTROPIC AGENT; QUETIAPINE; SCOPOLAMINE; SELEGILINE; SEROTONIN; SEROTONIN UPTAKE INHIBITOR; TRICYCLIC ANTIDEPRESSANT AGENT; UNINDEXED DRUG;

ACETYLCHOLINE BRAIN LEVEL; ACETYLCHOLINE RELEASE; ALCOHOL WITHDRAWAL; BRAIN INJURY; CATECHOLAMINE BRAIN LEVEL; COGNITION; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENTIATION; DRUG TISSUE LEVEL; EXTRACELLULAR SPACE; EXTRAPYRAMIDAL SYMPTOM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HYPOGLYCEMIA; HYPOTENSION; LOW DRUG DOSE; MICRODIALYSIS; NEUROTRANSMITTER RELEASE; NONHUMAN; PARKINSON DISEASE; PHARMACODYNAMICS; RELIABILITY; REVIEW; SENSITIVITY AND SPECIFICITY; SEROTONIN BRAIN LEVEL;

ACETYLCHOLINE; ANIMALS; BRAIN CHEMISTRY; CATECHOLAMINES; HUMANS; MICRODIALYSIS; NEUROTRANSMITTER AGENTS; PHARMACOLOGY;

EID: 33645836476     PISSN: 15507416     EISSN: None     Source Type: Journal    
DOI: 10.1208/aapsj080226     Document Type: Review

References (155)

1. Muller M. Science, medicine, and the future: microdialysis. BMJ. 2002;324:588-591.
2. de la Pena A, Liu P, Derendorf H. Microdialysis in peripheral tissues. Adv Drug Deliv Rev. 2000;45:189-216.
3. Yokoyama M, Suzuki E, Sato T, et al. Amygdalic levels of dopamine and serotonin rise upon exposure to conditioned fear stress without elevation of glutamate. Neurosci Lett. 2005;379:37-41.
4. Humpel C, Ebendal T, Olson L. Microdialysis: a way to study in vivo release of neurotrophic bioactivity: a critical summary. J Mol Med. 1996;74:523-526.
5. Tsai TH. Assaying protein unbound drugs using microdialysis techniques. J Chromatogr B Analyt Technol Biomed Life Sci. 2003;797:161-173.
6. Flechtner-Mors M, Jenkinson CP, Alt A, et al. Sympathetic regulation of glucose uptake by the alphal-adrenoceptor in human obesity. Obes Res. 2004;12:612-620.
7. Johansen MJ, Newman RA, Madden T. The use of microdialysis in pharmacokinetics and pharmacodynamics. Pharmacotherapy. 1997;17:464-481.
8. Banker MJ, Clark TH, Williams JA. Development and validation of a 96-well equilibrium dialysis apparatus for measuring plasma protein binding. J Pharm Sci. 2003;92:967-974.
9. Linhares MC, Kissinger PT. Pharmacokinetic monitoring in subcutaneous tissue using in vivo capillary ultrafiltration probes. Pharm Res. 1993;10:598-602.
10. Janle EM, Kissinger PT. Microdialysis and ultrafiltration. Adv Food Nutr Res. 1996;40:183-196.
11. Garrison KE, Pasas SA, Cooper JD, et al. A review of membrane sampling from biological tissues with applications in pharmacokinetics, metabolism and pharmacodynamics. Eur J Pharm Sci. 2002;17:1-12.
12. Leegsma-Vogt G, Janle E, Ash SR, et al. Utilization of in vivo ultrafiltration in biomedical research and clinical applications. Life Sci. 2003;73:2005-2018.
13. Major CJ, Read SE, Coates RA, et al. Comparison of saliva and blood for human immunodeficiency virus prevalence testing. J Infect Dis. 1991;163:699-702.
14. Muller M, Brunner M, Schmid R, et al. Comparison of three different experimental methods for the assessment of peripheral compartment pharmacokinetics in humans. Life Sci. 1998;62:PL227-PL234.
15. Hofman LF. Human saliva as a diagnostic specimen. J Nutr. 2001;131:1621S-1625S.
16. Borg N, Gotharson E, Benfeldt E, Groth L, Stable L. Distribution to the skin of penciclovir after oral famciclovir administration in healthy volunteers: comparison of the suction blister technique and cutaneous microdialysis. Acta Derm Venereol. 1999;79:274-277.
17. Keck FS, Kerner W, Meyerhoff C, et al. Combination of microdialysis and glucosensor permits continuous (on line) SC glucose monitoring in a patient operated device, I: in vitro evaluation. Horm Metab Res. 1991;23:617-618.
18. Keck FS, Meyerhoff C, Kerner W, et al. Combination of microdialysis and glucosensor permits continuous (on line) SC glucose monitoring in a patient operated device, II: evaluation in animals. Horm Metab Res. 1992;24:492-493.
19. Bolinder J, Ungerstedt U, Amer P. Long-term continuous glucose monitoring with microdialysis in ambulatory insulin-dependent diabetic patients. Lancet. 1993;342:1080-1085.
20. Freckmann G, Kalatz B, Pfeiffer B, et al. Recent advances in continuous glucose monitoring. Exp Clin Endocrinol Diabetes. 2001;109:S347-S357.
21. Liu P, Muller M, Derendorf H. Rational dosing of antibiotics: the use of plasma concentrations versus tissue concentrations. Int J Antimicrob Agents. 2002;19:285-290.
22. Flechtner-Mors M, Jenkinson CP, Alt A, et al. Sympathetic regulation of glucose uptake by the alpha 1-adrenoceptor in human obesity. Obes Res. 2004;12:612-620.
23. Muller M. Microdialysis in clinical drug delivery studies. Adv Drug Deliv Rev. 2000;45:255-269.
24. Hansen DK, Davies MI, Lunte SM, et al. Pharmacokinetic and metabolism studies using microdialysis sampling. J Pharm Sci. 1999;88:14-27.
25. de Lange EC, de Boer AG, Breimer DD. Methodological issues in microdialysis sampling for pharmacokinetic studies. Adv Drug Deliv Rev. 2000;45:125-148.
26. Parent M, Bush D, Rauw G, et al. Analysis of amino acids and catecholamines, 5-hydroxytryptamine and their metabolites in brain areas in the rat using in vivo microdialysis. Methods. 200 1;23:11-20.
27. Day JC, Kornecook TJ, Quirion R. Application of in vivo microdialysis to the study of cholinergic systems. Methods. 2001;23:21-39.
28. Hows ME, Lacroix L, Heidbreder C, et al. High-performance liquid chromatography/tandem mass spectrometric assay for the simultaneous measurement of dopamine, norepinephrine, 5-hydroxytryptamine and cocaine in biological samples. J Neurosci Methods. 2004;138:123-132.
29. Baseski HM, Watson CJ, Cellar NA, et al. Capillary liquid chromatography with MS3 for the determination of enkephalins in microdialysis samples from the striatum of anesthetized and freely-moving rats. J Mass Spectrom. 2005;40:146-153.
30. Bowser MT, Kennedy RT. In vivo monitoring of amine neurotransmitters using microdialysis with on-line capillary electrophoresis. Electrophoresis. 2001;22:3668-3676.
31. Huynh BH, Fogarty BA, Martin RS, et al. On-line coupling of microdialysis sampling with microchip-based capillary electrophoresis. Anal Chem. 2004;76:6440-6447.
32. Kanamori K, Ross BD. Suppression of glial glutamine release to the extracellular fluid studied in vivo by NMR and microdialysis in hyperammonemic rat brain. J Neurochem. 2005;94:74-85.
33. Lucas LH, Wilson SF, Lunte CE, et al. Concentration profiling in rat tissue by high-resolution magic-angle spinning NMR spectroscopy: investigation of a model drug. Anal Chem. 2005;77:2978-2984.
34. Mayer BX, Namiranian K, Dehghanyar P, et al. Comparison of UV and tandem mass spectrometric detection for the high-performance liquid chromatographic determination of diclofenac in microdialysis samples. J Pharm Biomed Anal. 2003;33:745-754.
35. Kanamori K, Kondrat RW, Ross BD. 13C enrichment of extracellular neurotransmitter glutamate in rat brain: combined mass spectrometry and NMR studies of neurotransmitter turnover and uptake into glia in vivo. Cell Mol Biol (Noisy-le-grand). 2003;49:819-836.
36. Lindon JC. HPLC-NMR-MS: past, present and future. Drug Discov Today. 2003;8:1021-1022.
37. Lindon JC, Nicholson JK, Wilson ID. Directly coupled HPLC-NMR and HPLC-NMR-MS in pharmaceutical research and development. J Chromatogr B Biomed Sci Appl. 2000;748:233-258.
38. Lommen A, Godejohann M, Venema DP, et al. Application of directly coupled HPLC-NMR-MS to the identification and confirmation of quercetin glycosides and phloretin glycosides in apple peel. Anal Chem. 2000;72:1793-1797.
39. Pepeu G, Giovannini MG. Changes in acetylcholine extracellular levels during cognitive processes. Learn Mem. 2004;11:21-27.
40. Ungerstedt U, Pycock C. Functional correlates of dopamine neurotransmission. Bull Schweiz Akad Med Wiss. 1974;30:44-55.
41. Bourne JA. Intracerebral microdialysis: 30 years as a tool for the neuroscientist. Clin Exp Pharmacol Physiol. 2003;30:16-24.
42. Khan SH, Shuaib A. The technique of intracerebral microdialysis. Methods. 2001;23:3-9.
43. Giovannini MG, Bartolini L, Kopf SR, et al. Acetylcholine release from the frontal cortex during exploratory activity. Brain Res. 1998;784:218-227.
44. Maysinger D, Herrera-Marschitz M, Carlsson A, et al. Striatal and cortical acetylcholine release in vivo in rats with unilateral decortication: effects of treatment with monosialoganglioside GMI. Brain Res. 1988;461:355-360.
45. Redmond JM, Gillinov AM, Blue ME, et al. The monosialoganglioside, GMI, reduces neurologic injury associated with hypothermic circulatory arrest. Surgery. 1993;114:324-332.
46. Watanabe H, Shimizu H. Effect of anticholinergic drugs on striatal acetylcholine release and motor activity in freely moving rats studied by brain microdialysis. Jpn J Phannacol. 1989;51:75-82.
47. Gatto GJ, Bohme GA, Caldwell WS, et al. TC-1734: an orally active neuronal nicotinic acetylcholine receptor modulator with antidepressant, neuroprotective and long-lasting cognitive effects. CNS Drug Rev. 2004; 10: 147-166.
48. Kurokawa M, Koga K, Kase H, et al. Adenosine A2a receptor-mediated modulation of striatal acetylcholine release in vivo. J Neurochem. 1996;66:1882-1888.
49. Buchholzer ML, Klein J. NMDA-induced acetylcholine release in mouse striatum: role of NO synthase isoforms. J Neurochem. 2002;82:1558-1560.
50. Kart E, Jocham G, Muller CP, et al. Neurokinin-1 receptor antagonism by SR140333: enhanced in vivo ACh in the hippocampus and promnestic post-trial effects. Peptides. 2004;25:1959-1969.
51. De Souza Silva MA, Hasenohrl RU, Tomaz C, et al. Differential modulation of frontal cortex acetylcholine by injection of substance P into the nucleus basalis magnocellularis region in the freely-moving vs. the anesthetized preparation. Synapse. 2000;38:243-253.
52. Gibbs RB, Gabor R, Cox T, et al. Effects of raloxifene and estradiol on hippocampal acetylcholine release and spatial learning in the rat. Psychoneuroendocrinology. 2004;29:741-748.
53. Bernard R, Lydic R, Baghdoyan HA. Hypocretin-1 causes G protein activation and increases ACh release in rat pons. Eur J Neurosci. 2003;18:1775-1785.
54. Rakovska A, Kiss JP, Raichev P, et al. Somatostatin stimulates striatal acetylcholine release by glutamatergic receptors: an in vivo microdialysis study. Neurochem Int. 2002;40:269-275.
55. Vazquez J, Baghdoyan HA. GABAA receptors inhibit acetylcholine release in cat pontine reticular formation: implications for REM sleep regulation. J Neurophysiol. 2004;92:2198-2206.
56. Tanase D, Baghdoyan HA, Lydic R. Dialysis delivery of an adenosine A1 receptor agonist to the pontine reticular formation decreases acetylcholine release and increases anesthesia recovery time. Anesthesiology. 2003;98:912-920.
57. Elvander E, Schott PA, Sandin J, et al. Intraseptal muscarinic ligands and galanin: influence on hippocampal acetylcholine and cognition. Neuroscience. 2004;126:541-557.
58. Jansson A, Olin K, Yoshitake T, et al. Effects of isoflurane on prefrontal acetylcholine release and hypothalamic Fos response in young adult and aged rats. Exp Neurol. 2004;190:535-543.
59. Giovannini MG, Giovannelli L, Bianchi L, et al. Glutamatergic modulation of cortical acetylcholine release in the rat: a combined in vivo microdialysis, retrograde tracing and immunohistochemical study. Eur J Neurosci. 1997;9:1678-1689.
60. Yamamuro Y, Hori K, Tanaka J, et al. Septo-hippocampal cholinergic system under the discrimination learning task in the rat: a microdialysis study with the dual-probe approach. Brain Res. 1995;684:1-7.
61. Moor E, Schirm E, Jacso J, et al. Involvement of medial septal glutamate and GABAA receptors in behaviour-induced acetylcholine release in the hippocampus: a dual probe microdialysis study. Brain Res. 1998;789:1-8.
62. Arnold HM, Nelson CL, Neigh GN, et al. Systemic and intraaccumbens administration of amphetamine differentially affects cortical acetylcholine release. Neuroscience. 2000;96:675-685.
63. Zetterstrom T, Sharp T, Marsden CA, et al. In vivo measurement of dopamine and its metabolites by intracerebral dialysis: changes after d-amphetamine. J Neurochem. 1983;41:1769-1773.
64. Sharp T, Zetterstrom T, Ljungberg T, et al. A direct comparison of amphetamine-induced behaviours and regional brain dopamine release in the rat using intracerebral dialysis. Brain Res. 1987;401:322-330.
65. Parada M, Hernandez L, Schwartz D, et al. Hypothalamic infusion of amphetamine increases scrotonin, dopamine and norepinephrine. Physiol Behav. 1988;44:607-610.
66. Okuda C, Segal DS, Kuczenski R. Deprenyl alters behavior and caudate dopamine through an amphetamine-like action. Pharmacol Biochem Behav. 1992;43:1075-1080.
67. Melega WP, Cho AK, Schmitz D, et al. 1-methamphetamine pharmacokinetics and pharmacodynamics for assessment of in vivo deprenyl-derived 1-methamphetamine. J Pharmacol Exp Ther. 1999;288:752-758.
68. Pira L, Mongeau R, Pani L. The atypical antipsychotic quetiapine increases both noradrenaline and dopamine release in the rat prefrontal cortex. Eur J Pharmacol. 2004;504:61-64.
69. Ma S, Morilak DA. Norepinephrine release in medial amygdala facilitates activation of the hypothalamic-pituitary-adrenal axis in response to acute immobilisation stress. J Neuroendocrinol. 2005;17:22-28.
70. Kushikata T, Hirota K, Kotani N, et al. Isoflurane increases norepinephrine release in the rat preoptic area and the posterior hypothalamus in vivo and in vitro: relevance to thermoregulation during anesthesia. Neuroscience. 2005;131:79-86.
71. Williams JM, Steketee JD. Time-dependent effects of repeated cocaine administration on dopamine transmission in the medial prefrontal cortex. Neurophamacology. 2005;48:51-61.
72. Fadda P, Scherma M, Fresu A, et al. Dopamine and serotonin release in dorsal striatum and nucleus accumbens is differentially modulated by morphine in DBA/2J and C57BL/6J mice. Synapse. 2005;56:29-38.
73. Yoshimoto K, McBride WJ, Lumeng L, et al. Alcohol stimulates the release of dopamine and serotonin in the nucleus accumbens. Alcohol. 1992;9:17-22.
74. Yim HJ, Schallert T, Randall PK, et al. Comparison of local and systemic ethanol effects on extracellular doparmine concentration in rat nucleus accumbens by microdialysis. Alcohol Clin Exp Res. 1998;22:367-374.
75. Gonzales RA, Weiss F. Suppression of ethanol-reinforced behavior by naltrexone is associated with attenuation of the ethanol-induced increase in dialysate dopamine levels in the nucleus accumbens. J Neurosci. 1998;18:10663-10671.
76. Nurmi M, Sinclair JD, Kiianmaa K. Dopamine release during ethanol drinking in AA rats. Alcohol Clin Exp Res. 1998;22:1628-1633.
77. Yoshimoto K, Ueda S, Kato B, et al. Alcohol enhances characteristic releases of dopamine and serotonin in the central nucleus of the amygdala. Neurochem Int. 2000;37:369-376.
78. Phillips TJ, Brown KJ, Burkhart-Kasch S, et al. Alcohol preference and sensitivity are markedly reduced in mice lacking dopamine D2 receptors. Nat Neurosci. 1998;1:610-615.
79. Budygin EA, Phillips PE, Robinson DL, et al. Effect of acute ethanol on striatal dopamine neurotransmission in ambulatory rats. J Pharmacol Exp Ther. 2001;297:27-34.
80. Olive MF, Nannini MA, Ou CJ, et al. Effects of acute acamprosate and homotaurine on ethanol intake and ethanol-stimulated mesolimbic dopamine release. Eur J Pharmacol. 2002;43 7:55-61.
81. Sharp T, Bramwell SR, Clark D, et al. In vivo measurement of extracellular 5-hydroxytryptamine in hippocampus of the anaesthetized rat using microdialysis: changes in relation to 5-hydroxytryptaminergic neuronal activity. J Neurochem. 1989;53:234-240.
82. Sprouse JS, Bradberry CW, Roth RH, et al. 3,4-Methylenedioxymethamphetamine-induced release of serotonin and inhibition of dorsal raphe cell firing: potentiation by L-tryptophan. Eur J Phannacol. 1990;178:313-320.
83. Ferre S, Artigas F. Clozapine decreases serotonin extracellular levels in the nucleus accumbens by a dopamine receptor-independent mechanism. Neurosci Lett. 1995;187:61-64.
84. Dailey JW, Reith ME, Steidley KR, et al. Carbamazepine-induced release of serotonin from rat hippocampus in vitro. Epilepsia. 1998;39:1054-1063.
85. Voigt JP, Kienzle F, Sohr R, et al. Feeding and 8-OH-DPAT-related release of serotonin in the rat lateral hypothalamus. Pharmacol Biochem Behav. 2000;65:183-189.
86. Hayashi M, Nakai T, Bandoh T, et al. Acute effect of simultaneous administration of tryptophan and ethanol on serotonin metabolites in the locus coeruleus in rats. Eur J Pharmacol. 2003;462:61-66.
87. Luparini MR, Garrone B, Pazzagh M, et al. A cortical GABA-5HT interaction in the mechanism of action of the antidepressant trazodone. Prog Neuropsychopharmacol Biol Psychiatry. 2004;28:1117-1127.
88. Celik T, Goren MZ, Cinar K, et al. Fatigue of cholestasis and the serotoninergic neurotransmitter system in the rat. Hepatology. 2005;41:731-737.
89. Owen JC, Whitton PS. Effects of amantadine and budipine on antidepressant drug-evoked changes in extracellular 5-HT in the frontal cortex of freely moving rats. Br J Pharmacol. 2005;145:587-592.
90. Hernandez L, Lee F, Hoebel BG. Simultaneous microdialysis and amphetamine infusion in the nucleus accumbens and striatum of freely moving rats: increase in extracellular dopamine and serotonin. Brain Res Bull. 1987;19:623-628.
91. Stenfors C, Ross SB. Changes in extracellular 5-HIAA concentrations as measured by in vivo microdialysis technique in relation to changes in 5-HT release. Psychopharmacology (Berl). 2004;172:119-128.
92. Rollema H, Clarke T, Sprouse JS, et al. Combined administration of a 5-hydroxytryptamine (5-HT)ID antagonist and a 5-HT reuptake inhibitor synergistically increases 5-HT release in guinea pig hypothalamus in vivo. J Neurochem. 1996;67:2204-2207.
93. Stenfors C, Magnusson T, Larsson LG, et al. Synergism between 5-HTIB/ID and 5-HTIA receptor antagonists on turnover and release of 5-HT in guinea-pig brain in vivo. Naunyn Schmiedebergs Arch Phamacol. 1999;359:110-116.
94. Segovia J, Tossman U, Herrera-Marschitz M, et al. Garmmaaminobutyric acid release in the globus pallidus in vivo after a 6-hydroxydopamine lesion in the substantia nigra of the rat. Neuroscl Lett. 1986;70:364-368.
95. Butcher SP, Sandberg M, Hagberg H, et al. Cellular origins of endogenous amino acids released into the extracellular fluid of the rat striatum during severe insulin-induced hypoglycemia. J Neurochem. 1987;48:722-728.
96. Wang J, Shen LL, Cao YX, et al. Effects of electroacupuncture on pressor response to angiotensin-(l -7) by amino acid release in the rostral ventrolateral medulla. Acupunct Electrother Res. 2003;28:25-34.
97. Touchon JC, Holmer HK, Moore C, et al. Apomorphine-induced alterations in striatal and substantia nigra pars reticulata glutamate following unilateral loss of striatal dopamine. Exp Neurol. 2005;193:131-140.
98. Ahmad S, Fowler LJ, Whitton PS. Effects of acute and chronic lamotrigine treatment on basal and stimulated extracellular amino acids in the hippocampus of freely moving rats. Brain Res. 2004;1029:41-47.
99. Quertemont E, de Neuville J, De Witte P. Changes in the amygdala amino acid microdialysate after conditioning with a cue associated with ethanol. Psychopharmacology (Berl). 1998;139:71-78.
100. Dahchour A, De Witte P. Ethanol and amino acids in the central nervous system: assessment of the pharmacological actions of acamprosate. Prog Neurobiol. 2000;60:343-362.
101. Dahchour A, Quertemont E, De Witte P. Acute ethanol increases taurine but neither glutamate nor GABA in the nucleus accumbens of male rats: a microdialysis study. Alcohol Alcohol. 1994;29:485-487.
102. Dahchour A, Quertemont E, De Witte P. Taurine increases in the nucleus accumbens microdialysate after acute ethanol administration to naive and chronically alcoholised rats. Brain Res. 1996;735:9-19.
103. Quertemont E, Goffaux V, Vlaminck AM, et al. Oral taurine supplementation modulates ethanol-conditioned stimulus preference. Alcohol. 1998;16:201-206.
104. Quertemont E, Lallemand F, Colombo G, et al. Taurine and ethanol preference: a microdialysis study using Sardinian alcohol-preferring and non-preferring rats. Eur Neuropsychopharmacol. 2000;10:377-383.
105. Kamer SN, Weiss F. Neurochemical characteristics associated with ethanol preference in selected alcohol-preferring and -nonpreferring rats: a quantitative microdialysis study. Alcohol Clin Exp Res. 2001;25:198-205.
106. Piepponen TP, Kiianmaa K, Ahtee L. Effects of ethanol on the accumbal output of dopamine, GABA and glutamate in alcohol-tolerant and alcohol-nontolerant rats. Pharmacol Biochem Behav. 2002;74:21-30.
107. Quertemont E, Linotte S, de Witte P. Differential taurine responsiveness to ethanol in high- and low-alcohol sensitive rats: a brain microdialysis study. Eur J Pharmacol. 2002;444:143-150.
108. Dahchour A, De Witte P. Effect of repeated ethanol withdrawal on glutamate microdialysate in the hippocampus. Alcohol Clin Exp Res. 1999;23:1698-1703.
109. Dahchour A, De Witte P, Bolo N, et al. Central effects of acamprosate: part 1. Acamprosate blocks the glutamate increase in the nucleus accumbens microdialysate in ethanol withdrawn rats. Psychiatry Res. 1998;82:107-114.
110. Dahchour A, De Witte P. Taurine blocks the glutamate increase in the nucleus accumbens microdialysate of ethanol-dependent rats. Pharmacol Biochem Behav. 2000;65:345-350.
111. Dahchour A, De Witte P. Excitatory and inhibitory amino acid changes during repeated episodes of ethanol withdrawal: an in vivo microdialysis study. Eur J Pharmacol. 2003;459:171-178.
112. Dahchour A, De Witte P. Acamprosate decreases the hypermotility during repeated ethanol withdrawal. Alcohol. 1999;18:77-81.
113. Dahchour A, De Witte P. Effects of acamprosate on excitatory amino acids during multiple ethanol withdrawal periods. Alcohol Clin Exp Res. 2003;27:465-470.
114. Rooyackers O. Microdialysis to investigate tissue amino acid kinetics. Curr Opin Clin Nutr Metab Care. 2005;8:77-82.
115. Timmerman W, Westerink BH. Brain microdialysis of GABA and glutamate: what does it signify? Synapse. 1997;27:242-261.
116. Baker DA, McFarland K, Lake RW, et al. Neuroadaptations in cystine-glutamate exchange underlie cocaine relapse. Nat Neurosci. 2003;6:743-749.
117. Lada MW, Vickroy TW, Kennedy RT. High temporal resolution monitoring of glutamate and aspartate in vivo using microdialysis online with capillary electrophoresis with laser-induced fluorescence detection. Anal Chem. 1997;69:4560-4565.
118. Lada MW, Vickroy TW, Kennedy RT. Evidence for neuronal origin and metabotropic receptor-mediated regulation of extracellular glutamate and aspartate in rat striatum in vivo following electrical stimulation of the prefrontal cortex. J Neurochem. 1998;70:617-625.
119. Rooyackers O, Myrenfors P, Nygren J, et al. Insulin stimulated glucose disposal in peripheral tissues studied with microdialysis and stable isotope tracers. Clin Nutr. 2004;23:743-752.
120. Hom TF, Engelmann M. In vivo microdialysis for nonapeptides in rat brain - a practical guide. Methods. 200 1;23:41-53.
121. Lindefors N, Brodin E, Ungerstedt U. Amphetamine facilitates the in vivo release of neurokinin A in the nucleus accumbens of the rat. Eur J Phamacol. 1989;160:417-420.
122. Lindefors N, Brodin E, Ungerstedt U. Subchronic haloperidol treatment decreases the in vivo release of tachykinins in rat substantia nigra. Eur JPharmacol. 1989; 161:95-98.
123. Gruber SH, Mathe AA. Effects of typical and atypical antipsychotics on neuropeptide Y in rat brain tissue and microdialysates from ventral striatum. J Neurosci Res. 2000;61:458-463.
124. Landgraf R, Neumann I, Holsboer F, et al. Interleukin- 1 beta stimulates both central and peripheral release of vasopressin and oxytocin in the rat. Eur J Neurosci. 1995;7:592-598.
125. Vasilaki A, Papasava D, Hoyer D, et al. The somatostatin receptor (sstl) modulates the release of somatostatin in the nucleus accumbens of the rat. Neuropharmacology. 2004;47:612-618.
126. Olive MF, Koenig HN, Nannini MA, Hodge CW. Stimulation of endorphin neurotransmission in the nucleus accumbens by ethanol, cocaine, and amphetamine. J Neurosci. 2001;21:RC184.
127. Roth-Deri I, Schindler CJ, Yadid G. A critical role for beta-endorphin in cocaine-seeking behavior. Neuroreport. 2004;15:519-521.
128. Herz A. Endogenous opioid systems ind alcohol addiction. Psychophamacology (Berl). 1997;129:99-111.
129. Solinas M, Zangen A, Thiriet N, et al. Beta-endorphin elevations in the ventral tegmental area regulate the discriminative effects of delta-9-tetrahydrocannabinol. Eur J Neurosci. 2004;19:3183-3192.
130. Beinfeld MC, Connolly KJ, Pierce RC. Cocaine treatment increases extracellular cholecystokinin (CCK) in the nucleus accumbens shell of awake, freely moving rats, an effect that is enhanced in rats that are behaviorally sensitized to cocaine. J Neurochem. 2002;81:1021-1027.
131. Emmett MR, Andren PE, Caprioli RM. Specific molecular mass detection of endogenously released neuropeptides using in vivo microdialysis/mass spectrometry. J Neurosci Methods. 1995;62:141-147.
132. Haskins WE, Wang Z, Watson CJ, et al. Capillary LC-MS2 at the attomole level for monitoring and discovering endogenous peptides in microdialysis samples collected in vivo. Anal Chem. 2001;73:5005-5014.
133. Sijbesma H, Schipper J, Molewijk HE, et al. 8-hydroxy-2-(di-N-propylamino)tetralin increases the activity of adenylate cyclase in the hippocampus of freely-moving rats. Neuropharmacology. 1991;30:967-975.
134. Mi Z, Herzer WA, Zhang Y, Jackson EK. 3-isobutyl-l-methylxanthine decreases renal cortical interstitial levels of adenosine and inosine. Life Sci. 1994;54:277-282.
135. Wa HQ, Fuxe K, Schwarcz R. Neuronal Al receptors mediate increase in extracellular kynurenic acid after local intrastriatal adenosine infusion. J Neurochem. 2004;90:621-628.
136. Giuffrida A, Parsons LH, Kerr TM, Rodriguez de Fonseca F, Navarro M, Piomelli D. Dopamine activation of endogenous cannabinoid signaling in dorsal striaturn. Nat Neurosci. 1999;2:358-363.
137. Yamamoto M, Koshimura K, Sohmiya M, et al. Effect of erythropoietin on nitric oxide production in the rat hippocampus using in vivo brain microdialysis. Neuroscience. 2004;128:163-168.
138. Hara S, Mukai T, Kurosaki K, et al. Characterization of suppression of nitric oxide production by carbon monoxide poisoning in the striatum of free-moving rats, as determined by in vivo brain microdialysis. Brain Res. 2003;979:27-36.
139. Yang WP, Oshida Y, Wu W, et al. Effect of daily voluntary running on in vivo insulin action in rat skeletal muscle and adipose tissue as determined by the microdialysis technique. Int J Sports Med. 1995; 16:99-104.
140. Rosdahl H, Hamrin K, Ungerstedt U, et al. A microdialysis method for the in situ investigation of the action of large peptide molecules in human skeletal muscle: detection of local metabolic effects of insulin. Int J Biol Macromol. 2000;28:69-73.
141. Canal CE, McNay EC, Gold PE. Increases in extracellular fluid glucose levels in the rat hippocampus following an anesthetic dose of pentobarbital or ketamine-xylazine: an in vivo microdialysis study. Physiol Behav. 2005;84:245-250.
142. Gardenfors F, Nilsson A, Ungerstedt U, et al. Adverse biochemical and physiological effects of prostacyclin in experimental brain oedema. Acta Anaesthesiol Scand. 2004;48:1316-1321.
143. Hamrin K, Henriksson J. Local effect of vanadate on interstitial glucose and lactate concentrations in human skeletal muscle. Life Sci. 2005;76:2329-2338.
144. Djurhuus CB, Gravholt CH, Nielsen S, Pedersen SB, Moller N, Schmitz O. Additive effects of cortisol and growth hormone on regional and systemic lipolysis in humans. Am J Physiol Endocrinol Metab. 2004;286:E488-E494.
145. Richterova B, Stich V, Moro C, et al. Effect of endurance training on adrenergic control of lipolysis in adipose tissue of obese women. J Clin Endocrinol Metab. 2004;89:1325-1331.
146. Djurhuus CB, Gravholt CH, Nielsen S, et al. Effects of cortisol on lipolysis and regional interstitial glycerol levels in humans. Am J Physiol Endocrinol Metab. 2002;283:El72-El77.
147. The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med. 1993;329:977-986.
148. UK Prospective Diabetes Study (LTKPDS) Group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet. 1998;352:837-853.
149. Nakahara D, Nakamura M, Iigo M, et al. Bimodal circadian secretion of melatonin from the pineal gland in a living CBA mouse. Proc Natl Acad Sci USA. 2003;100:9584-9589.
150. Perreau-Lenz S, Kalsbeek A, Van Der Vliet J, et al. In vivo evidence for a controlled offset of melatonin synthesis at dawn by the suprachiasmatic nucleus in the rat. Neuroscience. 2005;130:797-803.
151. Hoffner L, Nielsen JJ, Langberg H, et al. Exercise but not prostanoids enhance levels of vascular endothelial growth factor and other proliferative agents in human skeletal muscle interstitium. J Physiol. 2003;550:217-225.
152. Garvin S, Dabrosin C. Tamoxifen inhibits secretion of vascular endothelial growth factor in breast cancer in vivo. Cancer Res. 2003;63:8742-8748.
153. Sandeep TC, Andrew R, Homer NZ, et al. Increased in vivo regeneration of cortisol in adipose tissue in human obesity and effects of the 11beta-hydroxysteroid dehydrogenase type 1 inhibitor carbenoxolone. Diabetes. 2005;54:872-879.
154. Pau KY, Lee CJ, Cowles A, et al. Possible involvement of norepinephrine transporter activity in the pulsatility of hypothalamic gonadotropin-releasing hormone release: influence of the gonad. J Neuroendocrinol. 1998;10:21-29.
155. Lindley SE, Bengoechea TG, Wong DL, et al. Mesotelencephalic dopamine neurochemical responses to glucocorticoid administration and adrenalectomy in Fischer 344 and Lewis rats. Brain Res. 2002;958:414-422.